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1. 发明申请

WO2012005987A2 RHYTHM DISCRIMINATION USING INFORMATION INDICATIVE OF LEAD MOTION 审中-公开
标题翻译：用指示铅动作信息的节奏辨别
公开(公告)号：WO2012005987A2
公开(公告)日：2012-01-12
申请号：PCT/US2011041850
申请日：2011-06-24
申请人： SWEENEY ROBERT J , SHUROS ALLAN C , SIEJKO KRZYSZTOF Z , OLSON DAVID C , INGLE FRANK
发明人： SWEENEY ROBERT J , SHUROS ALLAN C , SIEJKO KRZYSZTOF Z , OLSON DAVID C , INGLE FRANK
IPC分类号： A61N1/37
CPC分类号： A61N1/36514 , A61B5/02133 , A61B5/026 , A61N1/08 , A61N1/36142 , A61N1/36578
摘要： Systems and methods for rhythm discrimination using the motion of an implantable lead are described. In an example, an implantable medical device can include a receiver circuit configured to be electrically coupled to an implantable lead and be configured to obtain information indicative of a movement of the implantable lead due at least in part to a motion of a heart. The device can include an arrhythmia detection circuit configured to determine an arrhythmia status using the information indicative of the movement of the implantable lead and an arrhythmia classification circuit configured to determine one or more of a location or a type of an arrhythmia, using the information indicative of the movement of the implantable lead, when the arrhythmia status indicates that an arrhythmia is occurring or has occurred.
摘要翻译：描述了使用可植入导线的运动进行节奏辨别的系统和方法。在一个示例中，可植入医疗设备可以包括接收器电路，该接收器电路被配置为电耦合到可植入引线并且被配置为获得指示可植入引线的移动的信息，这至少部分地由于心脏的运动。该装置可以包括心律失常检测电路，该心律失常检测电路被配置为使用指示可植入导联的移动的信息来确定心律失常状态，以及心律失常分类电路，其被配置为使用指示信息来指示心律失常的位置或类型中的一个或多个当心律失常状态表明心律失常正在发生或已经发生时，可植入导联的运动。

2. 发明申请

WO2011130531A3 FOCUSED ULTRASONIC RENAL DENERVATION 审中-公开
标题翻译：聚焦超声造影
公开(公告)号：WO2011130531A3
公开(公告)日：2011-12-15
申请号：PCT/US2011032524
申请日：2011-04-14
申请人： BOSTON SCIENT SCIMED INC , HASTINGS ROGER , SHUROS ALLAN C , INGLE FRANK , HOLLINGSWORTH MARK A
发明人： HASTINGS ROGER , SHUROS ALLAN C , INGLE FRANK , HOLLINGSWORTH MARK A
IPC分类号： A61N7/02 , A61B8/12 , A61B18/02
CPC分类号： A61N7/022 , A61B8/0891 , A61B8/12 , A61B8/4488 , A61B18/0206 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2090/3784 , A61N2007/003 , A61N2007/0095
摘要： Acoustic energy is delivered to innervated vascular that contributes to renal sympathetic nerve activity, such as innervated tissue of the renal artery and abdominal aorta. Focused acoustic energy is delivered via an intravascular device of sufficient power to ablate innervated renal or aortal tissue. Focused acoustic energy may be delivered via an intravascular or extracorporeal device to image and locate target innervated renal or aortal tissue. Intravascular, extravascular, or transvascular focused ultrasound devices provide for high precision denervation of innervated vascular to terminate renal sympathetic nerve activity.
摘要翻译：声能传递给有助于肾交感神经活动的神经支配的血管，如肾动脉和腹主动脉的神经支配组织。聚焦的声能通过具有足够功率的血管内装置输送以消融支配的肾脏或主动脉组织。聚焦的声能可以通过血管内或体外装置递送到图像和定位靶神经支配的肾或主动脉组织。血管内，血管外或经血管聚焦的超声装置提供神经支配血管的高精度去神经支配以终止肾交感神经活动。

