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1. 发明申请

WO2013025997A2 BRAIN STIMULATION METHODS FOR TREATING CENTRAL SENSITIVITY 审中-公开
标题翻译：用于治疗中枢敏感性的脑刺激方法
公开(公告)号：WO2013025997A2
公开(公告)日：2013-02-21
申请号：PCT/US2012/051359
申请日：2012-08-17
申请人： CEREPHEX CORPORATION , HARGROVE, Jeffrey, B.
发明人： HARGROVE, Jeffrey, B.
IPC分类号： A61N1/18 , A61N1/36 , A61N2/02 , A61N2/06 , A61N1/05
CPC分类号： A61N1/36025 , A61B5/0476 , A61B5/048 , A61B5/16 , A61B5/4058 , A61B5/415 , A61B5/418 , A61B5/4824 , A61B5/4836 , A61B5/7257 , A61N1/0456 , A61N1/06 , A61N1/36017 , A61N1/36021 , A61N1/37235 , A61N2/008
摘要： Methods are disclosed for stimulating targeted regions of a brain to alleviate symptoms, treat conditions and/or modify brain activities associated with central sensitivity in a subject. The methods may include selecting a subject suffering from central sensitivity, identifying regions of the brain involved in central sensitivity, and stimulating one or more of these regions of the brain.
摘要翻译：公开了用于刺激脑的目标区域以缓解症状，治疗病症和/或改变与受试者中心敏感性相关的脑活动的方法。所述方法可以包括选择患有中枢敏感性的受试者，识别参与中枢敏感性的脑的区域，以及刺激脑的这些区域中的一个或多个。

2. 发明申请

WO2009021075A3 APPARATUS AND METHOD FOR REMOTE ASSESSMENT AND THERAPY MANAGEMENT IN MEDICAL DEVICES VIA INTERFACE SYSTEMS 审中-公开
公开(公告)号：WO2009021075A3
公开(公告)日：2009-02-12
申请号：PCT/US2008/072389
申请日：2008-08-06
申请人： GREAT LAKES BIOSCIENCES, LLC , HARGROVE, Jeffrey, B. , FORD, Robert, M. , JOHNSON, Thomas, B.
发明人： HARGROVE, Jeffrey, B. , FORD, Robert, M. , JOHNSON, Thomas, B.
IPC分类号： G06Q50/00 , A61B5/00
摘要： A remote medical assessment and therapy management apparatus comprising a center user interface, a center computer coupleable with the center user interface. The center computer displays information via the center user interface for use in developing a therapeutic prescription and receives therapeutic control inputs from a user. A remote device includes a medical diagnostic instrument for acquiring biophysical data from a patient, a medical therapeutic instrument that provides a therapy to the patient, and a remote computer that receives diagnostic signals from the diagnostic instrument and transmits therapeutic control signals to the therapeutic instrument. A network interface is connected between the first center computer and the remote computer and transmits diagnostic signals from the remote computer to the center computer and control signals from the center computer to the therapeutic instrument via the remote computer.

3. 发明申请

WO2009021080A2 METHODS AND APPARATUS FOR ELECTRICAL STIMULATION OF TISSUES USING SIGNALS THAT MINIMIZE THE EFFECTS OF TISSUE IMPEDANCE 审中-公开
标题翻译：使用信号最小化组织阻抗的影响对组织进行电刺激的方法和设备
公开(公告)号：WO2009021080A2
公开(公告)日：2009-02-12
申请号：PCT/US2008/072395
申请日：2008-08-06
申请人： GREAT LAKES BIOSCIENCES, LLC , HARGROVE, Jeffrey, B.
发明人： HARGROVE, Jeffrey, B.
IPC分类号： A61N1/18 , A61N1/00
CPC分类号： A61N1/37247 , A61B5/0402 , A61B5/0476 , A61B5/048 , A61B5/0484 , A61B5/04842 , A61B5/0488 , A61B5/053 , A61B5/145 , A61B5/4519 , A61B5/6843 , A61B5/7257 , A61N1/36014 , A61N1/36025 , A61N1/36082 , A61N1/37235 , G06F19/00 , G06F19/3418 , G06Q50/22 , G16H50/70
摘要： A tissue stimulation system that generates an electrical tissue stimulation signal configured to reduce tissue impedance and increase depth of signal penetration. The use of leads is dynamically controlled and altered between conducting biopotential voltages, conducting electrical tissue stimulation signals, and grounding, in response to a computational analysis of biopotential data acquired from a region of tissue to be stimulated.
摘要翻译：产生电组织刺激信号的组织刺激系统，所述组织刺激信号被配置为减少组织阻抗并增加信号穿透深度。响应于从待刺激的组织区域获取的生物电势数据的计算分析，在导电生物电压，传导电子组织刺激信号和接地之间动态控制和改变导联的使用。

