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1. 发明申请

WO2004069983A9 MICROREACTOR ARCHITECTURE AND METHODS 审中-公开
标题翻译：微波炉结构和方法
公开(公告)号：WO2004069983A9
公开(公告)日：2005-02-03
申请号：PCT/US0325943
申请日：2003-08-19
申请人： BIOPROCESSORS CORP , RODGERS SETH T , RUSSO PETER A , SCHREYER HOWARD B , LEBLANC SEAN J , ZARUR ANDREY J , LI XINYU
发明人： RODGERS SETH T , RUSSO PETER A , SCHREYER HOWARD B , LEBLANC SEAN J , ZARUR ANDREY J , LI XINYU
IPC分类号： C12M1/00 , B01J19/00 , C12M1/34 , C12M1/36 , C12M3/00 , C12Q1/02 , C12R1/91 , G01N33/50 , G01N33/84 , C12M
CPC分类号： C12M23/16 , C12M41/26 , C12Q1/02 , G01N33/5005 , G01N33/84
摘要： The present invention generally relates to chemical, biological, and/or biochemical reactor chips and other reaction systems such as microreactor systems, as well as systems and methods for constructing and using such devices. In one aspect, a chip or other reaction system may be constructed so as to promote cell growth within it. In certain embodiments, the chips or other reaction systems of the invention include one or more reaction sites. The reaction sites can be very small, for example, with a volume of less than about 1 ml. In one aspect of the invention, a chip is able to detect, measure and/or control an environmental factor such as the temperature, pressure, CO2 concentration, O2 concentration, relative humidity, pH, etc. associated with one or more reaction sites, by using one or more sensors, actuators, processors, and/or control systems. In another aspect, the present invention is directed to materials and systems having humidity and/or gas control, for example, for use with a chip. Such materials may have high oxygen permeability and/or low water vapor permeability. The present invention, in still another aspect, generally relates to light interacting components suitable for use in chips and other reactor systems. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like.
摘要翻译：本发明一般涉及化学，生物和/或生化反应堆芯片和其他反应系统，例如微反应器系统，以及用于构建和使用这些装置的系统和方法。在一个方面，可以构建芯片或其它反应系统，以促进细胞内的细胞生长。在某些实施方案中，本发明的芯片或其它反应体系包括一个或多个反应位点。反应位点可以非常小，例如，体积小于约1ml。在本发明的一个方面，芯片能够检测，测量和/或控制与一个或多个反应位点相关联的环境因素例如温度，压力，CO 2浓度，O 2浓度，相对湿度，pH等，通过使用一个或多个传感器，致动器，处理器和/或控制系统。在另一方面，本发明涉及具有例如用于芯片的湿度和/或气体控制的材料和系统。这样的材料可以具有高氧渗透性和/或低水蒸汽渗透性。在另一方面，本发明通常涉及适用于芯片和其它反应器系统的光相互作用组件。这些组件可以包括波导，光纤，光源，光电检测器，光学元件等。

