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1. 发明申请

WO2008001341A1 MULTIPARTICULATE OSMOTIC DELIVERY SYSTEM 审中-公开
标题翻译：多功能运输系统
公开(公告)号：WO2008001341A1
公开(公告)日：2008-01-03
申请号：PCT/IE2007/000062
申请日：2007-06-26
申请人： BIOVAIL LABORATORIES INTERNATIONAL SRL , JACKSON, Graham , NGHIEM, Tien
发明人： JACKSON, Graham , NGHIEM, Tien
IPC分类号： A61K9/00 , A61K9/50
CPC分类号： A61K9/0004 , A61K9/5073
摘要： The invention relates to a pharmaceutical composition, comprising at least one micropartide comprising at least one core which is at least partially coated with at least one osmotic subcoat, and at least one outer coat which at least partially coats the at least one osmotic subcoat, wherein said at least one core comprises at least one drug, and at least one excipient, and said at least one osmotic subcoat comprises at least one osmotic agent and at least one osmotic deposition vehicle.
摘要翻译：本发明涉及一种药物组合物，其包含至少一种包含至少一个至少部分地被至少一个渗透性底层涂覆的芯的微粉末和至少部分涂覆至少一种渗透性底涂层的至少一种外涂层，其中所述至少一个核包含至少一种药物和至少一种赋形剂，并且所述至少一种渗透性底衣包含至少一种渗透剂和至少一种渗透沉积载体。

2. 发明申请

WO2010015567A3 CONTROLLED RELEASE FORMULATIONS USING INTELLIGENT POLYMERS 审中-公开
公开(公告)号：WO2010015567A3
公开(公告)日：2010-02-11
申请号：PCT/EP2009/059892
申请日：2009-07-30
申请人： BIOVAIL LABORATORIES INTERNATIONAL SRL , NGHIEM, Tien , JACKSON, Graham
发明人： NGHIEM, Tien , JACKSON, Graham
IPC分类号： A61K9/20 , A61K31/35
摘要： A controlled release pharmaceutical composition comprises (a) topiramate or a pharmaceutically acceptable salt thereof, (b) a first intelligent polymer component; and (c) a second intelligent polymer component having opposite wettability characteristics to the first intelligent polymer component. The polymer components are effective for controlled release of the pharmaceutically active substance from the composition.

3. 发明申请

WO2009095395A2 PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：药物组合物
公开(公告)号：WO2009095395A2
公开(公告)日：2009-08-06
申请号：PCT/EP2009/050924
申请日：2009-01-28
申请人： BIOVAIL LABORATORIES INTERNATIONAL SRL , WALSH, Edwin , JACKSON, Graham , OBEREGGER, Werner , XIAOPIN, Jin
发明人： WALSH, Edwin , JACKSON, Graham , OBEREGGER, Werner , XIAOPIN, Jin
IPC分类号： A61K9/32 , A61K9/36 , A61K31/137 , A61K31/343 , A61K31/554
CPC分类号： A61K9/2866 , A61K9/2077 , A61K9/209 , A61K9/284 , A61K9/5084 , A61K31/137 , A61K31/343 , A61K31/554 , A61K2300/00
摘要： The present invention relates to a pharmaceutical composition comprising a tablet core comprising a combination of actives selected from the group consisting of bupropion hydrochloride and escitalopram oxalate, bupropion hydrobromide and citalopram hydrochloride, bupropion hydrobromide and escitalopram oxalate, and bupropion hydrobromide and quetiapine fumarate, and at least one pharmaceutically acceptable excipient, and a control-releasing coat surrounding the tablet core, wherein said composition surprisingly provides for a synchronous release of the combination of active agents in-vitro . The once-daily pharmaceutical composition surprisingly also provides for enhanced absorption of bupropion hydrobromide when administered to a subject in need of such administration.
摘要翻译：本发明涉及一种药物组合物，其包含片芯，其包含选自盐酸安非他酮和草酸依托普兰，安非他酮氢溴酸盐和盐酸西酞普兰，安非他酮氢溴酸盐和草甘膦和安非他酮氢溴酸盐和富马酸喹硫平的活性物质的组合，至少一种药学上可接受的赋形剂和围绕片芯的对照释放包衣，其中所述组合物令人惊奇地提供活体剂在体外的组合的同步释放。每天一次的药物组合物令人惊奇地还提供了当给予需要这种给药的受试者时，加强安非他酮氢溴酸盐的吸收。

