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1. 发明申请

WO2006091853A2 METHOD OF CHEMICAL IMAGING TO DETERMINE TISSUE MARGINS DURING SURGERY 审中-公开
标题翻译：化学成像在手术期间确定组织标记的方法
公开(公告)号：WO2006091853A2
公开(公告)日：2006-08-31
申请号：PCT/US2006/006663
申请日：2006-02-24
申请人： CHEMIMAGE CORPORATION , MAIER, John, S. , STEWART, Shona , COHEN, Jeffrey , NELSON, Matthew
发明人： MAIER, John, S. , STEWART, Shona , COHEN, Jeffrey , NELSON, Matthew
IPC分类号： A61B6/00 , A61B18/18 , G01J3/44 , G01J3/40 , A61B5/00
CPC分类号： G01N21/65 , A61B5/0075 , A61B5/0084 , G01N2021/6484 , G01N2021/656 , G01N2201/08
摘要： A method and system to differentiate a tissue margins during various medical procedures. A region containing a biological tissue is irradiated, with a substantially monochromatic light. Raman spectroscopic data is obtained from the irradiated region. A boundary between a neoplastic portion and a non-neoplastic portion, in the region containing the biological tissue, is differentiated by evaluating the Raman spectroscopic data for at least one Raman spectroscopic value characteristic of either the neoplastic portion or the non-neoplastic portion. The neoplastic portion is selected for physical manipulation based on the differentiation of the boundary between the neoplastic portion and the non-neoplastic portion.
摘要翻译：在各种医疗过程中区分组织边缘的方法和系统。用基本上单色的光照射含有生物组织的区域。从照射区域获得拉曼光谱数据。在包含生物组织的区域中的肿瘤部分和非肿瘤部分之间的边界通过评估肿瘤部分或非肿瘤部分的至少一个拉曼光谱值特征的拉曼光谱数据来区分。基于肿瘤部分和非肿瘤部分之间的边界的分化，选择肿瘤部分用于物理操作。

2. 发明申请

WO2007056568A2 SPECTRAL IMAGING OF BIOFILMS 审中-公开
标题翻译：生物膜的光谱成像
公开(公告)号：WO2007056568A2
公开(公告)日：2007-05-18
申请号：PCT/US2006/043778
申请日：2006-11-09
申请人： CHEMIMAGE CORPORATION , MAIER, John, S. , COHEN, Jeffrey
发明人： MAIER, John, S. , COHEN, Jeffrey
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0227 , G01J3/0291 , G01J3/44 , G01N21/658 , G01N2021/656 , G01N2201/129
摘要： A spectroscopic method and system to identify a biofÊlm of a microorganism. A sample containing a sample microorganism is irradiated with substantially monochromatic radiation. A Raman data set is obtained based on radiation scattered from the irradiated sample. A database is searched in accordance with the Raman data set in order to identify a known Raman data set from the database. The database contains a plurality of known Raman data sets where each known Raman data set is associated with a known sessile form of a corresponding known microorganism. A sessile form of the sample microorganism is identified based on the known Raman data set identified by the searching.
摘要翻译：鉴定微生物生物膜的光谱方法和系统。用基本上单色的辐射照射含有样品微生物的样品。基于从辐射样品散射的辐射获得拉曼数据集。根据拉曼数据集搜索数据库，以便从数据库中识别已知的拉曼数据集。数据库包含多个已知的拉曼数据集，其中每个已知的拉曼数据集与相应的已知微生物的已知固定形式相关联。基于通过搜索识别的已知拉曼数据集，鉴定样品微生物的固定形式。

3. 发明申请

WO2007056560A3 SYSTEM AND METHOD FOR CYTOLOGICAL ANALYSIS BY RAMAN SPECTROSCOPIC IMAGING 审中-公开
公开(公告)号：WO2007056560A3
公开(公告)日：2007-05-18
申请号：PCT/US2006/043755
申请日：2006-11-09
申请人： CHEMIMAGE CORPORATION , MAIER, John, S. , COHEN, Jeffrey , McCLELLAND, Lindy , STEWART, Shona
发明人： MAIER, John, S. , COHEN, Jeffrey , McCLELLAND, Lindy , STEWART, Shona
IPC分类号： C12Q1/28 , C40B30/06 , C40B40/08 , C40B50/06 , G01N21/00 , A61K48/00 , G01N33/53
摘要： A method and system of differentially manipulating cells where the cells, suspended in a fluid, are irradiated with substantially monochromatic light. A Raman data set is obtained from the irradiated cells and where the data set is characteristic of a disease status. The data set is assessed to identify diseased cells. A Raman chemical image of the irradiated cells is also obtained. Based on the assessment and the Raman chemical image, the fluid in which the cells are suspended is differentially manipulated. The diseased cells are directed to a first location and other non-diseased cells are directed to a second location as part of the differential manipulation. The diseased cells may be treated with a physical stress, a chemical stress, and a iological stress and then returned to a patient from whom the diseased cells were obtained prior to the irradiation.

