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1. 发明申请

WO2006062627A1 METHOD AND APPARATUS FOR COATING A MEDICAL DEVICE BY ELECTROPLATING 审中-公开
标题翻译：用于通过电镀涂覆医疗装置的方法和装置
公开(公告)号：WO2006062627A1
公开(公告)日：2006-06-15
申请号：PCT/US2005/039461
申请日：2005-11-01
申请人： BOSTON SCIENTIFIC SCIMED, INC, , XU, Yixin , HELMUS, Michael N.
发明人： XU, Yixin , HELMUS, Michael N.
IPC分类号： C25D7/00 , C25D15/00 , A61L31/16 , C09D5/44 , C25D9/02
CPC分类号： A61L31/10 , A61L31/082 , A61L31/16 , A61L2300/606 , A61L2420/02 , C09D5/4492 , C25D9/00 , C25D9/02 , C25D15/00
摘要： Methods and apparatuses for coating surfaces of medical devices by electroplating are disclosed. In one embodiment, the invention includes a coating method in which a mixture of a therapeutic agent, and a plating material are electroplated onto the surface of the medical device. The electroplating method may be performed at a relatively low temperature to avoid destruction of the therapeutic agent. In another embodiment, a coating method is disclosed in which the coating is formed by suspending a therapeutic agent in an electrolytic solution and electroplating a plating material onto the medical device wherein the plating material carries the supended therapeutic agent. Thus, the coating of plating material contains the suspended therapeutic agent. These methods and apparatuses are used to apply one or more coating materials, simultaneously or in sequence by varying the electroplating voltage. In certain embodiments of the invention, the coating materials include therapeutic agents and cationic drugs.
摘要翻译：公开了通过电镀来涂覆医疗装置的表面的方法和装置。在一个实施方案中，本发明包括将治疗剂和电镀材料的混合物电镀在医疗装置的表面上的涂布方法。电镀方法可以在相对低的温度下进行以避免治疗剂的破坏。在另一个实施方案中，公开了一种涂覆方法，其中通过将治疗剂悬浮在电解溶液中并将电镀材料电镀到医疗装置上而形成涂层，其中电镀材料携带上述治疗剂。因此，电镀材料的涂层含有悬浮治疗剂。这些方法和装置用于通过改变电镀电压同时或依次施加一种或多种涂层材料。在本发明的某些实施方案中，涂层材料包括治疗剂和阳离子药物。

2. 发明申请

WO2005101045A1 MAGNETIC RESONANCE IMAGING OF A MEDICAL DEVICE AND PROXIMATE BODY TISSUE 审中-公开
标题翻译：医疗装置的磁共振成像和放射性组织
公开(公告)号：WO2005101045A1
公开(公告)日：2005-10-27
申请号：PCT/US2005/012678
申请日：2005-04-14
申请人： BOSTON SCIENTIFIC SCIMED, INC. , ZHONG, Sheng-Ping , HELMUS, Michael N. , SMITH, Scott R. , HAMMER, Bruce E.
发明人： ZHONG, Sheng-Ping , HELMUS, Michael N. , SMITH, Scott R. , HAMMER, Bruce E.
IPC分类号： G01R33/28
CPC分类号： G01R33/285
摘要： Medical devices incorporate therein imaging materials having selected MRI detectable nuclei to provide useful magnetic resonance images of the medical devices and proximate body tissue. Also, a method generates MRI images of such a medical device, and involves performing first and second MRI processes on a body portion including at least a portion of the medical device to obtain, respectively, first and second image data. The first MRI process is adapted to detect MRI detectable nuclei present in the proximate body tissue, and the second MRI process is adapted to detect the selected MRI detectable nuclei contained in the device's imaging material. The selected MRI detectable nuclei incorporated in the imaging material is not the same nuclei that the first MRI process is adapted to detect. The second image data are combined with the first image data to produce image data for the medical device and the proximate body tissue.
摘要翻译：医疗装置包括具有选定的MRI可检测核的成像材料，以提供医疗装置和邻近身体组织的有用的磁共振图像。此外，一种方法产生这种医疗装置的MRI图像，并且涉及在包括医疗装置的至少一部分的主体部分上执行第一和第二MRI处理，以分别获得第一和第二图像数据。第一MRI过程适于检测存在于邻近身体组织中的MRI可检测核，并且第二MRI过程适于检测包含在装置的成像材料中的所选择的MRI可检测核。在成像材料中并入的所选择的MRI检测核并不是第一个MRI过程适用于检测的核。第二图像数据与第一图像数据组合以产生用于医疗装置和邻近身体组织的图像数据。

3. 发明申请

WO2006099409A2 DRUG RELEASE REGIONS FOR MEDICAL DEVICES, WHICH INCLUDE POLYCYCLIC-STRUCTURE-CONTAINING POLYMERS 审中-公开
标题翻译：用于医疗设备的药物释放区域，其中包含多结构结构的聚合物
公开(公告)号：WO2006099409A2
公开(公告)日：2006-09-21
申请号：PCT/US2006/009111
申请日：2006-03-14
申请人： BOSTON SCIENTIFIC SCIMED, INC. , RANADE, Shrirang V. , HELMUS, Michael N. , RICHARD, Robert E.
发明人： RANADE, Shrirang V. , HELMUS, Michael N. , RICHARD, Robert E.
CPC分类号： A61L27/50 , A61L27/54 , A61L29/14 , A61L29/16 , A61L31/14 , A61L31/16 , A61L2300/602
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain polymeric release regions that control the release of one or more therapeutic agents. The polymeric release regions, in turn, contain one or more polymers that contain one or more rigid, nonplanar polycyclic molecular structures. The therapeutic agent is disposed beneath or within the polymeric release region.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含控制一种或多种治疗剂的释放的聚合物释放区域。聚合物释放区域又包含一种或多种含有一个或多个刚性非平面多环分子结构的聚合物。治疗剂设置在聚合物释放区域的下方或内部。

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