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1. 发明申请

WO2007011571A2 DIGITIZING BIOLOGY 审中-公开
标题翻译： DIGITIZING生物学
公开(公告)号：WO2007011571A2
公开(公告)日：2007-01-25
申请号：PCT/US2006/026777
申请日：2006-07-11
申请人： CHEMIMAGE CORPORATION , MAIER, John, S. , TREADO, Patrick, J. , COHEN, Jeffrey , NEISS, Jason
发明人： MAIER, John, S. , TREADO, Patrick, J. , COHEN, Jeffrey , NEISS, Jason
IPC分类号： G06F19/00 , A61B5/00
CPC分类号： G01N21/65
摘要： A method and apparatus for determining the progress of a disease. A pre-determined vector space is determined where the vector space mathematically describes a reference set of wavelength resolved data at a plurality of time intervals. A sample containing at least one cell is irradiated with light. Target data is collected where the target data corresponds to at least one of light emitted from or scattered by the sample and includes a plurality of spatially accurate wavelength resolved measurements of light. The target data is transformed into the pre-determined vector space for each spatially accurate wavelength resolved measurement of light. A distribution of transformed points is analyzed in the plurality of pre-determined vector space. Based on the analysis, a transition of a disease condition of the sample is classified.
摘要翻译：用于确定疾病进展的方法和装置。确定矢量空间，其中矢量空间以多个时间间隔数学地描述波长分辨数据的参考集合。用光照射含有至少一个电池的样品。收集目标数据，其中目标数据对应于由样本发射或散射的光中的至少一种，并且包括多个空间上精确的波长分辨的光测量。每个空间精确的波长分辨光测量，将目标数据转换成预定向量空间。在多个预定向量空间中分析变换点的分布。根据分析，对样本的疾病状况进行分类。

2. 发明申请

WO2006091853A2 METHOD OF CHEMICAL IMAGING TO DETERMINE TISSUE MARGINS DURING SURGERY 审中-公开
标题翻译：化学成像在手术期间确定组织标记的方法
公开(公告)号：WO2006091853A2
公开(公告)日：2006-08-31
申请号：PCT/US2006/006663
申请日：2006-02-24
申请人： CHEMIMAGE CORPORATION , MAIER, John, S. , STEWART, Shona , COHEN, Jeffrey , NELSON, Matthew
发明人： MAIER, John, S. , STEWART, Shona , COHEN, Jeffrey , NELSON, Matthew
IPC分类号： A61B6/00 , A61B18/18 , G01J3/44 , G01J3/40 , A61B5/00
CPC分类号： G01N21/65 , A61B5/0075 , A61B5/0084 , G01N2021/6484 , G01N2021/656 , G01N2201/08
摘要： A method and system to differentiate a tissue margins during various medical procedures. A region containing a biological tissue is irradiated, with a substantially monochromatic light. Raman spectroscopic data is obtained from the irradiated region. A boundary between a neoplastic portion and a non-neoplastic portion, in the region containing the biological tissue, is differentiated by evaluating the Raman spectroscopic data for at least one Raman spectroscopic value characteristic of either the neoplastic portion or the non-neoplastic portion. The neoplastic portion is selected for physical manipulation based on the differentiation of the boundary between the neoplastic portion and the non-neoplastic portion.
摘要翻译：在各种医疗过程中区分组织边缘的方法和系统。用基本上单色的光照射含有生物组织的区域。从照射区域获得拉曼光谱数据。在包含生物组织的区域中的肿瘤部分和非肿瘤部分之间的边界通过评估肿瘤部分或非肿瘤部分的至少一个拉曼光谱值特征的拉曼光谱数据来区分。基于肿瘤部分和非肿瘤部分之间的边界的分化，选择肿瘤部分用于物理操作。

3. 发明申请

WO2007056568A2 SPECTRAL IMAGING OF BIOFILMS 审中-公开
标题翻译：生物膜的光谱成像
公开(公告)号：WO2007056568A2
公开(公告)日：2007-05-18
申请号：PCT/US2006/043778
申请日：2006-11-09
申请人： CHEMIMAGE CORPORATION , MAIER, John, S. , COHEN, Jeffrey
发明人： MAIER, John, S. , COHEN, Jeffrey
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0227 , G01J3/0291 , G01J3/44 , G01N21/658 , G01N2021/656 , G01N2201/129
摘要： A spectroscopic method and system to identify a biofÊlm of a microorganism. A sample containing a sample microorganism is irradiated with substantially monochromatic radiation. A Raman data set is obtained based on radiation scattered from the irradiated sample. A database is searched in accordance with the Raman data set in order to identify a known Raman data set from the database. The database contains a plurality of known Raman data sets where each known Raman data set is associated with a known sessile form of a corresponding known microorganism. A sessile form of the sample microorganism is identified based on the known Raman data set identified by the searching.
摘要翻译：鉴定微生物生物膜的光谱方法和系统。用基本上单色的辐射照射含有样品微生物的样品。基于从辐射样品散射的辐射获得拉曼数据集。根据拉曼数据集搜索数据库，以便从数据库中识别已知的拉曼数据集。数据库包含多个已知的拉曼数据集，其中每个已知的拉曼数据集与相应的已知微生物的已知固定形式相关联。基于通过搜索识别的已知拉曼数据集，鉴定样品微生物的固定形式。

