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1. 发明申请

WO2008014199A3 SULFONYL COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR 审中-公开
标题翻译：调节CB2受体的磺化合物
公开(公告)号：WO2008014199A3
公开(公告)日：2008-04-03
申请号：PCT/US2007074076
申请日：2007-07-23
申请人： BOEHRINGER INGELHEIM INT , BOEHRINGER INGELHEIM PHARMA , BERRY ANGELA , CIRILLO PIER FRANCESCO , HICKEY EUGENE RICHARD , RIETHER DORIS , THOMSON DAVID S , ERMANN MONIKA , JENKINS JAMES EDWARD , MUSHI INNOCENT , TAYLOR MALCOLM , CHOWDHURY CHANDANA , PALMER CHRISTOPHER FRANCIS , BLUMIRE NIGEL
发明人： BERRY ANGELA , CIRILLO PIER FRANCESCO , HICKEY EUGENE RICHARD , RIETHER DORIS , THOMSON DAVID S , ERMANN MONIKA , JENKINS JAMES EDWARD , MUSHI INNOCENT , TAYLOR MALCOLM , CHOWDHURY CHANDANA , PALMER CHRISTOPHER FRANCIS , BLUMIRE NIGEL
IPC分类号： C07D215/38 , C07D213/75 , C07D217/22 , C07D231/40 , C07D233/88 , C07D235/30 , C07D261/14 , C07D261/20 , C07D263/28 , C07D263/58 , C07D277/56 , C07D277/60 , C07D277/62 , C07D285/08
CPC分类号： C07D261/14 , C07C317/44 , C07D213/75 , C07D215/38 , C07D217/22 , C07D231/40 , C07D233/88 , C07D235/30 , C07D249/14 , C07D261/20 , C07D263/28 , C07D263/58 , C07D271/07 , C07D271/113 , C07D277/46 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/04 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译：公开了式（I）的化合物。根据本发明的化合物与CB2受体结合并且是激动剂，拮抗剂或反向激动剂，并且可用于治疗炎症。作为激动剂的那些化合物另外可用于治疗疼痛。

2. 发明申请

WO2006027626A2 GOLF TRAINING DEVICE 审中-公开
标题翻译：高尔夫培训设备
公开(公告)号：WO2006027626A2
公开(公告)日：2006-03-16
申请号：PCT/GB2005/050143
申请日：2005-09-06
申请人： TAYLOR INNOVATION LTD. , TAYLOR, Malcolm, George
发明人： TAYLOR, Malcolm, George
IPC分类号： A63B47/00 , A63B69/00 , A63B69/36
CPC分类号： A63B69/3658 , A63B24/0021 , A63B24/0075 , A63B47/002 , A63B69/3667 , A63B2024/0012 , A63B2024/0031 , A63B2069/367 , A63B2220/52 , A63B2225/15 , A63B2225/30 , A63B2225/70 , A63B2230/62
摘要： A golf training device is provided for improving a user's address of a golf ball. The device comprises an input portion (10) for inputting influence data comprising information that might affect how the user should address the ball. The device also comprises a calculation portion (13) for calculating address data, based on the input influence data, specifying one or more aspects of an appropriate address for the user. The device also comprises a playing surface (9) and an indication portion (14) for indicating address information from beneath the playing surface to the user, based on the calculated address data, the information relating to how the user should address the ball. The address data may relate to the user's stance, for example stance alignment and stance width, the positions and angles of the user's feet, golf ball positioning, clubface alignment and positioning, and bodyweight distribution. In one embodiment, the indication portion comprises an array of light-emitting devices (14) beneath a playing surface (9) that are selectively illuminated to indicate the address information to the user, for example in the form of footprint-shaped areas to indicate feet placement. In another aspect, a golf training device is provided for improving a user's bodyweight distribution during a golf stroke.
摘要翻译：提供一种用于改善高尔夫球用户地址的高尔夫训练装置。该装置包括用于输入影响数据的输入部分（10），该影响数据包括可能影响用户应如何处理球的信息。该设备还包括用于基于输入的影响数据计算地址数据的计算部分（13），为用户指定适当地址的一个或多个方面。该装置还包括一个播放表面（9）和一个指示部分（14），用于根据所计算出的地址数据，指示用户应该如何处理球的信息来指示来自用户的玩家表面下方的地址信息。地址数据可以涉及用户的姿势，例如姿态对准和姿势宽度，用户脚的位置和角度，高尔夫球定位，杆面对齐和定位以及体重分布。在一个实施例中，指示部分包括在播放表面（9）下方的发光设备阵列（14），其被选择性地照亮以向用户指示地址信息，例如以足迹形状的区域的形式来指示脚放置。在另一方面，提供了一种高尔夫球训练装置，用于在高尔夫球打高压期间改善使用者的体重分布。

