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1. 发明申请

WO2007095264A1 METHOD AND APPARATUS FOR HEAT OR ELECTROMAGNETIC CONTROL OF GENE EXPRESSION 审中-公开
标题翻译：用于基因表达的热或电磁控制的方法和装置
公开(公告)号：WO2007095264A1
公开(公告)日：2007-08-23
申请号：PCT/US2007/003855
申请日：2007-02-12
申请人： CARDIAC PACEMAKERS, INC. , QU, Jihong , STOLEN, Craig
发明人： QU, Jihong , STOLEN, Craig
IPC分类号： C12N15/87 , A61N1/32 , A61N1/362 , A61K48/00
CPC分类号： A61N1/3627 , A61K48/0058 , A61N1/326 , A61N1/362 , A61N1/36514
摘要： A gene regulatory system controls biomarker, gene therapy or endogenous gene expression by emitting one or more forms of energy that regulate gene expression. The system may include a sensor to sense a signal indicative of a need for therapy. The regulation of gene expression is controlled based on the sensed signal and/or a user command. In one embodiment, the system delivers one or more electrical therapies in conjunction with controlling gene therapy or endogenous gene expression.
摘要翻译：基因调控系统通过发射调节基因表达的一种或多种形式的能量来控制生物标志物，基因治疗或内源基因表达。该系统可以包括用于感测指示治疗需要的信号的传感器。基于感测信号和/或用户命令来控制基因表达的调节。在一个实施方案中，该系统结合控制基因治疗或内源基因表达递送一种或多种电疗法。

2. 发明申请

WO2009011738A1 SYSTEMS FOR MODULATING TEMPERATURE FOR VASOACTIVE RESPONSE 审中-公开
标题翻译：用于调节温度反应的温度系统
公开(公告)号：WO2009011738A1
公开(公告)日：2009-01-22
申请号：PCT/US2008/007299
申请日：2008-06-11
申请人： CARDIAC PACEMAKERS, INC. , ARCOT-KRISHNAMURTHY, Shantha , SHUROS, Allan C. , QU, Jihong
发明人： ARCOT-KRISHNAMURTHY, Shantha , SHUROS, Allan C. , QU, Jihong
IPC分类号： A61F7/12
CPC分类号： A61F7/12 , A61F7/123 , A61F2007/0056 , A61F2007/0071 , A61F2007/0075 , A61F2007/126
摘要： Disclosed herein, among other things, is a device for providing a localized vasomodulation of a vessel. According to an embodiment, the device includes a thermal element configured to conduct thermal energy between the thermal element and a desired region of the vessel wall to elicit the localized vasomodulation of the vessel at the desired region. The device also includes a controller operationally connected to the thermal element. The controller is adapted to control the conduction of thermal energy between the thermal element and the desired region of the vessel wall to control the localized vasomodulation of the vessel at the desired region. In various embodiments, a sensor connected to the device provides feedback to the controller.
摘要翻译：这里公开了一种用于提供血管的局部血管调节的装置。根据实施例，该装置包括热元件，其被配置为在热元件和容器壁的期望区域之间传导热能，以引起容器在期望区域的局部血管调节。该装置还包括可操作地连接到热元件的控制器。控制器适于控制热元件与血管壁的所需区域之间的热能传导，以控制血管在所需区域的局部血管调节。在各种实施例中，连接到设备的传感器向控制器提供反馈。