4. 发明申请

WO2009056550A2 BUPROPION HYDROBROMIDE AND THERAPEUTIC APPLICATIONS 审中-公开
公开(公告)号：WO2009056550A2
公开(公告)日：2009-05-07
申请号：PCT/EP2008/064619
申请日：2008-10-28
申请人： BIOVAIL LABORATORIES INTERNATIONAL Srl , JACKSON, Graham , OBEREGGER, Werner , MAES, Paul , SALEH, Mohammad Ashty
发明人： JACKSON, Graham , OBEREGGER, Werner , MAES, Paul , SALEH, Mohammad Ashty
IPC分类号： A61K9/20 , A61K9/28
CPC分类号： A61K31/137 , A61K9/2013 , A61K9/284 , A61K9/2846 , A61K9/2866 , A61K9/2886
摘要： Bupropion hydrobromide formulations as well as their use for the treatment of conditions is described.
摘要翻译：描述氢溴酸安非他酮制剂及其用于治疗病症的用途。

5. 发明申请

WO2010018408A3 PHARMACEUTICAL COMPOSITIONS WITH TETRABENAZINE 审中-公开
公开(公告)号：WO2010018408A3
公开(公告)日：2010-02-18
申请号：PCT/GB2009/051013
申请日：2009-08-12
申请人： BIOVAIL LABORATORIES INTERNATIONAL (BARBADOS) SRL , DUFFIELD, Andrew, John , JACKSON, Graham , FRISBEE, Steven
发明人： DUFFIELD, Andrew, John , JACKSON, Graham , FRISBEE, Steven
IPC分类号： A61K9/16 , A61K9/20 , A61K9/28 , A61K9/50 , A61K31/4375 , A61P25/14
摘要： The present invention provides for a pharmaceutical composition that includes tetrabenazine and a release-retarding agent; and a method of treating a hyperkinetic movement disorder (e.g., Huntington's disease, chorea associated with Huntington's disease, hemiballismus, senile chorea, tic disorders, tardive dyskinesia, myoclonus, dystonia and/or Tourette's syndrome). The method includes administering an effective amount of the pharmaceutical composition, for a period of time effective to treat the hyperkinetic movement disorder.

6. 发明申请

WO2011019956A2 PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：药物组合物
公开(公告)号：WO2011019956A2
公开(公告)日：2011-02-17
申请号：PCT/US2010/045375
申请日：2010-08-12
申请人： BIOVAIL LABORATORIES INTERNATIONAL (BARBADOS) S.R.L. , DUFFIELD, Andrew John , JACKSON, Graham , FRISBEE, Steven E. , ERADIRI, Okponanabofa , LAI, John CK
发明人： DUFFIELD, Andrew John , JACKSON, Graham , FRISBEE, Steven E. , ERADIRI, Okponanabofa , LAI, John CK
IPC分类号： A61K9/16 , A61K9/20 , A61K9/28 , A61K9/50 , A61K31/4375 , A61P25/14
CPC分类号： A61K47/02 , A61K9/0004 , A61K9/0065 , A61K9/146 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2059 , A61K9/2077 , A61K9/2095 , A61K9/282 , A61K9/2853 , A61K9/2866 , A61K31/4745 , A61K47/26 , A61K47/34 , A61K47/36 , A61K47/38 , A61K2300/00
摘要： The present invention provides for a pharmaceutical composition that includes tetrabenazine and a release-retarding agent; and a method of treating a hyperkinetic movement disorder (e.g., Huntington's disease, chorea associated with Huntington's disease, hemiballismus, senile chorea, tic disorders, tardive dyskinesia, myoclonus, dystonia and/or Tourette's syndrome). The method includes administering an effective amount of the pharmaceutical composition, for a period of time effective to treat the hyperkinetic movement disorder.
摘要翻译：本发明提供一种药物组合物，其包含丁苯那嗪和释放阻滞剂; 以及治疗过度运动障碍（例如亨廷顿舞蹈病，与亨廷顿舞蹈病，偏头痛，老年性舞蹈病，抽搐障碍，迟发性运动障碍，肌阵挛，肌张力障碍和/或图雷特综合征相关的舞蹈病）的方法。该方法包括给予有效量的药物组合物一段有效治疗过度运动障碍的时间。

