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1. 发明申请

WO2011037980A8 SYSTEMS FOR EXTENDED DEPTH FREQUENCY DOMAIN OPTICAL COHERENCE TOMOGRAPHY (FDOCT) AND RELATED METHODS 审中-公开
标题翻译：用于扩展深度频域光学相干层析成像（FDOCT）的系统和相关方法
公开(公告)号：WO2011037980A8
公开(公告)日：2011-04-28
申请号：PCT/US2010049793
申请日：2010-09-22
申请人： BIOPTIGEN INC , BUCKLAND ERIC L , IZATT JOSEPH A , BOWER BRADLEY A , HART ROBERT H
发明人： BUCKLAND ERIC L , IZATT JOSEPH A , BOWER BRADLEY A , HART ROBERT H
IPC分类号： A61B3/117 , A61B3/10 , A61B3/12 , A61B5/00
CPC分类号： A61B3/102 , G01B9/0201 , G01B9/02078 , G01B9/02091
摘要： Systems for extended depth frequency domain optical coherence tomography are provided including a detection system configured to sample spectral elements at substantially equal frequency intervals, wherein a spectral width associated with the sampled spectral elements is not greater than one-half of the frequency interval. Related methods are also provided herein.
摘要翻译：提供用于扩展深度频域光学相干断层扫描的系统，其包括配置成以基本上相等的频率间隔对频谱元素进行采样的检测系统，其中与采样的频谱元素相关联的频谱宽度不大于频率间隔的一半。本文还提供了相关的方法。

2. 发明申请

WO2011037980A2 SYSTEMS FOR EXTENDED DEPTH FREQUENCY DOMAIN OPTICAL COHERENCE TOMOGRAPHY (FDOCT) AND RELATED METHODS 审中-公开
标题翻译：用于扩展深度频域域光学相关定位系统（FDOCT）及相关方法
公开(公告)号：WO2011037980A2
公开(公告)日：2011-03-31
申请号：PCT/US2010049793
申请日：2010-09-22
申请人： BIOPTIGEN INC , BUCKLAND ERIC L , IZATT JOSEPH A , BOWER BRADLEY A , HART ROBERT H
发明人： BUCKLAND ERIC L , IZATT JOSEPH A , BOWER BRADLEY A , HART ROBERT H
IPC分类号： A61B3/117 , A61B3/10 , A61B3/12 , A61B5/00
CPC分类号： A61B3/102 , G01B9/0201 , G01B9/02078 , G01B9/02091
摘要： Systems for extended depth frequency domain optical coherence tomography are provided including a detection system configured to sample spectral elements at substantially equal frequency intervals, wherein a spectral width associated with the sampled spectral elements is not greater than one-half of the frequency interval. Related methods are also provided herein.
摘要翻译：提供了用于扩展深度频域光学相干断层摄影的系统，其包括被配置为以基本上相等的频率间隔对频谱元素进行采样的检测系统，其中与采样的频谱元素相关联的频谱宽度不大于频率间隔的一半。本文还提供了相关方法。