2. 发明申请

WO2004069983A2 MICROREACTOR ARCHITECTURE AND METHODS 审中-公开
标题翻译：微波炉结构和方法
公开(公告)号：WO2004069983A2
公开(公告)日：2004-08-19
申请号：PCT/US0325943
申请日：2003-08-19
申请人： BIOPROCESSORS CORP , RODGERS SETH T , RUSSO PETER A , SCHREYER HOWARD B , LEBLANC SEAN J , ZARUR ANDREY J , LI XINYU
发明人： RODGERS SETH T , RUSSO PETER A , SCHREYER HOWARD B , LEBLANC SEAN J , ZARUR ANDREY J , LI XINYU
IPC分类号： C12M1/00 , B01J19/00 , C12M1/34 , C12M1/36 , C12M3/00 , C12Q1/02 , C12R1/91 , G01N33/50 , G01N33/84 , C12M
CPC分类号： C12M23/16 , C12M41/26 , C12Q1/02 , G01N33/5005 , G01N33/84
摘要： The present invention generally relates to chemical, biological, and/or biochemical reactor chips and other reaction systems such as microreactor systems, as well as systems and methods for constructing and using such devices. In one aspect, a chip or other reaction system may be constructed so as to promote cell growth within it. In certain embodiments, the chips or other reaction systems of the invention include one or more reaction sites. The reaction sites can be very small, for example, with a volume of less than about 1 ml. In one aspect of the invention, a chip is able to detect, measure and/or control an environmental factor such as the temperature, pressure, CO2 concentration, O2 concentration, relative humidity, pH, etc. associated with one or more reaction sites, by using one or more sensors, actuators, processors, and/or control systems. In another aspect, the present invention is directed to materials and systems having humidity and/or gas control, for example, for use with a chip. Such materials may have high oxygen permeability and/or low water vapor permeability. The present invention, in still another aspect, generally relates to light interacting components suitable for use in chips and other reactor systems. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like.
摘要翻译：本发明一般涉及化学，生物和/或生化反应堆芯片和其他反应系统，例如微反应器系统，以及用于构建和使用这些装置的系统和方法。在一个方面，可以构建芯片或其它反应系统，以促进细胞内的细胞生长。在某些实施方案中，本发明的芯片或其它反应体系包括一个或多个反应位点。反应位点可以非常小，例如，体积小于约1ml。在本发明的一个方面，芯片能够检测，测量和/或控制与一个或多个反应位点相关联的环境因素例如温度，压力，CO 2浓度，O 2浓度，相对湿度，pH等，通过使用一个或多个传感器，致动器，处理器和/或控制系统。在另一方面，本发明涉及具有例如用于芯片的湿度和/或气体控制的材料和系统。这样的材料可以具有高氧渗透性和/或低水蒸汽渗透性。在另一方面，本发明通常涉及适用于芯片和其它反应器系统的光相互作用组件。这些组件可以包括波导，光纤，光源，光电检测器，光学元件等。

3. 发明申请

WO2004016727A9 DETERMINATION AND/OR CONTROL OF REACTOR ENVIRONMENTAL CONDITIONS 审中-公开
公开(公告)号：WO2004016727A9
公开(公告)日：2004-05-27
申请号：PCT/US0325956
申请日：2003-08-19
申请人： BIOPROCESSORS CORP , MILLER SCOTT E , MALIN GENNADY , SCHREYER HOWARD B , RODGERS SETH T , ZARUR ANDREY J
发明人： MILLER SCOTT E , MALIN GENNADY , SCHREYER HOWARD B , RODGERS SETH T , ZARUR ANDREY J
IPC分类号： C12M1/00 , B01J19/00 , C12M1/34 , C12M1/36 , C12M3/00 , C12Q1/02 , C12R1/91 , G01N33/50 , G01N33/84 , C12Q1/00
CPC分类号： C12M23/16 , C12M41/26 , C12Q1/02 , G01N33/5005 , G01N33/84
摘要： The present invention generally relates to chemical, biological, and/or biochemical reactor chips and other reaction systems such as microreactor systems, as well as systems and methods for constructing and using such devices. In one aspect, a chip or other reaction system may be constructed so as to promote cell growth within it. In certain embodiments, the chips or other reaction systems of the invention include one or more reaction sites. The reaction sites can be very small, for example, with a volume of less than about 1 ml. In one aspect of the invention, a chip is able to detect, measure and/or control an environmental factor such as the temperature, pressure, CO2 concentration, 02 concentration, relative humidity, pH, etc. associated with one or more reaction sites, by using one or more sensors, actuators, processors, and/or control systems. In another aspect, the present invention is directed to materials and systems having humidity and/or gas control, for example, for use with a chip. Such materials may have high oxygen permeability and/or low water vapor permeability. The present invention, in still another aspect, generally relates to light-interacting components suitable for use in chips and other reactor systems. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like.

