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1. 发明申请

WO2007096618A2 2-[3H-THIAZOL-2-YLIDINEMETHYL]PYRIDINES AND RELATED COMPOUNDS AND THEIR USE 审中-公开
标题翻译： 2- [3H-噻唑-2-基]乙基]吡啶及其相关化合物及其用途
公开(公告)号：WO2007096618A2
公开(公告)日：2007-08-30
申请号：PCT/GB2007000608
申请日：2007-02-21
申请人： CANCER REC TECH LTD , BROWN ROBERT , PLUMB JANE , AHERNE GLADYS WYNNE , MCDONALD EDWARD , JONES KEITH , HILTON STEPHEN
发明人： BROWN ROBERT , PLUMB JANE , AHERNE GLADYS WYNNE , MCDONALD EDWARD , JONES KEITH , HILTON STEPHEN
CPC分类号： C07D513/04 , C07D417/06
摘要： The present invention pertains to certain 2-[3H-thiazol-2-ylidinemethyl]pyridine compounds and analogs thereof, which, inter alia, inhibit cell proliferation, treat cancer, etc., and more specifically to compounds of the following formula, wherein R A1 , R A2 , R A3 , R A4 , R B1 , R B2 , RNA, RNB, and X- are as defined herein. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit cell proliferation, and in the treatment of proliferative conditions such as cancer, etc.
摘要翻译：本发明涉及某些2- [3H-噻唑-2-基吡啶甲基]吡啶化合物及其类似物，其特别是抑制细胞增殖，治疗癌症等，更具体地涉及下式的化合物，其中R A1，A2 A2，R A3，S A4，R B1，R 2，R 2， RNA，RNB和X-如本文所定义。本发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在体外和体内的用途，以抑制细胞增殖，以及用于治疗增殖性疾病如癌症等。

2. 发明申请

WO2009030901A3 BIOMATERIAL SCAFFOLDS FOR CONTROLLED TISSUE GROWTH 审中-公开
标题翻译：用于控制组织生长的生物材料SCAFFOL
公开(公告)号：WO2009030901A3
公开(公告)日：2010-04-08
申请号：PCT/GB2008002982
申请日：2008-09-03
申请人： UCL BUSINESS PLC , BROWN ROBERT , ALEKSEEVA TIJNA
发明人： BROWN ROBERT , ALEKSEEVA TIJNA
IPC分类号： A61L27/24 , A61L27/46
CPC分类号： A61L27/58 , A61L27/24 , A61L27/38 , A61L27/50 , A61L27/52 , A61L27/56
摘要： This invention relates to biomaterials for directional tissue growth which comprise soluble fibres having a variable cross-sectional area which dissolve in a directional manner in situ, thereby controlling the direction and rate of formation of microchannels within the biomaterial and allowing vectored and timed channelling through the biomaterial. This may be useful, for example in directing the growth of blood vessels, nerves and other repair cells through the biomaterial in defined directions.
摘要翻译：本发明涉及用于定向组织生长的生物材料，其包含具有可变横截面积的可溶性纤维，其可以以原位方向的方式溶解，从而控制生物材料内微通道的形成方向和速率，并允许通过生物材料。这可能是有用的，例如在指定方向上通过生物材料引导血管，神经和其他修复细胞的生长。

3. 发明申请

WO2012109364A3 GRAPHIC NOTIFICATION FEEDBACK FOR INDICATING INDUCTIVE COUPLING AMONGST DEVICES 审中-公开
标题翻译：图形通知反馈用于指示各种器件的电感耦合
公开(公告)号：WO2012109364A3
公开(公告)日：2012-11-15
申请号：PCT/US2012024346
申请日：2012-02-08
申请人： HEWLETT PACKARD DEVELOPMENT CO , BERG SAMANTHA , LENOX KIMBERLY , BROWN ROBERT , KRUGLIKOV VITALY , CAHTTERJEE MANJIRNATH
发明人： BERG SAMANTHA , LENOX KIMBERLY , BROWN ROBERT , KRUGLIKOV VITALY , CAHTTERJEE MANJIRNATH
IPC分类号： H04W92/18 , G06K17/00 , H02J17/00
CPC分类号： G06F3/0481 , H02J7/025 , H02J50/10 , H04B5/0037 , H04B5/0075
摘要： A computing device is operated to detect a signal generated from an inductive signal interface. The detected signal may be generated by the device's inductive signal interface being in operational proximity to an inductive signal interface of another device. A notification feedback is generated that confirms an event related to the first and second computing device inductively signaling one another.
摘要翻译：操作计算设备以检测从感应信号接口产生的信号。检测到的信号可以通过设备的感应信号接口在操作上接近另一设备的感应信号接口来生成。生成通知反馈，其确认与第一和第二计算设备相关的事件以感应方式相互发信号。

