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1. 发明申请

WO2006091223A2 MULTIMODAL METHOD FOR IDENTIFYING HAZARDOUS AGENTS 审中-公开
标题翻译：用于识别危险剂的多模式方法
公开(公告)号：WO2006091223A2
公开(公告)日：2006-08-31
申请号：PCT/US2005/023705
申请日：2005-06-30
申请人： CHEMIMAGE CORPORATION , NEISS, Jason , NELSON, Matthew, P. , TREADO, Patrick , SCHWEITZER, Robert
发明人： NEISS, Jason , NELSON, Matthew, P. , TREADO, Patrick , SCHWEITZER, Robert
IPC分类号： G01J3/44
CPC分类号： G01J3/44 , G01J3/10 , G01J3/32 , G01N21/21 , G01N21/6428 , G01N21/6458 , G01N21/65 , G01N2021/6417 , G01N2021/6484 , G01N2021/656
摘要： The invention relates to apparatus and methods for assessing occurrence of a hazardous agent in a sample by performing multimodal spectral analysis of the sample. Methods of employing Raman spectroscopy for entities in a sample which exhibit one or more optical properties characteristic of a hazardous agent are disclosed. Devices and systems suitable for performing such methods are also disclosed.
摘要翻译：本发明涉及通过对样品进行多峰频谱分析来评估样品中危险剂的发生的装置和方法。公开了对具有特征性危险物质的一种或多种光学特性的样品中的实体采用拉曼光谱的方法。还公开了适于执行这些方法的装置和系统。

2. 发明申请

WO2007123555A2 TIME AND SPACE RESOLVED STANDOFF HYPERSPECTRAL IED EXPLOSIVES LIDAR DETECTOR 审中-公开
标题翻译：时间和空间分辨率高分辨率高分辨率激光雷达探测器
公开(公告)号：WO2007123555A2
公开(公告)日：2007-11-01
申请号：PCT/US2006/022647
申请日：2006-06-09
申请人： CHEMIMAGE CORPORATION , TREADO, Patrick, J. , NELSON, Matthew, P. , HUBBLE, Hugh, W., II , NEISS, Jason
发明人： TREADO, Patrick, J. , NELSON, Matthew, P. , HUBBLE, Hugh, W., II , NEISS, Jason
IPC分类号： G01J3/12
CPC分类号： G01J3/36 , G01J3/02 , G01J3/0221 , G01J3/0264 , G01J3/2823 , G01J3/44 , G01N21/359 , G01N21/6456 , G01N21/65 , G01N21/718 , G01N2021/1738 , G01N2021/174 , G01N2021/1744
摘要： A system and method for standoff detection of explosives and explosive residue. A laser light source illuminates a target area having an unknown sample producing luminescence emitted photons, scattered photons and plasma emitted photons. A first optical system directs light to the target area. A video capture device outputs a dynamic image of the target area. A second optical system collects photons, and directs collected photons to a first two-dimensional array of detection elements and/or to a fiber array spectral translator device which device includes a two-dimensional array of optical fibers drawn into a one-dimensional fiber stack. A spectrograph is coupled to the one-dimensional fiber stack of the fiber array spectral translator device, wherein the entrance slit of the spectrograph is coupled to the one dimensional fiber stack.
摘要翻译：爆炸物和爆炸物残留物检测的系统和方法。激光源照射具有未知样品的目标区域，产生发光的光子，散射的光子和等离子体发射的光子。第一光学系统将光引导到目标区域。视频采集装置输出目标区域的动态图像。第二光学系统收集光子，并将收集的光子引导到检测元件的第一二维阵列和/或光纤阵列光谱转换器装置，该装置包括被拉入一维光纤堆叠的光纤的二维阵列。光谱仪耦合到光纤阵列光谱转换器装置的一维光纤堆叠，其中光谱仪的入口狭缝耦合到一维光纤堆叠。

