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1. 发明申请

WO2021022320A1 COLONIC TREATMENT METHODS AND APPARATUS 审中-公开
公开(公告)号：WO2021022320A1
公开(公告)日：2021-02-11
申请号：PCT/AU2020/050774
申请日：2020-07-30
申请人： BORODY, Thomas Julius , MILIS, Antony
发明人： BORODY, Thomas Julius , MILIS, Antony
IPC分类号： A61B17/22 , A61B18/08 , A61B18/14 , A61L2/025 , A61B8/00
摘要： Provided are products of manufacture and methods for the removal and/or destruction of a biofilm in situ , e.g., a gastro-luminal biofilm, and for the treatment or amelioration of biofilm-associated diseases, infections and conditions, including and GI luminal infections. Provided are devices and apparatus, and methods for using them, for the removal, disruption and/or destruction of a biofilm in situ , e.g., a gastro-luminal biofilm. In alternative embodiments, provided are devices and apparatus, and methods, for enhancing biofilm dissolving or disrupting agents, or for administering biofilm dissolving or disrupting agents, where in alternative embodiments the biofilm comprises a gastro-luminal "unstirred layer", adherent layer or gastro-luminal mucus layer; or the biofilm comprises a matrix or a DNA-containing layer, or alternatively the biofilm comprises a polysaccharide gastro-luminal peripheral layer.

2. 发明申请

WO2014032108A1 LAXATIVE COMPOSITIONS AND METHODS FOR TREATING CONSTIPATION AND RELATED GASTROINTESTINAL DISEASES AND CONDITIONS 审中-公开
标题翻译：治疗组织和相关胃肠疾病和病症的风味组合物和方法
公开(公告)号：WO2014032108A1
公开(公告)日：2014-03-06
申请号：PCT/AU2013/000973
申请日：2013-08-29
申请人： BORODY, Thomas Julius
发明人： BORODY, Thomas Julius
IPC分类号： A61K9/22 , A61K9/54 , A61K31/538 , A61P1/00
CPC分类号： A61K9/48 , A61K9/28 , A61K9/4891 , A61K9/50 , A61K31/165 , A61K31/195 , A61K31/437 , A61K31/454 , A61K31/485 , A61K31/538 , A61K31/655 , A61K35/741 , A61K38/08 , A61K38/14 , A61K45/06 , A61K2035/115 , Y02A50/473 , A61K2300/00
摘要： In alternative embodiments, the invention provides compositions, e.g., formulations or preparations, used for treating, ameliorating or preventing constipation and other disorders with related gastrointestinal symptoms. In alternative embodiments, the invention provides compositions, e.g., formulations or preparations, used for treating, ameliorating or preventing conditions which benefit from increasing or speeding bowel transit, including for example: cyclic vomiting, reflux oesophagitis, autism enteropathy, flatulence, halitosis, Chronic Fatigue Syndrome (CFS), bloating, proctalgia fugax, small intestinal bacterial overgrowth (SIBO) and large intestinal bacterial overgrowth (LIBO), chronic nausea, functional dyspepsia and bloating. In alternative embodiments, the invention provides compositions, e.g., formulations or preparations, used for treating, ameliorating or preventing a constipation, a functional constipation, Irritable Bowel Syndrome (IBS)-constipation, a diverticulosis-associated constipation, a pseudo obstruction, a slow-transit constipation, a stasis with overflow and/or a diabetic gastro- paresis. In alternative embodiments, the invention provides pharmaceuticals and products (articles) of manufacture for delivering these compositions and formulations to an individual, e.g., a human or an animal.
摘要翻译：在替代实施方案中，本发明提供了用于治疗，改善或预防便秘和其它具有相关胃肠道症状的疾病的组合物，例如制剂或制剂。在替代实施方案中，本发明提供组合物，例如用于治疗，改善或预防有益于增加或加快肠道转运的病症的制剂或制剂，包括例如：环状呕吐，反流性食管炎，自闭症肠病，肠胃气胀，口臭，慢性疲劳综合征（CFS），腹胀，垂体痛，小肠细菌过度生长（SIBO）和大肠细菌过度生长（LIBO），慢性恶心，功能性消化不良和腹胀。在替代实施方案中，本发明提供了用于治疗，改善或预防便秘，功能性便秘，肠易激综合征（IBS） - 组合，憩室症相关便秘，伪梗阻，慢性转运便秘，有溢出和/或糖尿病性胃痛的淤滞。在替代实施方案中，本发明提供用于将这些组合物和制剂递送给个体，例如人或动物的药物和制品（制品）。