3. 发明申请

WO2011097293A1 SYMPATHETIC STIMULATION FOR IMPROVED MYOCARDIAL RELAXATION 审中-公开
标题翻译：改善心肌松弛的同步刺激
公开(公告)号：WO2011097293A1
公开(公告)日：2011-08-11
申请号：PCT/US2011/023468
申请日：2011-02-02
申请人： CARDIAC PACEMAKERS, INC. , SHUROS, Allan C. , ARCOT-KRISHNAMURTHY, Shantha , ALVAREZ, Guy
发明人： SHUROS, Allan C. , ARCOT-KRISHNAMURTHY, Shantha , ALVAREZ, Guy
IPC分类号： A61N1/362 , A61N1/365
CPC分类号： A61N1/36564 , A61N1/3621 , A61N1/365
摘要： Described are methods and devices for improving diastolic function with electrostimulation in heart failure patients who exhibit relatively normal systolic function. Such patients are characterized by impaired myocardial relaxation during diastole that prevents adequate filling of the ventricles during diastole to thereby reduce cardiac output. An implantable device is described for effecting strategic and periodic stimulation of the sympathetic nervous system to elicit myocardial adrenergic activation for improved myocardial relaxation.
摘要翻译：描述了用于在呈现相对正常的收缩功能的心力衰竭患者中用电刺激改善舒张功能的方法和装置。这些患者的特征在于舒张期期间的心肌松弛受损，其在舒张期期间阻止充足的心室充盈，从而降低心输出量。描述了可植入装置，用于促进交感神经系统的战略和周期性刺激，以引发心肌肾上腺素能活化以改善心肌松弛。

4. 发明申请

WO2010132203A1 PACING SYSTEM WITH SAFETY CONTROL DURING MODE TRANSITION 审中-公开
标题翻译：在模式转换期间具有安全控制的PACING系统
公开(公告)号：WO2010132203A1
公开(公告)日：2010-11-18
申请号：PCT/US2010/032676
申请日：2010-04-28
申请人： CARDIAC PACEMAKERS, INC. , SHUROS, Allan, C. , MOKELKE, Eric, A.
发明人： SHUROS, Allan, C. , MOKELKE, Eric, A.
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3688
摘要： A cardiac pacing system introduces a transitional period when pacing mode changes, such as when pacing starts and stops, or when one or more pacing parameter values change substantially. For each pacing parameter that changes substantially when the pacing mode changes, its value is adjusted incrementally over the transitional period to protect the heart from potentially harmful conditions associated with an abrupt change in the value of that pacing parameter.
摘要翻译：心脏起搏系统引入起搏模式改变的过渡时期，例如起搏开始和停止时，或当一个或多个起搏参数值发生显着变化时。对于每个起搏参数，当起搏模式发生变化时，其参数会发生显着变化，其过渡期间会逐渐调整其值，以保护心脏免受与该起搏参数值突然变化相关的潜在有害状况。

5. 发明申请

WO2010111028A1 EXTERNAL CARDIAC STIMULATION PATCH 审中-公开
标题翻译：外部心脏刺激贴
公开(公告)号：WO2010111028A1
公开(公告)日：2010-09-30
申请号：PCT/US2010/026640
申请日：2010-03-09
申请人： CARDIAC PACEMAKERS, INC. , SHUROS, Allan, C. , MOKELKE, Eric, A. , ESLER, James, A.
发明人： SHUROS, Allan, C. , MOKELKE, Eric, A. , ESLER, James, A.
IPC分类号： A61N1/36 , A61N1/362 , A61N1/37 , A61B5/0408 , A61B5/0464 , A61N1/39
CPC分类号： A61N1/3625 , A61N1/3627 , A61N1/37247 , A61N1/3925 , A61N1/3968 , A61N1/3993
摘要： An external cardiac stimulation patch integrates a transcutaneous cardiac stimulation device and body-surface electrodes with a skin patch. The skin patch is to be attached onto a patient to provide for electrical contacts between the body-surface electrodes and a patient. The transcutaneous cardiac stimulation device delivers pacing pulses to the heart of the patient through pacing electrodes selected from the body-surface electrodes.
摘要翻译：外部心脏刺激贴片将经皮心脏刺激装置和体表电极与皮肤贴片集成。将皮肤贴片贴在患者身上，以提供身体表面电极与患者之间的电接触。经皮心脏刺激装置通过选自身体表面电极的起搏电极将起搏脉冲提供给患者的心脏。