4. 发明申请

WO2009085968A1 BRAIN-RELATED CHRONIC PAIN DISORDER DIAGNOSIS AND ASSESSMENT METHOD 审中-公开
标题翻译：脑相关慢性疼痛症状诊断和评估方法
公开(公告)号：WO2009085968A1
公开(公告)日：2009-07-09
申请号：PCT/US2008/087451
申请日：2008-12-18
申请人： GREAT LAKES BIOSCIENCES, LLC , HARGROVE, Jeffrey, B.
发明人： HARGROVE, Jeffrey, B.
IPC分类号： A61B5/0476 , A61B5/05
CPC分类号： A61B5/0484 , A61B5/055 , A61B5/4824 , A61B6/037 , G06F19/00
摘要： A method for diagnosing and assessing a brain-related chronic pain disorder. The method includes assessing a subject's brain function, deterrnining the probability that a subject is suffering from chronic pain as a result of an abnormal brain function condition by obtaining a quantitative assessment of the subject's brain function, and making a statistical comparison between the subject's quantitative brain function assessment and either a database of quantitative assessments of the brain functions of normal, healthy individuals, or a database of quantitative assessments of the brain functions of individuals known to have been suffering from chronic pain as a result of the abnormal brain function condition.
摘要翻译：一种用于诊断和评估脑相关慢性疼痛障碍的方法。该方法包括评估受试者的脑功能，通过获得受试者脑功能的定量评估来确定受试者由于脑功能异常状况而遭受慢性疼痛的可能性，并且对受试者的定量脑进行统计学比较功能评估和正常健康个体的脑功能的定量评估数据库，或者由于异常脑功能状况已知患有慢性疼痛的个体的脑功能的定量评估数据库。

5. 发明申请

WO2003066157A3 TREATMENT OF NEUROLOGICAL DISORDERS USING ELECTRICAL STIMULATION 审中-公开
公开(公告)号：WO2003066157A3
公开(公告)日：2003-08-14
申请号：PCT/US2003/003316
申请日：2003-02-04
申请人： HARGROVE, Jeffrey, B. , STOKES, Theodore, J. , ESTY, Mary, L.
发明人： HARGROVE, Jeffrey, B. , STOKES, Theodore, J. , ESTY, Mary, L.
IPC分类号： A61N1/36
摘要： A computing device-controlled system (8) is described for the generation of amplitude-modulated pulse-width modulation signals for use in treating neurological dysfunction via cranial neurostimulation.