3. 发明申请

WO2020210878A1 COMPOSITIONS AND METHODS FOR TREATING, AMELIORATING AND PREVENTING H. PYLORI INFECTIONS 审中-公开
公开(公告)号：WO2020210878A1
公开(公告)日：2020-10-22
申请号：PCT/AU2020/050384
申请日：2020-04-17
申请人： BORODY, Thomas Julius
发明人： BORODY, Thomas Julius
IPC分类号： A61K31/506 , A61K31/43 , A61P31/04 , A61P1/04 , A61K31/4439 , A61K31/438 , A61K31/24 , A61K31/5383 , A61K31/7048 , A61K31/496
摘要： The application is directed to pharmaceutical combinations, compositions and kits comprising at least one H+/K+ ATPase inhibitor and an antibiotic compound and methods of use thereof in the treatment, prevention and amelioration of Helicobacter pylori infections in an individual. In alternative embodiments, the H+/K+ ATPase inhibitor is a potassium competitive acid blocker (PCAB) and the antibiotic compound is selected from the groups comprising penicillins, rifamycins, macrolides, PCABs, nitroimidazoles, fluoroquinolones, TG44, nitrofurans, thiazolides, salicylic acids and derivatives such as bismuths, and tetracyclines.

4. 发明申请

WO2017143386A1 COMPOSITIONS AND METHODS OF TREATMENT OF CHRONIC INFECTIOUS DISEASES 审中-公开
标题翻译：慢性感染性疾病的组合物和治疗方法
公开(公告)号：WO2017143386A1
公开(公告)日：2017-08-31
申请号：PCT/AU2017/000055
申请日：2017-02-24
申请人： BORODY, Thomas Julius
发明人： BORODY, Thomas Julius
IPC分类号： A61K35/741 , A61P1/00 , A61P31/04 , A61P37/00
CPC分类号： A61K35/74 , A61K9/00 , A61K9/0095 , A61K45/06
摘要： In alternative embodiments, provided are novel applications of bacteria which originate from the phylum of Actinobacteria and sub-order Corynebacterineae, family Dietziaceae , including genus Dietzia and other genera. Such bacilli can profoundly interfere with bacteria generally belonging to this and other phyla, and can be useful in treating chronic infections. Hence, such organisms can ameliorate or cure clinical infections caused by pathogens from this phylum such as Mycobacteriaceae and Mycobacterium such as M. tuberculosis and Mycobacterium avium subspecies paratuberculosis (MAP),
摘要翻译：在替代实施方案中，提供了来源于放线菌门和亚科棒杆菌科亚科（包括属）在内的细菌的新细菌应用 Dietzia和其他属。这样的杆菌可以深刻地干扰通常属于这个和其他门的细菌，并且可以用于治疗慢性感染。因此，这样的生物体可以改善或治疗由该门的病原体例如分枝杆菌科和分枝杆菌属如M引起的临床感染。结核分枝杆菌和鸟分枝杆菌亚种副结核病（MAP），