4. 发明申请

WO2004016729A3 SYSTEMS AND METHODS FOR CONTROL OF pH AND OTHER REACTOR ENVIRONMENTAL CONDITIONS 审中-公开
标题翻译：控制pH和其他反应器环境条件的系统和方法
公开(公告)号：WO2004016729A3
公开(公告)日：2005-06-30
申请号：PCT/US0325907
申请日：2003-08-19
申请人： BIOPROCESSORS CORP , MILLER SCOTT E , MALIN GENNADY , SCHREYER HOWARD B , RODGERS SETH T , ZARUR ANDREY J
发明人： MILLER SCOTT E , MALIN GENNADY , SCHREYER HOWARD B , RODGERS SETH T , ZARUR ANDREY J
IPC分类号： C12M1/00 , B01J19/00 , C12M1/34 , C12M1/36 , C12M3/00 , C12Q1/02 , C12R1/91 , G01N33/50 , G01N33/84
CPC分类号： C12M23/16 , C12M41/26 , C12Q1/02 , G01N33/5005 , G01N33/84
摘要： The present invention generally relates to chemical, biological, and/or biochemical reactor chips and other reaction systems such as microreactor systems, as well as systems and methods for constructing and using such devices. In one aspect, a chip or other reaction system may be constructed so as to promote cell growth within it. In certain embodiments, the chips or other reaction systems of the invention include one or more reaction sites. The reaction sites can be very small, for example, with a volume of less than about 1 ml. In one aspect of the invention, a chip is able to detect, measure and/or control an environmental factor such as the temperature, pressure, CO2 concentration, O2 concentration, relative humidity, pH, etc. associated with one or more reaction sites, by using one or more sensors, actuators, processors, and/or control systems. In another aspect, the present invention is directed to materials and systems having humidity and/or gas control, for example, for use with a chip. Such materials may have high oxygen permeability and/or low water vapor permeability. The present invention, in still another aspect, generally relates to light-interacting components suitable for use in chips and other reactor systems. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like.
摘要翻译：本发明一般涉及化学，生物和/或生化反应堆芯片和其他反应系统，例如微反应器系统，以及用于构建和使用这些装置的系统和方法。在一个方面，可以构建芯片或其它反应系统，以促进细胞内的细胞生长。在某些实施方案中，本发明的芯片或其它反应体系包括一个或多个反应位点。反应位点可以非常小，例如，体积小于约1ml。在本发明的一个方面，芯片能够检测，测量和/或控制与一个或多个反应位点相关联的环境因素例如温度，压力，CO 2浓度，O 2浓度，相对湿度，pH等，通过使用一个或多个传感器，致动器，处理器和/或控制系统。在另一方面，本发明涉及具有例如用于芯片的湿度和/或气体控制的材料和系统。这样的材料可以具有高氧渗透性和/或低水蒸汽渗透性。在另一方面，本发明通常涉及适用于芯片和其它反应器系统的光相互作用组分。这些组件可以包括波导，光纤，光源，光电检测器，光学元件等。

5. 发明申请

WO2004016727B1 DETERMINATION AND/OR CONTROL OF REACTOR ENVIRONMENTAL CONDITIONS 审中-公开
标题翻译：确定和/或控制反应堆环境条件
公开(公告)号：WO2004016727B1
公开(公告)日：2004-07-08
申请号：PCT/US0325956
申请日：2003-08-19
申请人： BIOPROCESSORS CORP , MILLER SCOTT E , MALIN GENNADY , SCHREYER HOWARD B , RODGERS SETH T , ZARUR ANDREY J
发明人： MILLER SCOTT E , MALIN GENNADY , SCHREYER HOWARD B , RODGERS SETH T , ZARUR ANDREY J
IPC分类号： C12M1/00 , B01J19/00 , C12M1/34 , C12M1/36 , C12M3/00 , C12Q1/02 , C12R1/91 , G01N33/50 , G01N33/84 , C12Q1/00
CPC分类号： C12M23/16 , C12M41/26 , C12Q1/02 , G01N33/5005 , G01N33/84
摘要： The present invention generally relates to chemical, biological, and/or biochemical reactor chips and other reaction systems such as microreactor systems, as well as systems and methods for constructing and using such devices. In one aspect, a chip or other reaction system may be constructed so as to promote cell growth within it. In certain embodiments, the chips or other reaction systems of the invention include one or more reaction sites. The reaction sites can be very small, for example, with a volume of less than about 1 ml. In one aspect of the invention, a chip is able to detect, measure and/or control an environmental factor such as the temperature, pressure, CO2 concentration, 02 concentration, relative humidity, pH, etc. associated with one or more reaction sites, by using one or more sensors, actuators, processors, and/or control systems. In another aspect, the present invention is directed to materials and systems having humidity and/or gas control, for example, for use with a chip. Such materials may have high oxygen permeability and/or low water vapor permeability. The present invention, in still another aspect, generally relates to light-interacting components suitable for use in chips and other reactor systems. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like.
摘要翻译：本发明一般涉及化学，生物和/或生物化学反应器芯片和其他反应系统，例如微反应器系统，以及用于构建和使用此类装置的系统和方法。在一个方面，可以构建芯片或其他反应系统以促进其内的细胞生长。在某些实施方案中，本发明的木片或其他反应体系包括一个或多个反应位点。反应位点可以非常小，例如体积小于约1ml。在本发明的一个方面中，芯片能够检测，测量和/或控制与一个或多个反应位点相关的环境因素，例如温度，压力，CO 2浓度，O 2浓度，相对湿度，pH等，通过使用一个或多个传感器，致动器，处理器和/或控制系统。另一方面，本发明涉及具有湿度和/或气体控制的材料和系统，例如用于芯片。这样的材料可以具有高的透氧性和/或低的水蒸汽渗透性。再一方面，本发明总体上涉及适用于芯片和其他反应器系统的光交互部件。这些部件可以包括波导，光纤，光源，光电探测器，光学元件等。

