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1. 发明申请

WO2004108269B1 APPARATUS AND METHOD FOR MANIPULATING SUBSTRATES 审中-公开
标题翻译：用于操纵基板的装置和方法
公开(公告)号：WO2004108269B1
公开(公告)日：2005-06-16
申请号：PCT/US2004018188
申请日：2004-06-07
申请人： BIOPROCESSORS CORP , ZARUR ANDREY J , RODGERS SETH T , BASQUE TODD A , MACGREGOR IAN K , JOHNSON TIMOTHY J
发明人： ZARUR ANDREY J , RODGERS SETH T , BASQUE TODD A , MACGREGOR IAN K , JOHNSON TIMOTHY J
IPC分类号： B01F9/00 , B01F11/00 , B01L7/00 , B01L9/00 , C12M1/00 , B01J19/00 , B01L3/00 , C12M3/04
CPC分类号： C12M23/08 , B01F9/0001 , B01F9/002 , B01F11/00 , B01L7/00 , B01L9/52 , B01L2300/0819 , B01L2300/0822 , B01L2300/0829 , B01L2400/0409 , C12M23/10 , C12M23/48 , C12M27/10 , C12M41/14 , Y10S435/809
摘要： This disclosure generally relates to systems and methods for manipulating chambers and other substrates for chemical, biological, or biochemical samples, such as cell culture and other chambers, within units such as incubators. In certain embodiments, the invention provides a technique for maintaining a plurality of substrates or chambers in a housing within which a predetermined environment is maintained, different from the environment external to the housing, and moving substrates or chambers in and out of the housing, in some cases without creating a large opening in the housing (e.g., by opening a door significantly larger than the substrates). A technique is provided, in certain embodiments, in which a plurality of substrates are mounted in fixed, secured relation to each other within a housing providing a predetermined, controlled environment, and are moved within the housing so that they can be evenly exposed to any differences in environment within the housing. In certain embodiments, the invention provides a technique for agitating a fluid within one or more chambers or substrates within a housing that can provide environmental control, in certain embodiments without physically stirring the fluid, such as with a stir bar or other stirring element in direct contact with the fluid. In still another embodiment, the invention provides a method for rotating a substrate or chamber about a substantially vertical and/or horizontal axis. In some cases, any of the above-described systems can be rotated at a speed sufficient to cause separation of a substance within the chamber or substrate.
摘要翻译：本公开总体上涉及用于在诸如培养箱的单元内操纵用于化学，生物或生物化学样品例如细胞培养物和其他室的室和其他基底的系统和方法。在某些实施例中，本发明提供了一种技术，用于维持壳体内的多个基板或腔室，在壳体内维持与壳体外部的环境不同的预定环境，并且将基板或腔室移入和移出壳体，某些情况下不会在外壳中产生大的开口（例如，通过打开比基板明显更大的门）。在某些实施例中提供了一种技术，其中多个基板在提供预定的受控环境的壳体内彼此固定且固定地安装并且在壳体内移动，使得它们可以均匀地暴露于任何住房环境的差异。在某些实施方案中，本发明提供了用于搅动壳体内的一个或多个腔室或衬底内的流体的技术，该流体可以提供环境控制，在某些实施方案中，在没有物理搅动流体的情况下，例如直接用搅拌棒或其他搅拌元件接触流体。在又一个实施例中，本发明提供了一种用于围绕大致竖直和/或水平轴旋转衬底或室的方法。在一些情况下，任何上述系统可以以足以引起腔室或基板内的物质分离的速度旋转。

