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1. 发明申请

WO2007014190A2 COMPUTERIZED FACTORIAL EXPERIMENTAL DESIGN AND CONTROL OF REACTION SITES AND ARRAYS THEREOF 审中-公开
标题翻译：反应点及其排列的计算机化实验设计与控制
公开(公告)号：WO2007014190A2
公开(公告)日：2007-02-01
申请号：PCT/US2006/028774
申请日：2006-07-25
申请人： BIOPROCESSORS CORP. , RODGERS, Seth, T. , ZHANG, Fan , SHAHEEN, Mohamed , ALEXANDER, Benjamin, R.
发明人： RODGERS, Seth, T. , ZHANG, Fan , SHAHEEN, Mohamed , ALEXANDER, Benjamin, R.
IPC分类号： C12M3/00 , B01J19/00
CPC分类号： C12M41/48 , G06F19/28
摘要： Computer-facilitated design of large-scale, multi-factorial cell culture experiments and the like, and control of reaction sites and/or arrays of reaction sites to perform such experiments using automated devices. In certain cases, the invention is directed to controlling a plurality of cell culture experiments, e.g., using an automated cell culture device. In one set of embodiments, a data structure or a "descriptor" for use with cell culture experiments is provided. The descriptor may be used, for instance, to control one or more cell culture experiments, to identify one or more cell culture experiments, and/or to identify or "tag" data arising from one or more cell culture experiments, e.g., for further analysis or recall.
摘要翻译：大规模多因子细胞培养实验等的计算机辅助设计以及使用自动设备进行这种实验的反应位点和/或反应位点阵列的控制。在某些情况下，本发明涉及控制多个细胞培养实验，例如使用自动细胞培养装置。在一组实施例中，数据结构或“描述符” 用于细胞培养实验。描述符可用于例如控制一个或多个细胞培养实验，识别一个或多个细胞培养实验，和/或识别或“标记” 数据来自一个或多个细胞培养实验，例如用于进一步分析或回忆。

2. 发明申请

WO2006066002A2 MICROREACTOR SIMULATION OF MACROREACTOR 审中-公开
标题翻译：微机器的微机械仿真
公开(公告)号：WO2006066002A2
公开(公告)日：2006-06-22
申请号：PCT/US2005/045430
申请日：2005-12-14
申请人： BIOPROCESSORS CORP. , ZARUR, Andrey, J. , RODGERS, Seth, T.
发明人： ZARUR, Andrey, J. , RODGERS, Seth, T.
IPC分类号： B01J19/00
CPC分类号： B01J19/0046 , B01J2219/00015 , B01J2219/00283 , B01J2219/00315 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/00599 , B01J2219/0074 , B01J2219/00743 , C12M41/00 , C12M41/48
摘要： A method of simulating, modeling or predicting a large scale bioreaction is provided. Conditions in a large scale bioreactor may be replicated in a microbioreactor to provide information that may aid in design, operation and/or maintenance of a large scale bioreaction.
摘要翻译：提供了一种模拟，建模或预测大规模生物反应的方法。可以在微生物反应器中复制大规模生物反应器中的条件以提供可有助于大规模生物反应的设计，操作和/或维护的信息。