7. 发明申请

WO2012152894A1 MOTOR VEHICLE HYDROCARBON TRAP AND METHOD 审中-公开
标题翻译：电动汽车油藏和方法
公开(公告)号：WO2012152894A1
公开(公告)日：2012-11-15
申请号：PCT/EP2012/058699
申请日：2012-05-10
申请人： JAGUAR CARS LTD. , JACKSON, Graham
发明人： JACKSON, Graham
IPC分类号： F02M35/02 , F02M35/12
CPC分类号： F02M35/12 , F02M25/08 , F02M35/0218 , F02M35/1216 , Y10T29/49229
摘要： Embodiments of the invention provide an apparatus for damping or attenuating acoustic vibrations in an air induction system of a motor vehicle, the apparatus defining a passageway through which induction air may be drawn to an engine of the vehicle, the apparatus comprising: damping means, the damping means being provided around the passageway for damping or attenuating acoustic vibrations in the induction air; and hydrocarbon trapping means, the hydrocarbon trapping means comprising a sheet of trapping material provided around at least a portion of the passageway, the trapping means being arranged to provide a flow-past hydrocarbon trap for trapping hydrocarbon vapours entering the passageway from the engine.
摘要翻译：本发明的实施例提供了一种用于阻尼或衰减机动车辆的空气感应系统中的声振动的装置，该装置限定了一个通道，通过该通道可以将感应空气抽吸到车辆的发动机，该装置包括：阻尼装置，阻尼装置设置在通道周围，用于阻尼或衰减感应空气中的声振动; 和烃捕获装置，所述烃捕获装置包括围绕所述通道的至少一部分设置的捕集材料片，所述捕集装置被布置成提供用于捕获从所述发动机进入所述通道的碳氢化合物蒸汽的流过的烃阱。

8. 发明申请

WO2008068731A1 EXTENDED RELEASE FORMULATIONS OF CARVEDILOL 审中-公开
标题翻译：卡维地洛的延长释放配方
公开(公告)号：WO2008068731A1
公开(公告)日：2008-06-12
申请号：PCT/IE2007/000119
申请日：2007-12-03
申请人： BIOVAIL LABORATORIES INTERNATIONAL S.R.L. , WALSH, Edwin , YOUNG, Anne Marie , JACKSON, Graham
发明人： WALSH, Edwin , YOUNG, Anne Marie , JACKSON, Graham
IPC分类号： A61K9/20 , A61K31/403
CPC分类号： A61K31/403 , A61K9/2031
摘要： An improved controlled release dosage form for once-daily administration of carvedilol is described. The controlled release dosage form comprises a therapeutically effective amount of carvedilol and/or a pharmaceutically acceptable salt thereof; one or more hydrophilic polymers; one or more pharmaceutically acceptable excipients; and a polyoxyalkylene block copolymer, a solid dispersion of carvedilol and an extrusion material or a combination of a polyoxyalkylene block copolymer, a solid dispersion of carvedilol and an extrusion material.
摘要翻译：描述了一种每日一次给予卡维地洛的改进的控释剂型。控释剂型包含治疗有效量的卡维地洛和/或其药学上可接受的盐; 一种或多种亲水聚合物; 一种或多种药学上可接受的赋形剂; 和聚氧化烯嵌段共聚物，卡维地洛的固体分散体和挤出材料或聚氧化烯嵌段共聚物，卡维地洛的固体分散体和挤出材料的组合。