4. 发明申请

WO2007056560A3 SYSTEM AND METHOD FOR CYTOLOGICAL ANALYSIS BY RAMAN SPECTROSCOPIC IMAGING 审中-公开
公开(公告)号：WO2007056560A3
公开(公告)日：2007-05-18
申请号：PCT/US2006/043755
申请日：2006-11-09
申请人： CHEMIMAGE CORPORATION , MAIER, John, S. , COHEN, Jeffrey , McCLELLAND, Lindy , STEWART, Shona
发明人： MAIER, John, S. , COHEN, Jeffrey , McCLELLAND, Lindy , STEWART, Shona
IPC分类号： C12Q1/28 , C40B30/06 , C40B40/08 , C40B50/06 , G01N21/00 , A61K48/00 , G01N33/53
摘要： A method and system of differentially manipulating cells where the cells, suspended in a fluid, are irradiated with substantially monochromatic light. A Raman data set is obtained from the irradiated cells and where the data set is characteristic of a disease status. The data set is assessed to identify diseased cells. A Raman chemical image of the irradiated cells is also obtained. Based on the assessment and the Raman chemical image, the fluid in which the cells are suspended is differentially manipulated. The diseased cells are directed to a first location and other non-diseased cells are directed to a second location as part of the differential manipulation. The diseased cells may be treated with a physical stress, a chemical stress, and a iological stress and then returned to a patient from whom the diseased cells were obtained prior to the irradiation.

5. 发明申请

WO2007038679A2 METHOD FOR CORRELATING SPECTROSCOPIC MEASUREMENTS WITH DIGITAL IMAGES OF CONTRAST ENHANCED TISSUE 审中-公开
标题翻译：用对数增强组织数字图像相关光谱测量的方法
公开(公告)号：WO2007038679A2
公开(公告)日：2007-04-05
申请号：PCT/US2006/037892
申请日：2006-09-27
申请人： CHEMIMAGE CORPORATION , COHEN, Jeffrey , MAIER, John, S.
发明人： COHEN, Jeffrey , MAIER, John, S.
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/02 , G01J3/0264 , G01J3/0289 , G01J3/0291 , G01N21/6458 , G01N21/6486 , G01N21/65 , G01N21/658 , G01N2021/6417 , G01N2021/6423 , G01N2021/656
摘要： A system and method of correlating Raman measurements with digital images of a treated sample and using this correlation to classify the disease state of the sample. A spectroscopic data set is obtained for the sample positioned in the field of view of a spectroscopic device. The positional information about the field of view is stored. With the sample removed from the field of view, the sample is treated with a contrast enhancing agent. Using the stored positional information for the field of view, the treated sample is repositioned in the spectroscopic device's field of view. A digital image of the treated sample positioned in the field of view is obtained. The first spectroscopic data set is linked with the digital image by defining a transformation to map the image spatial coordinates of the digital image to the spectral spatial coordinates of the spectroscopic data. A database having a plurality of spectroscopic data sets, for samples having well characterized pathology, is provided. Each spectroscopic data set is linked to a corresponding digital image, and each spectroscopic data set is associated with the known sample. Each corresponding digital image is associated with the known sample treated with a contrast enhancing agent. For the spectroscopic data set of the sample, the database is searched to identify a spectroscopic data set, of a known sample, matching the sample's spectroscopic data set.
摘要翻译：将拉曼测量与处理的样品的数字图像相关联并使用该相关性来分类样品的疾病状态的系统和方法。对于位于分光装置的视野中的样品获得光谱数据集。存储有关视场的位置信息。从样品中取出样品后，用对比度增强剂处理样品。使用存储的视场的位置信息，处理的样品在分光装置的视场中重新定位。获得位于视场中的被处理样品的数字图像。通过定义将数字图像的图像空间坐标映射到光谱数据的光谱空间坐标的变换，第一光谱数据集与数字图像相关联。提供了具有多个光谱数据集的数据库，用于具有良好表征的病理学的样本。每个光谱数据集与相应的数字图像相关联，并且每个光谱数据集与已知样本相关联。每个相应的数字图像与用对比度增强剂处理的已知样品相关联。对于样本的光谱数据集，搜索数据库以识别与样本的光谱数据集匹配的已知样本的光谱数据集。