3. 发明申请

WO2004108270B1 SYSTEM AND METHOD FOR PROCESS AUTOMATION 审中-公开
公开(公告)号：WO2004108270B1
公开(公告)日：2005-06-02
申请号：PCT/US2004018638
申请日：2004-06-07
申请人： BIOPROCESSORS CORP , RODGERS SETH T , MACGREGOR IAN K , BASQUE TODD A , MILLER SCOTT E , LU ZHIMIN , ZARUR ANDREY J , SHAHEEN MOHAMED
发明人： RODGERS SETH T , MACGREGOR IAN K , BASQUE TODD A , MILLER SCOTT E , LU ZHIMIN , ZARUR ANDREY J , SHAHEEN MOHAMED
IPC分类号： B01J19/00 , B01L3/00 , B25J7/00 , C40B40/10 , C40B70/00 , G01N35/00 , G01N35/02 , G01N35/04
CPC分类号： G01N35/0099 , B01J19/0046 , B01J2219/0031 , B01J2219/00315 , B01J2219/00317 , B01J2219/00364 , B01J2219/00376 , B01J2219/00387 , B01J2219/00389 , B01J2219/00479 , B01J2219/00495 , B01J2219/00542 , B01J2219/00545 , B01J2219/00549 , B01J2219/00563 , B01J2219/00565 , B01J2219/00585 , B01J2219/00659 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00704 , B01J2219/00725 , B01J2219/00743 , B01L3/5027 , B01L2300/021 , B01L2300/022 , B01L2300/024 , B01L2300/0803 , B01L2300/0806 , C40B40/10 , C40B70/00 , G01N2035/00158 , G01N2035/00366
摘要： Disclosed are systems and methods for manipulating chemical, biological, and/or biochemical samples, optionally supported on substrates and/or within chambers, for example biological samples contained on chips, within biological chambers, etc. In certain embodiments, an apparatus configured to be able to position a chamber or other substrate in one or more modules surrounding the apparatus is disclosed. The apparatus may be configured to be able to move the chamber or substrate in any set of directions, such as radially, vertically, and/or rotationally, with respect to the apparatus. The apparatus may be manually operated and/or automatically controlled. Examples of modules include, but are not limited to, stacking or holding modules, barcode readers, filling modules, sampling modules, incubation modules, sensor modules (e.g., for determining cell density, cell viability, pH, oxygen concentration, nutrient concentration, fluorescence measurements, etc.), assay modules (e.g., for ELISA or other biological assays), data analysis and management modules, control modules, etc. Sensors, control systems, and the like may also be positioned to facilitate operation of the device. Certain embodiments of the invention may be used, for example, to promote or optimize chemical synthesis or cell or biological growth, for instance, for the production of compounds such as drugs or other therapeutics.

4. 发明申请

WO2004112946A2 REACTOR WITH MEMORY COMPONENT 审中-公开
标题翻译：具有存储器组件的反应器
公开(公告)号：WO2004112946A2
公开(公告)日：2004-12-29
申请号：PCT/US2004/018637
申请日：2004-06-07
申请人： BIOPROCESSORS CORP. , ZARUR, Andrey, J. , MACGREGOR, Ian, K. , BASQUE, Todd, A. , RODGERS, Seth, T. , RUSSO, A., Peter , LEBLANC, Sean, J.
发明人： ZARUR, Andrey, J. , MACGREGOR, Ian, K. , BASQUE, Todd, A. , RODGERS, Seth, T. , RUSSO, A., Peter , LEBLANC, Sean, J.
IPC分类号： B01F
CPC分类号： B01L3/5027 , B01J19/0046 , B01J2219/0031 , B01J2219/00315 , B01J2219/00317 , B01J2219/00364 , B01J2219/00376 , B01J2219/00387 , B01J2219/00389 , B01J2219/00479 , B01J2219/00495 , B01J2219/00542 , B01J2219/00545 , B01J2219/00549 , B01J2219/00563 , B01J2219/00565 , B01J2219/00585 , B01J2219/00659 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00704 , B01J2219/00725 , B01J2219/00743 , B01L3/545 , B01L2300/021 , B01L2300/022 , B01L2300/024 , B01L2300/0806 , B01L2300/0816 , B01L2400/046 , C40B40/10 , C40B70/00 , G01N35/0099
摘要： The present invention provides techniques for conveniently and reliably storing and/or retrieving data associated with a chemical, biological, or biochemical chip, reactor, or reaction system. The data can pertain to the reactor; to chemical, biological, or biochemical species introduced into, taken from, or otherwise associated with the reactor; to conditions to which the reactor and/or some or all of its contents has been, is being, or will be exposed to, or the like. Various aspects of the present invention relate to memory and data storage components suitable for use in chips or other reaction systems. These components may include silicon integrated circuits, magnetic media, optical media, radio-frequency tags, smart cards, bar-codes and other kinds of data storage devices. The chip may contain a reaction site having a volume of less than about 2 ml. In some embodiments, the chip may be constructed in such a way as to be able to support a living cell. The chip may be used for imaging or analysis, or the chip may be used to facilitate a chemical or biological reaction, which may be light-sensitive or light activated in certain cases. Other facilitated reactions may include the production and/or consumption of a chemical or biological species. In some embodiments, the chip may include more than one component or component type, and/or more than one reaction site.
摘要翻译：本发明提供了用于方便和可靠地存储和/或检索与化学，生物或生物化学芯片，反应器或反应系统相关的数据的技术。数据可以与反应堆有关; 化学，生物或生物化学物质引入，取自或以其他方式与反应器相关; 反应器和/或其一部分或全部内容物已经或将要暴露于或类似物的条件。本发明的各个方面涉及适用于芯片或其他反应系统的存储器和数据存储组件。这些组件可以包括硅集成电路，磁介质，光介质，射频标签，智能卡，条形码和其他种类的数据存储设备。芯片可以含有体积小于约2ml的反应位点。在一些实施例中，芯片可以以能够支撑活细胞的方式构造。芯片可以用于成像或分析，或者芯片可以用于促进在某些情况下可能是光敏感或光激活的化学或生物反应。其他促进反应可能包括化学或生物物种的生产和/或消费。在一些实施方案中，芯片可以包括多于一种组分或组分类型，和/或多于一个反应位点。