6. 发明申请

WO2010104700A1 SYSTEMS FOR AUTONOMIC NERVE MODULATION COMPRISING ELECTRODES IMPLANTABLE IN A LYMPHATIC VESSEL 审中-公开
标题翻译：用于自动神经调节的系统，包括在LYMPHAIC VESSEL中可植入的电极
公开(公告)号：WO2010104700A1
公开(公告)日：2010-09-16
申请号：PCT/US2010/025899
申请日：2010-03-02
申请人： CARDIAC PACEMAKERS, INC. , SHUROS, Allan, C. , ZHAO, Weiying , HAMANN, Jason, J. , RUBLE, Stephen
发明人： SHUROS, Allan, C. , ZHAO, Weiying , HAMANN, Jason, J. , RUBLE, Stephen
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/0551 , A61N1/36114 , A61N1/36117 , A61N1/36185 , A61N1/36585
摘要： Various embodiments modulate autonomic neural activity in a body having a spinal cord, a subclavian vein and thoracic lymphatic vessels that include a thoracic duct and a right lymphatic duct. At least one programmed therapy is implemented using an implanted medical device to modulate autonomic neural activity. Implementing the therapy includes increasing or decreasing sympathetic activity in sympathetic nerves branching from a first region of the spinal cord using a first electrode (209) in the thoracic duct (204), and further includes increasing or decreasing parasympathetic activity in parasympathetic nerves adjacent to the desired thoracic lymphatic vessel or sympathetic activity in sympathetic nerves branching from a second region of the spinal cord using a second electrode (210) in the desired thoracic lymphatic vessel.
摘要翻译：各种实施方案调节具有脊髓，锁骨下静脉和包括胸导管和右淋巴管的胸部淋巴管的体内的自主神经活动。使用植入的医疗装置来实施至少一个编程治疗来调节自主神经活动。实施治疗包括使用胸导管（204）中的第一电极（209）从脊髓的第一区域分支的交感神经中增加或减少交感神经活动，并且还包括与副导管神经邻近的副交感神经活动增加或减少所需的胸部淋巴管或交感神经的交感神经活动，使用所需胸廓淋巴管中的第二电极（210）从脊髓的第二区域分支。

7. 发明申请

WO2009114096A1 SYSTEMS AND DEVICES FOR MODULATING AUTONOMIC TONE 审中-公开
标题翻译：用于调制自动音调的系统和设备
公开(公告)号：WO2009114096A1
公开(公告)日：2009-09-17
申请号：PCT/US2009/001374
申请日：2009-03-04
申请人： CARDIAC PACEMAKERS, INC. , SHUROS, Allan, C. , ARCOT-KRISHNAMURTHY, Shantha , KENKNIGHT, Bruce, H. , DAUM, Douglas, R.
发明人： SHUROS, Allan, C. , ARCOT-KRISHNAMURTHY, Shantha , KENKNIGHT, Bruce, H. , DAUM, Douglas, R.
IPC分类号： A61N1/36
CPC分类号： A61N1/362 , A61N1/36114 , A61N1/3627
摘要： Various system embodiments comprise means for intermittently delivering a sympathetic stimulus, including means for delivering a sequence of stress-inducing pacing pulses adapted to increase sympathetic tone during the stress-inducing pacing. The stress-inducing pacing results in a parasympathetic reflex after the sequence of stress-inducing pacing. The embodiment further includes means for delivering neural stimulation to elicit a parasympathetic response or a sympathetic response in a coordinated manner with respect to the sequence of stress-inducing pacing pulses. The neural stimulation is timed to elicit the parasympathetic response after the sequence of stress-inducing pacing pulses and concurrent with at least a portion of the parasympathetic reflex to the sequence of stress-inducing pacing to enhance a parasympathetic effect of the parasympathetic reflex, or to elicit the sympathetic response during the sequence of stress-inducing pulses to provide a larger sympathetic stimulus, resulting in an enhanced parasympathetic reflex in response to the large sympathetic stimulus.
摘要翻译：各种系统实施例包括用于间歇地递送交感刺激的装置，包括用于递送适于在应力诱导起搏期间增加交感神经张力的应力诱发起搏脉冲序列的装置。应激诱导起搏导致应激诱导起搏顺序后的副交感神经反射。该实施方案还包括用于递送神经刺激以相对于应力诱导起搏脉冲的序列以协调的方式引发副交感神经反应或交感反应的装置。神经刺激被定时以在应力诱发起搏脉冲序列之后引起副交感神经反应，并且与应激诱导起搏序列的至少一部分副交感神经反射并发，以增强副交感神经反射的副交感作用，或在应激诱导脉冲序列期间引起交感神经反应以提供更大的交感神经刺激，导致响应于大的交感神经刺激的增强的副交感神经反射。

