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1. 发明申请

WO2015112530A1 METHODS AND APPARATUS FOR ELECTRICAL STIMULATION 审中-公开
标题翻译：电刺激的方法和装置
公开(公告)号：WO2015112530A1
公开(公告)日：2015-07-30
申请号：PCT/US2015/012137
申请日：2015-01-21
申请人： CEREPHEX CORPORATION
发明人： HARGROVE, Jeffrey, B. , MAVITY, William, G. , BRIGGS, Lauren, R. , GENGREAU, Roger, Michael
IPC分类号： A61N1/32 , A61N1/34
CPC分类号： A61N1/36025 , A61B5/0476 , A61N1/0456 , A61N1/32 , A61N1/36021
摘要： A method of treating a neurological condition in a patient, the method including the step of applying an electrical stimulation from conductors to the patient's head at a stimulation application site. In some embodiments, the electrical stimulation includes a composite electrical signal further comprising at least one signal form configured to provide long-term treatment of the neurological condition and at least one signal form configured to provide analgesia for short-term pain relief. The invention also provides an electrical stimulation apparatus having an electrical signal generator adapted to provide an electrical signal form configured to provide long-term treatment of a neurological condition and to provide an electrical signal form configured to provide analgesia for short-term pain relief.
摘要翻译：一种治疗患者的神经病症的方法，所述方法包括在刺激施用部位将来自导体的电刺激施加到患者头部的步骤。在一些实施例中，电刺激包括复合电信号，还包括至少一种信号形式，其被配置为提供对神经病症的长期治疗和至少一种被配置为提供短期疼痛缓解的镇痛的信号形式。本发明还提供了具有电信号发生器的电刺激装置，其适于提供被配置为提供神经病症的长期治疗的电信号形式，并且提供被配置为提供短期疼痛缓解的止痛的电信号形式。

2. 发明申请

WO2014145487A1 CUTANEOUS ELECTRODE POSITIONING 审中-公开
标题翻译：不锈钢电极定位
公开(公告)号：WO2014145487A1
公开(公告)日：2014-09-18
申请号：PCT/US2014/030263
申请日：2014-03-17
申请人： CEREPHEX CORPORATION
发明人： HARGROVE, Jeffrey, B. , BRIGGS, Susan, R.
IPC分类号： A61N1/36 , A61N1/04 , A61B5/0476
CPC分类号： A61B5/6814 , A61B5/0476 , A61B5/0478 , A61B5/6831 , A61N1/0456 , A61N1/0484
摘要： A device and method for positioning a cutaneous electrode for delivery of electrical stimulation to a subject's head. A harness is worn on a subject's head with a first band of the harness worn in a closed loop around the subject's head and around a desired contact location on the subject's head. A tensioning strap of the harness is worn across the desired contact location and connected at spaced-apart attachment locations of the strap to spaced-apart attachment locations of the harness such that an electrode disposed over the desired contact location on the subject's head is held in place by the tensioning strap.
摘要翻译：用于定位皮肤电极以将电刺激递送到受检者头部的装置和方法。戴着主体的头戴着一根线束的第一条线束绕着被摄体头部的闭合环绕着被摄体头部所需的接触位置。线束的张紧带穿过期望的接触位置并且在带的间隔连接位置处连接到线束的间隔开的附接位置，使得设置在受试者头部上的期望接触位置上方的电极保持在放置张紧带。

