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1. 发明申请

WO2013036597A3 ANIMAL SPECIMEN POSITIONING SYSTEM 审中-公开
标题翻译：动物标本定位系统
公开(公告)号：WO2013036597A3
公开(公告)日：2013-05-02
申请号：PCT/US2012053901
申请日：2012-09-06
申请人： CARESTREAM HEALTH INC , HURLEY REX D , FEKE GILBERT , GELDHOF BENJAMIN , PAPINENI RAO
发明人： HURLEY REX D , FEKE GILBERT , GELDHOF BENJAMIN , PAPINENI RAO
IPC分类号： A01K15/04 , A61B5/05 , A61D7/00
CPC分类号： A01K1/0613
摘要： An animal specimen positioning system comprises a mount, at least two elongated receptacles sized and shaped to receive and hold an animal specimen, a connection system for securing the at least two elongated receptacles to the mount and an imaging adaptor for securing said animal positioning system to an imaging device. The at least two elongated receptacles may be configurable in a plurality of different orientations on the mount and the connection system may include a plurality of ports and connectors arranged in different positions. Various iterations of the animal specimen positioning system may together form a kit.
摘要翻译：动物样本定位系统包括支架，至少两个长形的容器，其尺寸和形状被设计成接收和保持动物样本，连接系统用于将至少两个细长的容器固定到支架，以及成像适配器，用于将所述动物定位系统固定到一个成像装置。所述至少两个细长容座可以在所述底座上以多个不同方向配置，并且所述连接系统可以包括布置在不同位置的多个端口和连接器。动物样本定位系统的各种迭代可以一起形成套件。

2. 发明申请

WO2013036597A9 ANIMAL SPECIMEN POSITIONING SYSTEM 审中-公开
标题翻译：动物标本定位系统
公开(公告)号：WO2013036597A9
公开(公告)日：2013-06-27
申请号：PCT/US2012053901
申请日：2012-09-06
申请人： CARESTREAM HEALTH INC , HURLEY REX D , FEKE GILBERT , GELDHOF BENJAMIN , PAPINENI RAO
发明人： HURLEY REX D , FEKE GILBERT , GELDHOF BENJAMIN , PAPINENI RAO
IPC分类号： A01K15/04 , A61B5/05 , A61D7/00
CPC分类号： A01K1/0613
摘要： An animal specimen positioning system comprises a mount, at least two elongated receptacles sized and shaped to receive and hold an animal specimen, a connection system for securing the at least two elongated receptacles to the mount and an imaging adaptor for securing said animal positioning system to an imaging device. The at least two elongated receptacles may be configurable in a plurality of different orientations on the mount and the connection system may include a plurality of ports and connectors arranged in different positions. Various iterations of the animal specimen positioning system may together form a kit.
摘要翻译：动物标本定位系统包括安装座，至少两个尺寸和形状适于接收和保持动物样本的细长容器，用于将至少两个细长插座固定到安装座的连接系统和用于将所述动物定位系统固定到成像装置。至少两个细长的插座可以在安装件上以多个不同的取向配置，并且连接系统可以包括布置在不同位置的多个端口和连接器。动物标本定位系统的各种迭代可以一起形成套件。

3. 发明申请

WO2009120281A3 SPATIAL ORIENTATION METHOD OF AN IMMOBILIZED SUBJECT 审中-公开
标题翻译：静止受试者的空间定向方法
公开(公告)号：WO2009120281A3
公开(公告)日：2009-12-23
申请号：PCT/US2009001694
申请日：2009-03-18
申请人： CARESTREAM HEALTH INC , FEKE GILBERT , PAPINENI RAO , CHEN SHOUPU , WOOD DOUGLAS , MCLAUGHLIN WILLIAM
发明人： FEKE GILBERT , PAPINENI RAO , CHEN SHOUPU , WOOD DOUGLAS , MCLAUGHLIN WILLIAM
IPC分类号： A61B6/00
CPC分类号： A61B5/0073 , A01K1/031 , A61B5/0035 , A61B6/04 , A61B6/4417 , A61B6/508 , A61B6/5235 , A61B6/5247 , A61B2503/40
摘要： Methods are disclosed for (A) adjusting the physical, spatial orientation of an immobilized subject in a multi-modal imaging system so as substantially to reproduce or match the physical, spatial orientation of a reference subject, wherein the reference subject is either (a) the same or (b) a different subject, either (1) during a prior imaging session for a later imaging session, or, in the case where a plurality of subjects is imaged in one imaging session, (2) during a contemporaneous imaging session; and (B) adjusting the virtual, spatial orientation of an immobilized subject in a set of multi-modal images.
摘要翻译：公开了用于（A）调整多模式成像系统中固定的受试者的物理，空间取向以便基本上重现或匹配参考对象的物理，空间取向的方法，其中参考对象是（a）相同或（b）不同的对象，（1）在先前的成像会话期间用于稍后的成像会话，或者在多个对象在一个成像会话中被成像的情况下，（2）在同时成像会话期间 ; 和（B）在一组多模态图像中调整固定的被摄体的虚拟空间取向。

