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1. 发明申请

WO2004069983A3 MICROREACTOR ARCHITECTURE AND METHODS 审中-公开
公开(公告)号：WO2004069983A3
公开(公告)日：2004-08-19
申请号：PCT/US2003/025943
申请日：2003-08-19
申请人： BIOPROCESSORS CORPORATION , RODGERS, Seth, T. , RUSSO, Peter, A. , SCHREYER, Howard, B. , LEBLANC, Sean, J. , ZARUR, Andrey, J. , LI, Xinyu
发明人： RODGERS, Seth, T. , RUSSO, Peter, A. , SCHREYER, Howard, B. , LEBLANC, Sean, J. , ZARUR, Andrey, J. , LI, Xinyu
IPC分类号： C12M1/34
摘要： The present invention generally relates to chemical, biological, and/or biochemical reactor chips and other reaction systems such as microreactor systems, as well as systems and methods for constructing and using such devices. In one aspect, a chip or other reaction system may be constructed so as to promote cell growth within it. In certain embodiments, the chips or other reaction systems of the invention include one or more reaction sites. The reaction sites can be very small, for example, with a volume of less than about 1 ml. In one aspect of the invention, a chip is able to detect, measure and/or control an environmental factor such as the temperature, pressure, CO 2 concentration, O 2 concentration, relative humidity, pH, etc. associated with one or more reaction sites, by using one or more sensors, actuators, processors, and/or control systems. In another aspect, the present invention is directed to materials and systems having humidity and/or gas control, for example, for use with a chip. Such materials may have high oxygen permeability and/or low water vapor permeability. The present invention, in still another aspect, generally relates to light interacting components suitable for use in chips and other reactor systems. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like.

2. 发明申请

WO2007062218A1 METHOD FOR PERFORMING FED-BATCH OPERATIONS IN SMALL VOLUME REACTORS 审中-公开
标题翻译：在小容量反应器中进行FED-BATCH操作的方法
公开(公告)号：WO2007062218A1
公开(公告)日：2007-05-31
申请号：PCT/US2006/045403
申请日：2006-11-22
申请人： BIOPROCESSORS CORP. , RUSSO, Peter, A. , BERGMAN, Phil , STEBULIS, Matt , HOPE, James , JOHNSON, Timothy, J. , SCHREYER, Howard, Brett
发明人： RUSSO, Peter, A. , BERGMAN, Phil , STEBULIS, Matt , HOPE, James , JOHNSON, Timothy, J. , SCHREYER, Howard, Brett
IPC分类号： C12P1/00 , C12M1/00
CPC分类号： C12P7/40 , B01J19/0093 , B01J2219/00038 , B01L3/5027 , C12M23/16 , C12M23/58 , C12M41/32 , C12M41/44 , C12P7/6463 , C12P13/04 , C12P19/34 , C12P33/00
摘要： Methods for forming chemical and/or biological products in reactors, and/or analyzing chemical and/or biological interactions in reactors are provided. The methods relate, more specifically, to forming such products and/or carrying out such analyses in small volume reactors with control over overall fluid volume in the reactors. The methods can be used to mimic processes in large scale reactors and/or to obtain reaction or interaction information relevant to large scale reactors (e.g., to adjust/optimize large- scale reactor processes). Advantageously, the methods can allow parameters of small scale reactors to be correlated with those of large scale reactors, where desired.
摘要翻译：提供了在反应器中形成化学和/或生物产物和/或分析反应器中的化学和/或生物相互作用的方法。所述方法更具体地涉及在具有对反应器中的总流体体积的控制的小体积反应器中形成这样的产物和/或进行这种分析。该方法可用于模拟大规模反应器中的工艺和/或获得与大规模反应器相关的反应或相互作用信息（例如，调整/优化大规模反应器工艺）。有利地，如果需要，这些方法可以允许小规模反应器的参数与大规模反应器的参数相关。