3. 发明申请

WO2005035033A3 APPARATUS AND METHOD FOR REMOVING GASSES FROM A LIQUID 审中-公开
标题翻译：从液体中去除大气的装置和方法
公开(公告)号：WO2005035033A3
公开(公告)日：2005-07-21
申请号：PCT/US2004033335
申请日：2004-10-08
申请人： SCIMED LIFE SYSTEMS INC , USHER KATHRYN M , FOSTER GEORGE R , KOLVEK EDWARD M , HARVEY ANDREW C , TAYLOR MALCOLM E , LOVELL THOMAS WILLIAMS , HART COLIN P , GIRZONE WILLIAM EDMUND
发明人： USHER KATHRYN M , FOSTER GEORGE R , KOLVEK EDWARD M , HARVEY ANDREW C , TAYLOR MALCOLM E , LOVELL THOMAS WILLIAMS , HART COLIN P , GIRZONE WILLIAM EDMUND
IPC分类号： A61M5/14 , A61M5/165 , A61M5/36 , A61M5/38 , B01D19/00 , B01D61/00 , B01D63/10 , B01D63/14
CPC分类号： B01D63/10 , A61M5/1408 , A61M5/36 , A61M5/385 , A61M2005/1657 , A61M2205/7527 , A61M2205/7536 , B01D19/0031 , B01D61/00 , B01D63/14 , B01D2313/18
摘要： Medical devices (112) for removing gasses, such as gas bubbles and/or dissolved gasses, from a liquid to be delivered to a patient, and methods of use and making of such devices (112). In at least some embodiments, a gas permeable membrane material is used in the construction of the gas removal devices. In some embodiments, layers of (52, 54) gas permeable membrane material are used to construct a filter structure (50) for removing gas from the liquid. In other embodiments, hollow tubes and/or fibers of the gas permeable membrane material are used to construct a filter structure for removing gas from the liquid. The gas removal devices (112) may be used in any of a broad variety of liquid delivery systems and/or configurations.
摘要翻译：用于从待输送到患者的液体中去除诸如气泡和/或溶解气体的气体的医疗装置（112）以及使用和制造这种装置的方法（112）。在至少一些实施例中，在气体去除装置的构造中使用透气膜材料。在一些实施例中，使用（52,54）透气膜材料的层来构造用于从液体中除去气体的过滤器结构（50）。在其他实施例中，气体可渗透膜材料的中空管和/或纤维用于构建用于从液体中除去气体的过滤器结构。气体去除装置（112）可以用于各种各样的液体输送系统和/或构造中的任何一种。

4. 发明申请

WO1995008045A1 WELL FILTER WITH PREPACKED FILTER ELEMENT 审中-公开
标题翻译：具有预滤器元件的过滤器
公开(公告)号：WO1995008045A1
公开(公告)日：1995-03-23
申请号：PCT/GB1994002005
申请日：1994-09-14
申请人： OVERSEAS WATER SERVICES LIMITED , TAYLOR, Malcolm, John
发明人： OVERSEAS WATER SERVICES LIMITED
IPC分类号： E21B43/08
CPC分类号： E21B43/082 , B01D29/111 , B01D29/15
摘要： A well tube (1) for use in deep wells which well tube is fabricated from glass fibre reinforced plastic and is provided with one or more apertures and a pre-pack filter material (3) bonded to the exterior of the well tube.
摘要翻译：井筒（1）用于深井，井管由玻璃纤维增强塑料制成，并且设有一个或多个孔和预先连接到井管外部的预过滤材料（3）。

