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1. 发明申请

WO2012085126A1 OXINDOLOPYRIMIDINE AS IGF1R RECEPTOR INHIBITORS 审中-公开
标题翻译：氧化吲哚并嘧啶作为IGF1R受体抑制剂
公开(公告)号：WO2012085126A1
公开(公告)日：2012-06-28
申请号：PCT/EP2011/073653
申请日：2011-12-21
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , TREU, Matthias , ZAHN, Stephan Karl , AMOUZEGH, Patricia , LECCI, Cristina , TYE, Heather
发明人： TREU, Matthias , ZAHN, Stephan Karl , AMOUZEGH, Patricia , LECCI, Cristina , TYE, Heather
IPC分类号： C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/14 , C07D487/08 , C07D491/10 , A61K31/506 , A61K31/5377 , A61P35/00
CPC分类号： C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/14 , C07D487/08 , C07D491/10
摘要： The present invention encompasses compounds of general formula (I) wherein the groups R 5 to R 10 , A, L 1 , B, m and p are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, pharmaceutical preparations which contain such compounds and their use as medicaments.
摘要翻译：本发明包括通式（I）的化合物，其中基团R 5至R 10，A，L 1，B，m和p如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病，含有这些化合物的药物制剂及其作为药物的用途。

2. 发明申请

WO2008098025A1 ARYLSULFONAMIDE COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR 审中-公开
标题翻译：调节CB2受体的ARYLSULFONAMIDE化合物
公开(公告)号：WO2008098025A1
公开(公告)日：2008-08-14
申请号：PCT/US2008/053117
申请日：2008-02-06
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG , THOMSON, David , RIETHER, Doris , ZINDELL, Renee, M. , HICKEY, Eugene, Richard , ERMANN, Monika , JENKINS, James, Edward , MUSHI, Innocent , TAYLOR, Malcolm , AMOUZEGH, Patricia , WALKER, Edward
发明人： THOMSON, David , RIETHER, Doris , ZINDELL, Renee, M. , HICKEY, Eugene, Richard , ERMANN, Monika , JENKINS, James, Edward , MUSHI, Innocent , TAYLOR, Malcolm , AMOUZEGH, Patricia , WALKER, Edward
IPC分类号： A01N41/06 , A61K31/18
CPC分类号： C07D401/12 , C07D215/08 , C07D217/06 , C07D271/06 , C07D413/04 , C07D413/12 , C07D417/12
摘要： Compounds are provided which bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, the compounds having the general formula (I) and the formula (IA) wherein, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and X have the meanings given in the specification, and the preparation and use thereof. The compounds are valuable CB2 receptor modulators.
摘要翻译：提供了与CB2受体的激动剂，拮抗剂或反向激动剂结合的化合物，具有通式（I）和式（IA）的化合物，其中R 1，R 2， 2，R 3，R 4，R 5，R 6，R 6， 7，R 8，8

3. 发明申请

WO2009055357A1 DIAZEPANE COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR 审中-公开
标题翻译：调节CB2受体的DIAZEPANE化合物
公开(公告)号：WO2009055357A1
公开(公告)日：2009-04-30
申请号：PCT/US2008/080591
申请日：2008-10-21
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG , CIRILLO, Pier, Francesco , HICKEY, Eugene, Richard , RIETHER, Doris , WU, Lifen , ZINDELL, Renee , AMOUZEGH, Patricia , ERMANN, Monika , WALKER, Edward
发明人： CIRILLO, Pier, Francesco , HICKEY, Eugene, Richard , RIETHER, Doris , WU, Lifen , ZINDELL, Renee , AMOUZEGH, Patricia , ERMANN, Monika , WALKER, Edward
IPC分类号： C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D495/04 , C07D495/14 , A61P29/00 , A61K31/5513
CPC分类号： C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D495/04 , C07D495/14
摘要： Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译：公开了式（I）的化合物。根据本发明的化合物与CB2受体结合并且是激动剂，拮抗剂或反向激动剂，并且可用于治疗炎症。作为激动剂的那些化合物另外可用于治疗疼痛。