3. 发明申请

WO2004069983A9 MICROREACTOR ARCHITECTURE AND METHODS 审中-公开
标题翻译：微波炉结构和方法
公开(公告)号：WO2004069983A9
公开(公告)日：2005-02-03
申请号：PCT/US0325943
申请日：2003-08-19
申请人： BIOPROCESSORS CORP , RODGERS SETH T , RUSSO PETER A , SCHREYER HOWARD B , LEBLANC SEAN J , ZARUR ANDREY J , LI XINYU
发明人： RODGERS SETH T , RUSSO PETER A , SCHREYER HOWARD B , LEBLANC SEAN J , ZARUR ANDREY J , LI XINYU
IPC分类号： C12M1/00 , B01J19/00 , C12M1/34 , C12M1/36 , C12M3/00 , C12Q1/02 , C12R1/91 , G01N33/50 , G01N33/84 , C12M
CPC分类号： C12M23/16 , C12M41/26 , C12Q1/02 , G01N33/5005 , G01N33/84
摘要： The present invention generally relates to chemical, biological, and/or biochemical reactor chips and other reaction systems such as microreactor systems, as well as systems and methods for constructing and using such devices. In one aspect, a chip or other reaction system may be constructed so as to promote cell growth within it. In certain embodiments, the chips or other reaction systems of the invention include one or more reaction sites. The reaction sites can be very small, for example, with a volume of less than about 1 ml. In one aspect of the invention, a chip is able to detect, measure and/or control an environmental factor such as the temperature, pressure, CO2 concentration, O2 concentration, relative humidity, pH, etc. associated with one or more reaction sites, by using one or more sensors, actuators, processors, and/or control systems. In another aspect, the present invention is directed to materials and systems having humidity and/or gas control, for example, for use with a chip. Such materials may have high oxygen permeability and/or low water vapor permeability. The present invention, in still another aspect, generally relates to light interacting components suitable for use in chips and other reactor systems. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like.
摘要翻译：本发明一般涉及化学，生物和/或生化反应堆芯片和其他反应系统，例如微反应器系统，以及用于构建和使用这些装置的系统和方法。在一个方面，可以构建芯片或其它反应系统，以促进细胞内的细胞生长。在某些实施方案中，本发明的芯片或其它反应体系包括一个或多个反应位点。反应位点可以非常小，例如，体积小于约1ml。在本发明的一个方面，芯片能够检测，测量和/或控制与一个或多个反应位点相关联的环境因素例如温度，压力，CO 2浓度，O 2浓度，相对湿度，pH等，通过使用一个或多个传感器，致动器，处理器和/或控制系统。在另一方面，本发明涉及具有例如用于芯片的湿度和/或气体控制的材料和系统。这样的材料可以具有高氧渗透性和/或低水蒸汽渗透性。在另一方面，本发明通常涉及适用于芯片和其它反应器系统的光相互作用组件。这些组件可以包括波导，光纤，光源，光电检测器，光学元件等。

4. 发明申请

WO2004069983A2 MICROREACTOR ARCHITECTURE AND METHODS 审中-公开
标题翻译：微波炉结构和方法
公开(公告)号：WO2004069983A2
公开(公告)日：2004-08-19
申请号：PCT/US0325943
申请日：2003-08-19
申请人： BIOPROCESSORS CORP , RODGERS SETH T , RUSSO PETER A , SCHREYER HOWARD B , LEBLANC SEAN J , ZARUR ANDREY J , LI XINYU
发明人： RODGERS SETH T , RUSSO PETER A , SCHREYER HOWARD B , LEBLANC SEAN J , ZARUR ANDREY J , LI XINYU
IPC分类号： C12M1/00 , B01J19/00 , C12M1/34 , C12M1/36 , C12M3/00 , C12Q1/02 , C12R1/91 , G01N33/50 , G01N33/84 , C12M
CPC分类号： C12M23/16 , C12M41/26 , C12Q1/02 , G01N33/5005 , G01N33/84
摘要： The present invention generally relates to chemical, biological, and/or biochemical reactor chips and other reaction systems such as microreactor systems, as well as systems and methods for constructing and using such devices. In one aspect, a chip or other reaction system may be constructed so as to promote cell growth within it. In certain embodiments, the chips or other reaction systems of the invention include one or more reaction sites. The reaction sites can be very small, for example, with a volume of less than about 1 ml. In one aspect of the invention, a chip is able to detect, measure and/or control an environmental factor such as the temperature, pressure, CO2 concentration, O2 concentration, relative humidity, pH, etc. associated with one or more reaction sites, by using one or more sensors, actuators, processors, and/or control systems. In another aspect, the present invention is directed to materials and systems having humidity and/or gas control, for example, for use with a chip. Such materials may have high oxygen permeability and/or low water vapor permeability. The present invention, in still another aspect, generally relates to light interacting components suitable for use in chips and other reactor systems. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like.
摘要翻译：本发明一般涉及化学，生物和/或生化反应堆芯片和其他反应系统，例如微反应器系统，以及用于构建和使用这些装置的系统和方法。在一个方面，可以构建芯片或其它反应系统，以促进细胞内的细胞生长。在某些实施方案中，本发明的芯片或其它反应体系包括一个或多个反应位点。反应位点可以非常小，例如，体积小于约1ml。在本发明的一个方面，芯片能够检测，测量和/或控制与一个或多个反应位点相关联的环境因素例如温度，压力，CO 2浓度，O 2浓度，相对湿度，pH等，通过使用一个或多个传感器，致动器，处理器和/或控制系统。在另一方面，本发明涉及具有例如用于芯片的湿度和/或气体控制的材料和系统。这样的材料可以具有高氧渗透性和/或低水蒸汽渗透性。在另一方面，本发明通常涉及适用于芯片和其它反应器系统的光相互作用组件。这些组件可以包括波导，光纤，光源，光电检测器，光学元件等。

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