6. 发明申请

WO2006138743A3 FLUID TRANSFER DEVICE 审中-公开
标题翻译：流体传输装置
公开(公告)号：WO2006138743A3
公开(公告)日：2007-03-15
申请号：PCT/US2006024529
申请日：2006-06-23
申请人： BIOPROCESSORS CORP , LEBLANC SEAN J , MACGREGOR IAN K , AUMOND BERNARDO , VELLA GEORGE J , RUSSO A PETER , RODGERS SETH T , ZARUR ANDREY J
发明人： LEBLANC SEAN J , MACGREGOR IAN K , AUMOND BERNARDO , VELLA GEORGE J , RUSSO A PETER , RODGERS SETH T , ZARUR ANDREY J
IPC分类号： B01L3/02
CPC分类号： B01L3/0275 , B01L2200/026 , B01L2200/027 , B01L2200/0689 , B01L2300/044 , B01L2300/0672 , B01L2300/0681
摘要： Fluid transfer devices described herein can include a body portion and a tip portion. A fluid pathway extends through the body and tip portions through which fluid may be transferred, for example, from a fluid-dispensing apparatus to a fluidic chamber of a microreactor. In some embodiments, the fluid transfer device is connected to the fluid-dispensing apparatus with an engaging element. The engaging element may be part of the body, and can enable the dispensing apparatus to repeatedly engage the body at one predetermined position. The body is capable of storing the fluid received from the dispensing apparatus. The tip portion may be formed of a rigid material (e.g., a metal), and/or may be configured to repeatedly pierce a septum without damaging either the tip or the body. Advantageously, in certain embodiments, the fluid transfer device can controllably transfer small volumes of fluid (e.g., 1 µL) with a high degree of accuracy.
摘要翻译：本文所述的流体输送装置可以包括主体部分和尖端部分。流体通道延伸穿过主体和尖端部分，流体可通过该尖端部分例如从流体分配装置传送到微反应器的流体室。在一些实施例中，流体输送装置用接合元件连接到流体分配装置。接合元件可以是主体的一部分，并且能够使得分配装置能够在一个预定位置反复地接合身体。身体能够储存从分配装置接收的流体。尖端部分可以由刚性材料（例如，金属）形成，和/或可以构造成反复刺穿隔膜而不损坏尖端或者身体。有利地，在某些实施方案中，流体转移装置可以高度准确地可控地传递小体积的流体（例如1μL）。

7. 发明申请

WO2006066002A3 MICROREACTOR SIMULATION OF MACROREACTOR 审中-公开
标题翻译：微反应器模拟微反应器
公开(公告)号：WO2006066002A3
公开(公告)日：2006-08-31
申请号：PCT/US2005045430
申请日：2005-12-14
申请人： BIOPROCESSORS CORP , ZARUR ANDREY J , RODGERS SETH T
发明人： ZARUR ANDREY J , RODGERS SETH T
IPC分类号： B01J19/00
CPC分类号： B01J19/0046 , B01J2219/00015 , B01J2219/00283 , B01J2219/00315 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/00599 , B01J2219/0074 , B01J2219/00743 , C12M41/00 , C12M41/48
摘要： A method of simulating, modeling or predicting a large scale bioreaction is provided. Conditions in a large scale bioreactor may be replicated in a microbioreactor to provide information that may aid in design, operation and/or maintenance of a large scale bioreaction.
摘要翻译：提供了模拟，建模或预测大规模生物反应的方法。大规模生物反应器中的条件可以在微生物反应器中复制以提供有助于设计，操作和/或维持大规模生物反应的信息。