4. 发明申请

WO2006003442A3 CELL-INDEPENDENT FABRICATION OF TISSUE EQUIVALENTS 审中-公开
标题翻译：细胞独立制备组织等效物
公开(公告)号：WO2006003442A3
公开(公告)日：2006-02-23
申请号：PCT/GB2005002631
申请日：2005-07-05
申请人： UCL BIOMEDICA PLC , BROWN ROBERT , NAZHAT SHOWAN , MUDERA VIVEK , WISEMAN MIKE
发明人： BROWN ROBERT , NAZHAT SHOWAN , MUDERA VIVEK , WISEMAN MIKE
IPC分类号： A61L27/24 , A61L27/38 , A61L27/52
CPC分类号： A61L27/52 , A61L27/24 , A61L27/38
摘要： This invention relates to cell-independent processes which mimic cellular bioremodelling and produce organised biomaterials which have mechanical properties and viable cell densities suitable for use as functional tissue implants. The biomaterials are produced by providing a gel comprising a matrix of scaffold fibres of and an interstitial fluid; and plastically compacting the gel to produce the biomaterial. The biomaterials may comprise 3D structures such as layering, alignment and meso-scale zonal heterogeneities of cells and matrix which mimic native tissue structure. Biomaterials with biomimetic structure as described herein may be useful in a range of therapeutic applications.
摘要翻译：本发明涉及模拟细胞生物重建和产生具有适合用作功能性组织植入物的机械性质和活细胞密度的组织生物材料的细胞非依赖性过程。生物材料通过提供包含支架纤维基质和间质液的凝胶来生产; 并且塑性地压实凝胶以产生生物材料。生物材料可以包括3D结构，例如模拟天然组织结构的细胞和基质的分层，比对和中尺度区带异质性。具有本文所述的仿生结构的生物材料可用于一系列治疗应用。

5. 发明申请

WO2007060459A3 BIO-ARTIFICIAL MATERIALS WITH TUNEABLE PROPERTIES 审中-公开
标题翻译：具有可调性能的生物人造材料
公开(公告)号：WO2007060459A3
公开(公告)日：2008-05-22
申请号：PCT/GB2006004414
申请日：2006-11-24
申请人： UCL BUSINESS PLC , CHEEMA UMBER , CHUO CHER-BING , BROWN ROBERT
发明人： CHEEMA UMBER , CHUO CHER-BING , BROWN ROBERT
IPC分类号： A61L27/24 , A61L27/38 , A61L27/52
CPC分类号： A61L27/24 , A61L27/38 , A61L27/52
摘要： This invention relates to methods for preparing biomaterials by applying multiple cycles of tensile loading to compacted collagen gels in order to fuse the collagen fibrils together within the compacted gels. This produces a biomaterial with improved material properties. Biomaterials produced by such methods may be useful, for example, as tissue equivalent implants, in the repair and/or replacement of damaged tissue in an individual.
摘要翻译：本发明涉及通过对压缩的胶原凝胶施加多个拉伸载荷的周期来制备生物材料的方法，以将胶原原纤维熔合在压实的凝胶内。这产生具有改善的材料性质的生物材料。通过这种方法生产的生物材料可能是有用的，例如作为组织等同植入物，在修复和/或替换个体中受损组织。