4. 发明申请

WO2009151554A3 TORSIONAL SUPPORT FOR CRANIOCAUDAL ROTATION OF ANIMALS 审中-公开
标题翻译：动物旋转旋转的扭转支持
公开(公告)号：WO2009151554A3
公开(公告)日：2010-03-04
申请号：PCT/US2009003380
申请日：2009-06-03
申请人： CARESTREAM HEALTH INC , FEKE GILBERT , GELDHOF BENJAMIN , LEEVY WARREN M , BRIDGES MARK E , MCLAUGHLIN WILLIAM E
发明人： FEKE GILBERT , GELDHOF BENJAMIN , LEEVY WARREN M , BRIDGES MARK E , MCLAUGHLIN WILLIAM E
IPC分类号： A61B6/02
CPC分类号： A61B5/0059 , A61B5/0035 , A61B5/0095 , A61B6/0428 , A61B6/0471 , A61B6/4417 , A61B6/508 , A61B2503/40
摘要： A torsional support apparatus is disclosed for craniocaudal rotation of test animals to enable multiple-view imaging. The animal is supported in a U-shaped loop of optically transparent material and the loop is moved to apply torsion to the animal to rotate it about its craniocaudal axis. Methods of imaging also are disclosed that use the torsional support technique.
摘要翻译：公开了一种扭转支撑装置，用于测试动物的头颈部旋转，以实现多视图成像。动物被支撑在光学透明材料的U形环中，并且环被移动以向动物施加扭转以围绕其头颅轴旋转。公开了使用扭转支撑技术的成像方法。

5. 发明申请

WO2009099526A3 APPARATUS AND METHOD FOR IMAGING IONIZING RADIATION 审中-公开
标题翻译：用于成像离子辐射的装置和方法
公开(公告)号：WO2009099526A3
公开(公告)日：2009-10-15
申请号：PCT/US2009000457
申请日：2009-01-23
申请人： CARESTREAM HEALTH INC , FEKE GILBERT , WOOD DOUGLAS O , VIZARD DOUGLAS L
发明人： FEKE GILBERT , WOOD DOUGLAS O , VIZARD DOUGLAS L
IPC分类号： G03B42/02 , G03C5/17
CPC分类号： A61B5/0059 , A61B6/00 , A61B6/4216 , A61B6/5241 , A61B6/583 , G03B42/023 , G21K2004/06
摘要： A system and method are disclosed for capturing a radiographic or autoradiographic image of an object, in which a support member is provided to receive the object in an immobilized state; a phosphor screen is provided to transduce ionizing radiation from the source to visible light; film or a digital capture device is provided for capturing an image using the visible light; and the phosphor screen is moved incrementally to facilitate reduction of phosphor screen mottle.
摘要翻译：公开了一种用于捕获物体的射线照相或放射自显影图像的系统和方法，其中提供支撑构件以在固定状态下接收物体; 提供荧光屏以将从源的电离辐射转换成可见光; 提供电影或数字捕获装置用于使用可见光捕获图像; 并且荧光屏逐渐移动以便于减少荧光屏斑点。