5. 发明申请

WO02083852A2 MICROFERMENTOR DEVICE AND CELL BASED SCREENING METHOD 审中-公开
标题翻译：微型器件和基于细胞的筛选方法
公开(公告)号：WO02083852A2
公开(公告)日：2002-10-24
申请号：PCT/US0211422
申请日：2002-04-10
申请人： BIOPROCESSORS CORP , ZARUR ANDREY J , SCHREYER H BRETT , FAMA LAWRENCE , HEIBEL ANNE
发明人： ZARUR ANDREY J , SCHREYER H BRETT , FAMA LAWRENCE , HEIBEL ANNE
IPC分类号： G01N33/50 , C12M1/34 , C12M1/36 , C12M3/00 , C12N20060101 , C12Q1/02 , C12Q1/04 , C12Q1/18 , G01N33/15 , C12N
CPC分类号： C12M23/16 , C12M41/12 , C12M41/26 , C12M41/32 , C12M41/36 , C12M41/40
摘要： A microfermentor device that can be used for a wide variety of purposes is described. The microfermentor device includes one or more cell growth chambers having a volume of less than 1 ml. The microfermentor device can be used to grow cells used for the production of useful compounds, e.g., therapeutic proteins, antibodies or small molecule drugs. The microfermentor device can also be used in various high-throughput screening assays. For example, the microfermentor device can be used to screen compounds to assess their effect on cell growth and/or a normal or abnormal biological function of a cell and/or their effect on the expression of a protein expressed by the cell. The device can also be used to investigate the effect of various environmental factors on cell growth, biological function or production of a cell product. The device, including various controlling components and sensing components can be microfabricated on a support material.
摘要翻译：描述了可用于各种目的的微发光装置。微发酵器装置包括一个或多个体积小于1ml的细胞生长室。微发酵器装置可用于生长用于生产有用化合物的细胞，例如治疗性蛋白质，抗体或小分子药物。微发酵装置也可用于各种高通量筛选试验。例如，微发光器件可用于筛选化合物以评估其对细胞生长和/或细胞的正常或异常生物学功能的影响和/或其对细胞表达的蛋白质表达的影响。该装置还可用于研究各种环境因素对细胞生长，生物功能或细胞产物生产的影响。包括各种控制部件和传感部件在内的装置可以在支撑材料上进行微制造。

6. 发明申请

WO2007098027A3 MICROREACTOR WITH AUXILIARY FLUID MOTION CONTROL 审中-公开
标题翻译：具有辅助流体运动控制的微型反应器
公开(公告)号：WO2007098027A3
公开(公告)日：2007-10-25
申请号：PCT/US2007004088
申请日：2007-02-15
申请人： BIOPROCESSORS CORP , JOHNSON TIMOTHY J , AUMOND BERNARDO
发明人： JOHNSON TIMOTHY J , AUMOND BERNARDO
IPC分类号： C12M1/02 , C12M1/06 , C12M1/09 , C12M1/10
CPC分类号： B01F11/0017 , B01F11/0071 , B01F13/0059 , B01L3/5027 , B03D2203/003 , C12M23/16 , C12M29/10 , C12M35/04 , C12M41/00
摘要： An apparatus for performing a biological or biochemical reaction that, in certain embodiments, has the ability to generate flow in a reaction site container by applying a force to a liquid medium that is outside of the reaction site container. In some embodiments, a flow generating component such as a gas bubble moves within a container and forces an agitating fluid to move through a reaction site container. In some embodiments, the movement of the agitating fluid applies shear stress to cells that are maintained within the reaction site container.
摘要翻译：一种用于进行生物或生物化学反应的装置，在某些实施方案中，其具有通过向在反应部位容器外部的液体介质施加力而在反应部位容器中产生流动的能力。在一些实施例中，诸如气泡的流产生组件在容器内移动并迫使搅拌流体移动通过反应部位容器。在一些实施例中，搅拌流体的运动将剪切应力施加到保持在反应部位容器内的细胞。