3. 发明申请

WO2012018991A3 COMPACT MULTIMODALITY OPTICAL COHERENCE TOMOGRAPHY IMAGING SYSTEMS AND RELATED METHODS AND COMPUTER PROGRAM PRODUCTS 审中-公开
标题翻译：紧凑的多模式光学相干成像系统及相关方法和计算机程序产品
公开(公告)号：WO2012018991A3
公开(公告)日：2012-05-03
申请号：PCT/US2011046559
申请日：2011-08-04
申请人： BIOPTIGEN INC , HUENING PETE , HART ROBERT H , BUCKLAND ERIC L , BOWER BRADLEY A
发明人： HUENING PETE , HART ROBERT H , BUCKLAND ERIC L , BOWER BRADLEY A
IPC分类号： A61B3/12
CPC分类号： A61B3/102 , A61B3/14 , G01B9/0203 , G01B9/02091
摘要： Systems for imaging a sample are provided. The system includes an optical coherence tomography (OCT) imaging portion having an associated OCT path (201) defined by one set of optical elements between an OCT signal delivery optical fiber and the sample; an image capture portion having an associated image capture path (202) defined by a second set of optical elements between an image capture device and the sample, different from the OCT path; and an illuminator portion having an associated illumination path (203) defined by a third set of optical elements between an illumination source and the sample. The OCT path, the image capture path, and the illuminator path have at least one optical element (207) in common, and the respective paths differ from each other by at least one optical element. The OCT path and the image capture path share a common intermediate conjugate image plane (206). Focal control is achieved for the OCT path and the image capture path concurrently through adjustment of one or more common optical elements distal to the common intermediate conjugate plane, such that focal control requires no differential adjustment between optical elements not in common to both paths.
摘要翻译：提供了用于成像样本的系统。该系统包括光学相干断层摄影（OCT）成像部分，其具有由OCT信号传送光纤和样本之间的一组光学元件限定的相关OCT路径（201）图像捕获部分具有与OCT路径不同的图像捕获装置和样本之间的第二组光学元件所定义的相关图像捕获路径; 以及照明器部分，具有由照明源和样本之间的第三组光学元件限定的相关联的照明路径（203）。 OCT路径，图像捕获路径和照明器路径具有共同的至少一个光学元件（207），并且各个路径由至少一个光学元件彼此不同。 OCT路径和图像捕获路径共享公共中间共轭像平面（206）。通过调整远离公共中间共轭平面的一个或多个共同的光学元件，通过同时进行OCT路径和图像捕获路径的焦点控制，使得焦点控制不需要在两个路径不共同的光学元件之间进行差分调整。

4. 发明申请

WO2009131701A2 OPTICAL COHERENCE TOMOGRAPHY (OCT) IMAGING SYSTEMS HAVING ADAPTABLE LENS SYSTEMS AND RELATED METHODS AND COMPUTER PROGRAM PRODUCTS 审中-公开
标题翻译：具有适应镜头系统的光学相干图像（OCT）成像系统及相关方法和计算机程序产品
公开(公告)号：WO2009131701A2
公开(公告)日：2009-10-29
申请号：PCT/US2009002535
申请日：2009-04-24
申请人： BIOPTIGEN INC , HART ROBERT H , BUCKLAND ERIC L , MYERS GLENN A , IZATT JOSPEH A
发明人： HART ROBERT H , BUCKLAND ERIC L , MYERS GLENN A , IZATT JOSPEH A
IPC分类号： A61B3/12 , A61B5/00
CPC分类号： A61B3/102 , A61B5/0066 , A61B5/0073 , G02B26/105
摘要： OCT imaging systems are provided for imaging a spherical-type eye including a source having an associated source arm path and a reference arm having an associated reference arm path coupled to the source path. The reference arm path has an associated reference arm path length. A sample is also provided having an associated sample arm path coupled to the source arm and reference arm paths. A lens having a focal power optimized for a diameter of the spherical-type eye is provided along with a reference arm path length adjustment module coupled to the reference arm. The reference arm path length adjustment module is configured to automatically adjust the reference arm path length such that the reference arm path length is based on an eye diameter of the subject.
摘要翻译：提供OCT成像系统用于对球形眼睛进行成像，该眼球包括具有相关联的源臂路径的源和具有耦合到源路径的相关参考臂路径的参考臂。参考臂路径具有相关联的参考臂路径长度。还提供具有与源臂和参考臂路径相连的相关联的样本臂路径的样本。具有针对球形眼的直径优化的聚焦功率的透镜与连接到参考臂的参考臂路径长度调节模块一起提供。参考臂路径长度调节模块被配置为自动调整参考臂路径长度，使得参考臂路径长度基于被摄体的眼睛直径。