4. 发明申请

WO2011037795A1 COMPOUNDS WHICH SELECTIVELY MODULATE THE CB2 RECEPTOR 审中-公开
标题翻译：选择性调节CB2受体的化合物
公开(公告)号：WO2011037795A1
公开(公告)日：2011-03-31
申请号：PCT/US2010/048883
申请日：2010-09-15
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BARTOLOZZI, Alessandra , RIETHER, Doris , ZINDELL, Renee , AMOUZEGH, Patricia , BLUMIRE, Nigel James , ERMANN, Monika , SCOTT, Robert, John , MUSHI, Innocent
发明人： BARTOLOZZI, Alessandra , RIETHER, Doris , ZINDELL, Renee , AMOUZEGH, Patricia , BLUMIRE, Nigel James , ERMANN, Monika , SCOTT, Robert, John , MUSHI, Innocent
IPC分类号： C07D413/04 , C07D413/06 , C07D413/14 , C07D417/04 , C07D417/14 , A61K31/427 , A61K31/422 , A61K31/4196 , A61P29/00
CPC分类号： C07D413/14 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/14
摘要： Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译：公开了式（I）的化合物。根据本发明的化合物与CB2受体结合并且是激动剂，拮抗剂或反向激动剂，并且可用于治疗炎症。作为激动剂的那些化合物另外可用于治疗疼痛。

5. 发明申请

WO2009140089A2 SULFONE COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR 审中-公开
标题翻译：调节CB2受体的SULFONE化合物
公开(公告)号：WO2009140089A2
公开(公告)日：2009-11-19
申请号：PCT/US2009/042665
申请日：2009-05-04
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG , HICKEY, Eugene, Richard , RIETHER, Doris , THOMSON, David, Smith , ZINDELL, Renee, M. , AMOUZEGH, Patricia , ERMANN, Monika , PALMER, Christopher, Francis , WHITTAKER, Mark
发明人： HICKEY, Eugene, Richard , RIETHER, Doris , THOMSON, David, Smith , ZINDELL, Renee, M. , AMOUZEGH, Patricia , ERMANN, Monika , PALMER, Christopher, Francis , WHITTAKER, Mark
IPC分类号： C07D271/10
CPC分类号： C07D413/04 , C07D271/06 , C07D403/04 , C07D405/14 , C07D413/14 , C07D417/04 , C07D417/14
摘要： Compounds which modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译：公开了调节CB2受体的化合物。根据本发明的化合物与CB2受体结合并且是激动剂，并且可用于治疗炎症。作为激动剂的那些化合物另外可用于治疗疼痛。

6. 发明申请

WO2010036630A3 SULFONYL COMPOUNDS WHICH SELECTIVELY MODULATE THE CB2 RECEPTOR 审中-公开
公开(公告)号：WO2010036630A3
公开(公告)日：2010-04-01
申请号：PCT/US2009/057776
申请日：2009-09-22
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BARTOLOZZI, Alessandra , BERRY, Angela , HICKEY, Eugene, Richard , OSTERMEIER, Markus , RIETHER, Doris , SAUER, Achim , THOMSON, David Smith , WU, Lifen , ZINDELL, Renee M. , AMOUZEGH, Patricia , BLUMIRE, Nigel James , EAST, Stephen Peter , ERMANN, Monika , KHOR, Someina , MUSHI, Innocent
发明人： BARTOLOZZI, Alessandra , BERRY, Angela , HICKEY, Eugene, Richard , OSTERMEIER, Markus , RIETHER, Doris , SAUER, Achim , THOMSON, David Smith , WU, Lifen , ZINDELL, Renee M. , AMOUZEGH, Patricia , BLUMIRE, Nigel James , EAST, Stephen Peter , ERMANN, Monika , KHOR, Someina , MUSHI, Innocent
IPC分类号： C07D413/12 , C07D261/14 , C07D413/14 , C07D249/14 , C07D413/04 , C07D405/12 , A61K31/4196 , A61K31/42 , A61P25/00 , A61P29/00 , A61P37/00 , A61P35/00 , A61P1/00
摘要： Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.

