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1. 发明申请

WO2006130743A1 ELECTROLYTICALLY DETACHABLE IMPLANTABLE DEVICES 审中-公开
标题翻译：电解可拆卸可植入装置
公开(公告)号：WO2006130743A1
公开(公告)日：2006-12-07
申请号：PCT/US2006/021212
申请日：2006-05-31
申请人： BOSTON SCIENTIFIC SCIMED, INC. , RAMZIPOOR, Kamal , MCGILL, Scott A. , WALLACE, Michael P. , YOUNG, Sarah , FORD, Russell B.
发明人： RAMZIPOOR, Kamal , MCGILL, Scott A. , WALLACE, Michael P. , YOUNG, Sarah , FORD, Russell B.
IPC分类号： A61B17/12
CPC分类号： A61B17/12145 , A61B17/12022 , A61B17/12113 , A61B2017/12063
摘要： Described herein are electrolytically detachable implantable devices and assemblies. In particular, implantable devices and assemblies that are flexible in or near the electrolytically erodable junction region are provided. Also provided are methods of using the devices and assemblies.
摘要翻译：这里描述的是电解可拆卸的可植入装置和组件。特别地，提供了在电解可腐蚀的接合区域中或其附近柔性的可植入装置和组件。还提供了使用装置和组件的方法。

2. 发明申请

WO2007118015A2 ELECTRO-ACTIVE POLYMER APPARATUS FOR THE DEPLOYMENT OF VASO-OCCLUSIVE COILS 审中-公开
标题翻译：用于配置血管阻塞性线圈的电活性聚合物装置
公开(公告)号：WO2007118015A2
公开(公告)日：2007-10-18
申请号：PCT/US2007/065389
申请日：2007-03-28
申请人： BOSTON SCIENTIFIC SCIMED, INC. , RAMZIPOOR, Kamal
发明人： RAMZIPOOR, Kamal
IPC分类号： A61B17/12 , A61F2/06
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B2017/00398 , A61B2017/1209
摘要： A vaso-occlusive delivery device includes an actuating member disposed at or adjacent to the distal end of a delivery member, the actuating member including an electroactive polymer that can be selectively biased to an expanded or non-expanded state by application of direct current of different polarities. A vaso-occlusive device such as a coil may be detachably secured to the delivery device by expanding the actuating member within a proximal end of the coil to form an interference or friction fit using a first direct current polarity, whereby the coil may be disengaged from the delivery member by application of direct current of a second, opposite polarity.
摘要翻译：血管阻塞递送装置包括设置在递送部件的远端处或附近的致动部件，致动部件包括电活性聚合物，该电活性聚合物可以选择性地偏置到扩张的或未扩张的通过施加不同极性的直流电流。诸如线圈之类的血管闭塞装置可通过在线圈的近端内使致动构件膨胀以使用第一直流极性形成干涉或摩擦配合而可拆卸地固定至递送装置，由此线圈可与输送构件通过施加第二极性相反的直流电。

3. 发明申请

WO2008144587A3 MEDICAL IMPLANT DETACHMENT SYSTEMS 审中-公开
公开(公告)号：WO2008144587A3
公开(公告)日：2008-11-27
申请号：PCT/US2008/064013
申请日：2008-05-16
申请人： BOSTON SCIENTIFIC SCIMED, INC. , FORD, Russell , MCGILL, Scott , TEOH, Clifford , WILLIAMS, Michael , RAMZIPOOR, Kamal , QUE, Like , HUANG, Ann , OO, Elena , MA, Christina , CHU, Stella
发明人： FORD, Russell , MCGILL, Scott , TEOH, Clifford , WILLIAMS, Michael , RAMZIPOOR, Kamal , QUE, Like , HUANG, Ann , OO, Elena , MA, Christina , CHU, Stella
IPC分类号： A61B17/12
摘要： An implant assembly comprises an elongated pusher member, and an implantable device (e.g., a vaso-occlusive device) mounted to the distal end of the pusher member. The implant assembly further comprises an electrolytically severable joint disposed on the pusher member, wherein the implantable device detaches from the pusher member when the severable joint is severed, and a return electrode carried by the distal end of the pusher member (e.g., a coil disposed about the pusher member) in proximity to, but electrically isolated from, the severable joint. The implant assembly further comprises a terminal carried by the proximal end of the pusher member in electrical communication with the severable joint.

