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1. 发明申请

WO2007035798A3 APPARATUS AND METHODS FOR IMPLANTING OBJECTS, SUCH AS BRONCHOSCOPICALLY IMPLANTING MARKERS IN THE LUNG OF PATIENTS 审中-公开
标题翻译：用于植入对象的装置和方法，例如在患者肺中的人造牙植入标记
公开(公告)号：WO2007035798A3
公开(公告)日：2009-04-23
申请号：PCT/US2006036585
申请日：2006-09-19
申请人： CALYPSO MED TECHNOLOGIES INC , MAYSE MARTIN L , DIMMER STEVEN C , HILDWEIN ROGER , NIELSON ERIC D
发明人： MAYSE MARTIN L , DIMMER STEVEN C , HILDWEIN ROGER , NIELSON ERIC D
IPC分类号： A61M25/00
CPC分类号： A61B90/39 , A61B1/018 , A61B1/2676 , A61B17/12104 , A61B17/12172 , A61B34/20 , A61B34/25 , A61B34/30 , A61B2017/00809 , A61B2017/00951 , A61B2034/2051 , A61B2034/252 , A61B2090/101 , A61B2090/3912 , A61B2090/3954 , A61B2090/3966 , A61B2090/397 , A61B2090/3987 , A61B2090/3991 , A61N2005/1009
摘要： Apparatuses and methods for implanting objects, such as a marker, in the lungs of patients. In one embodiment, a bronchoscopic catheter assembly for implanting an object in the lung of a patient includes a handle, a delivery catheter projecting outwardly from the handle, and a push wire contained within the catheter. In one aspect of this embodiment, the catheter can be configured to releasably hold a plurality of markers at a distal end. In another aspect of this embodiment, the push wire can be operably connected to the handle and axially moveable within the delivery catheter to eject the marker out of the catheter within the bronchi of the patient. In a further aspect of this embodiment, the marker can further include an anti-migration device associated with the marker for holding the marker in place once the marker is deployed in the bronchi. The anti-migration device can be integral with the marker or positioned proximate to the marker to prevent migration of the marker.
摘要翻译：用于在患者的肺中植入诸如标记物的物体的装置和方法。在一个实施例中，用于将物体植入患者肺部的支气管镜导管组件包括手柄，从手柄向外突出的输送导管以及容纳在导管内的推送线。在该实施例的一个方面中，导管可以被配置为可释放地将多个标记保持在远端。在该实施例的另一方面，推动线可以可操作地连接到手柄并且在输送导管内可轴向移动，以将患者的支气管内的标记物从导管中排出。在该实施例的另一方面，标记还可以包括与标记物相关联的抗迁移装置，一旦标记部署在支气管中，则将标记物保持在适当位置。抗迁移装置可以与标记物成一体或靠近标记物定位，以防止标记的迁移。

2. 发明申请

WO2008157727A3 METHODS AND APPARATUS FOR EXTERNAL BEAM RADIATION TREATMENTS OF RESECTION CAVITIES 审中-公开
公开(公告)号：WO2008157727A3
公开(公告)日：2008-12-24
申请号：PCT/US2008/067551
申请日：2008-06-19
申请人： CALYPSO MEDICAL TECHNOLOGIES, INC. , DIMMER, Steven, C. , QUIGLEY, Fergus , NIELSON, Eric, D.
发明人： DIMMER, Steven, C. , QUIGLEY, Fergus , NIELSON, Eric, D.
IPC分类号： A61N5/10
摘要： Apparatus and methods for external beam radiation treatments of resection cavities are described. One embodiment of such an apparatus comprises a stabilization device having an expandable member configured to (a) be implanted in a patient and (b) move from a first position for insertion into a resection cavity within the patient to a second position for stabilizing tissue of the cavity. The apparatus further includes an active marker coupled to the stabilization device and an electrically conductive line connected to the active marker. The active marker is configured to transmit a signal. The electrically conductive line has an internal portion coupled to the stabilization device and an external portion configured to be coupled to a signal generator and/or a signal processor located outside of the patient.