5. 发明申请

WO2005035033A2 APPARATUS AND METHOD FOR REMOVING GASSES FROM A LIQUID 审中-公开
标题翻译：从液体中去除大气的装置和方法
公开(公告)号：WO2005035033A2
公开(公告)日：2005-04-21
申请号：PCT/US2004/033335
申请日：2004-10-08
申请人： SCIMED LIFE SYSTEMS, INC. , USHER, Kathryn, M. , FOSTER, George, R. , KOLVEK, Edward, M. , HARVEY, Andrew, C. , TAYLOR, Malcolm, E. , LOVELL, Thomas, Williams , HART, Colin, P. , GIRZONE, William, Edmund
发明人： USHER, Kathryn, M. , FOSTER, George, R. , KOLVEK, Edward, M. , HARVEY, Andrew, C. , TAYLOR, Malcolm, E. , LOVELL, Thomas, Williams , HART, Colin, P. , GIRZONE, William, Edmund
IPC分类号： A61M5/36
CPC分类号： B01D63/10 , A61M5/1408 , A61M5/36 , A61M5/385 , A61M2005/1657 , A61M2205/7527 , A61M2205/7536 , B01D19/0031 , B01D61/00 , B01D63/14 , B01D2313/18
摘要： Medical devices for removing gasses, such as gas bubbles and/or dissolved gasses, from a liquid to be delivered to a patient, and methods of use and making of such devices. In at least some embodiments, a gas permeable membrane material is used in the construction of the gas removal devices. In some embodiments, layers of gas permeable membrane material are used to construct a filter structure for removing gas from the liquid. In other embodiments, hollow tubes and/or fibers of the gas permeable membrane material are used to construct a filter structure for removing gas from the liquid. The gas removal devices may be used in any of a broad variety of liquid delivery systems and/or configurations.
摘要翻译：用于从待输送到患者的液体中除去诸如气泡和/或溶解气体的气体的医疗装置，以及使用和制造这种装置的方法。在至少一些实施例中，在气体去除装置的构造中使用透气膜材料。在一些实施例中，使用透气膜材料层来构建用于从液体中除去气体的过滤器结构。在其他实施例中，气体可渗透膜材料的中空管和/或纤维用于构建用于从液体中除去气体的过滤器结构。气体去除装置可以用于各种各样的液体输送系统和/或构造中的任何一种。

6. 发明申请

WO2003013419A1 NIPPLE FOR A BABY BOTTLE 审中-公开
标题翻译：婴儿用品
公开(公告)号：WO2003013419A1
公开(公告)日：2003-02-20
申请号：PCT/US2002/025383
申请日：2002-08-09
申请人： THE FIRST YEARS INC. , GOLDMAN, Edward, J. , TAYLOR, Malcolm, E. , BRITTO, James, J. , DEPIANO, John , NGUYEN, Tuan, A.
发明人： GOLDMAN, Edward, J. , TAYLOR, Malcolm, E. , BRITTO, James, J. , DEPIANO, John , NGUYEN, Tuan, A.
IPC分类号： A61J11/00
CPC分类号： A61J11/002 , A61J9/00 , A61J11/02
摘要： A nipple for a baby bottle includes both inner (110) and outer (112) separable members. The inner member defines a valve passage (216) that can be selectively obstructed by a flap (210) of the outer member. The outer and inner members have respective flexible membranes that define a holding chamber (218) having the valve passage as an inlet and an aperture (204) at the tip of the outer member as an outlet. The flap inhibits flow from the holding chamber through the valve passage when the outer member is compressed, and deflects away from the valve passage to allow the holding chamber to receive a fluid through the valve passage when the outer member is released.
摘要翻译：用于婴儿奶瓶的乳头包括内部（110）和外部（112）可分离构件。内部构件限定可以被外部构件的翼片（210）选择性地阻挡的阀通道（216）。外部和内部构件具有相应的柔性膜，其限定具有作为入口的阀通道的保持室（218），并且在外部构件的尖端处形成作为出口的孔（204）。当外部构件被压缩时，挡板阻止从保持室流过阀通道，并且当外部构件被释放时，偏转离开阀通道以允许保持室接收通过阀通道的流体。