4. 发明申请

WO2007041407A1 COMBINED ELECTROLYTIC AND MECHANICAL SEPARATION BACKGROUND 审中-公开
标题翻译：组合电解和机械分离背景
公开(公告)号：WO2007041407A1
公开(公告)日：2007-04-12
申请号：PCT/US2006/038264
申请日：2006-09-28
申请人： BOSTON SCIENTIFIC SCIMED, INC. , RAMZIPOOR, Kamal
发明人： RAMZIPOOR, Kamal
IPC分类号： A61B17/12
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B2017/12054 , A61B2017/12063
摘要： Apparatus and method are disclosed by which a distal end portion of an elongate member may be deposited at selected sites in body passageways. The apparatus includes an elongate member having a detachable member for delivery to a target location. The apparatus also has a detachment zone adjacent the distal end section for rupturing when a combination of electrolytic and mechanical energy is applied. The detachment zone may include any of a broad variety or materials and/or structures, but is configured and/or adapted to rupture and/or break through the use of a combination of electrolytic and mechanical energy, thus achieving detachment of the detachable member. A catheter or other delivery device can be coupled to or surrounds the apparatus for delivery to a target location.
摘要翻译：公开了一种装置和方法，其中细长构件的远端部分可以沉积在身体通道中的选定位置处。该装置包括具有用于输送到目标位置的可拆卸构件的细长构件。该装置还具有邻近远端部分的分离区，用于在施加电解和机械能量的组合时破裂。分离区可以包括各种各样的材料和/或结构中的任何一种，但是被构造和/或适于破坏和/或破坏使用电解和机械能的组合，从而实现可拆卸构件的分离。导管或其他输送装置可以联接到或围绕该装置以输送到目标位置。

5. 发明申请

WO2006138536A1 VASO-OCCLUSIVE DELIVERY DEVICE WITH KINK RESISTANT, FLEXIBLE DISTAL END 审中-公开
标题翻译： VASO-OCCLUSIVE传送装置，具有抗振动，灵活的远端
公开(公告)号：WO2006138536A1
公开(公告)日：2006-12-28
申请号：PCT/US2006/023443
申请日：2006-06-14
申请人： BOSTON SCIENTIFIC SCIMED, INC. , HENRY, Bill , DALY, Charles , FORD, Russell , WILLIAMS, Michael , DUONG, Hanh , RAMZIPOOR, Kamal , TEOH, Clifford , MURPHY, Richard , HUFFMASTER, Andrew , MCGILL, Scott , DEVANEY, Hughie
发明人： HENRY, Bill , DALY, Charles , FORD, Russell , WILLIAMS, Michael , DUONG, Hanh , RAMZIPOOR, Kamal , TEOH, Clifford , MURPHY, Richard , HUFFMASTER, Andrew , MCGILL, Scott , DEVANEY, Hughie
IPC分类号： A61B17/12
CPC分类号： A61B17/12022 , A61B17/12109 , A61B17/12113 , A61B17/12154 , A61B2017/1205 , A61B2017/12054 , A61B2017/12063 , A61M25/09 , A61M2025/09133
摘要： A device (60) for delivering an occlusive element (62) includes an elongate sheath (64) having a lumen (66) therein. An elongate core member (68) is disposed within the lumen (66) and is formed from a proximal portion (68a) and distal portion (68b) connected via a joint (70). The distal portion (68b) of the elongate core member includes a severable junction (90) secured to the occlusive element ((62). A marker coil (78) is coaxially arranged around the distal portion of the elongate core member (68) and is partially disposed inside the sheath lumen (66). A coil member (80) is coaxially arranged around the distal portion (68b) of the elongate core member and coaxially arranged around at least a portion of the marker coil (78) extending outside the lumen (66) of the sheath (64). The coil member (80) is secured at a distal end thereof to the distal portion of the elongate core member (68b). The device (60) resists axial compression while allowing for radial bending.
摘要翻译：用于输送闭塞元件（62）的装置（60）包括其中具有内腔（66）的细长护套（64）。细长芯部件（68）设置在内腔（66）内，并由经由接头（70）连接的近端部分（68a）和远端部分（68b）形成。细长芯部件的远端部分（68b）包括固定到闭塞元件（62）上的可分开的接头（90），标记线圈（78）围绕细长芯部件（68）的远端部分同轴设置，线圈构件（80）围绕所述细长芯构件的远端部分（68b）同轴地布置，并且围绕所述标记线圈（78）的至少一部分同轴地布置，所述标记线圈护套（64）的内腔（66），线圈构件（80）的远端固定在细长芯构件（68b）的远端部分上，装置（60）抵抗轴向压缩同时允许径向弯曲。