5. 发明申请

WO2015143492A1 COMPOSITIONS FOR SOIL CARBON SEQUESTRATION AND RESTORATION AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：用于土壤碳排放和恢复的组合物及其制备和使用它们的方法
公开(公告)号：WO2015143492A1
公开(公告)日：2015-10-01
申请号：PCT/AU2015/000181
申请日：2015-03-27
申请人： BORODY, Thomas Julius , VINCIN, Robert
发明人： BORODY, Thomas Julius , VINCIN, Robert
IPC分类号： A01H5/10 , A01C1/06
CPC分类号： A01C21/005 , A01C1/06 , A01C21/00 , A01H5/10 , A01H5/12 , A01N25/00 , C05G3/00
摘要： In alternative embodiments, the invention provides compositions and methods for the restoration of soil carbon content by carbon sequestration, or storage of carbon in a stable and sustainable form, for example, in an exhausted soil. In alternative embodiments, use of compositions of the invention and practicing methods of the invention results in a net increase in Soil Organic Carbon (SOC). In alternative embodiments, the invention provides compositions comprising, or consisting of, a combination or a mixture of seeds, wherein the mixture comprises seeds of at least one C4 photosynthesis pathway grass and at least one of any member of the genus A triplex, or in alternative embodiments, the combination or mixture comprises seeds of at least two C4 photosynthesis pathway grasses and at least one of any member of the genus Atriplex .
摘要翻译：在替代实施方案中，本发明提供了通过碳封存或以稳定且可持续的形式（例如在排出的土壤中）保存碳来恢复土壤碳含量的组合物和方法。在替代实施方案中，使用本发明的组合物和本发明的实践方法导致土壤有机碳（SOC）的净增加。在替代实施方案中，本发明提供包含或由其组合或组合的组合或混合物的组合物，其中所述混合物包含至少一种C4光合作用途径草和至少一种任一种三联体的种子，或在替代实施方案中，组合或混合物包含至少两个C4光合作用途径草的种子和Atriplex属的任何成员中的至少一个。

6. 发明申请

WO2014078911A1 COMPOSITIONS FOR THE RESTORATION OF A FECAL MICROBIOTA AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：用于恢复FECAL MICROBIOTA的组合物及其制备和使用它们的方法
公开(公告)号：WO2014078911A1
公开(公告)日：2014-05-30
申请号：PCT/AU2013/001362
申请日：2013-11-26
申请人： BORODY, Thomas Julius
发明人： BORODY, Thomas Julius
IPC分类号： A61K35/38 , A61P1/00 , C07K14/195
CPC分类号： A61K35/38 , A61K9/19 , A61K9/2004 , A61K31/341 , A61K31/4164 , A61K31/4439 , A61K31/485 , A61K31/606 , A61K31/635 , A61K31/655 , A61K31/706 , A61K35/74 , A61K35/741 , A61K35/742 , A61K35/744 , A61K35/745 , A61K35/747 , A61K35/76 , A61K36/28 , A61K36/31 , A61K36/48 , A61K36/8962 , A61K38/40 , A61K38/465 , A61K38/47 , A61K38/51 , A61K45/06 , A61K2300/00 , C12N1/20 , C12Y301/21001 , C12Y302/01 , C12Y302/01052 , Y02A50/473
摘要： In alternative embodiments, the invention provides compositions and methods for treating various disorders and conditions in mammals, including chronic disorders in which there is a presence of an abnormal microbiota or an abnormal distribution of microflora in the gastrointestinal tract. In alternative embodiments, the invention provides liquid preparations or formulations derived from a human fecal material (e.g., a stool) processed, e.g., filtered and/or centrifuged, such that all bacteria, fungal spores and viruses are removed, but retaining the native biologically active molecules from the fecal material and bacteriophages. In alternative embodiments, the invention provides a "rough-", "incomplete-" or medium- filtered microbiota which still comprises native physiological components or nutritive agents for the bacteria, e.g., retains native biologically and nutritionally active components. In alternative embodiments, the invention provides a highly filtered or substantially purified microbiota in combination with, or having added back, a liquid preparation or formulation of the invention. In alternative embodiments, the invention provides compositions or formulations where the bacteria, or microbiota, component has been cultured, or cultured under anaerobic conditions, or harvested, stored and/or cultured under anaerobic conditions. In alternative embodiments, the invention provides various additives, compositions and donor restrictions for treating these disorders and conditions.
摘要翻译：在替代实施方案中，本发明提供用于治疗哺乳动物中各种病症和病症的组合物和方法，包括其中在胃肠道中存在异常微生物群或微生物群落的异常分布的慢性病症。在替代实施方案中，本发明提供来自人类粪便物质（例如，粪便）的液体制剂或制剂，例如经过过滤和/或离心处理，使得除去所有细菌，真菌孢子和病毒，但保留天然生物学来自粪便物质和噬菌体的活性分子。在替代实施方案中，本发明提供了一种“粗”，“不完全”或中等过滤的微生物群，其还包含细菌的天然生理成分或营养剂，例如保留天然生物和营养活性成分。在替代实施方案中，本发明提供与本发明的液体制剂或制剂组合或加入的高度过滤或基本上纯化的微生物群。在替代实施方案中，本发明提供其中细菌或微生物组分已经在厌氧条件下培养或培养，或在厌氧条件下收获，储存和/或培养的组合物或制剂。在替代实施方案中，本发明提供用于治疗这些疾病和病症的各种添加剂，组合物和供体限制。

