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1. 发明申请

WO2007126768A3 MEDICAL DEVICES COMPRISING A POROUS METAL OXIDE OR METAL MATERIAL AND A POLYMER COATING FOR DELIVERING THERAPEUTIC AGENTS 审中-公开
公开(公告)号：WO2007126768A3
公开(公告)日：2007-11-08
申请号：PCT/US2007/007488
申请日：2007-03-26
申请人： BOSTON SCIENTIFIC LIMITED , CHANDRASEKARAN, Chandru , RADHAKRISHNAN, Rajesh
发明人： CHANDRASEKARAN, Chandru , RADHAKRISHNAN, Rajesh
IPC分类号： A61L31/08
摘要： The invention relates generally to a medical device, such as an intravascular stent, for delivering a therapeutic agent to the body tissue of a patient, and a method for making such a medical device. More particularly, the invention pertains to a medical device having a metal oxide or metal material with a plurality of pores therein disposed on the surface of the medical device and a polymer disposed on the metal oxide or metal material. The invention also relates to medical devices having a surface and an outer region comprising a metal oxide or metal material having a plurality of pores therein and a polymer disposed on the metal oxide or metal material.

2. 发明申请

WO2007092158A1 ULTRASOUND ACTIVATED MEDICAL DEVICE 审中-公开
标题翻译：超声波激活医疗器械
公开(公告)号：WO2007092158A1
公开(公告)日：2007-08-16
申请号：PCT/US2007/001900
申请日：2007-01-25
申请人： BOSTON SCIENTIFIC SCIMED, INC. , RADHAKRISHNAN, Rajesh , CHANDRASEKARAN, Chandru
发明人： RADHAKRISHNAN, Rajesh , CHANDRASEKARAN, Chandru
IPC分类号： A61F2/82 , A61K9/00
CPC分类号： A61L27/54 , A61F2250/0068 , A61K9/0009 , A61K9/1075 , A61L27/34 , A61L27/50 , A61L2300/236 , A61L2300/256 , A61L2300/414 , A61L2300/432 , A61L2300/45 , A61L2300/604
摘要： A medical device (40) comprising a medical device body having drug-loaded vesicles (10) thereon. The vesicles are ultrasound sensitive and release the drug upon ultrasound stimulation. Also provided is a method for controlling drug release from a medical device using drug-loaded vesicles that are ultrasound sensitive.
摘要翻译：一种医疗装置（40），包括其上装有药物的囊泡（10）的医疗装置主体。囊泡是超声敏感的，并在超声刺激下释放药物。还提供了一种使用超声敏感的药物负载囊泡从医疗装置控制药物释放的方法。

3. 发明申请

WO2010014612A2 BIOERODIBLE ENDOPROSTHESIS 审中-公开
标题翻译：生物学上的内生性
公开(公告)号：WO2010014612A2
公开(公告)日：2010-02-04
申请号：PCT/US2009/051965
申请日：2009-07-28
申请人： BOSTON SCIENTIFIC SCIMED, INC. , RADHAKRISHNAN, Rajesh , CHANDRASEKARAN, Chandru , SCHEWE, Scott, R. , MERDAN, Ken
发明人： RADHAKRISHNAN, Rajesh , CHANDRASEKARAN, Chandru , SCHEWE, Scott, R. , MERDAN, Ken
IPC分类号： A61L31/02 , A61L31/04 , A61L31/14
CPC分类号： A61L31/08
摘要： An endoprosthesis includes a plurality of struts defining a flow passage. At least one strut includes (a) a body comprising a bioerodible material and having a thickness and (b) a coating overlying the body. The coating includes a plurality of regions that allow physiological fluids to contact a plurality of corresponding areas of the underlying body when the endoprosthesis is implanted in a physiological environment. The plurality of regions are sized and arranged so that the contacted areas of the body erode substantially through the body in the thickness direction while the coating remains on the body when the endoprosthesis is implanted in the physiological environment.
摘要翻译：内假体包括限定流动通道的多个支柱。至少一个支柱包括（a）包含生物腐蚀性材料并且具有厚度的主体和（b）覆盖在身体上的涂层。涂层包括多个区域，当内生假体植入生理环境时，允许生理流体接触下面身体的多个对应区域。多个区域的尺寸和布置使得当内部假体植入生理环境时，身体的接触区域在厚度方向上基本上穿过身体侵蚀，同时涂层保留在身体上。

