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1. 发明申请

WO2020014184A1 HEART SOUNDS AND PLETHYSMOGRAPHY BLOOD PRESSURE MEASUREMENT 审中-公开
公开(公告)号：WO2020014184A1
公开(公告)日：2020-01-16
申请号：PCT/US2019/040939
申请日：2019-07-09
申请人： CARDIAC PACEMAKERS, INC.
发明人： STAHMANN, Jeffrey E. , THAKUR, Pramodsingh Hirasingh
IPC分类号： A61B5/021 , A61B5/0215 , A61B5/0295 , A61B7/04
摘要： This document discusses, among other things, systems and methods to determine a blood pressure measurement of a subject, such as a systolic blood pressure of a subject, a diastolic blood pressure of the subject, or both, using received heart sound information and plethysmography information of the subject. The system can include a signal receiver circuit configured to receive the heart sound information and plethysmography information of the subject, and an assessment circuit configured to determine the systolic and diastolic blood pressure of the subject using the received heart sound information and the plethysmography information of the subject.

2. 发明申请

WO2019108482A1 METHODS AND SYSTEMS FOR DETECTING ATRIAL CONTRACTION TIMING FIDUCIALS AND DETERMINING A CARDIAC INTERVAL FROM A VENTRICULARLY IMPLANTED LEADLESS CARDIAC PACEMAKER 审中-公开
公开(公告)号：WO2019108482A1
公开(公告)日：2019-06-06
申请号：PCT/US2018/062469
申请日：2018-11-26
申请人： CARDIAC PACEMAKERS, INC.
发明人： STAHMANN, Jeffrey E. , MAILE, Keith R. , SIEJKO, Krzysztof Z. , SHUROS, Allan Charles
IPC分类号： A61N1/375 , A61N1/365
CPC分类号： A61N1/37512 , A61B5/686 , A61N1/36167 , A61N1/36564 , A61N1/36578 , A61N1/36585 , A61N1/3682 , A61N1/3706 , A61N1/37205 , A61N1/37252 , A61N1/3756 , A61N1/3925 , A61N1/39622 , A61N1/3968
摘要： A veiitricularlv implantable medical device that includes a sensing module that is configured to gather information during a cardiac cycle and to identify a cardiac interval based at least on part on the gathered information. Control circuitry in the implantable medical device is configured to deliver a ventricular pacing therapy to a patient's heart, wherein the ventricular pacing therapy is time dependent, at least in part, on the identified cardiac interval.

3. 发明申请

WO2019023093A1 SYSTEMS AND METHODS FOR DISAMBIGUATION OF POSTURE 审中-公开
公开(公告)号：WO2019023093A1
公开(公告)日：2019-01-31
申请号：PCT/US2018/043225
申请日：2018-07-23
申请人： CARDIAC PACEMAKERS, INC.
发明人： STAHMANN, Jeffrey E. , HATLESTAD, John D.
IPC分类号： A61B5/11 , A61B5/145 , A61N1/365 , A61N1/368 , A61N1/37 , A61N1/05
CPC分类号： A61B5/1116 , A61B5/1118 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B2562/0219 , A61N1/056 , A61N1/365 , A61N1/368 , A61N1/3702
摘要： Embodiments include medical device systems, medical devices, including accelerometers and chemical sensors, and methods of using the same to determine the posture of a patient. In an embodiment, a medical device system herein includes an accelerometer configured to generate a signal reflecting a position of a patient, a chemical sensor configured to generate a signal reflecting physiological analyte data of the patient and a controller in electrical communication with the accelerometer and the chemical sensor. The controller can be configured to determine a posture of the patient using the position signal generated by the accelerometer and the signal generated by the chemical sensor. Other embodiments are also included herein.

4. 发明申请

WO2019010112A1 SYSTEMS AND METHODS FOR MEDICAL ALERT MANAGEMENT 审中-公开
公开(公告)号：WO2019010112A1
公开(公告)日：2019-01-10
申请号：PCT/US2018/040550
申请日：2018-07-02
申请人： CARDIAC PACEMAKERS, INC.
发明人： AVERINA, Viktoria A. , THAKUR, Pramodsingh Hirasingh , WARIAR, Ramesh , AN, Qi , ZHANG, Yi , STAHMANN, Jeffrey E.
IPC分类号： A61N1/02 , A61N1/365 , A61N1/37 , A61B5/00 , A61N1/362
摘要： Systems and methods for managing machine-generated alerts of a medical event such as worsening heart failure (WHF) are described. A patient management system includes a patient database of information about a correspondence between a plurality of alert thresholds (ATHs) and corresponding clinical outcome indicators (COIs) for a plurality of patients. A control circuit can query the patient database for a matching patient that meets specific query criteria compared to a target patient, retrieve an ATH-COI correspondence associated with the matching patient, and determine the alert threshold using a user input of a COI and the retrieved ATH-COI correspondence. A medical event detector detects the medical event using physiological signals sensed from the target patient and the determined alert threshold.