6. 发明申请

WO2006130550A1 STRETCH-RESISTANT VASO-OCCLUSIVE DEVICES WITH FLEXIBLE DETACHMENT JUNCTIONS 审中-公开
标题翻译：具有柔性分离接头的抗拉伸VASO-OCCLUSIVE设备
公开(公告)号：WO2006130550A1
公开(公告)日：2006-12-07
申请号：PCT/US2006/020727
申请日：2006-05-31
申请人： BOSTON SCIENTIFIC SCIMED, INC. , RAMZIPOOR, Kamal , QUE, Like , DAO, Jimmy D. , CHANG, Esther
发明人： RAMZIPOOR, Kamal , QUE, Like , DAO, Jimmy D. , CHANG, Esther
IPC分类号： A61B17/12
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/12154 , A61B2017/00004 , A61B2017/12054 , A61B2017/12063
摘要： Disclosed herein are vaso-occlusive devices for forming occluding the vasculature of a patient. More particularly, disclosed herein are vaso-occlusive devices comprising at least one polymer structure and methods of making and using these devices. The device comprises a core element attached to a detachment junction at the distal end of a pusher wire and at least one polymer structure surrounding a substantial portion of the core element. The polymeric structure is attached to the distal end of the core element and to the detachment junction.
摘要翻译：本文公开了用于形成阻塞患者脉管系统的血管闭塞装置。更具体地，本文公开了包含至少一种聚合物结构的血管闭塞装置以及制造和使用这些装置的方法。该装置包括附接到推杆的远端处的分离连接处的核心元件和围绕核心元件的主要部分的至少一个聚合物结构。聚合物结构附接到芯元件的远端和分离连接处。

7. 发明申请

WO2006069123A1 VASO-OCCLUSIVE DEVICE HAVING PIVOTABLE COUPLING 审中-公开
标题翻译：具有可转动联轴器的VASO-OCCLUSIVE设备
公开(公告)号：WO2006069123A1
公开(公告)日：2006-06-29
申请号：PCT/US2005/046289
申请日：2005-12-20
申请人： BOSTON SCIENTIFIC LIMITED , RAMZIPOOR, Kamal , WALLACE, Michael, P.
发明人： RAMZIPOOR, Kamal , WALLACE, Michael, P.
IPC分类号： A61B17/12
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/12154 , A61B2017/00477 , A61B2017/12054 , A61B2017/12063 , A61B2017/12095
摘要： An assembly for occluding a vascular site (e.g., an aneurysm) of a human or veterinary patient includes a vaso-occlusive member, a pusher member having a distal end and a severable junction located proximal to the distal end, and a pivotable coupling that couples the pusher member to the occlusive member. As a severable junction is severed to detach the vaso-occlusive member from the pusher member, an axial force is applied by the vaso-occlusive member in a proximal direction, which buckles the pivotable coupling to laterally deflect the axial force. The lateral deflection of the axial force caused by the buckling of the pivotable coupling prevents the delivery catheter from being displaced from the aneurysmal neck by the axial force.
摘要翻译：用于闭塞人或兽医患者的血管部位（例如，动脉瘤）的组件包括血管闭塞构件，具有远端的推动器构件和位于远端附近的可分离接合部以及可枢转联接件推动器构件到闭塞构件。当可切断的连接处被切断以将血管闭塞构件从推动器构件分离时，轴向力由近端方向由血管闭塞构件施加，该近侧方向使可枢转联接器弯曲以横向偏转轴向力。由可枢转联轴器的弯曲引起的轴向力的横向偏转防止了输送导管被轴向力从动脉瘤颈移位。

