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1. 发明申请

WO2009023328A1 PROVIDING INTRABODY DATA SECURITY ON AN ACTIVE IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：在有源可植入医疗器械上提供内部数据安全
公开(公告)号：WO2009023328A1
公开(公告)日：2009-02-19
申请号：PCT/US2008/063769
申请日：2008-05-15
申请人： CARDIAC PACEMAKERS, INC. , STAHMANN, Jeffrey E. , HOYME, Kenneth P. , MAILE, Keith R. , JELATIS, George D. , TIMMONS, Michael J. , HUELSKAMP, Paul
发明人： STAHMANN, Jeffrey E. , HOYME, Kenneth P. , MAILE, Keith R. , JELATIS, George D. , TIMMONS, Michael J. , HUELSKAMP, Paul
IPC分类号： A61N1/372 , G06F21/00 , G06F19/00
CPC分类号： A61N1/37252 , G06F19/00 , G16H10/60
摘要： A system (130) and method (170) for providing intrabody data security on an active implantable medical device (103, 112) is presented. Data (191) is maintained through an active implantable medical device (103, 112). The data (191) is secured on the active implantable medical device (103, 112) among at least one other active implantable medical device (103, 112) wirelessly interfaced. At least one of access to and use of the data (191) with the other active implantable medical device (103, 112) is limited. Unauthorized changes to the form of the data (191) are prevented.
摘要翻译：提出了一种用于在主动植入式医疗设备（103,112）上提供体内数据安全性的系统（130）和方法（170）。通过有源可植入医疗装置（103,112）维持数据（191）。数据（191）在无线接口的至少一个其它有源可植入医疗装置（103,112）中固定在主动植入医疗装置（103,112）上。与另一个有源可植入医疗装置（103,112）的访问和使用数据（191）中的至少一个受到限制。防止对数据形式的未经授权的更改（191）。

2. 发明申请

WO2010093676A1 METHOD AND APPARATUS FOR INTRA-BODY ULTRASOUND COMMUNICATION 审中-公开
标题翻译：用于体内超声波通信的方法和装置
公开(公告)号：WO2010093676A1
公开(公告)日：2010-08-19
申请号：PCT/US2010/023729
申请日：2010-02-10
申请人： CARDIAC PACEMAKERS, INC. , BOON, Scot C. , MAILE, Keith R. , LINDER, William J. , HUELSKAMP, Paul , VIJAYAGOPAL, Ramprasad
发明人： BOON, Scot C. , MAILE, Keith R. , LINDER, William J. , HUELSKAMP, Paul , VIJAYAGOPAL, Ramprasad
IPC分类号： A61N1/372 , H04B13/00
CPC分类号： A61N1/37217 , A61N1/3727 , H04B11/00 , H04B13/005
摘要： An intra-body ultrasonic signal can be converted into a first electrical signal, a local oscillator signal can be generated in an implantable system. The first electrical signal and the local oscillator signal can be mixed in an implantable system, such as to generate a demodulated signal, processed, such as using a filter. The filtered, demodulated signal can be further processed, such as implantably determining a peak amplitude of the first portion of the demodulated signal received from the filter over a time interval, implantably generating a dynamic tracking threshold that starts at an amplitude proportional the first portion of the demodulated signal and exponentially decays over a time interval, and determining a noise floor in the absence of a received intra-body ultrasonic signal and implantably comparing the peak amplitude and the tracking threshold and generate the digital output based on the difference.
摘要翻译：体内超声波信号可以被转换成第一电信号，在可植入系统中可以产生本地振荡器信号。第一电信号和本地振荡器信号可以在可植入系统中混合，例如产生经处理的解调信号，例如使用滤波器。滤波后的解调信号可被进一步处理，诸如可植入地确定在时间间隔上从滤波器接收的解调信号的第一部分的峰值幅度，可植入地产生动态跟踪阈值，该动态跟踪阈值以与第所述解调信号在时间间隔上指数衰减，以及在没有接收到的体内超声波信号的情况下确定噪声本底，并且可植入地比较所述峰值幅度和跟踪阈值，并且基于所述差异生成所述数字输出。