7. 发明申请

WO2005009443A1 2-AMINO-4-HYDROXY-5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF T CELL ACTIVATION FOR THE TREATMENT OF INFLAMMATORY DISEASES 审中-公开
标题翻译： 2-氨基-4-羟基-5-嘧啶甲酰胺衍生物及相关化合物作为T细胞活化的抑制剂治疗炎症性疾病
公开(公告)号：WO2005009443A1
公开(公告)日：2005-02-03
申请号：PCT/US2004/020243
申请日：2004-06-24
申请人： AMGEN INC. , NUNES, Joseph J. , ZHU, Xiaotian , AMOUZEGH, Patricia , GHIRON, Chiara , JOHNSTON, David N. , POWER, Eoin, Christopher
发明人： NUNES, Joseph J. , ZHU, Xiaotian , AMOUZEGH, Patricia , GHIRON, Chiara , JOHNSTON, David N. , POWER, Eoin, Christopher
IPC分类号： A61K31/506
CPC分类号： C07D213/82 , C07D239/47 , C07D239/48
摘要： The present invention relates to pyrimidine or pyridine carboxamides or pharmaceutically-acceptable salts thereof. Also included is a method of treatment of inflammation, inhibition of T cell activation and proliferation, arthritis, rheumatoid arthritis, psoriatic arthritis, osteoarthritis, organ transplant, acute transplant or heterograft or homograft rejection, transplantation tolerance induction, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, including ulcerative colitis, Crohn's disease, lupus, contact hypersensitivity, delayed-type hypersensitivity, and gluten-sensitive enteropathy, type 1 diabetes, psoriasis, contact dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune polyglandular disease, autoimmune alopecia, pernicious anemia, vitiligo, autoimmune hypopituatarism, Guillain-Barre syndrome, glomerulonephritis, serum sickness, uticaria, allergic diseases, asthma, hayfever, allergic rhinitis, scleracielma, mycosis fungoides, dermatomyositis, alopecia areata, chronic actinic dermatitis, eczema, Behcet's disease, Pustulosis palmoplanteris, Pyoderma gangrenum, Sezary's syndrome, atopic dermatitis, systemic schlerosis, morphea, atopic dermatitis, colon carcinoma or thymoma in a mammal comprising administering a therapeutically-effective amount a compound as described above.
摘要翻译：本发明涉及嘧啶或吡啶甲酰胺或其药学上可接受的盐。还包括治疗炎症，抑制T细胞活化和增殖，关节炎，类风湿性关节炎，银屑病关节炎，骨关节炎，器官移植，急性移植或异种移植或同种移植物排斥，移植耐受性诱导，缺血或再灌注损伤，心肌梗死的方法，中风，多发性硬化，炎症性肠病，包括溃疡性结肠炎，克罗恩病，狼疮，接触性超敏反应，迟发型超敏反应和麸质敏感性肠病，1型糖尿病，牛皮癣，接触性皮炎，桥本氏甲状腺炎，干燥综合征，自身免疫性甲状腺功能亢进，艾迪生病，自身免疫性多腺病，自身免疫性脱发，恶性贫血，白癜风，自身免疫性低位症，吉兰巴利综合征，肾小球性肾炎，血清病，荨麻疹，过敏性疾病，哮喘，高粱，过敏性鼻炎，巩膜瘤，蕈样真菌病，皮肌炎，秃头症，慢性交感包括给予治疗有效量的如上所述的化合物，包括给予治疗有效量的上述化合物，其中，所述治疗有效量的治疗有效量的药物组合物包含给药治疗有效量的化合物。

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