3. 发明申请

WO2006135806A2 FORENSIC INTEGRATED SEARCH TECHNOLOGY 审中-公开
标题翻译：威信集成搜索技术
公开(公告)号：WO2006135806A2
公开(公告)日：2006-12-21
申请号：PCT/US2006/022618
申请日：2006-06-09
申请人： CHEMIMAGE CORPORATION , TREADO, Patrick, J. , SCHWEITZER, Robert , NEISS, Jason
发明人： TREADO, Patrick, J. , SCHWEITZER, Robert , NEISS, Jason
IPC分类号： G06F7/00
CPC分类号： G06F17/30536 , G06F19/703 , G06F19/709
摘要： A system and method to search spectra databases and to identify unknown materials. A library having a plurality of sublibraries is provided wherein each sublibrary contains a plurality of reference data sets generated by a corresponding one of a plurality of spectroscopic data generating instruments associated with the sublibrary. Each reference data set characterizes a corresponding known material. A plurality of test data sets is provided that is characteristic of an unknown material, wherein each test data set is generated by one or more of the plurality of spectroscopic data generating instruments. For each test data set, each sublibrary is searched where the sublibrary is associated with the spectroscopic data generating instrument used to generate the test data set. A corresponding set of scores for each searched sublibrary is produced, wherein each score in the set of scores indicates a likelihood of a match between one of the plurality of reference data sets in the searched sublibrary and the test data set. A set of relative probability values is calculated for each searched sublibrary based on the set of scores for each searched sublibrary. All relative probability values for each searched sublibrary are fused producing a set of final probability values that are used in determining whether the unknown material is represented through a known material characterized in the library. A highest final probability value is selected from the set of final probability values and compared to a minimum confidence value. The known material represented in the libraries having the highest final probability value is reported, if the highest final probability value is greater than or equal to the minimum confidence value.
摘要翻译：搜索光谱数据库并识别未知材料的系统和方法。提供具有多个子图库的库，其中每个子图库包含由与该子图书馆相关联的多个光谱数据生成装置中的相应一个生成的多个参考数据集。每个参考数据集表征相应的已知材料。提供了许多测试数据集，其是未知材料的特征，其中每个测试数据集由多个光谱数据产生装置中的一个或多个产生。对于每个测试数据集，搜索每个子图书馆，其中子图书馆与用于生成测试数据集的光谱数据生成工具相关联。产生每个搜索的子图库的相应的一组分数，其中该分数集中的每个分数表示搜索的子图库中的多个参考数据集之一与测试数据集之间的匹配的可能性。基于每个搜索的子图库的分数集合，针对每个搜索的子图书馆计算一组相对概率值。每个搜索的子图库的所有相对概率值被融合，产生用于确定未知材料是否通过库中表征的已知材料表示的一组最终概率值。从最终概率值的集合中选择最高的最终概率值并与最小置信度值进行比较。如果最大最终概率值大于或等于最小置信度值，则报告具有最高最终概率值的库中表示的已知材料。

4. 发明申请

WO2007011571A2 DIGITIZING BIOLOGY 审中-公开
标题翻译： DIGITIZING生物学
公开(公告)号：WO2007011571A2
公开(公告)日：2007-01-25
申请号：PCT/US2006/026777
申请日：2006-07-11
申请人： CHEMIMAGE CORPORATION , MAIER, John, S. , TREADO, Patrick, J. , COHEN, Jeffrey , NEISS, Jason
发明人： MAIER, John, S. , TREADO, Patrick, J. , COHEN, Jeffrey , NEISS, Jason
IPC分类号： G06F19/00 , A61B5/00
CPC分类号： G01N21/65
摘要： A method and apparatus for determining the progress of a disease. A pre-determined vector space is determined where the vector space mathematically describes a reference set of wavelength resolved data at a plurality of time intervals. A sample containing at least one cell is irradiated with light. Target data is collected where the target data corresponds to at least one of light emitted from or scattered by the sample and includes a plurality of spatially accurate wavelength resolved measurements of light. The target data is transformed into the pre-determined vector space for each spatially accurate wavelength resolved measurement of light. A distribution of transformed points is analyzed in the plurality of pre-determined vector space. Based on the analysis, a transition of a disease condition of the sample is classified.
摘要翻译：用于确定疾病进展的方法和装置。确定矢量空间，其中矢量空间以多个时间间隔数学地描述波长分辨数据的参考集合。用光照射含有至少一个电池的样品。收集目标数据，其中目标数据对应于由样本发射或散射的光中的至少一种，并且包括多个空间上精确的波长分辨的光测量。每个空间精确的波长分辨光测量，将目标数据转换成预定向量空间。在多个预定向量空间中分析变换点的分布。根据分析，对样本的疾病状况进行分类。