4. 发明申请

WO2007058841A1 COATED AND IMPRINTED MEDICAL DEVICES AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：涂覆和改进的医疗装置及其制造方法
公开(公告)号：WO2007058841A1
公开(公告)日：2007-05-24
申请号：PCT/US2006/043450
申请日：2006-11-07
申请人： BOSTON SCIENTIFIC SCIMED, INC. , RADHAKRISHNAN, Rajesh , CHANDRASEKARAN, Chandru
发明人： RADHAKRISHNAN, Rajesh , CHANDRASEKARAN, Chandru
IPC分类号： A61F2/06
CPC分类号： B05D1/42 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2420/02 , B05D5/02 , B41M3/006
摘要： The present invention relates generally to coated medical devices, preferably a stent, that has a drug-eluting surface completely or partially coated with a coating that is imprinted with an impression. In particular, the invention is directed to a coated medical device having a coating that comprises biologically active materials, polymers, or a combination thereof. The coating is imprinted with an impression by printing, molding, lithography, or embossing techniques. Preferably, the patterning imprinted on the coating is capable of releasing biologically active materials in different amounts, at different rates, and/or at different time periods. The invention also relates to methods of making and methods of using the coated medical device.
摘要翻译：本发明一般涉及具有药物洗脱表面的涂覆的医疗装置，优选支架，其完全或部分涂覆有印有印模的涂层。特别地，本发明涉及具有包含生物活性材料，聚合物或其组合的涂层的涂覆医疗装置。通过印刷，模塑，光刻或压花技术印刷印模。优选地，印刷在涂层上的图案能够以不同的速率和/或在不同的时间段以不同的量释放生物活性材料。本发明还涉及制造方法和使用涂覆的医疗装置的方法。

5. 发明申请

WO2009073549A1 MEDICAL ARTICLES THAT STIMULATE ENDOTHELIAL CELL MIGRATION 审中-公开
标题翻译：刺激内皮细胞迁移的医学文章
公开(公告)号：WO2009073549A1
公开(公告)日：2009-06-11
申请号：PCT/US2008/084960
申请日：2008-11-26
申请人： BOSTON SCIENTIFIC LIMITED , VANCAMP, Daniel , RADHAKRISHNAN, Rajesh , NIELSON, Eric , CHANDRASEKARAN, Verivada
发明人： VANCAMP, Daniel , RADHAKRISHNAN, Rajesh , NIELSON, Eric , CHANDRASEKARAN, Verivada
IPC分类号： A61N1/32 , A61F2/82 , A61F2/30 , A61F2/00 , A61L31/00 , A61N1/30
CPC分类号： A61N1/326 , A61L27/04 , A61L27/50 , A61L31/022 , A61L31/14 , A61N1/30
摘要： A medical article that includes (a) an electronically conductive substrate having a specific conductivity of at least 1 ?S/cm and (b) a galvanic couple that includes a first member and a second member arranged in sufficient proximity to each other to generate a localized electric field under physiological conditions. The first and second members are selected such that the galvanic couple exhibits an average plateau current density of at least 25 microamps/cm2 when short circuited in a zero resistance ammeter test at room temperature using a saline electrolyte.
摘要翻译：一种医疗制品，其包括（a）具有至少1μS/ cm的比电导率的电子导电基底和（b）包含第一构件和第二构件的电偶，所述第一构件和第二构件彼此靠近地布置以产生局部电场在生理条件下。选择第一和第二构件，使得当在室温下使用盐水电解质的零电阻电流表试验中短路时，电偶对的平均平均电流密度至少为25微安/ cm2。