4. 发明申请

WO2007038679A2 METHOD FOR CORRELATING SPECTROSCOPIC MEASUREMENTS WITH DIGITAL IMAGES OF CONTRAST ENHANCED TISSUE 审中-公开
标题翻译：用对数增强组织数字图像相关光谱测量的方法
公开(公告)号：WO2007038679A2
公开(公告)日：2007-04-05
申请号：PCT/US2006/037892
申请日：2006-09-27
申请人： CHEMIMAGE CORPORATION , COHEN, Jeffrey , MAIER, John, S.
发明人： COHEN, Jeffrey , MAIER, John, S.
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/02 , G01J3/0264 , G01J3/0289 , G01J3/0291 , G01N21/6458 , G01N21/6486 , G01N21/65 , G01N21/658 , G01N2021/6417 , G01N2021/6423 , G01N2021/656
摘要： A system and method of correlating Raman measurements with digital images of a treated sample and using this correlation to classify the disease state of the sample. A spectroscopic data set is obtained for the sample positioned in the field of view of a spectroscopic device. The positional information about the field of view is stored. With the sample removed from the field of view, the sample is treated with a contrast enhancing agent. Using the stored positional information for the field of view, the treated sample is repositioned in the spectroscopic device's field of view. A digital image of the treated sample positioned in the field of view is obtained. The first spectroscopic data set is linked with the digital image by defining a transformation to map the image spatial coordinates of the digital image to the spectral spatial coordinates of the spectroscopic data. A database having a plurality of spectroscopic data sets, for samples having well characterized pathology, is provided. Each spectroscopic data set is linked to a corresponding digital image, and each spectroscopic data set is associated with the known sample. Each corresponding digital image is associated with the known sample treated with a contrast enhancing agent. For the spectroscopic data set of the sample, the database is searched to identify a spectroscopic data set, of a known sample, matching the sample's spectroscopic data set.
摘要翻译：将拉曼测量与处理的样品的数字图像相关联并使用该相关性来分类样品的疾病状态的系统和方法。对于位于分光装置的视野中的样品获得光谱数据集。存储有关视场的位置信息。从样品中取出样品后，用对比度增强剂处理样品。使用存储的视场的位置信息，处理的样品在分光装置的视场中重新定位。获得位于视场中的被处理样品的数字图像。通过定义将数字图像的图像空间坐标映射到光谱数据的光谱空间坐标的变换，第一光谱数据集与数字图像相关联。提供了具有多个光谱数据集的数据库，用于具有良好表征的病理学的样本。每个光谱数据集与相应的数字图像相关联，并且每个光谱数据集与已知样本相关联。每个相应的数字图像与用对比度增强剂处理的已知样品相关联。对于样本的光谱数据集，搜索数据库以识别与样本的光谱数据集匹配的已知样本的光谱数据集。

5. 发明申请

WO2007011571A2 DIGITIZING BIOLOGY 审中-公开
标题翻译： DIGITIZING生物学
公开(公告)号：WO2007011571A2
公开(公告)日：2007-01-25
申请号：PCT/US2006/026777
申请日：2006-07-11
申请人： CHEMIMAGE CORPORATION , MAIER, John, S. , TREADO, Patrick, J. , COHEN, Jeffrey , NEISS, Jason
发明人： MAIER, John, S. , TREADO, Patrick, J. , COHEN, Jeffrey , NEISS, Jason
IPC分类号： G06F19/00 , A61B5/00
CPC分类号： G01N21/65
摘要： A method and apparatus for determining the progress of a disease. A pre-determined vector space is determined where the vector space mathematically describes a reference set of wavelength resolved data at a plurality of time intervals. A sample containing at least one cell is irradiated with light. Target data is collected where the target data corresponds to at least one of light emitted from or scattered by the sample and includes a plurality of spatially accurate wavelength resolved measurements of light. The target data is transformed into the pre-determined vector space for each spatially accurate wavelength resolved measurement of light. A distribution of transformed points is analyzed in the plurality of pre-determined vector space. Based on the analysis, a transition of a disease condition of the sample is classified.
摘要翻译：用于确定疾病进展的方法和装置。确定矢量空间，其中矢量空间以多个时间间隔数学地描述波长分辨数据的参考集合。用光照射含有至少一个电池的样品。收集目标数据，其中目标数据对应于由样本发射或散射的光中的至少一种，并且包括多个空间上精确的波长分辨的光测量。每个空间精确的波长分辨光测量，将目标数据转换成预定向量空间。在多个预定向量空间中分析变换点的分布。根据分析，对样本的疾病状况进行分类。