6. 发明申请

WO0037100A3 COMPOSITIONS AND METHODS FOR REDUCING OR PREVENTING FERTILIZATION IN FISH AND BIRDS 审中-公开
标题翻译：减少或防止鱼类和鸟类受精的组合物和方法
公开(公告)号：WO0037100A3
公开(公告)日：2000-12-07
申请号：PCT/CA9901225
申请日：1999-12-22
申请人： UNIV DALHOUSIE , BROWN ROBERT , POHAJDAK BILL , KIMMINS WARWICK CHARLES , HORROCKS JANET , MACLAREN LESLIE
发明人： BROWN ROBERT , POHAJDAK BILL , KIMMINS WARWICK CHARLES , HORROCKS JANET , MACLAREN LESLIE
IPC分类号： A61K39/00 , A61P15/18
CPC分类号： A61K39/0006 , A61K2039/55555
摘要： Disclosed is an immunocontraceptive vaccine composition comprising a teleost homolog of zona pellucida (TH-ZP), together with a pharmaceutically acceptable diluent or carrier, for reducing or preventing fertilization in a fish, and a method for its use. Also disclosed is an immunocontraceptive vaccine composition comprising an antigen from an inner perivitelline layer (IPVL), together with a pharmaceutically acceptable diluent or carrier, for reducing or preventing fertilization in a bird, and a method for its use.
摘要翻译：本发明公开了一种免疫避孕疫苗组合物及其使用方法，所述免疫避孕疫苗组合物包含透明质酸盐硬骨素同系物（TH-ZP）以及药学上可接受的稀释剂或载体，用于减少或防止鱼类受精。还公开了一种免疫避孕疫苗组合物及其使用方法，所述免疫避孕疫苗组合物包含来自内周卵磷脂层（IPVL）的抗原以及药学上可接受的稀释剂或载体，用于减少或预防鸟类受精。

7. 发明申请

WO2007100782A8 BIOMARKERS FOR AMYOTROPHIC LATERAL SCLEROSIS AND METHODS USING THE SAME 审中-公开
标题翻译：生物标志物对于侧卧位性心律失常及其使用方法
公开(公告)号：WO2007100782A8
公开(公告)日：2008-10-30
申请号：PCT/US2007004998
申请日：2007-02-27
申请人： METABOLON INC , MASSACHUSETTS GEN HOSPITAL , PAIGE LISA A , EVANS ANNE , LAWTON KAY A , HARVAN DON , MITCHELL MATTHEW W , CUDKOWICZ MERIT , BROWN ROBERT
发明人： PAIGE LISA A , EVANS ANNE , LAWTON KAY A , HARVAN DON , MITCHELL MATTHEW W , CUDKOWICZ MERIT , BROWN ROBERT
IPC分类号： A61K38/00 , G01N33/00 , G01N33/53
CPC分类号： G01N33/6896 , G01N2500/10 , G01N2800/28 , G01N2800/2835 , G01N2800/56 , Y10T436/24

8. 发明申请

WO0039702B1 SYSTEM AND METHOD FOR BROWSING AND COMPARING PRODUCTS 审中-公开
标题翻译：用于浏览和比较产品的系统和方法
公开(公告)号：WO0039702B1
公开(公告)日：2001-08-02
申请号：PCT/US9930317
申请日：1999-12-16
申请人： ICU MEDICAL INC , LOPEZ GEORGE A , BROWN ROBERT , PERKINS CRAIG , BREGMAN DOUG , PERKINS KEVIN
发明人： LOPEZ GEORGE A , BROWN ROBERT , PERKINS CRAIG , BREGMAN DOUG , PERKINS KEVIN
IPC分类号： G06F12/00 , G06F17/30 , G06Q30/06 , G06F17/60
CPC分类号： G06Q30/06 , G06Q30/0601 , G06Q30/0629
摘要： A system and method permit a user to browse and compare products of a merchant using information about a competitor. In one embodiment of the system and method, a page server serves a competitor electronic page to a customer browser which permits the user to select a competitor. The competitor electronic page includes a hyperlink having a manufacturer ID parameter, which hyperlink, when selected, issues a request to the page server for competitor product information. The request includes the manufacturer ID. Responsive to that request, the page server uses the manufacturer ID to form a query to present to a product database having competitive product information, manufacturer information, product information and associations between that information. A database engine processes the query and returns records satisfying the query. The records are used to construct a competitor product electronic page permitting a user to select a competitor product. The page server serves the competitor product electronic page to the customer browser.
摘要翻译：系统和方法允许用户使用关于竞争对手的信息来浏览和比较商家的产品。在系统和方法的一个实施例中，页面服务器将竞争者电子页面服务于允许用户选择竞争者的客户浏览器。竞争对手电子页面包括具有制造商ID参数的超链接，当选择该超链接时，向链接服务器发出竞争对手产品信息的请求。请求包括制造商ID。响应于该请求，页面服务器使用制造商ID形成查询，以呈现给具有竞争产品信息，制造商信息，产品信息以及该信息之间的关联的产品数据库。数据库引擎处理查询并返回满足查询的记录。记录用于构建竞争对手产品电子页面，允许用户选择竞争对手的产品。页面服务器为客户浏览器提供竞争对手的产品电子页面。