8. 发明申请

WO2004108270B1 SYSTEM AND METHOD FOR PROCESS AUTOMATION 审中-公开
公开(公告)号：WO2004108270B1
公开(公告)日：2005-06-02
申请号：PCT/US2004018638
申请日：2004-06-07
申请人： BIOPROCESSORS CORP , RODGERS SETH T , MACGREGOR IAN K , BASQUE TODD A , MILLER SCOTT E , LU ZHIMIN , ZARUR ANDREY J , SHAHEEN MOHAMED
发明人： RODGERS SETH T , MACGREGOR IAN K , BASQUE TODD A , MILLER SCOTT E , LU ZHIMIN , ZARUR ANDREY J , SHAHEEN MOHAMED
IPC分类号： B01J19/00 , B01L3/00 , B25J7/00 , C40B40/10 , C40B70/00 , G01N35/00 , G01N35/02 , G01N35/04
CPC分类号： G01N35/0099 , B01J19/0046 , B01J2219/0031 , B01J2219/00315 , B01J2219/00317 , B01J2219/00364 , B01J2219/00376 , B01J2219/00387 , B01J2219/00389 , B01J2219/00479 , B01J2219/00495 , B01J2219/00542 , B01J2219/00545 , B01J2219/00549 , B01J2219/00563 , B01J2219/00565 , B01J2219/00585 , B01J2219/00659 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00704 , B01J2219/00725 , B01J2219/00743 , B01L3/5027 , B01L2300/021 , B01L2300/022 , B01L2300/024 , B01L2300/0803 , B01L2300/0806 , C40B40/10 , C40B70/00 , G01N2035/00158 , G01N2035/00366
摘要： Disclosed are systems and methods for manipulating chemical, biological, and/or biochemical samples, optionally supported on substrates and/or within chambers, for example biological samples contained on chips, within biological chambers, etc. In certain embodiments, an apparatus configured to be able to position a chamber or other substrate in one or more modules surrounding the apparatus is disclosed. The apparatus may be configured to be able to move the chamber or substrate in any set of directions, such as radially, vertically, and/or rotationally, with respect to the apparatus. The apparatus may be manually operated and/or automatically controlled. Examples of modules include, but are not limited to, stacking or holding modules, barcode readers, filling modules, sampling modules, incubation modules, sensor modules (e.g., for determining cell density, cell viability, pH, oxygen concentration, nutrient concentration, fluorescence measurements, etc.), assay modules (e.g., for ELISA or other biological assays), data analysis and management modules, control modules, etc. Sensors, control systems, and the like may also be positioned to facilitate operation of the device. Certain embodiments of the invention may be used, for example, to promote or optimize chemical synthesis or cell or biological growth, for instance, for the production of compounds such as drugs or other therapeutics.

9. 发明申请

WO2005121310A2 CREATION OF SHEAR IN A REACTOR 审中-公开
标题翻译：在反应器中形成剪切
公开(公告)号：WO2005121310A2
公开(公告)日：2005-12-22
申请号：PCT/US2005020081
申请日：2005-06-07
申请人： BIOPROCESSORS CORP , JOHNSON TIMOTHY J , AUMOND BERNARDO , BENOIT BRIAN O , VELLA GEORGE J , RODGERS SETH T , ZARUR ANDREY J
发明人： JOHNSON TIMOTHY J , AUMOND BERNARDO , BENOIT BRIAN O , VELLA GEORGE J , RODGERS SETH T , ZARUR ANDREY J
IPC分类号： B01F13/00 , B01F13/08 , B01J19/00 , B01L3/00 , C12M1/02 , C12M1/06 , C12M1/12 , C12M3/00
CPC分类号： B01F13/005 , B01F9/08 , B01F13/0052 , B01F13/0054 , B01F13/0055 , B01F13/0059 , B01F13/0098 , B01F13/0818 , B01F13/0827 , B01J2219/00488 , B01J2219/00605 , B01J2219/00621 , B01L3/5025 , B01L3/5027 , B01L3/50273 , B01L3/502746 , B01L2300/0877 , B01L2300/0887 , C12M23/16 , C12M23/24 , C12M35/04
摘要： An apparatus for performing a biological or biochemical reaction that, in certain embodiments, has the ability to apply shear stress to a component of a liquid sample and includes a biological or biochemical reactor comprising a container having a volume of less than about 2 mL and containing a liquid sample, and a shear-generating element, the shear-generating element being contained within the apparatus and constructed and arranged so that the entire shear-generating element moves along a selected path of motion intersecting a first location within the apparatus and a second location within the apparatus, with or without rotational movement is described. A method of applying shear stress to a component of a liquid sample that includes moving a liquid or gaseous shear-generating element within an apparatus along a selected path of motion to create a reproducible and controllable level of shear stress at a selected location within the liquid sample is also disclosed.
摘要翻译：一种用于进行生物或生物化学反应的装置，其在某些实施方案中具有向液体样品的组分施加剪切应力的能力，并且包括生物或生物化学反应器，其包含体积小于约2mL的容器并且含有液体样品和剪切产生元件，所述剪切产生元件被包含在所述设备内，并被构造和布置成使得整个剪切产生元件沿着与所述设备内的第一位置相交的运动的选定路径移动，并且第二描述了具有或不具有旋转运动的装置内的位置。将剪切应力施加到液体样品的组分的方法，其包括沿着选定的运动路径移动装置内的液体或气体剪切产生元件，以在液体内的选定位置产生可再现和可控的剪切应力水平样品也被披露。