6. 发明申请

WO2007055981A2 INVASIVE AND NON-INVASIVE CHEMOMETRY 审中-公开
标题翻译：入侵和非入侵化学
公开(公告)号：WO2007055981A2
公开(公告)日：2007-05-18
申请号：PCT/US2006/042538
申请日：2006-11-01
申请人： CHEMIMAGE CORPORATION , TREADO, Patrick, J. , MAIER, John, S. , COHEN, Jeffrey, K. , DEMUTH, Joseph, E.
发明人： TREADO, Patrick, J. , MAIER, John, S. , COHEN, Jeffrey, K. , DEMUTH, Joseph, E.
IPC分类号： A61B5/00
CPC分类号： G06F19/10 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/1459 , A61B5/415 , A61B5/418 , A61B5/4519
摘要： The invention relates to methods and devices for assessing one or more components of blood or a selected tissue in an animal. The present invention permits non-invasive assessment of blood or tissue components in a body structure containing multiple tissue types by assessing multiple regions of the animal's body for an optical characteristic of the blood or the tissue of interest and separately assessing one or more optical (e.g., Raman or NIR) characteristics of the blood or tissue component for one or more regions that exhibit the optical characteristic of the blood or the tissue of interest.
摘要翻译：本发明涉及用于评估动物中血液或选定组织的一种或多种组分的方法和装置。本发明通过评估动物身体的多个区域以获得血液或感兴趣的组织的光学特征，并且分别评估一种或多种光学（例如，血液或组织）的身体结构中的血液或组织成分的非侵入性评估。，拉曼或NIR）特征，其表现出血液或感兴趣的组织的光学特征的一个或多个区域。

7. 发明申请

WO2006005022A2 DYNAMIC CHEMICAL IMAGING OF BIOLOGICAL CELLS AND OTHER SUBJECTS 审中-公开
标题翻译：生物细胞和其他物质的动态化学成像
公开(公告)号：WO2006005022A2
公开(公告)日：2006-01-12
申请号：PCT/US2005/023638
申请日：2005-06-30
申请人： CHEMIMAGE CORPORATION , MAIER, John, S. , TREADO, Patrick, J. , VOIGT, Thomas, C. , TUSCHEL, David
发明人： MAIER, John, S. , TREADO, Patrick, J. , VOIGT, Thomas, C. , TUSCHEL, David
IPC分类号： G01J3/44
CPC分类号： G01N21/6456 , G01J3/2803 , G01J3/32 , G01J3/36 , G01J3/44 , G01N21/359 , G01N21/6486 , G01N21/65 , G01N21/658 , G01N2021/656
摘要： The invention relates to methods of dynamic chemical imaging, including methods of cellular imaging. The method comprises illuminating at least a portion of a cell with substantially monochromatic light and assessing Raman-shifted light scattered from the illuminated portion at a plurality of discrete times. The Raman-shifted light can be assessed at a plurality of Raman shift (RS) values at each of the discrete times, and the RS values can be selected to be characteristic of a pre-selected component at each of the discrete times. Multivariate analysis of Raman spectral features of the images thus obtained can yield the location and chemical identity of components in the field of view. This information can be combined or overlaid with other spectral data (e.g., a visible microscopic image) obtained from the field of view.
摘要翻译：本发明涉及动态化学成像的方法，包括细胞成像的方法。该方法包括用基本上单色的光照射单元的至少一部分，并且在多个离散时间评估从照射部分散射的拉曼偏移光。拉曼位移光可以在每个离散时间的多个拉曼位移（RS）值处被评估，并且RS值可以被选择为在每个离散时间处的预选分量的特征。由此获得的图像的拉曼光谱特征的多变量分析可以产生组件在视场中的位置和化学特性。该信息可以与从视野获得的其他光谱数据（例如，可见的显微图像）组合或覆盖。