9. 发明申请

WO0039702A3 SYSTEM AND METHOD FOR BROWSING AND COMPARING PRODUCTS 审中-公开
标题翻译：用于浏览和比较产品的系统和方法
公开(公告)号：WO0039702A3
公开(公告)日：2001-03-01
申请号：PCT/US9930317
申请日：1999-12-16
申请人： ICU MEDICAL INC , LOPEZ GEORGE A , BROWN ROBERT , PERKINS CRAIG , BREGMAN DOUG , PERKINS KEVIN
发明人： LOPEZ GEORGE A , BROWN ROBERT , PERKINS CRAIG , BREGMAN DOUG , PERKINS KEVIN
IPC分类号： G06F12/00 , G06F17/30 , G06Q30/06 , G06F17/60
CPC分类号： G06Q30/06 , G06Q30/0601 , G06Q30/0629
摘要： A system and method permit a user to browse and compare products of a merchant using information about a competitor. In one embodiment of the system and method, a page server serves a competitor electronic page to a customer browser which permits the user to select a competitor. The competitor electronic page includes a hyperlink having a manufacturer ID parameter, which hyperlink, when selected, issues a request to the page server for competitor product information. The request includes the manufacturer ID. Responsive to that request, the page server uses the manufacturer ID to form a query to present to a product database having competitive product information, manufacturer information, product information and associations between that information. A database engine processes the query and returns records satisfying the query. The records are used to construct a competitor product electronic page permitting a user to select a competitor product. The page server serves the competitor product electronic page to the customer browser.
摘要翻译：系统和方法允许用户使用关于竞争者的信息来浏览和比较商家的产品。在该系统和方法的一个实施例中，页面服务器将竞争者电子页面提供给允许用户选择竞争者的顾客浏览器。竞争者电子页面包括具有制造商ID参数的超链接，该超链接在被选择时向页面服务器发出竞争者产品信息的请求。该请求包含制造商ID。响应于该请求，页面服务器使用制造商ID来形成询问以呈现给具有竞争性产品信息，制造商信息，产品信息以及该信息之间的关联的产品数据库。数据库引擎处理查询并返回满足查询的记录。这些记录用于构建竞争对手的产品电子页面，允许用户选择竞争对手的产品。页面服务器将竞争对手的产品电子页面提供给客户浏览器。

10. 发明申请

WO2009150536A3 SIGNAL PROCESSING WITH FAST S-TRANSFORMS 审中-公开
标题翻译：信号处理与快速S变换
公开(公告)号：WO2009150536A3
公开(公告)日：2010-02-04
申请号：PCT/IB2009006116
申请日：2009-06-10
申请人： UTI LIMITED PARTNERSHIP , BROWN ROBERT , LAUZON LOUIS M , FRAYNE RICHARD
发明人： BROWN ROBERT , LAUZON LOUIS M , FRAYNE RICHARD
IPC分类号： G06F17/14
CPC分类号： G06F17/148
摘要： The ability to examine the frequency content of a signal is critical in a variety of fields, and many techniques have been proposed to fill this need, including the Fourier and wavelet family of transforms. One of these, the S-transform, is a Fourier based transform that provides simultaneous time and frequency information similar to the wavelet transform but uses sinusoidal basis functions to produce true frequency and globally referenced phase measurements. It has been shown to be useful in several medical imaging applications but its use is limited due to high computational requirements of the original, continuous form. The described embodiments include a general framework for describing linear time-frequency transforms, using the Fourier, wavelet and S-transforms as examples. As an illustration of the utility of this formalism, a fast discrete S-transform algorithm is developed that has the same computational complexity as the fast Fourier transform.
摘要翻译：检查信号的频率内容的能力在各种领域中是至关重要的，并且已经提出了许多技术来满足这种需要，包括傅立叶变换和小波变换族。其中之一，S变换是基于傅立叶的变换，其提供类似于小波变换的同时时间和频率信息，但是使用正弦基函数来产生真实的频率和全局参考相位测量。已被证明在几种医学成像应用中是有用的，但由于原始连续形式的高计算要求，其使用受到限制。所描述的实施例包括用于描述线性时间 - 频率变换的一般框架，使用傅立叶，小波和S变换作为示例。作为这种形式主义效用的一个例证，开发了具有与快速傅立叶变换相同的计算复杂度的快速离散S变换算法。

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