5. 发明申请

WO2015017375A8 PROCEDURAL OPTICAL COHERENCE TOMOGRAPHY (OCT) FOR SURGERY AND RELATED SYSTEMS AND METHODS 审中-公开
公开(公告)号：WO2015017375A8
公开(公告)日：2015-09-03
申请号：PCT/US2014048552
申请日：2014-07-29
申请人： BIOPTIGEN INC
发明人： BUCKLAND ERIC L , DHALLA AL-HAFEEZ , HART ROBERT H
IPC分类号： A61F9/007 , A61B3/10 , A61B19/00 , A61F9/008
CPC分类号： A61B3/102 , A61B3/0025 , A61B3/0041 , A61B3/1005 , A61B3/103 , A61B3/107 , A61B2034/108 , A61B2090/3735 , A61F2/16 , A61F2009/00851
摘要： Methods for performing a surgical procedure using optical coherence tomography (OCT) are provided. The method includes orienting the subject for the surgical procedure, wherein orienting comprises imaging a region of the subject that contains a structure having a known orientational asymmetry, testing the image for the presence and location of the structure, and confirming correct orientation of the subject using the OCT image of the structure having the known orientational asymmetry; obtaining at least one image of the surgical region of the subject using OCT and constructing an initial structural view of the surgical region; computing at least one clinical parameter relevant as an end point for assessing the outcome of the surgical procedure using data derived from the OCT image; periodically assessing a surgical process and monitoring clinical outcomes related to the surgical procedure using changes to the OCT-derived structural view of the surgical region OCT or the changes to the computed clinical parameters derived from the at least an OCT image; determining if a surgical plan for the surgical procedure needs modification based on the periodic assessment and/or monitoring; modifying the surgical plan for the surgical procedure if it is determined modification is needed; and repeatedly assessing and monitoring, determining and modifying until it is determined that modification is not needed.

6. 发明申请

WO2017083188A3 ILLUMINATION FIELD DIAPHRAGMS FOR USE IN MICROSCOPES AND RELATED METHODS AND SYSTEMS 审中-公开
标题翻译：用于显微镜的照明场隔膜及相关方法和系统
公开(公告)号：WO2017083188A3
公开(公告)日：2017-06-22
申请号：PCT/US2016060497
申请日：2016-11-04
申请人： BIOPTIGEN INC
发明人： SAXER CHRISTOPHER , DHALLA AL-HAFEEZ Z , HART ROBERT H , BUCKLAND ERIC L
IPC分类号： A61B3/12 , G02B5/00 , G02B21/00
CPC分类号： G02B21/0012 , A61B3/102 , A61B3/12 , A61B3/1225 , G02B5/005 , G02B7/006 , G02B21/02 , G02B21/06 , G02B21/22
摘要： Field diaphragms for use in surgical microscopes are provided. The field diaphragms are positioned along an optical axis of a microscope illumination system. The field diaphragms include a frame portion (590) configured to be received by the surgical microscope; and a non-circularly symmetric mask portion (591( integrated with the frame portion. The mask portion is aligned such that marginal rays from an edge of the field diaphragm along a meridian of minimum diameter that reflect from a surface of an objective lens of the microscope reflect outside of an acceptance angle for relay through any ocular channel of the microscope.
摘要翻译：提供了用于手术显微镜的场隔膜。场光阑沿着显微照明系统的光轴定位。场隔板包括构造成由手术显微镜接收的框架部分（590）和一个非圆形对称的荫罩部分（591）（与框架部分集成在一起），荫罩部分是这样对准的，使得从场光阑的边缘沿着最小直径子午线的边缘光线从物镜表面反射显微镜反射在通过显微镜的任何目镜通道接收的角度之外。