3. 发明申请

WO2018081713A1 SYSTEMS FOR ACTIVITY LEVEL PACING 审中-公开
标题翻译：用于活动水平起飞的系统
公开(公告)号：WO2018081713A1
公开(公告)日：2018-05-03
申请号：PCT/US2017/059048
申请日：2017-10-30
申请人： CARDIAC PACEMAKERS, INC
发明人： KANE, Michael J. , HUELSKAMP, Paul
IPC分类号： A61N1/365 , A61N1/375
摘要： Systems and devices for pacing a heart of a patient are disclosed. This may include determining a motion level of the patient using a motion sensor of an implantable medical device secured relative to a patient's heart, and setting a pacing rate based at least in part on the patient's motion level. The patient's motion level may be determined by, for example, comparing the motion level sensed by the motion sensor during a current heart beat to a motion level associated with one or more previous heart beats. Noise may occur in the motion level measurements during those heart beats that transition between an intrinsically initiated heart beat and pace initiated heart beat. Various techniques may be applied to the motion level measurements to help reduce the effect of such noise.
摘要翻译：披露了用于起搏患者心脏的系统和设备。这可以包括使用相对于患者的心脏固定的可植入医疗设备的运动传感器来确定患者的运动水平，并且至少部分地基于患者的运动水平来设置起搏速率。例如，可以通过将在当前心脏跳动期间由运动传感器感测的运动水平与与一个或多个先前心脏跳动相关联的运动水平进行比较来确定患者的运动水平。运动水平测量过程中可能会出现噪声，这些心跳在内在启动的心跳和心跳起搏心跳之间转换。各种技术可应用于运动水平测量，以帮助减少这种噪音的影响。

4. 发明申请

WO2016033197A3 MEDICAL DEVICE WITH TRIGGERED BLANKING PERIOD 审中-公开
标题翻译：带触发式消隐期的医疗设备
公开(公告)号：WO2016033197A3
公开(公告)日：2016-03-03
申请号：PCT/US2015/046971
申请日：2015-08-26
申请人： CARDIAC PACEMAKERS, INC.
发明人： STAHMANN, Jeffrey E. , KANE, Michael J. , HUELSKAMP, Paul , MAILE, Keith R.
IPC分类号： A61N1/37 , A61N1/372 , A61N1/375 , A61N1/39
摘要： An implantable cardiac rhythm system includes a first implantable medical device configured to detect a first heartbeat from a first location, and a second implantable medical device configured to detect the first heart beat of the patient from a second location. The second implantable medical device, upon detecting the first heart beat, may communicate an indication of the detected first heart beat to the first implantable medical device, and in response, the first implantable medical device may institute a blanking period having a blanking period duration such that a T-wave of the detected first heart beat is blanked out by the first implantable medical device so as to not be interpreted as a subsequent second heart beat. In some instances, the first implantable medical device is an SICD and the second implantable medical device is a LCP.
摘要翻译：可植入心脏节律系统包括被配置为检测来自第一位置的第一心跳的第一可植入医疗装置以及被配置为从第二位置检测患者的第一心跳的第二可植入医疗装置。第二植入式医疗设备在检测到第一心脏跳动时可以将检测到的第一心跳的指示传达给第一植入式医疗设备，并且作为响应，第一植入式医疗设备可以设置具有消隐周期持续时间的消隐时段所检测到的第一心跳的T波被第一可植入医疗装置消隐以便不被解释为随后的第二心跳。在一些情况下，第一植入式医疗装置是SICD，而第二植入式医疗装置是LCP。

5. 发明申请

WO2016022395A1 MEDICAL DEVICE FOR COMMUNICATION WITH AN IMPLANTABLE LEADLESS CARDIAC PACEMAKER ONLY DURING TIMES BETWEEN BLANKING PERIODS 审中-公开
标题翻译：用于通风的医疗设备只有在空白期之间的时间内才能使用可植入的无铅心脏辅助器
公开(公告)号：WO2016022395A1
公开(公告)日：2016-02-11
申请号：PCT/US2015/042940
申请日：2015-07-30
申请人： CARDIAC PACEMAKERS, INC.
发明人： MAILE, Keith R. , KANE, Michael J. , HUELSKAMP, Paul , JUFFER, Lance E. , STAHMANN, Jeffrey E.
IPC分类号： A61N1/37 , A61N1/372 , A61N1/39 , A61B5/0402
CPC分类号： A61N1/37217 , A61B5/0402 , A61N1/3702 , A61N1/37252 , A61N1/37288 , A61N1/3756 , A61N1/3956 , G16H40/63
摘要： A medical device comprises a communication module for communicating with an implantable leadless cardiac pacemaker through body tissue and a controller operatively coupled to the communication module. The controller is configured to identify intrinsic heartbeats (1502a-1502c), provide message blanking periods (1510a-1510c) and communicate (1504, 1505, 1515) with the implantable leadless cardiac pacemaker via the communication module only during times between the message blanking periods.
摘要翻译：医疗装置包括通信模块，用于通过身体组织与可植入的无引线心脏起搏器进行通信，以及可操作地耦合到通信模块的控制器。控制器被配置为仅在消息消隐期间（1502a-1502c）期间识别固有心跳（1502a-1502c），通过通信模块提供消息消隐周期（1510a-1510c）和与可植入无引线心脏起搏器的通信（1504,1505,1515）。