5. 发明申请

WO2017120550A1 PROGRESSIVE ADAPTIVE DATA TRANSFER 审中-公开
标题翻译：渐进式自适应数据传输
公开(公告)号：WO2017120550A1
公开(公告)日：2017-07-13
申请号：PCT/US2017/012641
申请日：2017-01-06
申请人： CARDIAC PACEMAKERS, INC.
发明人： STAHMANN, Jeffrey E. , SIMMS, Howard D., Jr.
IPC分类号： A61N1/372
CPC分类号： G06F19/345 , A61N1/37252 , G06F19/00 , G06F19/3418 , G16H50/20
摘要： An interrogation system for a medical device includes a memory storing a diagnostic algorithm, a processor configured to run the diagnostic algorithm, and a communication module configured to facilitate data transfer between the interrogation system and the medical device. The diagnostic algorithm is configured to reach a diagnostic conclusion based on data from the medical device. The diagnostic algorithm is configured to iteratively interrogate the medical device for the data from the medical device until the diagnostic algorithm reaches the diagnostic conclusion, each iterative interrogation requesting additional data as compared to prior iterations. The communication module is configured to receive the additional data from the medical device in response to each iterative interrogation. The diagnostic algorithm is further configured to store an indication of the diagnostic conclusion within the memory.
摘要翻译：用于医疗设备的询问系统包括存储诊断算法的存储器，配置成运行诊断算法的处理器以及配置成促进询问系统和医疗设备之间的数据传输的通信模块。诊断算法配置为基于来自医疗设备的数据达到诊断结论。诊断算法被配置为迭代地询问医疗设备中的来自医疗设备的数据，直到诊断算法达到诊断结论为止，与先前的迭代相比，每个迭代询问请求附加数据。通信模块被配置为响应于每次迭代询问从医疗装置接收附加数据。诊断算法还被配置为在存储器中存储诊断结论的指示。

6. 发明申请

WO2017003815A1 SYSTEMS AND METHODS FOR NORMALIZATION OF CHEMICAL SENSOR DATA BASED ON FLUID STATE CHANGES 审中-公开
标题翻译：基于流体状态变化的化学传感器数据正常化的系统和方法
公开(公告)号：WO2017003815A1
公开(公告)日：2017-01-05
申请号：PCT/US2016/038989
申请日：2016-06-23
申请人： CARDIAC PACEMAKERS, INC.
发明人： STAHMANN, Jeffrey E.
IPC分类号： A61B5/00 , A61N1/372 , A61B5/145 , A61B5/1459 , A61B5/08 , A61B5/11 , A61N1/36
CPC分类号： A61B5/1473 , A61B5/0031 , A61B5/01 , A61B5/05 , A61B5/08 , A61B5/1116 , A61B5/1118 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1459 , A61B5/686 , A61B5/6861 , A61B5/7221 , A61B5/746 , A61B2562/0219 , A61N1/36 , A61N1/36557 , A61N1/37288
摘要： Embodiments herein include implantable medical systems, devices and methods including chemical sensors. In an embodiment, an implantable medical device system includes a chemical sensor; a fluid state sensor such as a posture sensor; an activity sensor; and/or a respiration sensor. The implantable medical device system can further include normalization circuitry receiving data from the chemical sensor and the fluid state sensor and normalizing the chemical sensor data based on data from the fluid state sensor. In an embodiment, a method of operating an implantable medical device system is included. The method can include measuring the amount of a chemical analyte using a chemical sensor, measuring the fluid status in a patient using a fluid state sensor, and normalizing the measured amount of the chemical analyte as indicated by the chemical sensor using normalization circuitry based on data from the fluid state sensor. Other embodiments are also included herein.
摘要翻译：本文的实施方案包括可植入医疗系统，包括化学传感器的装置和方法。在一个实施例中，可植入医疗装置系统包括化学传感器; 诸如姿势传感器的流体状态传感器; 活动传感器; 和/或呼吸传感器。可植入医疗装置系统还可包括从化学传感器和流体状态传感器接收数据的归一化电路，并根据来自流体状态传感器的数据对化学传感器数据进行标准化。在一个实施例中，包括操作可植入医疗装置系统的方法。该方法可以包括使用化学传感器测量化学分析物的量，使用流体状态传感器测量患者的流体状态，以及使用基于数据的归一化电路由化学传感器指示的化学分析物的测量量进行归一化从流体状态传感器。本文还包括其它实施例。