6. 发明申请

WO2009134363A3 VARIABLE CONDENSER FOR DELIVERY OF ILLUMINATION 审中-公开
标题翻译：用于交付照明的可变冷凝器
公开(公告)号：WO2009134363A3
公开(公告)日：2010-02-18
申请号：PCT/US2009002597
申请日：2009-04-29
申请人： CARESTREAM HEALTH INC , FEKE GILBERT
发明人： FEKE GILBERT
IPC分类号： F21V8/00 , F21V5/04
CPC分类号： G02B6/04 , G02B6/0008 , G02B26/103
摘要： A variable condenser for delivery of illumination, including a recursively nested circle-to-line fiber optic shape-converting cable and a focusable input lens system. At the input of the fiber optic cable, sets of individual optical fibers comprise successively smaller annuli recursively nested about a common center. At the output of the fiber optic cable, the sets of individual optical fibers comprise pairs of line segments recursively nested about the line midpoint, whereby the nesting level of the pairs of line segments has an exact or an approximate correspondence to the nesting level of the annuli. The output may be split into a plurality of lines, whereby the sets of individual optical fibers are distributed among the plurality of lines. The input lens system has a single adjustable focus means to vary the radius of an illumination spot incident upon the input of the fiber optic cable circle input.
摘要翻译：用于传输照明的可变电容器，包括递归嵌套的圆形到光纤形状转换电缆和可调焦输入透镜系统。在光纤电缆的输入端，单独的光纤组包括相对较小的环，其相对于公共中心递归地嵌套。在光纤电缆的输出处，各组光纤包括一对线段，其以线中点递归地嵌套，由此线段对的嵌套级别具有与嵌套级别的精确或近似对应关系环带。输出可以被分成多条线，由此各组光纤分布在多条线之间。输入透镜系统具有单个可调节聚焦装置，以改变入射到光纤光缆圆输入端的照明点的半径。

7. 发明申请

WO2007081385A8 MICROFLUIDIC DEVICES AND METHODS OF USE IN THE FORMATION AND CONTROL OF NANOREACTORS 审中-公开
标题翻译：微流体装置及其在纳米复合材料的形成与控制中的应用
公开(公告)号：WO2007081385A8
公开(公告)日：2008-11-27
申请号：PCT/US2006021280
申请日：2006-06-01
申请人： RAINDANCE TECHNOLOGIES INC , LINK DARREN R , BOITARD LAURENT , BRANCIFORTE JEFFREY , CHARLES YVES , FEKE GILBERT , LU JOHN Q , MARRAN DAVID , TABATABAI AHMADALI , WEINER MICHAEL , HINZ WOLFGANG , ROTHBERG JONATHAN M
发明人： LINK DARREN R , BOITARD LAURENT , BRANCIFORTE JEFFREY , CHARLES YVES , FEKE GILBERT , LU JOHN Q , MARRAN DAVID , TABATABAI AHMADALI , WEINER MICHAEL , HINZ WOLFGANG , ROTHBERG JONATHAN M
IPC分类号： G01N33/536 , B01J19/00 , C07B61/00 , C07K1/04 , C12Q1/68 , G01N33/68
CPC分类号： C12N15/1075 , B01F3/0807 , B01F13/0071 , B01F13/0076 , B01J19/0046 , B01J2219/00286 , B01J2219/00459 , B01J2219/00466 , B01J2219/00468 , B01J2219/00479 , B01J2219/005 , B01J2219/00576 , B01J2219/00599 , B01J2219/00702 , B01J2219/0072 , B01J2219/00743 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L3/502761 , B01L3/502784 , B01L3/502792 , B01L3/565 , B01L7/52 , B01L2200/027 , B01L2200/0621 , B01L2200/0647 , B01L2200/0652 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0896 , B01L2400/0415 , B01L2400/0424 , B01L2400/0487 , B01L2400/084 , B82Y5/00 , B82Y30/00 , C07K1/047 , C12Q1/6804 , C12Q1/6816 , C12Q1/6825 , C12Q1/6834 , C12Q1/686 , C12Q1/6869 , C12Q1/6874 , C12Q1/6876 , C12Q2525/161 , C12Q2561/119 , C12Q2563/103 , C12Q2563/107 , C12Q2563/159 , C12Q2565/537 , C12Q2565/629 , C12Q2600/16 , C40B30/04 , C40B40/04 , C40B50/08 , C40B60/08 , C40B60/12 , C40B70/00 , G01N21/6428 , G01N21/6445 , G01N21/6458 , G01N33/536 , G01N33/542 , G01N33/543 , G01N33/6845 , G01N33/6854 , G01N2500/10
摘要： The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. Such methods can include labeling a library of compounds by emulsifying aqueous solutions of the compounds and aqueous solutions of unique liquid labels on a microfluidic device, which includes a plurality of electrically addressable, channel bearing fluidic modules integrally arranged on a microfabricated substrate such that a continuous channel is provided for flow of immiscible fluids, whereby each compound is labeled with a unique liquid label, pooling the labeled emulsions, coalescing the labeled emulsions with emulsions containing a specific cell or enzyme, thereby forming a nanoreactor, screening the nanoreactors for a desirable reaction between the contents of the nanoreactor, and decoding the liquid label, thereby identifying a single compound from a library of compounds.
摘要翻译：本发明提供了可用于进行高通量筛选测定和组合化学的新型微流体装置和方法。这样的方法可以包括通过将化合物的水溶液和独特的液体标签的水溶液乳化在微流体装置上来标记化合物文库，所述微流体装置包括多个可电寻址的通道支承的流体模块，其整体地布置在微细加工的基底上，提供了用于不混溶流体流动的通道，由此每种化合物用独特的液体标记标记，汇集标记的乳液，将标记的乳液与含有特定细胞或酶的乳液聚结，从而形成纳米反应器，筛选纳米反应器以获得所需的反应在纳米反应器的内容物之间，并解码液体标签，从而从化合物文库鉴定单一化合物。