6. 发明申请

WO2009035946A1 DISTINGUISHING BETWEEN INVASIVE DUCTAL CARCINOMA AND INVASIVE LOBULAR CARCINOMA USING RAMAN MOLECULAR IMAGING 审中-公开
标题翻译：使用拉曼分子成像检测入侵性肺癌和入侵性肺癌之间的差异
公开(公告)号：WO2009035946A1
公开(公告)日：2009-03-19
申请号：PCT/US2008/075609
申请日：2008-09-08
申请人： CHEMIMAGE CORPORATION , MAIER, John , COHEN, Jeffrey , STEWART, Shona
发明人： MAIER, John , COHEN, Jeffrey , STEWART, Shona
IPC分类号： G01N33/48 , G01J3/44 , G06F19/00
CPC分类号： G01J3/02 , A61B5/0059 , A61B5/417 , G01J3/0291 , G01J3/0294 , G01J3/28 , G01J3/2823 , G01J3/36 , G01J3/44 , G01J2003/2826 , G01N21/65 , G01N33/57415 , G01N2021/656 , G01N2201/1293 , G01N2201/1296 , Y02A90/26
摘要： A system and method to provide a diagnosis of the breast disease state of a test breast sample. A database containing a plurality of reference Raman data sets is provided where each reference Raman data set has an associated known breast sample and an associated known breast disease state. A test breast sample is irradiated with substantially monochromatic light to generate scattered photons resulting in a test Raman data set. The test Raman data set is compared to the plurality of reference Raman data sets using a chemometric technique. Based on the comparison, a diagnosis of a breast disease state of the test breast sample is provided. The breast disease state includes invasive ductal carcinoma or invasive lobular carcinoma disease state.
摘要翻译：一种用于提供测试乳房样品的乳腺疾病状态诊断的系统和方法。提供了包含多个参考拉曼数据集的数据库，其中每个参考拉曼数据集具有相关联的已知乳房样本和相关联的已知乳腺疾病状态。用基本上单色的光照射测试乳房样品以产生散射光子，得到测试拉曼数据集。使用化学计量技术将测试拉曼数据集与多个参考拉曼数据集进行比较。基于比较，提供了测试乳房样品的乳腺疾病状态的诊断。乳腺疾病状态包括浸润性导管癌或侵袭性小叶癌疾病状态。

7. 发明申请

WO2008100582A9 SPECTROSCOPIC SYSTEM AND METHOD FOR PREDICTING OUTCOME OF DISEASE 审中-公开
公开(公告)号：WO2008100582A9
公开(公告)日：2008-08-21
申请号：PCT/US2008/001988
申请日：2008-02-14
申请人： CHEMIMAGE CORPORATION , MAIER, John , COHEN, Jeffrey , PANZA, Janice, L. , STEWART, Shona , DRAUGH, Amy, J.
发明人： MAIER, John , COHEN, Jeffrey , PANZA, Janice, L. , STEWART, Shona , DRAUGH, Amy, J.
IPC分类号： C12Q1/00
摘要： A system and method to predict the progression of disease of a test sample is provided A group of known biological samples is provided, each having an associated known outcome including a non-diseased or diseased sample. A Raman data set is obtained for each known biological sample. Each data set is analyzed to identify a diseased or non-diseased reference data set. A first database is generated which contains reference Raman data sets for all diseased samples. A second-database is generated which contains reference data sets for all non-diseased samples. A test Raman data set of a test biological sample having an unknown disease status is received. A diagnostic is provided as to whether the test sample is non-diseased or diseased The diagnostic is obtained by comparing the test data set against the reference data sets in the databases using a chemometric technique to predict the progression of disease.