6. 发明申请

WO2009097526A2 BRAIN-RELATED CHRONIC PAIN DISORDER TREATMENT METHOD AND APPARATUS 审中-公开
标题翻译：脑相关慢性疼痛症状治疗方法和装置
公开(公告)号：WO2009097526A2
公开(公告)日：2009-08-06
申请号：PCT/US2009/032639
申请日：2009-01-30
申请人： GREAT LAKES BIOSCIENCES, LLC , HARGROVE, Jeffrey, B. , FORD, Robert, M. , BERANEK, Buckley, D.
发明人： HARGROVE, Jeffrey, B. , FORD, Robert, M. , BERANEK, Buckley, D.
IPC分类号： A61N1/36 , A61N1/32 , A61N1/08
CPC分类号： A61N1/08 , A61B5/04004 , A61B5/0402 , A61B5/0476 , A61B5/048 , A61B5/04842 , A61B5/0488 , A61B5/053 , A61B5/145 , A61B5/4519 , A61B5/4824 , A61B5/6843 , A61B5/7257 , A61N1/0408 , A61N1/0472 , A61N1/0529 , A61N1/36017 , A61N1/36021 , A61N1/36025 , A61N1/37235
摘要： A method for treating brain-related chronic pain disorders in human subjects includes assessing the brain function of a subject suffering from chronic pain, diagnosing a chronic pain-related abnormal brain condition, and mitigating the abnormal brain activity by applying an electrical stimulation signal to tissues corresponding to at least one area of abnormal brain activity.
摘要翻译：用于治疗人类受试者脑部相关的慢性疼痛障碍的方法包括通过向组织施加电刺激信号来评估患有慢性疼痛的受试者的脑功能，诊断慢性疼痛相关的异常脑部疾病，以及减轻异常脑活动对应于至少一个异常脑活动区域。

7. 发明申请

WO2015112530A1 METHODS AND APPARATUS FOR ELECTRICAL STIMULATION 审中-公开
标题翻译：电刺激的方法和装置
公开(公告)号：WO2015112530A1
公开(公告)日：2015-07-30
申请号：PCT/US2015/012137
申请日：2015-01-21
申请人： CEREPHEX CORPORATION
发明人： HARGROVE, Jeffrey, B. , MAVITY, William, G. , BRIGGS, Lauren, R. , GENGREAU, Roger, Michael
IPC分类号： A61N1/32 , A61N1/34
CPC分类号： A61N1/36025 , A61B5/0476 , A61N1/0456 , A61N1/32 , A61N1/36021
摘要： A method of treating a neurological condition in a patient, the method including the step of applying an electrical stimulation from conductors to the patient's head at a stimulation application site. In some embodiments, the electrical stimulation includes a composite electrical signal further comprising at least one signal form configured to provide long-term treatment of the neurological condition and at least one signal form configured to provide analgesia for short-term pain relief. The invention also provides an electrical stimulation apparatus having an electrical signal generator adapted to provide an electrical signal form configured to provide long-term treatment of a neurological condition and to provide an electrical signal form configured to provide analgesia for short-term pain relief.
摘要翻译：一种治疗患者的神经病症的方法，所述方法包括在刺激施用部位将来自导体的电刺激施加到患者头部的步骤。在一些实施例中，电刺激包括复合电信号，还包括至少一种信号形式，其被配置为提供对神经病症的长期治疗和至少一种被配置为提供短期疼痛缓解的镇痛的信号形式。本发明还提供了具有电信号发生器的电刺激装置，其适于提供被配置为提供神经病症的长期治疗的电信号形式，并且提供被配置为提供短期疼痛缓解的止痛的电信号形式。

8. 发明申请

WO2013169838A1 METHOD AND APPARATUS FOR TREATING CENTRALIZED PAIN 审中-公开
标题翻译：用于治疗中央疼痛的方法和装置
公开(公告)号：WO2013169838A1
公开(公告)日：2013-11-14
申请号：PCT/US2013/040045
申请日：2013-05-08
申请人： CEREPHEX CORPORATION
发明人： HARGROVE, Jeffrey, B.
IPC分类号： A61N1/36 , A61N2/00 , A61B5/0476 , A61N1/08 , A61N5/02
CPC分类号： A61N1/36021 , A61B5/0468 , A61B5/0484 , A61B5/4824 , A61B5/483 , A61N1/0472 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/36014 , A61N1/36017 , A61N1/36025 , A61N1/36071 , A61N1/36139 , A61N1/36192 , A61N2/00 , A61N2/006 , A61N2/02 , G09B19/00
摘要： A method for alleviating centralized pain in human subjects includes assessing the brain of a subject suffering from pain, diagnosing abnormal brain function associated with centralized pain, locating at least one area of abnormal brain function associated with the centralized pain, and alleviating the abnormal brain function by applying a cortical stimulation signal to tissues corresponding to the at least one area of abnormal brain function.
摘要翻译：减轻人体中枢疼痛的方法包括评估患有疼痛的受试者的大脑，诊断与集中性疼痛相关的异常脑功能，确定与集中疼痛相关的至少一个异常脑功能区域，以及减轻脑功能异常通过将皮质刺激信号应用于与异常脑功能的至少一个区域相对应的组织。