7. 发明申请

WO2012079118A1 GASTRIC AND COLONIC FORMULATIONS AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译： GASTRIC和COLONIC制剂及其制造和使用方法
公开(公告)号：WO2012079118A1
公开(公告)日：2012-06-21
申请号：PCT/AU2011/001609
申请日：2011-12-13
申请人： BORODY, Thomas Julius , RAMRAKHA, Sanjay , SAXON, John , WETTSTEIN, Antony
发明人： BORODY, Thomas Julius , RAMRAKHA, Sanjay , SAXON, John , WETTSTEIN, Antony
IPC分类号： A61K31/4402 , A61K31/4412 , A61K31/047 , A61P1/10
CPC分类号： A61K31/538 , A61K31/047 , A61K31/4402 , A61K31/4412 , A61K45/06 , A61K2300/00
摘要： In alternative embodiments, the invention provides compositions, e.g., formulations, used for gastric, gastrointestinal and/or colonic treatments or lavage, e.g., orthostatic lavage, e.g., for inducing the purgation (e.g., cleansing) of a gastrointestinal (GI) tract, including a colon; and methods for making and using them. In alternative embodiments, compositions and methods of the invention are used for the amelioration, treatment and/or prevention of constipation, for the treatment of abdominal pain, particularly non-specific abdominal pain, and diarrhea, including diarrhea caused by a drug side effect, a psychological condition, a disease or a condition such as Crohn's Disease, a poison, a toxin or an infection, e.g., a toxin-mediated traveler's diarrhea. In alternative embodiments, the invention provides pharmaceuticals and products (articles) of manufacture for delivering these compositions and formulations to an individual, e.g., a human or an animal.
摘要翻译：在替代实施方案中，本发明提供用于胃，胃肠和/或结肠治疗或灌洗的组合物，例如制剂，例如直立灌洗，例如用于诱导胃肠道（GI）道的清除（例如，清洁）包括一个冒号以及制作和使用它们的方法。在替代实施方案中，本发明的组合物和方法用于改善，治疗和/或预防便秘，用于治疗腹痛，特别是非特异性腹痛，以及腹泻，包括由药物副作用引起的腹泻，心理状况，疾病或克罗恩病，毒素，毒素或感染如毒素介导的旅行者腹泻等病症。在替代实施方案中，本发明提供用于将这些组合物和制剂递送给个体，例如人或动物的药物和制品（制品）。