3. 发明申请

WO2006115693A3 METHOD AND APPARATUS FOR PACING DURING REVASCULARIZATION 审中-公开
公开(公告)号：WO2006115693A3
公开(公告)日：2006-11-02
申请号：PCT/US2006/011972
申请日：2006-03-30
申请人： CARDIAC PACEMAKERS, INC. , SHUROS, Allan , BAYNHAM, Tamara Colette , QU, Jihong , PASTORE, Joseph M. , KRAMER, Andrew P. , PRINZEN, Frits W. , VANAGT, Ward Y.R. , CORNELUSSEN, Richard N.
发明人： SHUROS, Allan , BAYNHAM, Tamara Colette , QU, Jihong , PASTORE, Joseph M. , KRAMER, Andrew P. , PRINZEN, Frits W. , VANAGT, Ward Y.R. , CORNELUSSEN, Richard N.
IPC分类号： A61N1/37 , A61B18/14 , A61M25/00 , A61B17/22 , A61F2/06 , A61M29/02
摘要： Cardiac protection pacing is applied to prevent or reduce cardiac injury and/or occurrences of arrhythmia associated with an ischemic event including the occlusion of a blood vessel during a revascularization procedure. Pacing pulses are generated from a pacemaker and delivered through one or more pacing electrodes incorporated onto a percutaneous transluminal vascular intervention (PTVI) device used in the revascularization procedure. The pacemaker generates the pacing pulses according to a predetermined cardiac protection pacing sequence before, during, and/or after the ischemic event.

4. 发明申请

WO2009025812A2 APPARATUS TO TREAT AND PREVENT ATRIAL TACHYARRHYTHMIAS 审中-公开
标题翻译：用于治疗和预防心房心律失常的装置
公开(公告)号：WO2009025812A2
公开(公告)日：2009-02-26
申请号：PCT/US2008/009898
申请日：2008-08-20
申请人： CARDIAC PACEMAKERS, INC. , QU, Jihong , SIH, Haris J. , SCHWARTZ, Mark , SINHA, Prashant
发明人： QU, Jihong , SIH, Haris J. , SCHWARTZ, Mark , SINHA, Prashant
IPC分类号： A61K47/48
CPC分类号： A61N1/3621 , A61M5/14276 , A61N1/0568 , A61N1/0587 , A61N1/3962
摘要： The invention provides a cardiac rhythm management system which includes a tachyarrhythmia detection and classification circuit programmed to detect and classify a tachyarrhythmia, a biologic therapy delivery device configured to deliver or regulate an expression cassette suitable for terminating or preventing atrial fibrillation (AF), and a control circuit coupled to the tachyarrhythmia detection and classification circuit and the biologic therapy delivery device. Also provided is an implantable medical device for use in a body having a cardiovascular system, which includes an implantable device body including at least a cardiovascular portion configured to be in the cardiovascular system, and an expression cassette incorporated into the cardiovascular portion of the implantable device body, the expression cassette selected to express a gene product that terminates or prevents AF. Further provided are methods which employ particular expression cassettes to prevent, inhibit or treat AF.
摘要翻译：本发明提供了一种心律管理系统，其包括快速心律失常检测和分类电路，该快速心律失常检测和分类电路被编程为检测和分类快速性心律失常;生物治疗输送装置，其被配置为输送或调节适于终止或预防的表达盒心房颤动（AF）以及耦合到快速性心律失常检测和分类电路以及生物治疗传递装置的控制电路。还提供了一种用于具有心血管系统的身体的可植入医疗装置，该装置包括可植入装置主体，该可植入装置主体包括至少一个配置成位于心血管系统内的心血管部分，以及一个并入可植入装置的心血管部分中的表达盒选择表达盒以表达终止或防止AF的基因产物。进一步提供了使用特定表达盒来预防，抑制或治疗AF的方法。