5. 发明申请

WO2007087315A2 METHOD AND SYSTEM FOR COMBINED RAMAN AND LIBS DETECTION 审中-公开
标题翻译：用于组合拉曼和LIBS检测的方法和系统
公开(公告)号：WO2007087315A2
公开(公告)日：2007-08-02
申请号：PCT/US2007/001799
申请日：2007-01-23
申请人： CHEMIMAGE CORPORATION , BECKSTEAD, Jeffrey , TREADO, Patrick, J. , NELSON, Matthew , HUBBLE, Hugh, W., II , NEISS, Jason
发明人： BECKSTEAD, Jeffrey , TREADO, Patrick, J. , NELSON, Matthew , HUBBLE, Hugh, W., II , NEISS, Jason
IPC分类号： G01J3/44
CPC分类号： G01J3/44 , G01J3/02 , G01J3/0218 , G01J3/0272 , G01J3/28 , G01J3/443 , G01N21/65 , G01N21/718 , G01N2201/0221
摘要： In one embodiment, the disclosure relates to a method for interrogating a sample by: illuminating a first region of the sample with a first illumination pattern to obtain a plurality of first sample photons; illuminating a second region of the sample with a second illumination pattern to obtain a plurality of second sample photons; processing the plurality of first sample photons to obtain a characteristic atomic emission of the first region and processing the plurality of second sample photons to obtain a Raman spectrum; and identifying the sample through at least one of the characteristic atomic emission of the first region or the Raman spectrum of the second region of the sample.
摘要翻译：在一个实施例中，本公开涉及一种用于询问样本的方法，其中：用第一照明图案照射样品的第一区域以获得多个第一样品光子; 用第二照明图案照射样品的第二区域以获得多个第二样品光子; 处理多个第一样品光子以获得第一区域的特征原子发射并处理多个第二样品光子以获得拉曼光谱; 以及通过样品的第二区域的第一区域的特征性原子发射或拉曼光谱中的至少一个来识别样品。

6. 发明申请

WO2007081874A3 SYSTEM AND METHOD FOR CLASIFYING CELLS AND THE PHARMACEUTICAL TREATMENT OF SUCH CELLS USING RAMAN SPECTROSCOPY 审中-公开
公开(公告)号：WO2007081874A3
公开(公告)日：2007-07-19
申请号：PCT/US2007/000397
申请日：2007-01-05
申请人： CHEMIMAGE CORPORATION , PANZA, Janice, L. , MAIER, John , NEISS, Jason
发明人： PANZA, Janice, L. , MAIER, John , NEISS, Jason
IPC分类号： C12Q1/00
摘要： A system and method to distinguish normal cells from apoptotic cells. A pre-determined vector space is selected where the vector space mathematically describes a first plurality of reference Raman data sets for normal cells and a second plurality of reference Raman data sets for apoptotic cells. A sample is irradiated with substantially monochromatic light generating a target Raman data set based on scattered photons. The target Raman data set is transformed into a vector space defined by the pre-determined vector space. A distribution of transformed data is analyzed in the pre-determined vector space. Based on the analysis, the sample is classified as containing normal cells, apoptotic cells, and a combination of normal and apoptotic cells. The sample includes the step of treating the sample with a pharmaceutical agent prior to irradiating the sample. Based on the classification, the therapeutic efficiency of the pharmaceutical agent is assessed.

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