8. 发明申请

WO2013059881A1 ELECTROLYTE PURGATIVES 审中-公开
标题翻译：电解质
公开(公告)号：WO2013059881A1
公开(公告)日：2013-05-02
申请号：PCT/AU2012/001315
申请日：2012-10-27
申请人： BORODY, Thomas Julius , RAMRAKHA, Sanjay , SAXON, John , WETTSTEIN, Antony
发明人： BORODY, Thomas Julius , RAMRAKHA, Sanjay , SAXON, John , WETTSTEIN, Antony
IPC分类号： A61K31/538 , A61K31/70 , A61K33/00 , A61K33/06 , A61K33/14 , A61P1/10
CPC分类号： A61K31/538 , A23L33/10 , A23L33/16 , A61K9/48 , A61K31/70 , A61K31/7004 , A61K33/00 , A61K33/06 , A61K33/14 , A61K47/02 , A61K47/10 , Y02A50/475 , Y02A50/481 , A61K2300/00
摘要： The invention provides compositions for use in purgatives, for use as purgatives, and to methods for inducing purgation of the colon. In alternative embodiments, the invention provides compositions, e.g., a purgative, comprising: a water-soluble sodium salt (especially sodium sulphate), a water-soluble potassium salt (especially potassium sulphate), and a water-soluble magnesium salt (especially magnesium sulphate); and, compositions further comprising: a bisoxatin, or a detergent stool softening agent (such as sodium picosulphate) and/or a water-soluble sugar (such as xylose or equivalent); or, compositions having these ingredients at different amounts, but at equivalent proportions. In alternative embodiments, the invention provides purgative compositions comprising electrolytes, salts, sugars, bisoxatin, dyes and biofilm disruptors.
摘要翻译：本发明提供用于清洁剂中的用作清洁剂的组合物，以及用于诱导结肠清除的方法。在替代实施方案中，本发明提供组合物，例如泻药，其包含：水溶性钠盐（特别是硫酸钠），水溶性钾盐（特别是硫酸钾）和水溶性镁盐（特别是镁硫酸酯）; 和还包含二氧化还原剂或洗涤剂粪便软化剂（例如硫酸铂钠）和/或水溶性糖（如木糖或等同物）的组合物; 或具有不同量但具有相同比例的这些成分的组合物。在替代实施方案中，本发明提供了包含电解质，盐，糖，二氧化还原酶，染料和生物膜破坏剂的泻药组合物。

9. 发明申请

WO2009097651A1 METHODS AND COMPOSITIONS FOR TREATING INFLAMMATORY BOWEL DISEASE 审中-公开
标题翻译：用于治疗炎症性皮肤病的方法和组合物
公开(公告)号：WO2009097651A1
公开(公告)日：2009-08-13
申请号：PCT/AU2009/000129
申请日：2009-02-05
申请人： GIACONDA LIMITED , BORODY, Thomas Julius
发明人： BORODY, Thomas Julius
IPC分类号： A61K31/395 , A61K31/7048 , A61K31/498 , A61P31/04
CPC分类号： A61K31/7048 , A61K9/0053 , A61K9/48 , A61K31/395 , A61K31/435 , A61K31/438 , A61K31/44 , A61K31/498 , A61K47/10 , A61K2300/00
摘要： The present disclosure provides improved compositions comprising rifabutin, clarithromycin, and clofazimine for use in the treatment of Inflammatory Bowel Diseases. In one instance, the compositions may comprise a formulation of rifabutin, clarithromycin, and clofazimine in a single dosage form, such as a capsule, tablet, etc., with one or more specific excipients.
摘要翻译：本公开提供了改进的组合物，其包含用于治疗炎症性肠病的利福布丁，克拉霉素和氯法齐嗪。在一种情况下，组合物可以包含具有一种或多种特定赋形剂的单一剂型的利福布丁，克拉霉素和氯法齐明的制剂，例如胶囊，片剂等。

10. 发明申请

WO2021003535A1 METHOD FOR GUT MUCOSA PREPARATION TO ENHANCE MICROBIAL ENGRAFTMENT 审中-公开
公开(公告)号：WO2021003535A1
公开(公告)日：2021-01-14
申请号：PCT/AU2020/050724
申请日：2020-07-13
申请人： MILIS, Antony , BORODY, Thomas Julius
发明人： MILIS, Antony , BORODY, Thomas Julius
IPC分类号： A61K35/74 , A61K35/37 , A61K35/741 , A61P1/00
摘要： In alternative embodiments, provided are products of manufacture for microbiome transplantation and engraftment, including fecal microbiota transplantation (FMT) delivery devices, and methods for using them, including methods for replacing an individual's gastrointestinal (GI), e.g., colonic, microbiome, and methods for the treatment, amelioration or prevention of an in situ microbiome space, or a gastrointestinal (GI) disease, infection or condition or a disease or condition caused by, initiated by or exacerbated by a pathological microbiome, e.g., pathological GI or colonic microbiome. In particular a method for microbiome transplantation and engraftment in an individual in need thereof, the method comprising: removing of some or all colonic fecal material from the colon of the individual in need thereof by washing out colonic fecal material from the colon, wherein said washing out comprises administering a formulation comprising a biofilm dissolving or disrupting agent to the colon, and administering a FMT material, liquid, formulation or solution, or a normal microbiome, to the individual in need thereof.

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