9. 发明申请

WO2014145487A1 CUTANEOUS ELECTRODE POSITIONING 审中-公开
标题翻译：不锈钢电极定位
公开(公告)号：WO2014145487A1
公开(公告)日：2014-09-18
申请号：PCT/US2014/030263
申请日：2014-03-17
申请人： CEREPHEX CORPORATION
发明人： HARGROVE, Jeffrey, B. , BRIGGS, Susan, R.
IPC分类号： A61N1/36 , A61N1/04 , A61B5/0476
CPC分类号： A61B5/6814 , A61B5/0476 , A61B5/0478 , A61B5/6831 , A61N1/0456 , A61N1/0484
摘要： A device and method for positioning a cutaneous electrode for delivery of electrical stimulation to a subject's head. A harness is worn on a subject's head with a first band of the harness worn in a closed loop around the subject's head and around a desired contact location on the subject's head. A tensioning strap of the harness is worn across the desired contact location and connected at spaced-apart attachment locations of the strap to spaced-apart attachment locations of the harness such that an electrode disposed over the desired contact location on the subject's head is held in place by the tensioning strap.
摘要翻译：用于定位皮肤电极以将电刺激递送到受检者头部的装置和方法。戴着主体的头戴着一根线束的第一条线束绕着被摄体头部的闭合环绕着被摄体头部所需的接触位置。线束的张紧带穿过期望的接触位置并且在带的间隔连接位置处连接到线束的间隔开的附接位置，使得设置在受试者头部上的期望接触位置上方的电极保持在放置张紧带。

10. 发明申请

WO2014018661A1 METHOD AND APPARATUS FOR DIAGNOSING AND ASSESSING CENTRAL PAIN 审中-公开
标题翻译：用于诊断和评估中央疼痛的方法和装置
公开(公告)号：WO2014018661A1
公开(公告)日：2014-01-30
申请号：PCT/US2013/051867
申请日：2013-07-24
申请人： CEREPHEX CORPORATION
发明人： HARGROVE, Jeffrey, B.
IPC分类号： A61B5/0476 , A61B5/0482
CPC分类号： A61B5/4827 , A61B5/0053 , A61B5/0057 , A61B5/0476 , A61B5/0484 , A61B5/055 , A61B5/4064 , A61B5/483 , A61B5/7235 , A61B5/7257 , G06F19/00
摘要： Methods for central pain diagnosis and assessment, symptom severity prediction, and therapeutic intervention effect determination. The diagnosis and assessment method includes a statistical comparison between a subject's quantitative brain function assessment and either a database of quantitative assessments of brain functions of healthy individuals, or a database of quantitative assessments of brain functions of individuals known to have been suffering from chronic pain as a result of the abnormal brain function condition. Diagnosis and assessment may be accomplished using a neuroimaging device to sense and generate images representing central nervous system function, using a sensory stimulation device to stimulate brain activities associated with central sensitivity, and using a computing device to command the sensory stimulation device and neuroimaging device to test for the presence of central pain.
摘要翻译：中枢疼痛诊断和评估方法，症状严重程度预测和治疗干预效果测定。诊断和评估方法包括：受试者的定量脑功能评估与健康人脑功能定量评估数据库之间的统计学比较，或者已知患有慢性疼痛的个体的脑功能定量评估数据库是脑功能异常状况的结果。诊断和评估可以使用神经成像装置来实现，以感测和产生表示中枢神经系统功能的图像，使用感觉刺激装置来刺激与中心敏感性相关联的脑活动，并且使用计算装置来命令感觉刺激装置和神经成像装置测试中枢疼痛的存在。

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