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    • 1. 发明申请
    • BRANCHED AND MULTI-CHAIN NUCLEIC ACID SWITCHES FOR SENSING AND SCREENING
    • 用于检测和筛选的分支和多链核酸开关
    • WO2006076046A3
    • 2007-02-15
    • PCT/US2005027527
    • 2005-08-02
    • UNIV SYRACUSEBORER PHILIP NHUDSON BRUCE S
    • BORER PHILIP NHUDSON BRUCE S
    • C12Q1/68
    • C12N15/115C12N2310/16C12N2310/3517C12Q1/6818C12Q1/70C12Q1/701C12Q2541/101C12Q2525/313C12Q2525/205C12Q2525/301C12Q2565/301
    • Embodiments of the invention relate to a branched or multichain nucleic acid switch adapted to switch from a first conformation to a second conformation upon ligand binding. The switch includes a probe strand, P, which includes the ligand binding domain; a switching framework which includes a cover strand (C), and a tether that holds P and C together and a signaling apparatus. Some embodiments include a toggle strand (T) where now the tether holds P, C, T, and the signaling apparatus together. As the switch changes between the first and second conformations; the signaling apparatus reports the state of the switch. The signaling entity is typically a lumiphore and a quencher located along the switching framework. Nucleic acid switches have applications in real time assays for diverse agents including infectious agents, environmental toxins, and terrorist agents, as well as screening' methods for such agents. Further applications are found for nanoelectronics, nanofabrication and nanomachines.
    • 本发明的实施方案涉及适合于在配体结合后从第一构象切换至第二构象的分枝或多核酸核酸开关。 该开关包括探针链P,其包含配体结合结构域; 包括盖股(C)和将P和C保持在一起的系绳和信号装置的开关框架。 一些实施例包括肘节线束(T),其中绳索现在将P,C,T和信号装置保持在一起。 随着开关在第一种和第二种构象之间变化, 信令装置报告交换机的状态。 信令实体通常是沿交换框架定位的发光体和猝灭剂。 核酸开关可用于实时分析各种物质,包括传染物,环境毒素和恐怖分子,以及筛选这些物质的方法。 纳米电子学,纳米加工和纳米机器还有其他应用。
    • 3. 发明申请
    • BRANCHED AND MULTI-CHAIN NUCLEIC ACID SWITCHES FOR SENSING AND SCREENING
    • 用于感测和筛选的分支和多链式核酸开关
    • WO2006076046A9
    • 2007-04-05
    • PCT/US2005027527
    • 2005-08-02
    • UNIV SYRACUSEBORER PHILIP NHUDSON BRUCE S
    • BORER PHILIP NHUDSON BRUCE S
    • C12Q1/68
    • C12N15/115C12N2310/16C12N2310/3517C12Q1/6818C12Q1/70C12Q1/701C12Q2541/101C12Q2525/313C12Q2525/205C12Q2525/301C12Q2565/301
    • Embodiments of the invention relate to a branched or multichain nucleic acid switch adapted to switch from a first conformation to a second conformation upon ligand binding. The switch includes a probe strand, P, which includes the ligand binding domain; a switching framework which includes a cover strand (C), and a tether that holds P and C together and a signaling apparatus. Some embodiments include a toggle strand (T) where now the tether holds P, C, T, and the signaling apparatus together. As the switch changes between the first and second conformations; the signaling apparatus reports the state of the switch. The signaling entity is typically a lumiphore and a quencher located along the switching framework. Nucleic acid switches have applications in real time assays for diverse agents including infectious agents, environmental toxins, and terrorist agents, as well as screening' methods for such agents. Further applications are found for nanoelectronics, nanofabrication and nanomachines.
    • 本发明的实施方案涉及一种支链或多链核酸开关,其适于在配体结合时从第一构象切换到第二构象。 该开关包括探针链,其包括配体结合结构域; 包括盖链(C)和将P和C保持在一起的系链和信号装置的切换框架。 一些实施例包括切换链(T),其中系绳将P,C,T和信令装置保持在一起。 当开关在第一和第二构象之间变化时; 信令装置报告交换机的状态。 信令实体通常是沿着交换框架定位的集线器和猝熄器。 核酸开关可用于多种试剂的实时测定,包括感染因子,环境毒素和恐怖分子,以及筛选这些药剂的方法。 发现纳米电子学,纳米制造和纳米机械的其他应用。