2. 发明申请

WO2004108269A2 APPARATUS AND METHOD FOR MANIPULATING SUBSTRATES 审中-公开
标题翻译：用于操作基板的装置和方法
公开(公告)号：WO2004108269A2
公开(公告)日：2004-12-16
申请号：PCT/US2004018188
申请日：2004-06-07
申请人： BIOPROCESSORS CORP , ZARUR ANDREY J , RODGERS SETH T , BASQUE TODD A , MACGREGOR IAN K , JOHNSON TIMOTHY J
发明人： ZARUR ANDREY J , RODGERS SETH T , BASQUE TODD A , MACGREGOR IAN K , JOHNSON TIMOTHY J
IPC分类号： B01F9/00 , B01F11/00 , B01L7/00 , B01L9/00 , C12M1/00 , B01J19/00 , B01L3/00 , C12M3/04
CPC分类号： C12M23/08 , B01F9/0001 , B01F9/002 , B01F11/00 , B01L7/00 , B01L9/52 , B01L2300/0819 , B01L2300/0822 , B01L2300/0829 , B01L2400/0409 , C12M23/10 , C12M23/48 , C12M27/10 , C12M41/14 , Y10S435/809
摘要： This disclosure generally relates to systems and methods for manipulating chambers and other substrates for chemical, biological, or biochemical samples, such as cell culture and other chambers, within units such as incubators. In certain embodiments, the invention provides a technique for maintaining a plurality of substrates or chambers in a housing within which a predetermined environment is maintained, different from the environment external to the housing, and moving substrates or chambers in and out of the housing, in some cases without creating a large opening in the housing (e.g., by opening a door significantly larger than the substrates). A technique is provided, in certain embodiments, in which a plurality of substrates are mounted in fixed, secured relation to each other within a housing providing a predetermined, controlled environment, and are moved within the housing so that they can be evenly exposed to any differences in environment within the housing. In certain embodiments, the invention provides a technique for agitating a fluid within one or more chambers or substrates within a housing that can provide environmental control, in certain embodiments without physically stirring the fluid, such as with a stir bar or other stirring element in direct contact with the fluid. In still another embodiment, the invention provides a method for rotating a substrate or chamber about a substantially vertical and/or horizontal axis. In some cases, any of the above-described systems can be rotated at a speed sufficient to cause separation of a substance within the chamber or substrate.
摘要翻译：本公开总体上涉及用于在诸如培养箱的单元内操作用于化学，生物或生化样品（例如细胞培养物和其它室）的室和其它底物的系统和方法。在某些实施例中，本发明提供了一种用于将多个基板或腔室保持在壳体内的技术，在壳体内保持预定环境，不同于壳体外部的环境，以及将基板或室移入和移出壳体，一些情况下，在外壳中不会形成大的开口（例如，通过打开比基板大得多的门）。在某些实施例中提供了一种技术，其中多个基板以固定的，固定的关系安装在提供预定的受控环境的壳体内，并且在壳体内移动，使得它们可以均匀地暴露于任何房屋环境差异。在某些实施例中，本发明提供了一种用于在一个或多个腔室内的流体搅拌的技术，其可以在某些实施例中提供环境控制，而不用物理地搅拌流体，例如直接用搅拌棒或其它搅拌元件与流体接触。在另一个实施例中，本发明提供了一种用于围绕基本垂直和/或水平轴线旋转衬底或室的方法。在一些情况下，任何上述系统可以以足以使物质在室或衬底内分离的速度旋转。

3. 发明申请

WO2004108270B1 SYSTEM AND METHOD FOR PROCESS AUTOMATION 审中-公开
公开(公告)号：WO2004108270B1
公开(公告)日：2005-06-02
申请号：PCT/US2004018638
申请日：2004-06-07
申请人： BIOPROCESSORS CORP , RODGERS SETH T , MACGREGOR IAN K , BASQUE TODD A , MILLER SCOTT E , LU ZHIMIN , ZARUR ANDREY J , SHAHEEN MOHAMED
发明人： RODGERS SETH T , MACGREGOR IAN K , BASQUE TODD A , MILLER SCOTT E , LU ZHIMIN , ZARUR ANDREY J , SHAHEEN MOHAMED
IPC分类号： B01J19/00 , B01L3/00 , B25J7/00 , C40B40/10 , C40B70/00 , G01N35/00 , G01N35/02 , G01N35/04
CPC分类号： G01N35/0099 , B01J19/0046 , B01J2219/0031 , B01J2219/00315 , B01J2219/00317 , B01J2219/00364 , B01J2219/00376 , B01J2219/00387 , B01J2219/00389 , B01J2219/00479 , B01J2219/00495 , B01J2219/00542 , B01J2219/00545 , B01J2219/00549 , B01J2219/00563 , B01J2219/00565 , B01J2219/00585 , B01J2219/00659 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00704 , B01J2219/00725 , B01J2219/00743 , B01L3/5027 , B01L2300/021 , B01L2300/022 , B01L2300/024 , B01L2300/0803 , B01L2300/0806 , C40B40/10 , C40B70/00 , G01N2035/00158 , G01N2035/00366
摘要： Disclosed are systems and methods for manipulating chemical, biological, and/or biochemical samples, optionally supported on substrates and/or within chambers, for example biological samples contained on chips, within biological chambers, etc. In certain embodiments, an apparatus configured to be able to position a chamber or other substrate in one or more modules surrounding the apparatus is disclosed. The apparatus may be configured to be able to move the chamber or substrate in any set of directions, such as radially, vertically, and/or rotationally, with respect to the apparatus. The apparatus may be manually operated and/or automatically controlled. Examples of modules include, but are not limited to, stacking or holding modules, barcode readers, filling modules, sampling modules, incubation modules, sensor modules (e.g., for determining cell density, cell viability, pH, oxygen concentration, nutrient concentration, fluorescence measurements, etc.), assay modules (e.g., for ELISA or other biological assays), data analysis and management modules, control modules, etc. Sensors, control systems, and the like may also be positioned to facilitate operation of the device. Certain embodiments of the invention may be used, for example, to promote or optimize chemical synthesis or cell or biological growth, for instance, for the production of compounds such as drugs or other therapeutics.