8. 发明申请

WO2007050602A2 AUTOMATED ACQUISITION OF SPECTRAL DATA AND IMAGE DATA 审中-公开
标题翻译：自动采集光谱数据和图像数据
公开(公告)号：WO2007050602A2
公开(公告)日：2007-05-03
申请号：PCT/US2006/041471
申请日：2006-10-24
申请人： CHEMIMAGE CORPORATION , MAIER, John, S. , TREADO, Patrick, J. , NELSON, Matthew , MCCLELLAND, Lindy , STEWART, Shona
发明人： MAIER, John, S. , TREADO, Patrick, J. , NELSON, Matthew , MCCLELLAND, Lindy , STEWART, Shona
IPC分类号： H04B10/08 , H04B17/00
CPC分类号： G01N21/65 , G01J3/28 , G01J3/2823 , G01J3/44 , G01N21/274 , G01N2021/656
摘要： A system and method to automatically obtain spectra for samples. The method involves a two phase process including a photobleaching phase and a spectral acquisition phase. In the photobleaching phase, a series of spectral data sets of a sample are collected. A relative difference is determined between the background of subsequent spectral data sets is determined and compared to a predetermined threshold value. If threshold difference is less than the relative difference between the background of subsequent spectral data sets, the steps of collecting a series of spectra data sets is automatically repeated. In the spectrum acquisition phase, a series of Raman data sets of the sample are collected until a target SNR is obtained.
摘要翻译：自动获取样品光谱的系统和方法。该方法涉及包括光漂白相和光谱采集阶段的两相过程。在漂白漂白阶段，收集样品的一系列光谱数据集。在确定后续光谱数据集的背景并将其与预定阈值进行比较之间确定相对差。如果阈值差小于随后的光谱数据集的背景之间的相对差，则自动重复收集一系列光谱数据集的步骤。在频谱采集阶段，收集样本的一系列拉曼数据集，直到获得目标SNR。

9. 发明申请

WO2006007063A3 METHOD AND APPARATUS FOR PEAK COMPENSATION IN AN OPTICAL FILTER 审中-公开
公开(公告)号：WO2006007063A3
公开(公告)日：2006-01-19
申请号：PCT/US2005/016140
申请日：2005-05-06
申请人： CHEMIMAGE CORPORATION , MAIER, John, S. , NEISS, Jason, H. , STEWART, Shona
发明人： MAIER, John, S. , NEISS, Jason, H. , STEWART, Shona
IPC分类号： G01J3/44 , G01N21/65
摘要： In one embodiment the disclosure relates to a method and a system for determining the corrected wavelength of a photon scattered by a sample. The method includes the steps of determining a wavelength of a photon scattered from a sample exposed to illuminating photons and passed through a tunable filter and correcting the determined wavelength of the photon as a function of the temperature of the tunable filter and as a function of the bandpass set point of the tunable filter. The step of correcting the determined wavelength can further include determining an offset and adding the offset to the determined wavelength of the photon.

10. 发明申请

WO2005010474A2 METHOD AND APPARATUS FOR MULTIWAVELENGTH IMAGING SPECTROMETER 审中-公开
标题翻译：多波长成像光谱仪的方法和装置
公开(公告)号：WO2005010474A2
公开(公告)日：2005-02-03
申请号：PCT/US2004/022712
申请日：2004-07-19
申请人： CHEMIMAGE CORPORATION , MAIER, John, S. , TREADO, Patrick, J. , WANG, Chenhui
发明人： MAIER, John, S. , TREADO, Patrick, J. , WANG, Chenhui
IPC分类号： G01J
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0224 , G01J3/0229 , G01J3/0256 , G01J3/0264 , G01J3/0272 , G01J3/0283 , G01J3/10 , G01J3/44 , G01J3/4406 , G01N21/6456 , G01N2021/6417 , G01N2021/6423 , G01N2021/6471 , G01N2201/0221 , G01N2201/0627 , G02F1/133371 , G02F1/1347
摘要： The disclosure generally relates to a method and apparatus for multi-wavelength imaging spectrometer. More specifically, in one embodiment, the disclosure relates to an optical filter for passing photons therethrough. The filter includes a first filter stage and a second filter stage. The first filter stage may include a first retarder element and a first liquid crystal cell. The first element may include an input face and an output face. One of the first element faces is not oriented substantially normal to the trajectory of photons passing through the filter.
摘要翻译：本公开一般涉及用于多波长成像光谱仪的方法和装置。更具体地，在一个实施例中，本发明涉及一种用于使光子通过其的滤光器。该滤波器包括第一滤波器级和第二滤波级。第一滤波器级可以包括第一延迟元件和第一液晶单元。第一元件可以包括输入面和输出面。第一元件面之一不是基本上垂直于通过过滤器的光子的轨迹。

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