7. 发明申请

WO2007062218A1 METHOD FOR PERFORMING FED-BATCH OPERATIONS IN SMALL VOLUME REACTORS 审中-公开
标题翻译：在小容量反应器中进行FED-BATCH操作的方法
公开(公告)号：WO2007062218A1
公开(公告)日：2007-05-31
申请号：PCT/US2006/045403
申请日：2006-11-22
申请人： BIOPROCESSORS CORP. , RUSSO, Peter, A. , BERGMAN, Phil , STEBULIS, Matt , HOPE, James , JOHNSON, Timothy, J. , SCHREYER, Howard, Brett
发明人： RUSSO, Peter, A. , BERGMAN, Phil , STEBULIS, Matt , HOPE, James , JOHNSON, Timothy, J. , SCHREYER, Howard, Brett
IPC分类号： C12P1/00 , C12M1/00
CPC分类号： C12P7/40 , B01J19/0093 , B01J2219/00038 , B01L3/5027 , C12M23/16 , C12M23/58 , C12M41/32 , C12M41/44 , C12P7/6463 , C12P13/04 , C12P19/34 , C12P33/00
摘要： Methods for forming chemical and/or biological products in reactors, and/or analyzing chemical and/or biological interactions in reactors are provided. The methods relate, more specifically, to forming such products and/or carrying out such analyses in small volume reactors with control over overall fluid volume in the reactors. The methods can be used to mimic processes in large scale reactors and/or to obtain reaction or interaction information relevant to large scale reactors (e.g., to adjust/optimize large- scale reactor processes). Advantageously, the methods can allow parameters of small scale reactors to be correlated with those of large scale reactors, where desired.
摘要翻译：提供了在反应器中形成化学和/或生物产物和/或分析反应器中的化学和/或生物相互作用的方法。所述方法更具体地涉及在具有对反应器中的总流体体积的控制的小体积反应器中形成这样的产物和/或进行这种分析。该方法可用于模拟大规模反应器中的工艺和/或获得与大规模反应器相关的反应或相互作用信息（例如，调整/优化大规模反应器工艺）。有利地，如果需要，这些方法可以允许小规模反应器的参数与大规模反应器的参数相关。

8. 发明申请

WO2006066002A3 MICROREACTOR SIMULATION OF MACROREACTOR 审中-公开
标题翻译：微反应器模拟微反应器
公开(公告)号：WO2006066002A3
公开(公告)日：2006-08-31
申请号：PCT/US2005045430
申请日：2005-12-14
申请人： BIOPROCESSORS CORP , ZARUR ANDREY J , RODGERS SETH T
发明人： ZARUR ANDREY J , RODGERS SETH T
IPC分类号： B01J19/00
CPC分类号： B01J19/0046 , B01J2219/00015 , B01J2219/00283 , B01J2219/00315 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/00599 , B01J2219/0074 , B01J2219/00743 , C12M41/00 , C12M41/48
摘要： A method of simulating, modeling or predicting a large scale bioreaction is provided. Conditions in a large scale bioreactor may be replicated in a microbioreactor to provide information that may aid in design, operation and/or maintenance of a large scale bioreaction.
摘要翻译：提供了模拟，建模或预测大规模生物反应的方法。大规模生物反应器中的条件可以在微生物反应器中复制以提供有助于设计，操作和/或维持大规模生物反应的信息。