5. 发明申请

WO2007021413A2 BIOLOGIC DEVICE FOR REGULATION OF GENE EXPRESSION 审中-公开
标题翻译：用于调节基因表达的生物学装置
公开(公告)号：WO2007021413A2
公开(公告)日：2007-02-22
申请号：PCT/US2006/027209
申请日：2006-07-13
申请人： CARDIAC PACEMAKERS, INC. , WAGNER, Darrell, O. , SIH, Haris, J. , QU, Jihong , ROSS, Jeffrey , GIROUARD, Steven , HEIL, Ronald, W., Jr.
发明人： WAGNER, Darrell, O. , SIH, Haris, J. , QU, Jihong , ROSS, Jeffrey , GIROUARD, Steven , HEIL, Ronald, W., Jr.
IPC分类号： A61K48/00 , A61N1/05
CPC分类号： A61K48/0008 , A61K48/0083 , A61N1/05
摘要： A system and device are provided which include a gene regulatory system controlling expression of one or more expression cassettes present in or released by the device, by emitting one or more stimulations. An expression cassette includes a regulatable transcription control element that is responsive to the emitted stimulations linked to an open reading frame of interest. The system optionally includes a sensor to sense a parameter indicative of a need, a telemetry module to receive an external command, or a programmable device, for regulating gene expression of the open reading frame.
摘要翻译：提供了一种系统和装置，其包括通过发出一种或多种刺激来控制存在于装置中或由装置释放的一个或多个表达盒的表达的基因调控系统。表达盒包括可调控的转录控制元件，其响应于与感兴趣的开放读框连接的发射刺激。系统可选地包括用于感测指示需要的参数的传感器，用于接收外部命令的遥测模块或用于调节开放阅读框的基因表达的可编程装置。

6. 发明申请

WO2009032485A1 MEDICAL DEVICE ELECTRODES HAVING CELLS DISPOSED ON NANOSTRUCTURES 审中-公开
标题翻译：具有纳米结构处理细胞的医疗器械电极
公开(公告)号：WO2009032485A1
公开(公告)日：2009-03-12
申请号：PCT/US2008/072811
申请日：2008-08-11
申请人： CARDIAC PACEMAKERS, INC. , STAHMANN, Jeffrey E. , SALO, Rodney W. , QU, Jihong
发明人： STAHMANN, Jeffrey E. , SALO, Rodney W. , QU, Jihong
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/0565
摘要： Electrodes for tissue stimulation and sensing can comprise a support with nanostructures disposed on the support. Pairs of the electrodes can be placed in close proximity to one another. When electrical energy is supplied to the electrodes, an electrical field (and possibly an electrical current) can be established between the nanostructures on the electrodes. The nanostructures may have cells disposed thereon, for example myocardial cells, myocardial progenitor cells, neural cells and/or stem cells. In addition, the electrodes can be arranged in arrays.
摘要翻译：用于组织刺激和感测的电极可以包括具有设置在支撑体上的纳米结构的支撑体。电极对可以彼此靠近放置。当向电极提供电能时，可以在电极上的纳米结构之间建立电场（和可能的电流）。纳米结构可以具有设置在其上的细胞，例如心肌细胞，心肌祖细胞，神经细胞和/或干细胞。此外，电极可以排列成阵列。

7. 发明申请

WO2009032484A3 MEDICAL DEVICE ELECTRODES INCLUDING NANOSTRUCTURES 审中-公开
公开(公告)号：WO2009032484A3
公开(公告)日：2009-03-12
申请号：PCT/US2008/072807
申请日：2008-08-11
申请人： CARDIAC PACEMAKERS, INC. , STAHMANN, Jeffrey E. , SALO, Rodney W. , QU, Jihong
发明人： STAHMANN, Jeffrey E. , SALO, Rodney W. , QU, Jihong
IPC分类号： A61N1/05
摘要： Electrodes for tissue stimulation and sensing can comprise a support with nanostructures disposed on the support. Pairs of the electrodes can be placed in close proximity to one another. When electrical energy is supplied to the electrodes, an electrical field (and possibly an electrical current) can be established between the nanostructures on the electrodes. The nanostructures may have cells disposed thereon, for example myocardial cells, myocardial progenitor cells, neural cells and/or stem cells. In addition, the electrodes can be arranged in arrays.