6. 发明申请

WO2017040320A1 SYSTEMS AND METHODS FOR CARDIO-RESPIRATORY PACING 审中-公开
标题翻译：心脏呼吸系统和方法
公开(公告)号：WO2017040320A1
公开(公告)日：2017-03-09
申请号：PCT/US2016/049078
申请日：2016-08-26
申请人： CARDIAC PACEMAKERS, INC.
发明人： KANE, Michael J. , SHUROS, Allan Charles , HUELSKAMP, Paul , HAASL, Benjamin J. , MAILE, Keith R.
IPC分类号： A61N1/375 , A61N1/362
CPC分类号： A61N1/36585 , A61N1/3611 , A61N1/362 , A61N1/36514 , A61N1/36521 , A61N1/36535 , A61N1/36542 , A61N1/3756
摘要： Systems, devices, and methods for pacing a heart of a patient are disclosed. In some embodiments, a method for pacing a patient's heart may include determining a posture of the patient and determining if the determined posture corresponds to a predetermined sleep posture. If the determined posture correspond to the predetermined sleep posture, the method may further comprise determining a respiration phase of the patient and pacing the patient's heart at a pacing rate that is modulated based on the determined respiration phase of the patient. If the determined posture does not correspond to the predetermined sleep posture, the method may pace the patient's heart at a pacing rate that is not dependent on the respiration phase of the patient.
摘要翻译：公开了用于起搏患者心脏的系统，装置和方法。在一些实施例中，用于起搏患者心脏的方法可以包括确定患者的姿势并确定所确定的姿势是否对应于预定的睡眠姿势。如果确定的姿势对应于预定的睡眠姿势，则该方法还可以包括确定患者的呼吸阶段并且以基于所确定的患者的呼吸阶段调制的起搏速率起搏患者的心脏。如果确定的姿势不对应于预定的睡眠姿势，则该方法可以以不依赖于患者的呼吸阶段的起搏速率来调节患者的心脏。

7. 发明申请

WO2017035215A2 SPATIAL CONFIGURATION OF A MOTION SENSOR IN AN IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：可移植医疗设备中运动传感器的空间配置
公开(公告)号：WO2017035215A2
公开(公告)日：2017-03-02
申请号：PCT/US2016/048360
申请日：2016-08-24
申请人： CARDIAC PACEMAKERS, INC.
发明人： KANE, Michael J. , LINDER, William J. , BALCZEWSKI, Ron A. , MI, Bin , HATLESTAD, John D. , HUELSKAMP, Paul , MAILE, Keith R.
IPC分类号： A61N1/375 , A61N1/365 , A61N1/372 , A61B5/00
CPC分类号： A61N1/36542 , A61B5/02028 , A61B5/0402 , A61B5/1116 , A61B5/1118 , A61B5/6869 , A61N1/36514 , A61N1/36578 , A61N1/36585 , A61N1/3702 , A61N1/37205 , A61N1/37235 , A61N1/3756 , G06F19/00
摘要： Implantable devices having motion sensors. In some examples the a configuration is generated for the implantable device to use the motion sensor in an energy preserving mode in which one or more axis of detection of the motion sensor is disabled or ignored. In some examples the motion sensor outputs along multiple axes are analyzed to determine which axes best correspond to certain patient parameters including patient motion/activity and/or cardiac contractility. In other examples the output of the motion sensor is observed across patient movements or postures to develop conversion parameters to determine a patient standard frame of reference relative to outputs of the motion sensor of an implanted device.
摘要翻译：具有运动传感器的植入式装置。在一些示例中，生成针对可植入装置的配置，以能量保存模式使用运动传感器，其中运动传感器的一个或多个检测轴被禁用或忽略。在一些示例中，分析沿着多个轴的运动传感器输出，以确定哪些轴最佳地对应于包括患者运动/活动和/或心脏收缩力的某些患者参数。在其他示例中，运动传感器的输出在患者运动或姿势之间观察以产生转换参数，以相对于植入装置的运动传感器的输出确定患者标准参考系。