3. 发明申请

WO2014018661A1 METHOD AND APPARATUS FOR DIAGNOSING AND ASSESSING CENTRAL PAIN 审中-公开
标题翻译：用于诊断和评估中央疼痛的方法和装置
公开(公告)号：WO2014018661A1
公开(公告)日：2014-01-30
申请号：PCT/US2013/051867
申请日：2013-07-24
申请人： CEREPHEX CORPORATION
发明人： HARGROVE, Jeffrey, B.
IPC分类号： A61B5/0476 , A61B5/0482
CPC分类号： A61B5/4827 , A61B5/0053 , A61B5/0057 , A61B5/0476 , A61B5/0484 , A61B5/055 , A61B5/4064 , A61B5/483 , A61B5/7235 , A61B5/7257 , G06F19/00
摘要： Methods for central pain diagnosis and assessment, symptom severity prediction, and therapeutic intervention effect determination. The diagnosis and assessment method includes a statistical comparison between a subject's quantitative brain function assessment and either a database of quantitative assessments of brain functions of healthy individuals, or a database of quantitative assessments of brain functions of individuals known to have been suffering from chronic pain as a result of the abnormal brain function condition. Diagnosis and assessment may be accomplished using a neuroimaging device to sense and generate images representing central nervous system function, using a sensory stimulation device to stimulate brain activities associated with central sensitivity, and using a computing device to command the sensory stimulation device and neuroimaging device to test for the presence of central pain.
摘要翻译：中枢疼痛诊断和评估方法，症状严重程度预测和治疗干预效果测定。诊断和评估方法包括：受试者的定量脑功能评估与健康人脑功能定量评估数据库之间的统计学比较，或者已知患有慢性疼痛的个体的脑功能定量评估数据库是脑功能异常状况的结果。诊断和评估可以使用神经成像装置来实现，以感测和产生表示中枢神经系统功能的图像，使用感觉刺激装置来刺激与中心敏感性相关联的脑活动，并且使用计算装置来命令感觉刺激装置和神经成像装置测试中枢疼痛的存在。

4. 发明申请

WO2013169838A1 METHOD AND APPARATUS FOR TREATING CENTRALIZED PAIN 审中-公开
标题翻译：用于治疗中央疼痛的方法和装置
公开(公告)号：WO2013169838A1
公开(公告)日：2013-11-14
申请号：PCT/US2013/040045
申请日：2013-05-08
申请人： CEREPHEX CORPORATION
发明人： HARGROVE, Jeffrey, B.
IPC分类号： A61N1/36 , A61N2/00 , A61B5/0476 , A61N1/08 , A61N5/02
CPC分类号： A61N1/36021 , A61B5/0468 , A61B5/0484 , A61B5/4824 , A61B5/483 , A61N1/0472 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/36014 , A61N1/36017 , A61N1/36025 , A61N1/36071 , A61N1/36139 , A61N1/36192 , A61N2/00 , A61N2/006 , A61N2/02 , G09B19/00
摘要： A method for alleviating centralized pain in human subjects includes assessing the brain of a subject suffering from pain, diagnosing abnormal brain function associated with centralized pain, locating at least one area of abnormal brain function associated with the centralized pain, and alleviating the abnormal brain function by applying a cortical stimulation signal to tissues corresponding to the at least one area of abnormal brain function.
摘要翻译：减轻人体中枢疼痛的方法包括评估患有疼痛的受试者的大脑，诊断与集中性疼痛相关的异常脑功能，确定与集中疼痛相关的至少一个异常脑功能区域，以及减轻脑功能异常通过将皮质刺激信号应用于与异常脑功能的至少一个区域相对应的组织。

5. 发明申请

WO2013025997A2 BRAIN STIMULATION METHODS FOR TREATING CENTRAL SENSITIVITY 审中-公开
标题翻译：用于治疗中枢敏感性的脑刺激方法
公开(公告)号：WO2013025997A2
公开(公告)日：2013-02-21
申请号：PCT/US2012/051359
申请日：2012-08-17
申请人： CEREPHEX CORPORATION , HARGROVE, Jeffrey, B.
发明人： HARGROVE, Jeffrey, B.
IPC分类号： A61N1/18 , A61N1/36 , A61N2/02 , A61N2/06 , A61N1/05
CPC分类号： A61N1/36025 , A61B5/0476 , A61B5/048 , A61B5/16 , A61B5/4058 , A61B5/415 , A61B5/418 , A61B5/4824 , A61B5/4836 , A61B5/7257 , A61N1/0456 , A61N1/06 , A61N1/36017 , A61N1/36021 , A61N1/37235 , A61N2/008
摘要： Methods are disclosed for stimulating targeted regions of a brain to alleviate symptoms, treat conditions and/or modify brain activities associated with central sensitivity in a subject. The methods may include selecting a subject suffering from central sensitivity, identifying regions of the brain involved in central sensitivity, and stimulating one or more of these regions of the brain.
摘要翻译：公开了用于刺激脑的目标区域以缓解症状，治疗病症和/或改变与受试者中心敏感性相关的脑活动的方法。所述方法可以包括选择患有中枢敏感性的受试者，识别参与中枢敏感性的脑的区域，以及刺激脑的这些区域中的一个或多个。

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