7. 发明申请

WO2008098025A1 ARYLSULFONAMIDE COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR 审中-公开
标题翻译：调节CB2受体的ARYLSULFONAMIDE化合物
公开(公告)号：WO2008098025A1
公开(公告)日：2008-08-14
申请号：PCT/US2008/053117
申请日：2008-02-06
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG , THOMSON, David , RIETHER, Doris , ZINDELL, Renee, M. , HICKEY, Eugene, Richard , ERMANN, Monika , JENKINS, James, Edward , MUSHI, Innocent , TAYLOR, Malcolm , AMOUZEGH, Patricia , WALKER, Edward
发明人： THOMSON, David , RIETHER, Doris , ZINDELL, Renee, M. , HICKEY, Eugene, Richard , ERMANN, Monika , JENKINS, James, Edward , MUSHI, Innocent , TAYLOR, Malcolm , AMOUZEGH, Patricia , WALKER, Edward
IPC分类号： A01N41/06 , A61K31/18
CPC分类号： C07D401/12 , C07D215/08 , C07D217/06 , C07D271/06 , C07D413/04 , C07D413/12 , C07D417/12
摘要： Compounds are provided which bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, the compounds having the general formula (I) and the formula (IA) wherein, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and X have the meanings given in the specification, and the preparation and use thereof. The compounds are valuable CB2 receptor modulators.
摘要翻译：提供了与CB2受体的激动剂，拮抗剂或反向激动剂结合的化合物，具有通式（I）和式（IA）的化合物，其中R 1，R 2， 2，R 3，R 4，R 5，R 6，R 6， 7，R 8，8

8. 发明申请

WO2008039645A1 COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR 审中-公开
标题翻译：调节CB2受体的化合物
公开(公告)号：WO2008039645A1
公开(公告)日：2008-04-03
申请号：PCT/US2007/078341
申请日：2007-09-13
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG , BERRY, Angela , CIRILLO, Pier Francesco , HICKEY, Eugene Richard , RIETHER, Doris , THOMSON, David , ZINDELL, Renee M. , ERMANN, Monika , JENKINS, James Edward , MUSHI, Innocent , TAYLOR, Malcolm , CHOWDHURY, Chandana , PALMER, Christopher Francis , BLUMIRE, Nigel
发明人： BERRY, Angela , CIRILLO, Pier Francesco , HICKEY, Eugene Richard , RIETHER, Doris , THOMSON, David , ZINDELL, Renee M. , ERMANN, Monika , JENKINS, James Edward , MUSHI, Innocent , TAYLOR, Malcolm , CHOWDHURY, Chandana , PALMER, Christopher Francis , BLUMIRE, Nigel
IPC分类号： C07C317/44 , A61K31/16 , A61P29/00 , A61P37/00 , C07D213/75 , C07D215/38 , C07D217/22 , C07D231/40 , C07D261/12 , C07D277/46 , C07D277/82 , C07D309/04 , C07D403/12 , C07D405/12 , C07D407/12
CPC分类号： C07C317/44 , C07D213/75 , C07D215/38 , C07D217/22 , C07D231/40 , C07D261/12 , C07D277/46 , C07D277/82 , C07D309/04 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/04 , C07D413/12 , C07D417/12
摘要： Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译：公开了式（I）的化合物。根据本发明的化合物结合并且是CB 2受体的激动剂，拮抗剂或反向激动剂，并且可用于治疗炎症。那些作为激动剂的化合物还可用于治疗疼痛。