3. 发明申请

WO2008082698A2 MEDICAL DEVICES AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：医疗器械及其制造方法
公开(公告)号：WO2008082698A2
公开(公告)日：2008-07-10
申请号：PCT/US2007/073844
申请日：2007-07-19
申请人： BOSTON SCIENTIFIC SCIMED, INC. , NIELSON, Eric , VAN CAMP, Dan
发明人： NIELSON, Eric , VAN CAMP, Dan
IPC分类号： A61L27/40 , A61L31/12 , A61F2/06 , B22F1/02
CPC分类号： C22C32/00 , A61F2/0077 , A61F2/91 , A61F2230/0054 , A61L31/10 , A61L31/124 , C25F3/22 , Y10T428/12014 , Y10T428/12049 , Y10T428/24372 , Y10T428/24413 , Y10T428/25 , Y10T428/252
摘要： Medical devices, such as, for example, endoprostheses, and related methods are disclosed.
摘要翻译：公开了医疗装置，例如内假体，以及相关方法。

4. 发明申请

WO2008082698A3 MEDICAL DEVICES AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：医疗器械及其制造方法
公开(公告)号：WO2008082698A3
公开(公告)日：2008-12-11
申请号：PCT/US2007073844
申请日：2007-07-19
申请人： BOSTON SCIENT SCIMED INC , NIELSON ERIC , VAN CAMP DAN
发明人： NIELSON ERIC , VAN CAMP DAN
IPC分类号： A61L31/12 , A61L27/42
CPC分类号： C22C32/00 , A61F2/0077 , A61F2/91 , A61F2230/0054 , A61L31/10 , A61L31/124 , C25F3/22 , Y10T428/12014 , Y10T428/12049 , Y10T428/24372 , Y10T428/24413 , Y10T428/25 , Y10T428/252
摘要： A Medical device comprising a composite material comprising a matrix, and a plurality of particles in the matrix, the particles and the matrix having different chemical compositions, wherein the the particles protrude from the surface of the composite material by an average height of at least about 100 nanometers.
摘要翻译：一种包括复合材料的医疗装置，所述复合材料包括基质和所述基质中的多个颗粒，所述颗粒和所述基质具有不同的化学组成，其中所述颗粒从所述复合材料的表面突出至少大约的平均高度 100纳米。

5. 发明申请

WO2007078517A2 INTERNAL MEDICAL DEVICES CONTAINING PEROXIDE-CONVERTING CATALYSTS 审中-公开
标题翻译：含有过氧化碳转化催化剂的内部医疗装置
公开(公告)号：WO2007078517A2
公开(公告)日：2007-07-12
申请号：PCT/US2006/046326
申请日：2006-12-04
申请人： BOSTON SCIENTIFIC SCIMED, INC. , WEBER, Jan , NIELSON, Eric, D.
发明人： WEBER, Jan , NIELSON, Eric, D.
CPC分类号： A61L31/082 , A61K31/727 , A61K38/44 , A61L31/128 , A61L31/148 , C12Y111/01006
摘要： The present invention is directed to implantable and insertable medical devices (also referred to herein as internal medical devices), which contain one or more peroxide- converting catalysts. According to an aspect of the invention, internal medical devices are provided, which contain (a) a substrate and (b) a peptide-containing, peroxide- converting catalyst disposed over at least a portion of the substrate. According to another aspect of the invention, internal medical devices are provided which contain a catalyst binding entity. The catalyst binding entity is adapted to bind to endogenous peroxide- converting catalyst upon implantation or insertion of the devices into patients. In another aspect of the invention, internal medical devices are provided which contain a biodegradable region that in turn contains a peroxide-converting catalyst. These devices release the catalyst in conjunction with degradation of the biodegradable region. In yet another aspect of the invention, internal medical devices are provided which contain a substrate, a multilayer region disposed over at least a portion of the substrate, and a peroxide-converting catalyst disposed within the multilayer region. The multilayer region, in turn, contains a plurality of charged layers of alternating charge, which charged layers further contain a plurality of polyelectrolyte containing layers.
摘要翻译：本发明涉及含有一种或多种过氧化物转化催化剂的可植入和可插入医疗装置（本文也称为内部医疗装置）。根据本发明的一个方面，提供了内部医疗装置，其包含（a）基底和（b）设置在基底的至少一部分上的含肽的过氧化物转化催化剂。根据本发明的另一方面，提供了含有催化剂结合实体的内部医疗装置。催化剂结合实体适于在将装置植入或插入患者体内时结合内源性过氧化物转化催化剂。在本发明的另一方面，提供了含有可生物降解区域的内部医疗装置，其又含有过氧化物转化催化剂。这些装置与可生物降解区域的降解相结合释放催化剂。在本发明的另一方面，提供了内部医疗装置，其包含衬底，设置在衬底的至少一部分上的多层区域和设置在所述多层区域内的过氧化物转化催化剂。多层区域又包含多个交替电荷的带电层，该带电层还含有多个含聚电解质的层。