8. 发明申请

WO2015187350A1 BIOABSORBABLE STENTS 审中-公开
标题翻译：生物耐药性
公开(公告)号：WO2015187350A1
公开(公告)日：2015-12-10
申请号：PCT/US2015/031376
申请日：2015-05-18
申请人： AMARANTH MEDICAL PTE , RAMZIPOOR, Kamal
发明人： RAMZIPOOR, Kamal , LEE, Chang Y.
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2002/91558 , A61F2002/91575 , A61F2210/0004 , A61F2210/0076 , A61F2250/003 , A61F2250/0035 , A61F2250/0067 , A61L31/06 , A61L31/148 , A61L2420/08 , C08L67/04
摘要： Tubular casting processes, such as dip-coating, may be used to form substrates from polymeric solutions which may be used to fabricate implantable devices such as stents. The polymeric substrates may have multiple layers which retain the inherent properties of their starting materials and which are sufficiently ductile to prevent brittle fracture. Parameters such as the number of times the mandrel is immersed, the duration of time of each immersion within the solution, as well as the delay time between each immersion or the drying or curing time between dips and withdrawal rates of the mandrel from the solution may each be controlled to result in the desired mechanical characteristics. Additional post-processing may also be utilized to further increase strength of the substrate or to alter its shape.
摘要翻译：可以使用诸如浸涂的管状浇铸工艺从聚合物溶液形成基底，其可用于制造可植入装置，例如支架。聚合物基材可以具有多个层，其保持其起始材料的固有性质，并且其具有足够的延展性以防止脆性断裂。浸入芯棒的次数，溶液中每次浸渍的持续时间以及每次浸渍之间的延迟时间，浸渍之间的干燥或固化时间以及心轴从溶液中提取速率之类的参数可以每个都被控制以产生期望的机械特性。还可以使用额外的后处理来进一步增加基底的强度或改变其形状。

9. 发明申请

WO2015023390A1 BIORESORBABLE SCAFFOLD FOR TREATMENT OF BIFURCATION LESION 审中-公开
标题翻译：用于治疗痔疮的生物活性成分
公开(公告)号：WO2015023390A1
公开(公告)日：2015-02-19
申请号：PCT/US2014/047089
申请日：2014-07-17
申请人： AMARANTH MEDICAL PTE. , RAMZIPOOR, Kamal
发明人： RAMZIPOOR, Kamal , LEE, Chang Y.
IPC分类号： A61F2/856
CPC分类号： A61F2/954 , A61F2/856 , A61F2/915 , A61F2/958 , A61F2002/91575 , A61F2210/0004 , A61F2210/0076 , A61F2240/001 , A61L31/04 , A61L31/06 , C08L67/04
摘要： Bioresorbable scaffolds for treatment of bifurcation lesion are described herein. Generlly, an expandable scaffold may be fabricated from a high molecular weight isotropic PLLA material, wherein the scaffold incorporates one or more strain relief features which are configured to allow side branch treatment.
摘要翻译：本文描述了用于治疗分叉病变的生物可吸收支架。通常，可扩展的支架可以由高分子量各向同性的PLLA材料制成，其中支架结合了一个或多个应变消除特征，其被配置为允许侧支处理。

10. 发明申请

WO2010085314A1 STERILIZATION METHODS AND APPARATUS 审中-公开
标题翻译：灭菌方法和装置
公开(公告)号：WO2010085314A1
公开(公告)日：2010-07-29
申请号：PCT/US2009/069740
申请日：2009-12-29
申请人： AMARANTH MEDICAL PTE. , RAMZIPOOR, Kamal , LEE, Chang Yeul , EL-NOUNOU, Fozan O.
发明人： RAMZIPOOR, Kamal , LEE, Chang Yeul , EL-NOUNOU, Fozan O.
IPC分类号： A61M29/00
CPC分类号： A61L2/20 , A61F2/958 , A61L2/08 , A61L2/087 , A61L2/206 , A61L2/208 , A61L2202/10 , A61L2202/24 , A61M25/0097 , A61M25/10 , A61M2025/0019
摘要： Sterilization methods for implantable prostheses are described where a polymeric stent may be sterilized, e.g., via ETO sterilization, at a temperature below a glass transition temperature of the stent. A separate delivery catheter may be sterilized separately and the stent and delivery catheter may then be combined in an aseptic or semi-aseptic environment and sterilized as an assembled system such that the requirements for sterilizing the system are relatively lower. Additionally and/or alternatively, valve and filter assemblies may be used with an optional mandrel assembly for maintaining sterility of the internal components of a catheter system.
摘要翻译：描述了可植入假体的灭菌方法，其中可以在低于支架的玻璃化转变温度的温度下，例如经由ETO灭菌将聚合物支架灭菌。单独的输送导管可以单独灭菌，然后将支架和输送导管组合在无菌或半无菌环境中并作为组装系统消毒，使得对系统消毒的要求相对较低。另外和/或替代地，阀和过滤器组件可以与可选的心轴组件一起使用，以保持导管系统的内部组件的无菌性。

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