10. 发明申请

WO2004108269B1 APPARATUS AND METHOD FOR MANIPULATING SUBSTRATES 审中-公开
标题翻译：用于操纵基板的装置和方法
公开(公告)号：WO2004108269B1
公开(公告)日：2005-06-16
申请号：PCT/US2004018188
申请日：2004-06-07
申请人： BIOPROCESSORS CORP , ZARUR ANDREY J , RODGERS SETH T , BASQUE TODD A , MACGREGOR IAN K , JOHNSON TIMOTHY J
发明人： ZARUR ANDREY J , RODGERS SETH T , BASQUE TODD A , MACGREGOR IAN K , JOHNSON TIMOTHY J
IPC分类号： B01F9/00 , B01F11/00 , B01L7/00 , B01L9/00 , C12M1/00 , B01J19/00 , B01L3/00 , C12M3/04
CPC分类号： C12M23/08 , B01F9/0001 , B01F9/002 , B01F11/00 , B01L7/00 , B01L9/52 , B01L2300/0819 , B01L2300/0822 , B01L2300/0829 , B01L2400/0409 , C12M23/10 , C12M23/48 , C12M27/10 , C12M41/14 , Y10S435/809
摘要： This disclosure generally relates to systems and methods for manipulating chambers and other substrates for chemical, biological, or biochemical samples, such as cell culture and other chambers, within units such as incubators. In certain embodiments, the invention provides a technique for maintaining a plurality of substrates or chambers in a housing within which a predetermined environment is maintained, different from the environment external to the housing, and moving substrates or chambers in and out of the housing, in some cases without creating a large opening in the housing (e.g., by opening a door significantly larger than the substrates). A technique is provided, in certain embodiments, in which a plurality of substrates are mounted in fixed, secured relation to each other within a housing providing a predetermined, controlled environment, and are moved within the housing so that they can be evenly exposed to any differences in environment within the housing. In certain embodiments, the invention provides a technique for agitating a fluid within one or more chambers or substrates within a housing that can provide environmental control, in certain embodiments without physically stirring the fluid, such as with a stir bar or other stirring element in direct contact with the fluid. In still another embodiment, the invention provides a method for rotating a substrate or chamber about a substantially vertical and/or horizontal axis. In some cases, any of the above-described systems can be rotated at a speed sufficient to cause separation of a substance within the chamber or substrate.
摘要翻译：本公开总体上涉及用于在诸如培养箱的单元内操纵用于化学，生物或生物化学样品例如细胞培养物和其他室的室和其他基底的系统和方法。在某些实施例中，本发明提供了一种技术，用于维持壳体内的多个基板或腔室，在壳体内维持与壳体外部的环境不同的预定环境，并且将基板或腔室移入和移出壳体，某些情况下不会在外壳中产生大的开口（例如，通过打开比基板明显更大的门）。在某些实施例中提供了一种技术，其中多个基板在提供预定的受控环境的壳体内彼此固定且固定地安装并且在壳体内移动，使得它们可以均匀地暴露于任何住房环境的差异。在某些实施方案中，本发明提供了用于搅动壳体内的一个或多个腔室或衬底内的流体的技术，该流体可以提供环境控制，在某些实施方案中，在没有物理搅动流体的情况下，例如直接用搅拌棒或其他搅拌元件接触流体。在又一个实施例中，本发明提供了一种用于围绕大致竖直和/或水平轴旋转衬底或室的方法。在一些情况下，任何上述系统可以以足以引起腔室或基板内的物质分离的速度旋转。

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