6. 发明申请

WO2007035798A2 APPARATUS AND METHODS FOR IMPLANTING OBJECTS, SUCH AS BRONCHOSCOPICALLY IMPLANTING MARKERS IN THE LUNG OF PATIENTS 审中-公开
标题翻译：用于植入对象的装置和方法，例如在患者肺中的人造牙植入标记
公开(公告)号：WO2007035798A2
公开(公告)日：2007-03-29
申请号：PCT/US2006/036585
申请日：2006-09-19
申请人： CALYPSO MEDICAL TECHNOLOGIES, INC. , MAYSE, Martin, L. , DIMMER, Steven, C. , HILDWEIN, Roger , NIELSON, Eric, D.
发明人： MAYSE, Martin, L. , DIMMER, Steven, C. , HILDWEIN, Roger , NIELSON, Eric, D.
IPC分类号： A61M25/09
CPC分类号： A61B90/39 , A61B1/018 , A61B1/2676 , A61B17/12104 , A61B17/12172 , A61B34/20 , A61B34/25 , A61B34/30 , A61B2017/00809 , A61B2017/00951 , A61B2034/2051 , A61B2034/252 , A61B2090/101 , A61B2090/3912 , A61B2090/3954 , A61B2090/3966 , A61B2090/397 , A61B2090/3987 , A61B2090/3991 , A61N2005/1009
摘要： Apparatuses and methods for implanting objects, such as a marker, in the lungs of patients. In one embodiment, a bronchoscopic catheter assembly for implanting an object in the lung of a patient includes a handle, a delivery catheter projecting outwardly from the handle, and a push wire contained within the catheter. In one aspect of this embodiment, the catheter can be configured to releasably hold a plurality of markers at a distal end. In another aspect of this embodiment, the push wire can be operably connected to the handle and axially moveable within the delivery catheter to eject the marker out of the catheter within the bronchi of the patient. In a further aspect of this embodiment, the marker can further include an anti-migration device associated with the marker for holding the marker in place once the marker is deployed in the bronchi. The anti-migration device can be integral with the marker or positioned proximate to the marker to prevent migration of the marker.
摘要翻译：用于在患者的肺中植入诸如标记物的物体的装置和方法。在一个实施例中，用于将物体植入患者肺部的支气管镜导管组件包括手柄，从手柄向外突出的输送导管以及容纳在导管内的推送线。在该实施例的一个方面中，导管可以被配置为可释放地将多个标记物保持在远端。在该实施例的另一方面，推动导线可以可操作地连接到手柄并且在输送导管内可轴向移动，以将患者的支气管内的标记物从导管中排出。在该实施例的另一方面，标记还可以包括与标记物相关联的抗迁移装置，一旦标记部署在支气管中，则将标记物保持在适当位置。抗迁移装置可以与标记物成一体或靠近标记物定位，以防止标记的迁移。

