专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2022058733A1 AGENTS FOR USE IN THE TREATMENT OF AMYLOIDOSIS 审中-公开
公开(公告)号：WO2022058733A1
公开(公告)日：2022-03-24
申请号：PCT/GB2021/052404
申请日：2021-09-16
申请人： UCL BUSINESS PLC
发明人： BELLOTTI, Vittorio , CORAZZA, Alessandra , MANGIONE, Palma Patrizia , PEPYS, Mark Brian , SWAIN, Christopher , TAYLOR, Graham Walter
IPC分类号： C07C229/58 , C07C235/52 , C07C317/18 , C07D213/79 , C07D213/80 , C07D231/12 , C07D257/04 , C07D263/34 , C07D263/57 , C07D277/56 , A61P43/00 , A61K31/4402 , A61K31/423 , A61K31/196
摘要： The present invention relates to compounds for stabilising the native tetrameric form of transthyretin and protecting it from proteolytic cleavage; compounds for use in the prevention and treatment of transthyretin amyloidosis; and agents and medicaments comprising such compounds. The compounds are based on a general structure A-L-B, wherein A is a group of formula (II) or of formula (III): or of formula (IV) or of formula (V) B is a group of formula (III), (IV), or (V), or a group of formula (VI) or a group of formula –R10Z, wherein: Z is selected from -CO2R', -CONR'R'', -SO2R' wherein R' and R'' are independently H or C1-C4 alkyl; and R10 is a C1-C4 alkylene or alkenylene group; and L represents a linker group which is a saturated or unsaturated chain of 5 to 13 carbon atoms.

2. 发明申请

WO2020055575A1 POLYAROMATIC HYDROCARBON ADDITIVES FOR HYDRATE INHIBITON 审中-公开
公开(公告)号：WO2020055575A1
公开(公告)日：2020-03-19
申请号：PCT/US2019/047957
申请日：2019-08-23
申请人： MULTI-CHEM GROUP, LLC , UCL BUSINESS PLC
发明人： PRINCE, Philippe , VO, Loan , MONTEIRO, Deepak, S. , BUI, Tai, Duc , STRIOLO, Alberto
IPC分类号： C10L3/10 , C09K8/52
摘要： Methods involving anti-agglomerant hydrate inhibitors and polyaromatic hydrocarbons for hydrate inhibition are provided. In some embodiments, the methods include introducing a hydrate inhibitor composition including an anti-agglomerant hydrate inhibitor into a fluid including (i) water and (ii) one of gas, liquid hydrocarbon, and any combination thereof; and introducing a polyaromatic hydrocarbon into the fluid.

3. 发明申请

WO2020039183A1 FACTOR IX ENCODING NUCLEOTIDES 审中-公开
公开(公告)号：WO2020039183A1
公开(公告)日：2020-02-27
申请号：PCT/GB2019/052339
申请日：2019-08-20
申请人： UCL BUSINESS PLC
发明人： NATHWANI, Amit , MCINTOSH, Jenny
IPC分类号： C12N9/64 , A61P7/04 , C12N15/864 , A61K38/48
摘要： The present invention relates to polynucleotides comprising a Factor IX nucleotide sequence, wherein the Factor IX nucleotide sequence comprises a coding sequence that encodes a Factor IX protein or fragment thereof and wherein a portion of the coding sequence is not wild type. The present invention further relates to viral particles comprising a recombinant genome comprising the polynucleotide of the invention, compositions comprising the polynucleotides or viral particles, and methods and uses of the polynucleotides, viral particles or compositions.

4. 发明申请

WO2019229454A1 APPARATUS AND METHOD FOR ANALYSING FUNCTIONAL MRI DATA 审中-公开
公开(公告)号：WO2019229454A1
公开(公告)日：2019-12-05
申请号：PCT/GB2019/051495
申请日：2019-05-31
申请人： UCL BUSINESS PLC
发明人： HUTEL, Michael , OURSELIN, Sebastien
IPC分类号： G01R33/48 , G01R33/56
摘要： A system and method are provided for analysing a functional magnetic resonance imaging (MRI) scan representing a time-sequence, comprising t time points, of images comprising v voxels, where each scan can be represented by a data matrix X ∈ ℝ t x v . The method comprises modelling the scan data X as the convolution of neural activation time courses N ∈ ℝ + t x v and a haemodynamic filter Ψ, and performing an inverse operation to estimate N from X and Ψ. The method further comprises decomposing the neural activation time courses N into multiple brain network components by representing N as the product of a first matrix H defining, for each component, a spatial map of the voxels belonging to that component, and a second matrix W defining, for each component, the time sequence of activation of that component during the scan. In other implementations, the matrix decomposition may be performed before the deconvolution.

5. 发明申请

WO2019223880A1 SYSTEM AND METHOD FOR DETERMINING THE PERCEPTUAL LOAD AND THE LEVEL OF STIMULUS PERCEPTION OF A HUMAN BRAIN 审中-公开
公开(公告)号：WO2019223880A1
公开(公告)日：2019-11-28
申请号：PCT/EP2018/063809
申请日：2018-05-25
申请人： TOYOTA MOTOR EUROPE , UCL BUSINESS PLC
发明人： AMBECK-MADSEN, Jonas , LAVIE, Nilli , BRUCKMAIER, Merit , TACHTSIDIS, Ilias
IPC分类号： A61B5/1455 , A61B5/18
摘要： The invention relates to method of determining the perceptual load of a human brain. The perceptual load is induced by a predetermined task carried out by the human The method comprises the steps of: • measuring with a functional near-infrared spectroscopy (fNIRS) sensor device a metabolic activity of the human brain while the task is carried out, • determining the perceptual load as a function of a measured change in metabolic activity. The invention further relates to a method of determining the level of stimulus perception corresponding systems.