6. 发明申请

WO2009059098A2 ENDOPROSTHESIS COATING 审中-公开
标题翻译：内部涂层
公开(公告)号：WO2009059098A2
公开(公告)日：2009-05-07
申请号：PCT/US2008/081945
申请日：2008-10-31
申请人： BOSTON SCIENTIFIC LIMITED , SCHOENLE, Victor , SCHEWE, Scott R. , RADHAKRISHNAN, Rajesh
发明人： SCHOENLE, Victor , SCHEWE, Scott R. , RADHAKRISHNAN, Rajesh
IPC分类号： A61L31/08
CPC分类号： A61L33/00 , A61L31/082 , A61L31/088 , A61L31/14 , C23C14/025 , C23C14/046 , C23C14/08 , C23C14/3464 , C23C14/352
摘要： A method includes: providing a tubular substrate in a chamber, the tubular substrate having a lumen, an abluminal surface and a luminal surface; providing a target in the lumen; depositing a first coating onto the abluminal surface and a second coating onto the luminal surface while keeping the tubular substrate in the chamber. An endoprosthesis, such as a stent, including a first coating on at least one portion of its abluminal surface and a second coating on at least one portion of its luminal surface is also disclosed.
摘要翻译：一种方法包括：在腔室中提供管状基底，所述管状基底具有内腔，腔内表面和腔表面; 在管腔中提供目标; 将第一涂层沉积到腔内表面上，并将第二涂层沉积到腔表面上，同时将管状基底保持在腔室中。还公开了内置假体，例如支架，其包括其外侧表面的至少一部分上的第一涂层和其管腔表面的至少一部分上的第二涂层。

7. 发明申请

WO2018208944A1 AUTOMATIC CAMERA PARAMETER ADJUSTMENT ON A PLANT TREATMENT SYSTEM 审中-公开
公开(公告)号：WO2018208944A1
公开(公告)日：2018-11-15
申请号：PCT/US2018/031841
申请日：2018-05-09
申请人： BLUE RIVER TECHNOLOGY INC. , RADHAKRISHNAN, Rajesh , REDDEN, Lee Kamp , OSTROWSKI, James Patrick
发明人： RADHAKRISHNAN, Rajesh , REDDEN, Lee Kamp , OSTROWSKI, James Patrick , HALLIGAN, Deaglan , PELL, Edward William Jeffcott , BROWN, Thomas Welch
IPC分类号： G06K9/00 , G06K9/32 , G06K9/62 , G06T7/00 , H04N13/00
摘要： A plant treatment system automatically adjusts camera operation parameters for a camera used by the plant treatment system to identify and treat plants in a field. The plant treatment system can generate image segments of images received from the camera and classify the image segments based on whether the image segments represent plants. The plant treatment system determines whether each of the image segments is over- or under-exposed and adjusts the camera operation parameters for the camera based on the exposure classification of the image segments. Alternatively, the plant treatment system may use a plant detection model to identify plant pixels within an image that represent plants. The plant treatment system can then determine whether the identified plant pixels are over- or under-exposed and adjust the camera operation parameters accordingly.

8. 发明申请

WO2007137389A1 UTILISATION DE COMPOSANTS OBTENUS DU MARGOUSIER (AZADIRACHTA INDICA) POUR LE TRAITEMENT DU VIH/SIDA 审中-公开
标题翻译：使用从NEEM树（AZADIRACHTA INDICA）获得的化合物治疗艾滋病毒/艾滋病
公开(公告)号：WO2007137389A1
公开(公告)日：2007-12-06
申请号：PCT/CA2006/001970
申请日：2006-12-04
申请人： 2033261 ONTARIO INC , RADHAKRISHNAN, Rajesh
发明人： RADHAKRISHNAN, Rajesh
IPC分类号： A61K36/58 , A61P31/18
CPC分类号： A61K35/20 , A61K36/58 , A61K2300/00
摘要： Une composition pharmaceutique pour le traitement de patients atteints du virus de l'immunodéficience humaine est divulguée. Cette composition comprend une quantité effective des éléments suivants : composants obtenus du margousier ( Azadirachta Indica ); et un complément protéique. On peut produire cette composition de la manière suivante : en immergeant de la poudre de margousier dans de l'eau de manière à ce que celle-ci puisse extraire des composants de cette même poudre de margousier afin de produire un extrait aqueux; et en mélangeant l'extrait aqueux avec un complément protéique pour former une boisson. Une méthode de traitement pour un patient atteint du virus de l'immunodéficience humaine est aussi divulguée. Cette méthode peut comprendre l'étape consistant à administrer cette boisson oralement au même patient.
摘要翻译：公开了一种用于治疗患有人体免疫缺陷病毒的患者的药物化合物。该化合物包含有效量的以下元素：从楝树（Azadirachta Indica）获得的化合物; 和蛋白质补充剂。该化合物可以如下制备：将楝树的粉末浸入水中，使得其中的组分可以被提取以产生水提取物; 并通过将水提取物与蛋白质补充剂混合来进行饮料。还公开了患有人类免疫缺陷病毒的患者的治疗方法。该方法可以包括向同一患者口服施用该饮料的步骤。