7. 发明申请

WO2008157727A2 METHODS AND APPARATUS FOR EXTERNAL BEAM RADIATION TREATMENTS OF RESECTION CAVITIES 审中-公开
标题翻译：外照射辐射处理方法和装置
公开(公告)号：WO2008157727A2
公开(公告)日：2008-12-24
申请号：PCT/US2008067551
申请日：2008-06-19
申请人： CALYPSO MED TECHNOLOGIES INC , DIMMER STEVEN C , QUIGLEY FERGUS , NIELSON ERIC D
发明人： DIMMER STEVEN C , QUIGLEY FERGUS , NIELSON ERIC D
IPC分类号： A61N5/10
CPC分类号： A61N5/1015 , A61B2090/3958 , A61N5/1049 , A61N2005/1051
摘要： Apparatus and methods for external beam radiation treatments of resection cavities are described. One embodiment of such an apparatus comprises a stabilization device having an expandable member configured to (a) be implanted in a patient and (b) move from a first position for insertion into a resection cavity within the patient to a second position for stabilizing tissue of the cavity. The apparatus further includes an active marker coupled to the stabilization device and an electrically conductive line connected to the active marker. The active marker is configured to transmit a signal. The electrically conductive line has an internal portion coupled to the stabilization device and an external portion configured to be coupled to a signal generator and/or a signal processor located outside of the patient.
摘要翻译：描述了用于切除腔的外部束辐射治疗的装置和方法。这种装置的一个实施例包括具有可扩张构件的稳定装置，所述可扩张构件构造成（a）植入患者体内，并且（b）从用于插入患者体内切除腔的第一位置移动到第二位置，以稳定组织空腔。该装置还包括耦合到稳定装置的有源标记和连接到有源标记的导电线。活动标记被配置为发送信号。导电线具有连接到稳定装置的内部部分和被配置为耦合到位于病人外部的信号发生器和/或信号处理器的外部部分。

8. 发明申请

WO2007078517A3 INTERNAL MEDICAL DEVICES CONTAINING PEROXIDE-CONVERTING CATALYSTS 审中-公开
标题翻译：含有过氧化碳转化催化剂的内部医疗装置
公开(公告)号：WO2007078517A3
公开(公告)日：2008-08-28
申请号：PCT/US2006046326
申请日：2006-12-04
申请人： BOSTON SCIENT SCIMED INC , WEBER JAN , NIELSON ERIC D
发明人： WEBER JAN , NIELSON ERIC D
IPC分类号： A61L31/16 , A61L31/08
CPC分类号： A61L31/082 , A61K31/727 , A61K38/44 , A61L31/128 , A61L31/148 , C12Y111/01006
摘要： The present invention is directed to implantable and insertable medical devices (also referred to herein as internal medical devices), which contain one or more peroxide- converting catalysts. According to an aspect of the invention, internal medical devices are provided, which contain (a) a substrate and (b) a peptide-containing, peroxide- converting catalyst disposed over at least a portion of the substrate. According to another aspect of the invention, internal medical devices are provided which contain a catalyst binding entity. The catalyst binding entity is adapted to bind to endogenous peroxide- converting catalyst upon implantation or insertion of the devices into patients. In another aspect of the invention, internal medical devices are provided which contain a biodegradable region that in turn contains a peroxide-converting catalyst. These devices release the catalyst in conjunction with degradation of the biodegradable region. In yet another aspect of the invention, internal medical devices are provided which contain a substrate, a multilayer region disposed over at least a portion of the substrate, and a peroxide-converting catalyst disposed within the multilayer region. The multilayer region, in turn, contains a plurality of charged layers of alternating charge, which charged layers further contain a plurality of polyelectrolyte containing layers.
摘要翻译：本发明涉及含有一种或多种过氧化物转化催化剂的可植入和可插入医疗装置（本文也称为内部医疗装置）。根据本发明的一个方面，提供了内部医疗装置，其包含（a）基底和（b）设置在基底的至少一部分上的含肽的过氧化物转化催化剂。根据本发明的另一方面，提供了含有催化剂结合实体的内部医疗装置。催化剂结合实体适于在将装置植入或插入患者体内时结合内源性过氧化物转化催化剂。在本发明的另一方面，提供了含有可生物降解区域的内部医疗装置，其又含有过氧化物转化催化剂。这些装置与可生物降解区域的降解相结合释放催化剂。在本发明的另一方面，提供了内部医疗装置，其包含衬底，设置在衬底的至少一部分上的多层区域和设置在所述多层区域内的过氧化物转化催化剂。多层区域又包含多个交替电荷的带电层，该带电层还含有多个含聚电解质的层。