8. 发明申请

WO2009012094A1 OSMOMETRIC HEART MONITORING DEVICE AND METHODS 审中-公开
标题翻译： OSMOMETRIC心脏监测装置及方法
公开(公告)号：WO2009012094A1
公开(公告)日：2009-01-22
申请号：PCT/US2008/069499
申请日：2008-07-09
申请人： CARDIAC PACEMAKERS, INC. , SHUROS, Allan, Charles , MOKELKE, Eric, A. , KANE, Michael, John , QU, Jihong
发明人： SHUROS, Allan, Charles , MOKELKE, Eric, A. , KANE, Michael, John , QU, Jihong
IPC分类号： A61B5/07 , A61N1/365 , A61N1/37 , G01N13/04 , G01N33/84 , A61N1/05 , A61B5/00
CPC分类号： A61N1/3702 , A61B5/0006 , A61B5/02028 , A61B5/076 , A61B5/14539 , A61B5/14546 , A61B5/4869 , A61B2562/02 , A61N1/05 , A61N1/36521 , A61N1/36557 , G01N13/04
摘要： Embodiments of the invention are related to monitoring devices and methods with osmometric sensors, amongst other things. In an embodiment, the invention includes an implantable heart failure monitoring system including an osmometric sensor, the osmometric sensor configured to generate a signal corresponding to the osmotic strength of a bodily fluid, and a controller in communication with the osmometric sensor, the controller configured to receive and process the signal corresponding to the osmotic strength of a bodily fluid. Other aspects and embodiments are provided herein.
摘要翻译：本发明的实施例涉及到具有渗压传感器的监测装置和方法以及其它方面。在一个实施例中，本发明包括可植入心力衰竭监测系统，其包括渗透传感器，所述渗透传感器被配置为产生对应于体液的渗透强度的信号，以及与所述渗透传感器通信的控制器，所述控制器被配置为接收和处理对应于体液渗透强度的信号。本文提供了其它方面和实施例。

9. 发明申请

WO2008042473A1 DEVICES, VECTORS AND METHODS FOR INDUCIBLE CARDIOPROTECTION 审中-公开
标题翻译：用于诱导性心脏保护的装置，载体和方法
公开(公告)号：WO2008042473A1
公开(公告)日：2008-04-10
申请号：PCT/US2007/069643
申请日：2007-05-24
申请人： CARDIAC PACEMAKERS, INC. , QU, Jihong , KRAMER, Andrew P. , RUBLE, Stephen
发明人： QU, Jihong , KRAMER, Andrew P. , RUBLE, Stephen
IPC分类号： C12N15/85
CPC分类号： C12N15/85 , A61K48/0058 , C12N2800/40 , C12N2830/002 , C12N2830/008
摘要： Vectors, systems having implantable devices and methods useful to detect or treat ischemia are provided.
摘要翻译：提供了具有可植入装置的载体，系统和用于检测或治疗缺血的方法。

10. 发明申请

WO2006113407A3 HYDROGEL BIOSCAFFOLDINGS AND BIOMEDICAL DEVICE COATINGS 审中-公开
公开(公告)号：WO2006113407A3
公开(公告)日：2006-10-26
申请号：PCT/US2006/014021
申请日：2006-04-13
申请人： ADVANCED CARDIOVASCULAR SYSTEMS, INC. , CLAUDE, Charles , KWOK, Connie , MICHAL, Gene , QU, Jihong , LIAO, Sophia
发明人： CLAUDE, Charles , KWOK, Connie , MICHAL, Gene , QU, Jihong , LIAO, Sophia
IPC分类号： A61L27/52 , A61L27/20 , A61L31/10 , A61L31/14 , A61K9/00
摘要： Bioscaffoldings formed of hydrogels that are crosslinked in situ in an infarcted region of the heart (myocardium) by a Michael's addition reaction or by a disulfide bond formed by an oxidative process are described. Each of the bioscaffoldings described includes hyaluronan as one of the hydrogel components and the other component is selected from collagen, collagen-laminin, poly-1- lysine, and fibrin. The bioscaffolding may further include an alginate component. The bioscaffoldings may have biofunctional groups such as angiogenic factors and stem cell homing factors bound to the collagen, collagen-laminin, poly-1- lysine, or fibrinogen hydrogel component. In particular, the biofunctional groups may be PRl 1, PR39, VEGF, bFGF, a polyarginine/DNA plasmid complex, or a DNA/polyethyleneimine (PEI) complex. Additionally, the hydrogel components may be injected into the infarct region along with stem cells and microspheres containing stem cell homing factors. The bioscaffolding may be formed on a stent or a cardiac medical device.

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