9. 发明申请

WO2005120698A2 CONTROL OF REACTOR ENVIRONMENTAL CONDITIONS 审中-公开
标题翻译：反应器环境条件控制
公开(公告)号：WO2005120698A2
公开(公告)日：2005-12-22
申请号：PCT/US2005019914
申请日：2005-06-07
申请人： BIOPROCESSORS CORP , RODGERS SETH T , RUSSO A PETER , LEBLANC SEAN J , LEROUX DENIS
发明人： RODGERS SETH T , RUSSO A PETER , LEBLANC SEAN J , LEROUX DENIS
IPC分类号： B01D61/00 , B01J19/00 , B01L3/00 , C12M3/06 , C40B60/14
CPC分类号： B01D61/002 , B01J19/0093 , B01J2219/00317 , B01J2219/00743 , B01J2219/00783 , B01J2219/00822 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00862 , B01J2219/00873 , B01J2219/00889 , B01J2219/00907 , B01J2219/00961 , B01J2219/0097 , B01L3/5025 , B01L3/502707 , B01L2200/12 , B01L2200/143 , B01L2300/0816 , B01L2300/0887 , B01L2300/10 , B01L2300/12 , B01L2300/163 , B01L2300/1822 , B01L2400/046 , C12P1/00 , C40B60/14
摘要： The present disclosure generally relates to chemical, biological, and/or biochemical reactor chips and/or reaction systems such as microreactor systems, as well as methods for constructing and using such systems. In some cases, humidity control materials are utilized to provide beneficially high rates of gas exchange. The humidity control materials may be used, in certain instances, to provide at least adequate, and in certain embodiments superior, gas exchange for systems having small volumes. In some cases, the currently disclosed materials include certain polymers, e.g., poly(acetylene)s such as poly(alkylacetylene)s. The polymers may be at least partially halogenated (for example, fluorinated) in some instances. In certain embodiments, a chip and/or a reaction system may be constructed so as to promote cell growth within it. In some embodiments, the chips may include one or more reaction sites. The reaction sites can be very small, for example, with a volume of less than about 1 ml. In certain embodiments, a reaction system is able to detect, measure and/or control an environmental factor such as the temperature, pressure, CO2 concentration, 02 concentration, relative humidity, pH, etc., associated with one or more reaction sites, by using one or more sensors, actuators, processors, and/or control systems. In certain embodiments, the present disclosure discloses materials and systems having humidity and/or gas control, for example, for use with a reaction system. Such materials may have high oxygen permeability and/or low water vapor permeability. In certain embodiments, the disclosed devices can employ light-interacting components suitable for use in reaction systems. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like.
摘要翻译：本公开一般涉及化学，生物和/或生化反应堆芯片和/或反应系统，例如微反应器系统，以及用于构建和使用这种系统的方法。在一些情况下，使用湿度控制材料来提供有利的高比例的气体交换。在某些情况下，可以使用湿度控制材料，以在具有小体积的系统中提供至少足够的且在某些实施方案中优异的气体交换。在一些情况下，目前公开的材料包括某些聚合物，例如聚（乙炔）如聚（烷基乙炔）。在某些情况下，聚合物可以至少部分卤化（例如氟化）。在某些实施方案中，可以构建芯片和/或反应系统以促进细胞内的细胞生长。在一些实施方案中，芯片可以包括一个或多个反应位点。反应位点可以非常小，例如，体积小于约1ml。在某些实施方案中，反应体系能够通过以下方式检测，测量和/或控制与一个或多个反应位点相关联的环境因素例如温度，压力，CO 2浓度，O 2浓度，相对湿度，pH等使用一个或多个传感器，致动器，处理器和/或控制系统。在某些实施方案中，本公开公开了具有例如用于反应体系的湿度和/或气体控制的材料和系统。这样的材料可以具有高氧气渗透性和/或低水蒸气渗透性。在某些实施方案中，所公开的装置可以使用适合用于反应系统的光相互作用组分。这些组件可以包括波导，光纤，光源，光电检测器，光学元件等。

10. 发明申请

WO2004108269A3 APPARATUS AND METHOD FOR MANIPULATING SUBSTRATES 审中-公开
公开(公告)号：WO2004108269A3
公开(公告)日：2004-12-16
申请号：PCT/US2004/018188
申请日：2004-06-07
申请人： BIOPROCESSORS CORP. , ZARUR, Andrey, J. , RODGERS, Seth, T. , BASQUE, Todd, A. , MACGREGOR, Ian, K. , JOHNSON, Timothy, J.
发明人： ZARUR, Andrey, J. , RODGERS, Seth, T. , BASQUE, Todd, A. , MACGREGOR, Ian, K. , JOHNSON, Timothy, J.
IPC分类号： B01J19/00
摘要： This disclosure generally relates to systems and methods for manipulating chambers and other substrates for chemical, biological, or biochemical samples, such as cell culture and other chambers, within units such as incubators. In certain embodiments, the invention provides a technique for maintaining a plurality of substrates or chambers in a housing within which a predetermined environment is maintained, different from the environment external to the housing, and moving substrates or chambers in and out of the housing, in some cases without creating a large opening in the housing (e.g., by opening a door significantly larger than the substrates). A technique is provided, in certain embodiments, in which a plurality of substrates are mounted in fixed, secured relation to each other within a housing providing a predetermined, controlled environment, and are moved within the housing so that they can be evenly exposed to any differences in environment within the housing. In certain embodiments, the invention provides a technique for agitating a fluid within one or more chambers or substrates within a housing that can provide environmental control, in certain embodiments without physically stirring the fluid, such as with a stir bar or other stirring element in direct contact with the fluid. In still another embodiment, the invention provides a method for rotating a substrate or chamber about a substantially vertical and/or horizontal axis. In some cases, any of the above-described systems can be rotated at a speed sufficient to cause separation of a substance within the chamber or substrate.

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