9. 发明申请

WO2007137386A1 COMPOSITIONS AND METHODS FOR THE CURE OF HIV/AIDS 审中-公开
标题翻译：艾滋病毒/艾滋病治疗的组成和方法
公开(公告)号：WO2007137386A1
公开(公告)日：2007-12-06
申请号：PCT/CA2006/000867
申请日：2006-05-26
申请人： DEVARAJAN, Anitha , RADHAKRISHNAN, Rajesh
发明人： RADHAKRISHNAN, Rajesh
IPC分类号： A61K36/58 , A61K35/20 , A61P31/18
CPC分类号： A61K35/20 , A61K36/58 , A61K2300/00
摘要： A pharmaceutical composition for the treatment of patients with human immunodeficiency virus infection is disclosed. The composition comprises effective amounts of: components obtained from Neem (Azadirachta Indica); and a protein supplement. This composition can be produced by: contacting powdered Neem with water to allow said water to extract components from said Neem powder to produce an aqueous extract; and mixing the aqueous extract with a protein supplement to form a drink. A method for treating a patient with human immunodeficiency virus infection is also disclosed. This method can comprise the step of orally administering to said patient the drink.
摘要翻译：公开了用于治疗患有人体免疫缺陷病毒感染的患者的药物组合物。组合物包含有效量的由Neem（Azadirachta Indica）获得的组分; 和蛋白质补充剂。该组合物可以通过以下方法制备：使粉末状的Neem与水接触，以使所述水从所述Neem粉末中提取组分以产生水提取物; 并将水提取物与蛋白质补充剂混合以形成饮料。还公开了一种治疗患有人体免疫缺陷病毒感染的患者的方法。该方法可以包括向所述患者口服所述饮料的步骤。

10. 发明申请

WO2018208947A1 AUTOMATED PLANT DETECTION USING IMAGE DATA 审中-公开
公开(公告)号：WO2018208947A1
公开(公告)日：2018-11-15
申请号：PCT/US2018/031845
申请日：2018-05-09
申请人： BLUE RIVER TECHNOLOGY INC. , REDDEN, Lee Kamp , PADWICK, Christopher Grant , RADHAKRISHNAN, Rajesh , OSTROWSKI, James Patrick
发明人： REDDEN, Lee Kamp , PADWICK, Christopher Grant , RADHAKRISHNAN, Rajesh , OSTROWSKI, James Patrick
IPC分类号： A01G1/00 , A01M21/04 , G01N33/00 , G06K9/00 , G06K9/20 , G06K9/62 , H04N7/18
摘要： A plant treatment platform uses a plant detection model to detect plants as the plant treatment platform travels through a field. The plant treatment platform receives image data from a camera that captures images of plants (e.g., crops or weeds) growing in the field. The plant treatment platform applies pre-processing functions to the image data to prepare the image data for processing by the plant detection model. For example, the plant treatment platform may reformat the image data, adjust the resolution or aspect ratio, or crop the image data. The plant treatment platform applies the plant detection model to the pre-processed image data to generate bounding boxes for the plants. The plant treatment platform then can apply treatment to the plants based on the output of the machine-learned model.

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