8. 发明申请

WO2009021178A1 RAMAN DIFFERENCE SPECTRA BASED DISEASE CLASSIFICATION 审中-公开
标题翻译：拉曼差异谱分类疾病分类
公开(公告)号：WO2009021178A1
公开(公告)日：2009-02-12
申请号：PCT/US2008/072617
申请日：2008-08-08
申请人： CHEMIMAGE CORPORATION , MAIER, John , COHEN, Jeffrey , STEWART, Shona
发明人： MAIER, John , COHEN, Jeffrey , STEWART, Shona
IPC分类号： C12Q1/00
CPC分类号： G06K9/00127
摘要： A method to diagnosis disease states of unknown samples is provided wherein a test Raman date set for unknown samples is generated A reference Raman database is also provided where the database contains a plurality of reference Raman data sets and a plurality of reference Raman difference data sets The reference Raman difference data set is generated by determining a difference between a first reference Raman data set and a second reference Raman data set First and second reference Raman data sets are associated with first and second known samples and associated with one or more of first and second known disease states and first and second known clinical outcomes A diagnosis is provided of whether the unknown sample has first or second disease states by comparing the test Raman data set to said plurality of reference Raman difference data sets in the reference Raman database using a chemometπc technique
摘要翻译：提供了一种用于诊断未知样品的疾病状态的方法，其中生成针对未知样品的测试拉曼日期。还提供了参考拉曼数据库，其中数据库包含多个参考拉曼数据集和多个参考拉曼差异数据集通过确定第一参考拉曼数据集和第二参考拉曼数据集之间的差异来生成参考拉曼差异数据集。第一和第二参考拉曼数据集与第一和第二已知样本相关联，并与第一和第二参考拉曼数据集中的一个或多个相关联已知疾病状态和第一和第二已知临床结果通过使用化学计量技术将参考拉曼数据库中的测试拉曼数据集与所述多个参考拉曼差异数据集进行比较来提供未知样本是否具有第一或第二疾病状态的诊断

9. 发明申请

WO2009035942A1 DISTINGUISHING BETWEEN RENAL ONCOCYTOMA AND CHROMOPHOBE RENAL CELL CARCINOMA USING RAMAN MOLECULAR IMAGING 审中-公开
标题翻译：使用拉坦分子成像技术检测肾上腺癌和染色质细胞癌细胞
公开(公告)号：WO2009035942A1
公开(公告)日：2009-03-19
申请号：PCT/US2008/075598
申请日：2008-09-08
申请人： CHEMIMAGE CORPORATION , MAIER, John , COHEN, Jeffrey , STEWART, Shona
发明人： MAIER, John , COHEN, Jeffrey , STEWART, Shona
IPC分类号： G01N33/48 , G01J3/44 , G06F19/00
CPC分类号： G01J3/10 , A61B5/0071 , A61B5/0075 , A61B5/417 , A61B5/7264 , G01J3/02 , G01J3/0291 , G01J3/0294 , G01J3/2823 , G01J3/32 , G01J3/44 , G01J2003/2826 , G01N21/65 , G01N21/658 , G01N2021/656 , G01N2201/1293 , G01N2201/1296 , G02B21/365 , G06F19/00 , G16H50/70
摘要： A system and method to provide a diagnosis of the renal disease state of a test renal sample. A database containing a plurality of reference Raman data sets is provided where each reference Raman data set has an associated known renal sample and an associated known renal disease state. A test renal sample is irradiated with substantially monochromatic light to generate scattered photons resulting in a test Raman data set. The test Raman data set is compared to the plurality of reference Raman data sets using a chemometric technique. Based on the comparison, a diagnosis of a renal disease state of the test renal sample is provided. The renal disease state includes renal oncocytoma or chromophobe renal carcinoma disease state.
摘要翻译：一种用于提供测试肾脏样本的肾脏疾病状态诊断的系统和方法。提供了包含多个参考拉曼数据集的数据库，其中每个参考拉曼数据集具有相关联的已知肾脏样本和相关联的已知肾病状态。用基本单色光照射测试肾脏样品，以产生散射光子，得到测试拉曼数据集。使用化学计量技术将测试拉曼数据集与多个参考拉曼数据集进行比较。基于比较，提供了测试肾脏样本的肾脏疾病状态的诊断。肾脏疾病状态包括肾细胞瘤或发色团肾癌疾病状态。

10. 发明申请

WO2020037315A1 DISCRIMINATION OF CALCULI AND TISSUES WITH MOLECULAR CHEMICAL IMAGING 审中-公开
公开(公告)号：WO2020037315A1
公开(公告)日：2020-02-20
申请号：PCT/US2019/047064
申请日：2019-08-19
申请人： CHEMIMAGE CORPORATION
发明人： COHEN, Jeffrey , TREADO, Patrick , STEWART, Shona , GOMER, Heather , SAMIEI, Arash , ZRIMSEK, Alyssa , WANG, Jihang
IPC分类号： A61B1/07 , A61B90/30
摘要： Systems and methods for the detection of calculi in the biliary system are disclosed. The systems include an illumination source, one or more filters that filter a first set of illumination photons and a second set of illumination photons, as well as associated processors and detectors. The system is also designed to generates image data sets and generated information related to the location of the calculi.

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