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1. 发明申请

WO2009025812A2 APPARATUS TO TREAT AND PREVENT ATRIAL TACHYARRHYTHMIAS 审中-公开
标题翻译：用于治疗和预防心房心律失常的装置
公开(公告)号：WO2009025812A2
公开(公告)日：2009-02-26
申请号：PCT/US2008/009898
申请日：2008-08-20
申请人： CARDIAC PACEMAKERS, INC. , QU, Jihong , SIH, Haris J. , SCHWARTZ, Mark , SINHA, Prashant
发明人： QU, Jihong , SIH, Haris J. , SCHWARTZ, Mark , SINHA, Prashant
IPC分类号： A61K47/48
CPC分类号： A61N1/3621 , A61M5/14276 , A61N1/0568 , A61N1/0587 , A61N1/3962
摘要： The invention provides a cardiac rhythm management system which includes a tachyarrhythmia detection and classification circuit programmed to detect and classify a tachyarrhythmia, a biologic therapy delivery device configured to deliver or regulate an expression cassette suitable for terminating or preventing atrial fibrillation (AF), and a control circuit coupled to the tachyarrhythmia detection and classification circuit and the biologic therapy delivery device. Also provided is an implantable medical device for use in a body having a cardiovascular system, which includes an implantable device body including at least a cardiovascular portion configured to be in the cardiovascular system, and an expression cassette incorporated into the cardiovascular portion of the implantable device body, the expression cassette selected to express a gene product that terminates or prevents AF. Further provided are methods which employ particular expression cassettes to prevent, inhibit or treat AF.
摘要翻译：本发明提供了一种心律管理系统，其包括快速心律失常检测和分类电路，该快速心律失常检测和分类电路被编程为检测和分类快速性心律失常;生物治疗输送装置，其被配置为输送或调节适于终止或预防的表达盒心房颤动（AF）以及耦合到快速性心律失常检测和分类电路以及生物治疗传递装置的控制电路。还提供了一种用于具有心血管系统的身体的可植入医疗装置，该装置包括可植入装置主体，该可植入装置主体包括至少一个配置成位于心血管系统内的心血管部分，以及一个并入可植入装置的心血管部分中的表达盒选择表达盒以表达终止或防止AF的基因产物。进一步提供了使用特定表达盒来预防，抑制或治疗AF的方法。

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