7. 发明申请

WO2014197553A3 OPTICAL COHERENCE TOMOGRAPHY IMAGING SYSTEM AND OPTICAL LASER SCANNING SYSTEM COMPRISING BEAM SHAPING OPTICAL SYSTEM WITH A LENS TRIPLET, WHERE SECOND AND THIRD LENS ARE MOVABLE 审中-公开
标题翻译：光学相干成像系统和光学激光扫描系统，包括具有透镜三棱镜的光束形成光学系统，其中第二和第三透镜可移动
公开(公告)号：WO2014197553A3
公开(公告)日：2015-04-02
申请号：PCT/US2014040836
申请日：2014-06-04
申请人： BIOPTIGEN INC
发明人： BUCKLAND ERIC L , MURNAN ANDREW , FARMIGA NESTOR O , HART ROBERT H , SAXER CHRISTOPHER
IPC分类号： A61B3/10 , G02B26/08 , G02B26/10
CPC分类号： A61B3/102 , A61B3/1025 , G01B9/02038 , G01B9/02042 , G01B9/02091 , G02B19/0014 , G02B23/2407
摘要： An optical coherence tomography (OCT) imaging system and an laser scanning system are provided. The OCT system is provided with: a source of broadband optical radiation coupled to a sample arm of the OCT imaging system; a beam shaping optical assembly in the sample arm, the beam shaping optical assembly being configured to receive optical radiation from the source as a beam of optical radiation and to shape the spatial profile of the beam of optical radiation; a scan mirror assembly coupled to the beam shaping optical assembly; and objective lens assembly coupled to the beam shaping optical assembly. In the saser scanning system is also provided with a beam shaping optical assembly being configured to receive optical radiation from a laser source. The beam shaping optical assembly of both systems includes a lens assembly configured to change a NA of the OCT system without changing a focus; to change a focus of the OCT system without changing a NA of the system; or to change both the NA and the focus of the OCT system responsive to a control input.
摘要翻译：提供光学相干断层扫描（OCT）成像系统和激光扫描系统。 OCT系统提供有：耦合到OCT成像系统的样本臂的宽带光辐射源; 光束整形光学组件被配置为从光源接收作为光辐射束的光辐射并且对光辐射束的空间分布进行整形; 耦合到光束整形光学组件的扫描镜组件; 以及耦合到光束整形光学组件的物镜组件。在激光扫描系统中还设置有被配置为从激光源接收光辐射的光束整形光学组件。两个系统的光束整形光学组件包括配置成改变OCT系统的NA而不改变焦点的透镜组件; 改变OCT系统的重点，而不改变系统的NA; 或者响应于控制输入来改变OCT系统的NA和焦点。

8. 发明申请

WO2015017375A2 PROCEDURAL OPTICAL COHERENCE TOMOGRAPHY (OCT) FOR SURGERY AND RELATED SYSTEMS AND METHODS 审中-公开
标题翻译：手术与相关系统及方法的相关光学相干（OCT）
公开(公告)号：WO2015017375A2
公开(公告)日：2015-02-05
申请号：PCT/US2014048552
申请日：2014-07-29
申请人： BIOPTIGEN INC
发明人： BUCKLAND ERIC L , DHALLA AL-HAFEEZ , HART ROBERT H
IPC分类号： A61F9/007
CPC分类号： A61B3/102 , A61B3/0025 , A61B3/0041 , A61B3/1005 , A61B3/103 , A61B3/107 , A61B2034/108 , A61B2090/3735 , A61F2/16 , A61F2009/00851
摘要： Methods for performing a surgical procedure using optical coherence tomography (OCT) are provided. The method includes orienting the subject for the surgical procedure, wherein orienting comprises imaging a region of the subject that contains a structure having a known orientational asymmetry, testing the image for the presence and location of the structure, and confirming correct orientation of the subject using the OCT image of the structure having the known orientational asymmetry; obtaining at least one image of the surgical region of the subject using OCT and constructing an initial structural view of the surgical region; computing at least one clinical parameter relevant as an end point for assessing the outcome of the surgical procedure using data derived from the OCT image; periodically assessing a surgical process and monitoring clinical outcomes related to the surgical procedure using changes to the OCT-derived structural view of the surgical region OCT or the changes to the computed clinical parameters derived from the at least an OCT image; determining if a surgical plan for the surgical procedure needs modification based on the periodic assessment and/or monitoring; modifying the surgical plan for the surgical procedure if it is determined modification is needed; and repeatedly assessing and monitoring, determining and modifying until it is determined that modification is not needed.
摘要翻译：提供了使用光学相干断层扫描（OCT）进行外科手术的方法。该方法包括使被检体定向于外科手术，其中定向包括成像包含具有已知取向不对称的结构的受试者的区域，测试该图像的结构的存在和位置，以及使用具有已知取向不对称性的结构的OCT图像; 使用OCT获得所述受试者的手术区域的至少一个图像，并且构建所述手术区域的初始结构图; 计算至少一个临床参数，作为使用从OCT图像得到的数据来评估外科手术结果的终点; 周期性地评估外科手术过程并且使用对来自手术区域OCT的OCT衍生的结构视图的改变或由至少OCT图像导出的计算的临床参数的变化来监测与外科手术相关的临床结果; 确定外科手术手术方案是否需要基于定期评估和/或监测进行修改; 如果需要修改，则修改外科手术的手术计划; 并重复评估和监测，确定和修改，直到确定不需要修改为止。

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