9. 发明申请

WO2006027626A3 GOLF TRAINING DEVICE 审中-公开
标题翻译：高尔夫培训设备
公开(公告)号：WO2006027626A3
公开(公告)日：2006-07-13
申请号：PCT/GB2005050143
申请日：2005-09-06
申请人： TAYLOR INNOVATION LTD , TAYLOR MALCOLM GEORGE
发明人： TAYLOR MALCOLM GEORGE
IPC分类号： A63B69/36 , A63B47/00 , A63B69/00
CPC分类号： A63B69/3658 , A63B24/0021 , A63B24/0075 , A63B47/002 , A63B69/3667 , A63B2024/0012 , A63B2024/0031 , A63B2069/367 , A63B2220/52 , A63B2225/15 , A63B2225/30 , A63B2225/70 , A63B2230/62
摘要： A golf training device comprises an input portion (10) for inputting influence data comprising information that might affect how the user should address the ball, a calculation portion (13) for calculating address data, based on the input influence data, a playing surface (9). and an indication portion (14) for indicating address information from beneath the playing surface to the user, based on the calculated address data, . relating to how the user should address the ball. In another aspect, a golf training device is provided for improving a user's bodyweight distribution during a golf stroke, comprising measurement means for providing a time series of bodyweight distribution measurements storage means for storing the time series of measurements and indication means for providing a comparison against a corresponding ideal.
摘要翻译：高尔夫球训练装置包括：输入部分（10），用于输入包括可能影响用户应如何处理球的信息的影响数据;基于输入影响数据计算地址数据的计算部分（13），播放表面 9）。以及用于基于所计算的地址数据向玩家表面向用户指示地址信息的指示部分（14）。涉及用户如何处理球。另一方面，提供一种高尔夫球训练装置，用于改善在高尔夫球击中的使用者的体重分布，包括测量装置，用于提供时间序列的体重分布测量存储装置，用于存储测量的时间序列和指示装置，以提供与相应的理想。

10. 发明申请

WO2005004801A2 INDOLE, AZAINDOLE AND RELATED HETEROCYCLIC N-SUBSTITUTED PIPERAZINE DERIVATIVES 审中-公开
标题翻译：吲哚，氮杂和相关杂环N-取代的哌嗪衍生物
公开(公告)号：WO2005004801A2
公开(公告)日：2005-01-20
申请号：PCT/US2004/019890
申请日：2004-06-22
申请人： BRISTOL-MYERS SQUIBB COMPANY , YEUNG, Kap-Sun , FARKAS, Michelle , KADOW, John, F. , MEANWELL, Nicholas, A. , TAYLOR, Malcolm , JOHNSTON, David , COULTER, Thomas, Stephen , WRIGHT, J.J. Kim
发明人： YEUNG, Kap-Sun , FARKAS, Michelle , KADOW, John, F. , MEANWELL, Nicholas, A. , TAYLOR, Malcolm , JOHNSTON, David , COULTER, Thomas, Stephen , WRIGHT, J.J. Kim
IPC分类号： A61K
CPC分类号： C07D413/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D471/04 , C07D491/04
摘要： This invention provides compounds of Formula (I), including pharmaceutically accceptable salts thereof, having drug and bio-affecting properties, their pharmaceutical compositions and method of use. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS. The compounds of Formula (I) have the formula (I) wherein: Z is (a); Q is selected from the group consisting of Formulas (b), (c), (d), (e), (f); m is 2; A is selected from the group consisting of cinnolinyl, napthyridinyl, quinoxalinyl, pyridinyl, pyrimidinyl, quinolinyl, isoquinolinyl, quinazolinyl, azabenzofuryl, and phthalazinyl each of which may be optionally substituted with one or two groups independently selected from methyl, methoxy, hydroxy, amino and halogen; and W is selected from the Formula (g).
摘要翻译：本发明提供具有药物和生物影响特性的药学上可接受的盐的式（I）化合物，其药物组合物和使用方法。这些化合物具有独特的抗病毒活性，无论是单独使用还是与其他抗病毒药，抗感染剂，免疫调节剂或HIV进入抑制剂组合使用。更具体地说，本发明涉及艾滋病毒和艾滋病的治疗。式（I）的化合物具有式（I）其中：Z是（a）; Q选自式（b），（c），（d），（e），（f）; m为2; A选自噌啉基，萘啶基，喹喔啉基，吡啶基，嘧啶基，喹啉基，异喹啉基，喹唑啉基，氮杂苯并呋喃基和酞嗪基，其各自可以任选被一个或两个独立地选自甲基，甲氧基，羟基，氨基和卤素; W选自式（g）。

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