8. 发明申请

WO2009102613A2 METHODS OF MONITORING HEMODYNAMIC STATUS FOR RYHTHM DISCRIMINATION WITHIN THE HEART 审中-公开
标题翻译：监测血液动力学状态以监测心脏中淋巴细胞分化的方法
公开(公告)号：WO2009102613A2
公开(公告)日：2009-08-20
申请号：PCT/US2009/033211
申请日：2009-02-05
申请人： CARDIAC PACEMAKERS, INC. , SHUROS, Allan, C. , LI, Dan , NI, Quan
发明人： SHUROS, Allan, C. , LI, Dan , NI, Quan
IPC分类号： A61B5/0464 , A61N1/365
CPC分类号： A61N1/36585 , A61N1/36578
摘要： Systems and methods of performing rhythm discrimination within a patient's body using sensed hemodynamic signals are disclosed. The method can include the steps of receiving an electrical activity signal from an electrode located within or near the heart, detecting an event of the heart based on the received electrical activity signal, sensing one or more mechanical measurements using a sensor located within the body, analyzing a mechanical activity signal received from the sensor, and confirming the type of event based on the mechanical and electrical activity signals. The sensor can comprise a single pressure sensor configured to sense both atrial and ventricular activity within the heart.
摘要翻译：公开了使用感测的血液动力学信号在患者身体内执行节奏辨别的系统和方法。该方法可以包括以下步骤：从位于心脏内或心脏附近的电极接收电活动信号;基于所接收的电活动信号检测心脏事件;使用位于身体内的传感器感测一个或多个机械测量; 分析从传感器接收的机械活动信号，以及基于机械和电活动信号确认事件的类型。该传感器可以包括配置为感测心脏内的心房和心室活动的单个压力传感器。

9. 发明申请

WO2009076578A1 CARDIAC LEAD PLACEMENT USING MULTIPLE SPATIALLY DISTRIBUTED SENSORS 审中-公开
标题翻译：使用多个分布式传感器的CARDIAC导线安装
公开(公告)号：WO2009076578A1
公开(公告)日：2009-06-18
申请号：PCT/US2008/086520
申请日：2008-12-12
申请人： CARDIAC PACEMAKERS, INC. , ARCOT-KRISHNAMURTHY, Shantha , NI, Quan , STUCKY, Michael , SHUROS, Allan
发明人： ARCOT-KRISHNAMURTHY, Shantha , NI, Quan , STUCKY, Michael , SHUROS, Allan
IPC分类号： A61N1/365 , A61N1/368 , A61B5/00 , A61B8/00
CPC分类号： A61N1/056 , A61N1/36514
摘要： Systems and methods facilitate placement of a lead in or on a patient's heart. At least one reference sensor is positioned at a right heart location of a patient's heart and a cardiac lead apparatus comprising at least one lead apparatus sensor is advanced to a plurality of left heart locations. Using the reference sensor and the lead apparatus sensor, a distance parameter indicative of a distance between the reference and lead apparatus sensors is measured for each of the plurality of left heart locations. Strain or stress estimates are determined for the plurality of left heart locations derived from the distance parameter measurements. Using the strain or stress estimates, a physician perceivable output is produced indicating suitability of the left heart locations as pacing sites.
摘要翻译：系统和方法有利于将铅放置在患者心脏中或患者的心脏上。至少一个参考传感器位于患者心脏的右心脏位置，并且包括至少一个引导装置传感器的心脏引导装置前进到多个左心脏位置。使用参考传感器和引导装置传感器，针对多个左心脏位置中的每一个测量指示参考和引导装置传感器之间的距离的距离参数。对于从距离参数测量导出的多个左心脏位置确定应变或应力估计。使用应变或压力估计，产生医生可感知的输出，指示左心脏位置作为起搏部位的适合性。

10. 发明申请

WO2009042140A1 CLOSED-LOOP CONTROL OF INTERMITTENT EXCITATORY CARDIAC STIMULATION FOR THERAPEUTIC EFFECT 审中-公开
标题翻译：间歇性激素治疗效果的闭环控制
公开(公告)号：WO2009042140A1
公开(公告)日：2009-04-02
申请号：PCT/US2008/011057
申请日：2008-09-24
申请人： CARDIAC PACEMAKERS, INC. , ARCOT-KRISHNAMURTHY, Shantha , SHUROS, Allan C. , HARTEMINK, Christopher
发明人： ARCOT-KRISHNAMURTHY, Shantha , SHUROS, Allan C. , HARTEMINK, Christopher
IPC分类号： A61N1/362
CPC分类号： A61N1/3627
摘要： A device and method for delivering electrical stimulation to the heart in order to improve cardiac function in heart failure patients. The stimulation is delivered as high-output pacing in which the stimulation is excitatory and also of sufficient energy to augment myocardial contractility. In order to provide a consistent hemodynamic response, the high-output pacing is optimized by delivering it using different parameter sets, evaluating the hemodynamic response thereto as reflected by one or more measured physiological variables, and selecting the parameter set with the best hemodynamic response.
摘要翻译：用于向心脏递送电刺激以改善心力衰竭患者的心脏功能的装置和方法。刺激作为高产出起搏，其中刺激是兴奋性的，并且具有足够的能量以增加心肌收缩力。为了提供一致的血流动力学响应，通过使用不同的参数组递送高输出起搏，通过一个或多个测量的生理变量反映的血液动力学响应进行评估，并且选择具有最佳血液动力学响应的参数集来优化高输出起搏。

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