7. 发明申请

WO2016033177A1 ENERGY ADAPTIVE COMMUNICATION FOR MEDICAL DEVICES 审中-公开
标题翻译：用于医疗器械的能量自适应通信
公开(公告)号：WO2016033177A1
公开(公告)日：2016-03-03
申请号：PCT/US2015/046940
申请日：2015-08-26
申请人： CARDIAC PACEMAKERS, INC.
发明人： STAHMANN, Jeffrey E. , HUELSKAMP, Paul , KANE, Michael J. , MAILE, Keith R.
IPC分类号： A61N1/375 , A61N1/372 , A61N1/37
CPC分类号： A61N1/37288 , A61N1/371 , A61N1/37217 , A61N1/37241 , A61N1/37276 , A61N1/3756 , A61N1/3956
摘要： System and methods for energy adaptive communications between medical devices are disclosed. In one example, a medical device includes a communication module configured to deliver a plurality of pulses to tissue of a patient, where each pulse has an amount of energy. A control module operatively coupled to the communication module, may be configured to, for each delivered pulse, determine whether the delivered pulse produces an unwanted stimulation of the patient and to change the amount of energy of the plurality of pulses over time so as to identify an amount of energy that corresponds to an unwanted stimulation threshold for the pulses. The control module may then set a maximum energy value for communication pulses that is below the unwanted stimulation threshold, and may deliver communication pulses below the maximum energy value during communication with another medical device.
摘要翻译：公开了用于医疗装置之间能量自适应通信的系统和方法。在一个示例中，医疗设备包括通信模块，其被配置为向患者的组织递送多个脉冲，其中每个脉冲具有一定量的能量。可操作地耦合到通信模块的控制模块可以被配置为，对于每个递送的脉冲，确定所递送的脉冲是否产生患者的不期望的刺激并且随时间改变多个脉冲的能量的量以便识别对应于脉冲的不期望的刺激阈值的能量的量。控制模块然后可以设置低于不需要的刺激阈值的通信脉冲的最大能量值，并且可以在与另一医疗设备通信期间将通信脉冲递送到最大能量值以下。

8. 发明申请

WO2016033087A1 DISPLAY OF TEMPORALLY ALIGNED HEART INFORMATION FROM SEPARATE IMPLANTABLE MEDICAL DEVICES ON AN EXTRACORPOREAL DISPLAY 审中-公开
标题翻译：从分离的医疗器械显示临时显示的临时心脏信息
公开(公告)号：WO2016033087A1
公开(公告)日：2016-03-03
申请号：PCT/US2015/046757
申请日：2015-08-25
申请人： CARDIAC PACEMAKERS, INC.
发明人： STAHMANN, Jeffrey E. , KANE, Michael J. , HUELSKAMP, Paul , MAILE, Keith R.
IPC分类号： A61N1/362 , A61N1/375 , A61N1/39 , A61N1/372 , A61B5/044 , A61B5/02 , A61B5/042 , A61B5/0404
CPC分类号： A61B5/0404 , A61B5/02 , A61B5/042 , A61B5/044 , A61N1/3621 , A61N1/3702 , A61N1/37235 , A61N1/37247 , A61N1/37288 , A61N1/3756 , A61N1/3925 , A61N1/3962
摘要： A cardiac rhythm management system includes a first implantable device such as a defibrillator and a second implantable device such as a leadless cardiac pacemaker. A programmer is configured to receive and display heart data emanating from the implantable defibrillator and from the leadless cardiac pacemaker. The heart data emanating from the leadless cardiac pacemaker is displayed in temporal alignment with the heart data emanating from the implantable defibrillator.
摘要翻译：心律管理系统包括诸如除颤器的第一可植入装置和诸如无引线心脏起搏器的第二可植入装置。程序员被配置为接收和显示从可植入除颤器和无引线心脏起搏器发出的心脏数据。从无引线心脏起搏器发出的心脏数据与从可植入除颤器发出的心脏数据时间对准显示。