6. 发明申请

WO2019220108A1 CHIMERIC ANTIGEN RECEPTOR 审中-公开
公开(公告)号：WO2019220108A1
公开(公告)日：2019-11-21
申请号：PCT/GB2019/051329
申请日：2019-05-15
申请人： UCL BUSINESS PLC
发明人： PULÉ, Martin
IPC分类号： C07K16/28 , C07K14/725 , C07K14/705 , C12N5/0783 , A61P35/00
摘要： The present invention provides a chimeric antigen receptor (CAR) comprising a CD21- binding domain, a transmembrane domain and an intracellular domain.

7. 发明申请

WO2019193326A1 DRAINAGE DEVICE AND METHODS 审中-公开
公开(公告)号：WO2019193326A1
公开(公告)日：2019-10-10
申请号：PCT/GB2019/050949
申请日：2019-04-02
申请人： UCL BUSINESS PLC
发明人： BOUREMEL, Yann , KHAW, Peng Tee
IPC分类号： A61F9/007
摘要： A drainage device (7) for use in an eye to drain aqueous humour so as to reduce intraocular pressure or for treating glaucoma. The device has a multi-lumen tube having a first end (11), a second end (12) opposite the first end, and a plurality of lumen (13,14,15) extending between the first end and the second end. At least one of the lumen is sealed at the first end. A flow through the multi-lumen tube is adjusted by forming at least one aperture (20) open in one of the lumen through a wall of the tube and/or sealing at least one aperture open in one of the lumen. The tube has a longitudinal axis through the first end and the second end, and an outer surface extending between the first end and the second end. A cross-section perpendicular to the longitudinal axis has a non-circular shape at the outer surface with an aspect ratio of at least 3:1.

8. 发明申请

WO2019122819A1 NERVE STIMULATION DEVICE FOR UNIDIRECTIONAL STIMULATION AND CURRENT STEERING 审中-公开
公开(公告)号：WO2019122819A1
公开(公告)日：2019-06-27
申请号：PCT/GB2018/053602
申请日：2018-12-11
申请人： GALVANI BIOELECTRONICS LIMITED , UCL BUSINESS PLC
发明人： BASHIRULLAH, Rizwan , HUNSBERGER, Gerald Edwin , DONEGA, Matteo , CHEW, Daniel , HOLDER, David , ARISTOVICH, Kirill
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/0556 , A61N1/3605 , A61N1/36053 , A61N1/36182
摘要： A nerve interface device comprising: at least one cuff portion having an assembled position in which the cuff portion forms at least part of a passageway for receiving a nerve along a longitudinal axis passing through the passageway; and first and second rings of electrodes mounted on the at least one cuff portion, each ring of electrodes comprising a plurality of electrodes. Each electrode in the first ring has a corresponding longitudinally-aligned electrode in the second ring so as to form a plurality of pairs of electrodes spaced apart from each other along the longitudinal axis. The plurality of pairs of electrodes includes at least a first pair of electrodes, the first pair of electrodes mounted on the at least one cuff portion. The at least one cuff portion comprises an asymmetric configuration about a central axis perpendicular to the longitudinal cuff axis.

9. 发明申请

WO2019092437A1 IMPROVED LIPID-PEPTIDE NANOCOMPLEX FORMULATION FOR MRNA DELIVERY TO CELLS 审中-公开
公开(公告)号：WO2019092437A1
公开(公告)日：2019-05-16
申请号：PCT/GB2018/053253
申请日：2018-11-09
申请人： UCL BUSINESS PLC
发明人： GRANT-SERROUKH, Dania , HART, Stephen, Lewis
IPC分类号： A61K9/00 , A61K9/127 , A61K48/00 , A61K47/64 , A61K38/16
CPC分类号： A61K9/0019 , A61K9/1272 , A61K9/1277 , A61K39/00 , A61K47/543 , A61K47/6455 , A61K47/6911 , C07K7/06 , C07K7/08 , C07K2319/74 , C12N15/88
摘要： A liposome comprising a cationic lipid, a phospholipid and a peptide and optionally consisting of from 20 to 50% by molarity cholesterol, based on the total amount of lipids,for use in non-viral gene delivery systems, for example,in the formation of lipopolyplex transfection vectors for the delivery of mRNA to cells.

10. 发明申请

WO2019012245A1 A WHISPERING GALLERY MODE INERTIAL SENSOR AND METHOD 审中-公开
公开(公告)号：WO2019012245A1
公开(公告)日：2019-01-17
申请号：PCT/GB2018/051712
申请日：2018-06-20
申请人： UCL BUSINESS PLC
发明人： LI, Ying Lia , BARKER, Peter Francis
IPC分类号： G01C19/72 , G01C19/5642 , G01P15/18
摘要： A whispering gallery mode inertial sensor is provided. The whispering gallery mode inertial sensor comprises a whispering gallery mode resonator; an evanescent coupler configured to couple with an evanescent field of the whispering gallery mode resonator so that light is transmitted to and received from the whispering galley mode resonator by the evanescent coupler; a displacement sensor configured to determine a displacement of the whispering gallery mode resonator according to the light received from the whispering gallery mode resonator by the evanescent coupler; a controller configured to determine an acceleration and/or rate of rotations experienced by the whispering gallery mode resonator based on the displacement of the whispering gallery mode resonator, the controller being further configured to apply a restoring force to the whispering gallery mode resonator in a closed feedback loop based on the displacement of the whispering gallery mode resonator in order to maintain a predetermined mechanical state of the whispering gallery mode resonator; and a timing sensor configured to determine a timing signal based on an optical frequency comb produced by the whispering gallery mode resonator. A method of operating the whispering gallery mode inertial sensor is also provided.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式