9. 发明申请

WO2007003051A1 SHEET-LIKE PRODUCTS EXHIBITING OLEOPHOBIC AND HYDROPHOBIC PROPERTIES 审中-公开
标题翻译：展示产品和产品性能
公开(公告)号：WO2007003051A1
公开(公告)日：2007-01-11
申请号：PCT/CA2006/001097
申请日：2006-07-04
申请人： ASTENJOHNSON, INC. , BAKER, Samuel , JACKSON, Graham , WIRTZ, Dietmar
发明人： BAKER, Samuel , JACKSON, Graham , WIRTZ, Dietmar
IPC分类号： D21H17/33 , B32B23/02 , D21H17/52 , D21H17/60 , D21H27/30 , D21J3/12
CPC分类号： D21H21/16 , D21H17/13 , D21H17/35 , D21H17/59 , D21H21/52 , Y10T428/24802 , Y10T428/3154
摘要： A method of manufacturing a cellulosic sheet having at least one of hydrophobic and oleophobic properties comprises the steps of depositing a stock of cellulosic fibres onto at least one forming fabric at an impingement zone and forming a web therefrom in a formation process; combining a water-based composition comprising an adhesion promoter, an organic nanoparticulate polymer and a fluorocarbon with the web at a preselected combination stage prior to a heating stage at which the web is subjected to a temperature exceeding 60° C; and heat-curing the composition with the web during a drying process. A water-based composition for imparting at least one of hydrophobic and oleophobic properties to a cellulosic sheet during manufacture comprises an adhesion promoter, an organic nanoparticulate polymer and a fluorocarbon. A cellulosic sheet or layer thereof has at least one of hydrophobic and oleophobic properties. Improved resistance of cellulosic sheets to oil or water is obtained.
摘要翻译：制造具有疏水性和疏油性中的至少一种的纤维素片的方法包括以下步骤：在形成过程中将纤维素纤维的原料沉积在冲击区上的至少一种成形织物上; 在纤维网经受超过60℃的加热阶段之前，在预选组合阶段将包含粘合促进剂，有机纳米颗粒聚合物和碳氟化合物的水基组合物与所述纤维网结合; 并在干燥过程中用纸幅热固化组合物。在制造过程中赋予纤维素片材疏水性和疏油性中的至少一种的水性组合物包含粘合促进剂，有机纳米颗粒聚合物和碳氟化合物。纤维素片或其层具有疏水性和疏油性中的至少一种。获得了纤维素片对油或水的耐受性提高。

10. 发明申请

WO2008057293A2 METHODS AND COMPOSITIONS FOR PRION DECONTAMINATION 审中-公开
标题翻译：用于消除去污的方法和组合物
公开(公告)号：WO2008057293A2
公开(公告)日：2008-05-15
申请号：PCT/US2007/022750
申请日：2007-10-26
申请人： E. I. DU PONT DE NEMOURS AND COMPANY , CROUD, Vincent, Brian , JACKSON, Graham , COLLINGE, John
发明人： CROUD, Vincent, Brian , JACKSON, Graham , COLLINGE, John
CPC分类号： A61L2/16 , A01N37/16 , A23L3/3499 , A23L3/3508 , A23L3/3571 , A61L2/186 , A61L2202/24 , C11D3/386 , C11D3/3947 , C11D3/48 , C11D11/0041 , A01N2300/00 , A01N25/30 , A01N37/46 , A01N61/00 , A01N63/00 , A01N63/02 , A01N63/04 , A01N65/00
摘要： The invention relates to compositions and methods for prion degradation, decontamination or disinfection. The composition comprises an oxidizing agent, one or more proteases and a surfactant such as an ionic surfactant/detergent. The method comprises contacting a prion contaminated entity with a prion-degrading composition comprising an effective amount of an oxidizing agent, an effective amount of at least one protease, and an effective amount of a surfactant. The components of the composition may be contacted with a prion-contaminated entity sequentially or simultaneously using an aqueous composition. Typically at least two different proteases are used for optimal efficacy. Preferably the oxidizing agent comprises peracetyl ions or a source thereof. The invention also relates to kits comprising the various reagents.
摘要翻译：本发明涉及朊病毒降解，去污或消毒的组合物和方法。组合物包含氧化剂，一种或多种蛋白酶和表面活性剂如离子表面活性剂/洗涤剂。该方法包括使朊病毒污染的实体与包含有效量的氧化剂，有效量的至少一种蛋白酶和有效量的表面活性剂的朊病毒降解组合物接触。组合物的组分可以使用水性组合物依次或同时与朊病毒污染的实体接触。通常使用至少两种不同的蛋白酶来获得最佳疗效。氧化剂优选包含全乙酰离子或其源。本发明还涉及包含各种试剂的试剂盒。

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