8. 发明申请

WO2007081386A2 MICROFLUIDIC DEVICES AND METHODS OF USE 审中-公开
标题翻译：微流体装置及其使用方法
公开(公告)号：WO2007081386A2
公开(公告)日：2007-07-19
申请号：PCT/US2006021286
申请日：2006-06-01
申请人： RAINDANCE TECHNOLOGIES INC , LINK DARREN R , BOITARD LAURENT , BRANCIFORTE JEFFREY , CHARLES YVES , FEKE GILBERT , LU JOHN Q , MARRAN DAVID , TABATABAI AHMADALI , WEINER MICHAEL , HINZ WOLFGANG , ROTHBERG JONATHAN M
发明人： LINK DARREN R , BOITARD LAURENT , BRANCIFORTE JEFFREY , CHARLES YVES , FEKE GILBERT , LU JOHN Q , MARRAN DAVID , TABATABAI AHMADALI , WEINER MICHAEL , HINZ WOLFGANG , ROTHBERG JONATHAN M
IPC分类号： B01L3/00 , B01F13/00 , G01N15/14
CPC分类号： C12N15/1075 , B01F3/0807 , B01F13/0071 , B01F13/0076 , B01J19/0046 , B01J2219/00286 , B01J2219/00459 , B01J2219/00466 , B01J2219/00468 , B01J2219/00479 , B01J2219/005 , B01J2219/00576 , B01J2219/00599 , B01J2219/00702 , B01J2219/0072 , B01J2219/00743 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L3/502761 , B01L3/502784 , B01L3/502792 , B01L3/565 , B01L7/52 , B01L2200/027 , B01L2200/0621 , B01L2200/0647 , B01L2200/0652 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0896 , B01L2400/0415 , B01L2400/0424 , B01L2400/0487 , B01L2400/084 , B82Y5/00 , B82Y30/00 , C07K1/047 , C12Q1/6804 , C12Q1/6816 , C12Q1/6825 , C12Q1/6834 , C12Q1/686 , C12Q1/6869 , C12Q1/6874 , C12Q1/6876 , C12Q2525/161 , C12Q2561/119 , C12Q2563/103 , C12Q2563/107 , C12Q2563/159 , C12Q2565/537 , C12Q2565/629 , C12Q2600/16 , C40B30/04 , C40B40/04 , C40B50/08 , C40B60/08 , C40B60/12 , C40B70/00 , G01N21/6428 , G01N21/6445 , G01N21/6458 , G01N33/536 , G01N33/542 , G01N33/543 , G01N33/6845 , G01N33/6854 , G01N2500/10
摘要： The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. The device can include a plurality of electrically addressable, channel bearing fluidic modules integrally arranged on a microfabricated substrate such that a continuous channel is provided for flow of immiscible fluids.
摘要翻译：本发明提供了可用于进行高通量筛选测定和组合化学的新型微流体装置和方法。该装置可以包括多个可电寻址的通道支承流体模块，其一体地布置在微加工基板上，使得提供用于不混溶流体流动的连续通道。