8. 发明申请

WO2017035209A1 TEMPORAL CONFIGURATION OF A MOTION SENSOR IN AN IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：可移植医疗设备中运动传感器的时间配置
公开(公告)号：WO2017035209A1
公开(公告)日：2017-03-02
申请号：PCT/US2016/048353
申请日：2016-08-24
申请人： CARDIAC PACEMAKERS, INC.
发明人： KANE, Michael J. , LINDER, William J. , HAASL, Benjamin J. , HUELSKAMP, Paul , MAILE, Keith R. , BALCZEWSKI, Ron A. , MI, Bin , HATLESTAD, John D. , SHUROS, Allan Charles
IPC分类号： A61N1/375 , A61N1/365 , A61N1/37 , A61B5/00 , A61B5/11 , A61N1/372
CPC分类号： A61N1/36542 , A61B5/0452 , A61B5/1107 , A61B5/1118 , A61B5/686 , A61B5/6869 , A61B2562/0219 , A61N1/36578 , A61N1/3684 , A61N1/371 , A61N1/37205 , A61N1/3756
摘要： Methods and devices for configuring the use of a motion sensor in an implantable cardiac device. The electrical signals of the patient's heart are observed and may be correlated to the physical motion of the heart as detected by the motion sensor of the implantable cardiac device in order to facilitate temporal configuration of motion sensor data collection that avoids detecting cardiac motion in favor of overall motion of the patient. The implantable device comprises trigger means for determining that a predefined event has occurred in the heart of the patient using a signal from the electrodes and sampling means for sampling an output of the motion sensor in response to the trigger means. In another aspect, the implantable device comprises sampling means for sampling a signal from a motion sensor in the ID, baseline calculation means for analyzing the sampled signal over time to generate a baseline output of the motion sensor, present state means for determining a present state indicator from the sampled signal, comparing means to compare the present state indicator to the baseline to yield a difference, activity characterizing means to analyze the difference to determine the patient's activity level.
摘要翻译：用于配置在可植入心脏装置中使用运动传感器的方法和装置。观察患者心脏的电信号，并且可以与由可植入心脏装置的运动传感器检测到的心脏物理运动相关，以便于运动传感器数据收集的时间配置，避免检测心脏运动，有利于患者的整体运动。可植入装置包括触发装置，用于使用来自电极的信号和用于响应于触发装置对运动传感器的输出采样的采样装置来确定在患者的心脏中发生了预定事件。在另一方面，可植入装置包括用于从ID中的运动传感器采样信号的采样装置，用于随时间分析采样信号以生成运动传感器的基线输出的基线计算装置，用于确定当前状态的当前状态装置来自采样信号的指示符，比较装置将当前状态指示符与基线进行比较以产生差异，活动表征手段来分析差异以确定患者的活动水平。

9. 发明申请

WO2016022397A1 MEDICAL DEVICE SYSTEMS WITH MULTIPLE COMMUNICATION MODES 审中-公开
标题翻译：具有多种通信模式的医疗设备系统
公开(公告)号：WO2016022397A1
公开(公告)日：2016-02-11
申请号：PCT/US2015/042954
申请日：2015-07-30
申请人： CARDIAC PACEMAKERS, INC.
发明人： STAHMANN, Jeffrey E. , MAILE, Keith R. , KOOP, Brendan E. , KANE, Michael J. , LUDWIG, Jacob M. , HUELSKAMP, Paul
IPC分类号： A61N1/362 , A61N1/372
CPC分类号： A61N1/37288 , A61N1/362 , A61N1/371 , A61N1/37205 , A61N1/37211 , A61N1/3727 , A61N1/3756
摘要： Medical device systems and methods with multiple communication modes. An example medical device system may include a first medical device and a second medical device communicatively coupled to the first medical device. The first medical device may be configured to communicate information to the second medical device in a first communication mode. The first medical device may further be configured to communicate information to the second medical device in a second communication mode after determining that one or more of the communication pulses captured the heart of the patient.
摘要翻译：具有多种通信模式的医疗设备系统和方法。示例性医疗设备系统可以包括通信地耦合到第一医疗设备的第一医疗设备和第二医疗设备。第一医疗设备可以被配置为以第一通信模式向第二医疗设备传送信息。第一医疗设备还可以被配置为在确定一个或多个通信脉冲捕获患者的心脏之后，以第二通信模式将信息传送到第二医疗设备。

10. 发明申请

WO2018119434A2 WIRELESS COMMUNICATION BETWEEN MULTIPLE IMPLANTED DEVICES 审中-公开
公开(公告)号：WO2018119434A2
公开(公告)日：2018-06-28
申请号：PCT/US2017/068294
申请日：2017-12-22
申请人： CARDIAC PACEMAKERS, INC.
发明人： KOOP, Brendan Early , LINDER, William J. , MAILE, Keith R. , HUELSKAMP, Paul , JUFFER, Lance Eric , LUDWIG, Jacob M.
IPC分类号： A61N1/372
摘要： Implantable medical devices (IMD), such as but not limited to leadless cardiac pacemakers (LCP), neuro-stimulators (NS), and/or implantable monitors (IM), may be configured to communicate using more than one mode of communication and/or more than one communication vector. In some cases, the implantable medical device may be configured to switch between communication modes, vectors, and/or communication paths, which may help improve communication reliability and/or communication speed between devices.

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