9. 发明申请

WO2009015104A2 IMPLANTABLE DEVICES AND METHODS FOR EXTERNAL BEAM RADIATION TREATMENTS 审中-公开
标题翻译：外部射束辐射治疗的可植入装置和方法
公开(公告)号：WO2009015104A2
公开(公告)日：2009-01-29
申请号：PCT/US2008/070682
申请日：2008-07-21
申请人： CALYPSO MEDICAL TECHNOLOGIES, INC. , NIELSON, Eric, D. , DIMMER, Steven, C. , KRAG, David, N. , MATE, Timothy, P. , PEREZ, Roland , QUIGLEY, Fergus
发明人： NIELSON, Eric, D. , DIMMER, Steven, C. , KRAG, David, N. , MATE, Timothy, P. , PEREZ, Roland , QUIGLEY, Fergus
IPC分类号： A61N5/01
CPC分类号： A61N5/1049 , A61N2005/1051
摘要： Implantable devices and methods for external beam radiation treatments are disclosed. One embodiment of an implantable device for guided radiation therapy comprises an active marker configured to be positioned within the patient and to transmit a non-ionizing wireless signal in response to a non-ionizing wirelessly transmitted source energy. The device further includes a fastening unit coupled to the active marker and configured to (a) hold the marker within a desired distance of a target in the tissue and (b) inhibit deformation of tissue from moving the active marker relative to the target.
摘要翻译：公开了用于外部束辐射处理的可植入装置和方法。用于引导放射治疗的可植入装置的一个实施例包括被配置为定位在患者体内并且响应于非电离无线发射的源能发射非电离无线信号的活动标记。该装置还包括紧固单元，其联接到主动标记并且被配置为（a）将标记保持在组织中的目标的期望距离内，并且（b）抑制组织相对于目标移动主动标记物的变形。

10. 发明申请

WO2006031602A1 DIVERSION DEVICE TO INCREASE CEREBRAL BLOOD FLOW 审中-公开
标题翻译：分流装置增加脑血流量
公开(公告)号：WO2006031602A1
公开(公告)日：2006-03-23
申请号：PCT/US2005/032030
申请日：2005-09-08
申请人： BOSTON SCIENTIFIC SCIMED, INC. , VANCAMP, Daniel , NIELSON, Eric, D.
发明人： VANCAMP, Daniel , NIELSON, Eric, D.
IPC分类号： A61B17/12
CPC分类号： A61B17/12136 , A61B17/12022 , A61B17/12036 , A61B17/12109 , A61B17/12172 , A61B2017/00004 , A61B2017/00243 , A61B2017/00575 , A61B2017/00579 , A61B2017/00592 , A61B2017/00597 , A61B2017/00615
摘要： Methods and devices provide for temporary partial aortic occlusion to achieve diversion of blood flow to the brain in patients suffering from cerebral ischemia. The device includes an expandable frame and membrane that is inserted into the aorta to partially occlude blood flow.
摘要翻译：方法和装置提供临时部分主动脉闭塞以在患有脑缺血的患者中实现血流向大脑的转移。该装置包括可扩张的框架和膜，其插入主动脉以部分阻塞血流。

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