9. 发明申请

WO2016022396A1 COMMUNICATIONS IN A MEDICAL DEVICE SYSTEM 审中-公开
标题翻译：医疗器械系统的通讯
公开(公告)号：WO2016022396A1
公开(公告)日：2016-02-11
申请号：PCT/US2015/042947
申请日：2015-07-30
申请人： CARDIAC PACEMAKERS, INC.
发明人： MAILE, Keith R. , KANE, Michael J. , HUELSKAMP, Paul , JUFFER, Lance E. , STAHMANN, Jeffrey E.
IPC分类号： A61N1/372 , A61B5/00
CPC分类号： A61N1/37288 , A61B5/0024 , A61B5/0028 , A61N1/37217 , A61N1/3962 , G06F19/00 , G06F19/3418 , H04L7/04 , H04L27/02
摘要： Systems and methods for communicating between medical devices. In one example, a method for communicating between a plurality of medical devices in a medical device system comprises, with a first medical device, communicating a first message to a second medical device. The method further comprises, with the second medical device, receiving the first message, wherein the first message comprises a plurality of communication pulses. A first set of the plurality of communication pulses represent a synchronization portion of the first message. A second set of the plurality of communication pulses represent a relative device address portion of the first message. A third set of the plurality of communication pulses represent a command portion of the first message. A fourth set of the plurality of communication pulses represent a payload portion of the first message.
摘要翻译：用于医疗设备之间通信的系统和方法。在一个示例中，用于在医疗设备系统中的多个医疗设备之间进行通信的方法包括用第一医疗设备将第一消息传送到第二医疗设备。该方法还包括与第二医疗设备接收第一消息，其中第一消息包括多个通信脉冲。多个通信脉冲的第一组表示第一消息的同步部分。多个通信脉冲的第二组表示第一消息的相对设备地址部分。多个通信脉冲的第三组表示第一消息的命令部分。多个通信脉冲的第四组表示第一消息的有效载荷部分。

10. 发明申请

WO2016022390A1 COMMUNICATIONS IN A MEDICAL DEVICE SYSTEM 审中-公开
标题翻译：医疗设备系统中的通信
公开(公告)号：WO2016022390A1
公开(公告)日：2016-02-11
申请号：PCT/US2015/042918
申请日：2015-07-30
申请人： CARDIAC PACEMAKERS, INC.
发明人： MAILE, Keith R. , KANE, Michael J. , HUELSKAMP, Paul , JUFFER, Lance E. , STAHMANN, Jeffrey E.
IPC分类号： A61N1/372 , A61B5/00
CPC分类号： A61N1/37288 , A61B5/0024 , A61B5/0028 , A61B5/0031 , A61N1/37217 , A61N1/37252 , G06F19/00 , G06F19/321
摘要： Systems and methods for communicating between medical devices. In one example, an implantable medical device comprises a communication module configured to receive commands from other medical devices, wherein the commands include a relative address and a command payload; a memory unit that stores a relative address and a unique identifier of the implantable medical device; a processing module coupled to the communication module and the memory unit, the processing module configured to: determine whether the relative address of a received command matches the relative address stored in the memory unit of the implantable medical device; if the relative address of the received command matches the relative address stored in the memory unit of the implantable medical device, execute the received command; and if the relative address of the received command does not match the relative address stored in the memory unit of the implantable medical device, ignore the received command.
摘要翻译：用于医疗设备之间通信的系统和方法。在一个示例中，可植入医疗设备包括被配置为从其他医疗设备接收命令的通信模块，其中所述命令包括相对地址和命令有效载荷; 存储单元，其存储所述可植入医疗装置的相对地址和唯一标识符; 耦合到所述通信模块和所述存储器单元的处理模块，所述处理模块被配置为：确定所接收命令的相对地址是否与存储在所述可植入医疗设备的存储器单元中的相对地址匹配; 如果接收到的命令的相对地址与存储在可植入医疗装置的存储单元中的相对地址匹配，则执行接收到的命令; 并且如果接收到的命令的相对地址与存储在可植入医疗设备的存储器单元中的相对地址不匹配，则忽略所接收的命令。

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