9. 发明申请

WO2007081385A2 MICROFLUIDIC DEVICES AND METHODS OF USE IN THE FORMATION AND CONTROL OF NANOREACTORS 审中-公开
标题翻译：微流体装置和用于形成和控制纳米反应器的方法
公开(公告)号：WO2007081385A2
公开(公告)日：2007-07-19
申请号：PCT/US2006021280
申请日：2006-06-01
申请人： RAINDANCE TECHNOLOGIES INC , LINK DARREN R , BOITARD LAURENT , BRANCIFORTE JEFFREY , CHARLES YVES , FEKE GILBERT , LU JOHN Q , MARRAN DAVID , TABATABAI AHMADALI , WEINER MICHAEL , HINZ WOLFGANG , ROTHBERG JONATHAN M
发明人： LINK DARREN R , BOITARD LAURENT , BRANCIFORTE JEFFREY , CHARLES YVES , FEKE GILBERT , LU JOHN Q , MARRAN DAVID , TABATABAI AHMADALI , WEINER MICHAEL , HINZ WOLFGANG , ROTHBERG JONATHAN M
IPC分类号： G01N33/536 , B01J19/00 , C07B61/00 , C07K1/04 , C12Q1/68 , G01N33/68
CPC分类号： C12N15/1075 , B01F3/0807 , B01F13/0071 , B01F13/0076 , B01J19/0046 , B01J2219/00286 , B01J2219/00459 , B01J2219/00466 , B01J2219/00468 , B01J2219/00479 , B01J2219/005 , B01J2219/00576 , B01J2219/00599 , B01J2219/00702 , B01J2219/0072 , B01J2219/00743 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L3/502761 , B01L3/502784 , B01L3/502792 , B01L3/565 , B01L7/52 , B01L2200/027 , B01L2200/0621 , B01L2200/0647 , B01L2200/0652 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0896 , B01L2400/0415 , B01L2400/0424 , B01L2400/0487 , B01L2400/084 , B82Y5/00 , B82Y30/00 , C07K1/047 , C12Q1/6804 , C12Q1/6816 , C12Q1/6825 , C12Q1/6834 , C12Q1/686 , C12Q1/6869 , C12Q1/6874 , C12Q1/6876 , C12Q2525/161 , C12Q2561/119 , C12Q2563/103 , C12Q2563/107 , C12Q2563/159 , C12Q2565/537 , C12Q2565/629 , C12Q2600/16 , C40B30/04 , C40B40/04 , C40B50/08 , C40B60/08 , C40B60/12 , C40B70/00 , G01N21/6428 , G01N21/6445 , G01N21/6458 , G01N33/536 , G01N33/542 , G01N33/543 , G01N33/6845 , G01N33/6854 , G01N2500/10
摘要： The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. Such methods can include labeling a library of compounds by emulsifying aqueous solutions of the compounds and aqueous solutions of unique liquid labels on a microfluidic device, which includes a plurality of electrically addressable, channel bearing fluidic modules integrally arranged on a microfabricated substrate such that a continuous channel is provided for flow of immiscible fluids, whereby each compound is labeled with a unique liquid label, pooling the labeled emulsions, coalescing the labeled emulsions with emulsions containing a specific cell or enzyme, thereby forming a nanoreactor, screening the nanoreactors for a desirable reaction between the contents of the nanoreactor, and decoding the liquid label, thereby identifying a single compound from a library of compounds.
摘要翻译：本发明提供了用于进行高通量筛选测定和组合化学的新型微流体装置和方法。这样的方法可以包括通过乳化化合物的水溶液和独特液体标签的水溶液在微流体装置上标记化合物文库，所述微流体装置包括整体地布置在微制造基底上的多个可电寻址的流道承载流体模块，通道用于不混溶流体的流动，由此每种化合物用独特的液体标签标记，汇集标记的乳液，使标记的乳液与含有特定细胞或酶的乳液聚结，由此形成纳米反应器，筛选纳米反应器以获得期望的反应在纳米反应器的内容物之间，以及解码液体标签，从而从化合物文库中鉴定单一化合物。

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