4. 发明申请

WO2004108270A3 SYSTEM AND METHOD FOR PROCESS AUTOMATION 审中-公开
标题翻译：用于过程自动化的系统和方法
公开(公告)号：WO2004108270A3
公开(公告)日：2005-04-21
申请号：PCT/US2004018638
申请日：2004-06-07
申请人： BIOPROCESSORS CORP , RODGERS SETH T , MACGREGOR IAN K , BASQUE TODD A , MILLER SCOTT E , LU ZHIMIN , ZARUR ANDREY J , SHAHEEN MOHAMED
发明人： RODGERS SETH T , MACGREGOR IAN K , BASQUE TODD A , MILLER SCOTT E , LU ZHIMIN , ZARUR ANDREY J , SHAHEEN MOHAMED
IPC分类号： B01J19/00 , B01L3/00 , B25J7/00 , C40B40/10 , C40B70/00 , G01N35/00 , G01N35/02 , G01N35/04
CPC分类号： G01N35/0099 , B01J19/0046 , B01J2219/0031 , B01J2219/00315 , B01J2219/00317 , B01J2219/00364 , B01J2219/00376 , B01J2219/00387 , B01J2219/00389 , B01J2219/00479 , B01J2219/00495 , B01J2219/00542 , B01J2219/00545 , B01J2219/00549 , B01J2219/00563 , B01J2219/00565 , B01J2219/00585 , B01J2219/00659 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00704 , B01J2219/00725 , B01J2219/00743 , B01L3/5027 , B01L2300/021 , B01L2300/022 , B01L2300/024 , B01L2300/0803 , B01L2300/0806 , C40B40/10 , C40B70/00 , G01N2035/00158 , G01N2035/00366
摘要： Disclosed are systems and methods for manipulating chemical, biological, and/or biochemical samples, optionally supported on substrates and/or within chambers, for example biological samples contained on chips, within biological chambers, etc. In certain embodiments, an apparatus configured to be able to position a chamber or other substrate in one or more modules surrounding the apparatus is disclosed. The apparatus may be configured to be able to move the chamber or substrate in any set of directions, such as radially, vertically, and/or rotationally, with respect to the apparatus. The apparatus may be manually operated and/or automatically controlled. Examples of modules include, but are not limited to, stacking or holding modules, barcode readers, filling modules, sampling modules, incubation modules, sensor modules (e.g., for determining cell density, cell viability, pH, oxygen concentration, nutrient concentration, fluorescence measurements, etc.), assay modules (e.g., for ELISA or other biological assays), data analysis and management modules, control modules, etc. Sensors, control systems, and the like may also be positioned to facilitate operation of the device. Certain embodiments of the invention may be used, for example, to promote or optimize chemical synthesis or cell or biological growth, for instance, for the production of compounds such as drugs or other therapeutics.
摘要翻译：公开了用于操纵化学，生物学和/或生物化学样品的系统和方法，任选地在衬底和/或腔室内支撑，例如包含在芯片上，生物室内的生物样品等。在某些实施方案中，公开了能够将腔室或其他衬底定位在围绕设备的一个或多个模块中。该装置可以被配置为能够相对于该装置以任何一组方向（例如径向，垂直和/或旋转地）移动腔室或衬底。该装置可以手动操作和/或自动控制。模块的示例包括但不限于堆叠或保持模块，条形码读取器，填充模块，采样模块，孵化模块，传感器模块（例如，用于确定细胞密度，细胞活力，pH，氧浓度，营养浓度，荧光测量等），测定模块（例如，用于ELISA或其他生物测定），数据分析和管理模块，控制模块等。传感器，控制系统等也可以被定位以便于设备的操作。本发明的某些实施方案可用于例如促进或优化化学合成或细胞或生物生长，例如用于生产化合物如药物或其它治疗剂。

5. 发明申请

WO2004108270A8 SYSTEM AND METHOD FOR PROCESS AUTOMATION 审中-公开
标题翻译：用于过程自动化的系统和方法
公开(公告)号：WO2004108270A8
公开(公告)日：2005-03-10
申请号：PCT/US2004018638
申请日：2004-06-07
申请人： BIOPROCESSORS CORP , RODGERS SETH T , MACGREGOR IAN K , BASQUE TODD A , MILLER SCOTT E , LU ZHIMIN , ZARUR ANDREY J , SHAHEEN MOHAMED
发明人： RODGERS SETH T , MACGREGOR IAN K , BASQUE TODD A , MILLER SCOTT E , LU ZHIMIN , ZARUR ANDREY J , SHAHEEN MOHAMED
IPC分类号： B01J19/00 , B01L3/00 , B25J7/00 , C40B40/10 , C40B70/00 , G01N35/00 , G01N35/02 , G01N35/04
CPC分类号： G01N35/0099 , B01J19/0046 , B01J2219/0031 , B01J2219/00315 , B01J2219/00317 , B01J2219/00364 , B01J2219/00376 , B01J2219/00387 , B01J2219/00389 , B01J2219/00479 , B01J2219/00495 , B01J2219/00542 , B01J2219/00545 , B01J2219/00549 , B01J2219/00563 , B01J2219/00565 , B01J2219/00585 , B01J2219/00659 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00704 , B01J2219/00725 , B01J2219/00743 , B01L3/5027 , B01L2300/021 , B01L2300/022 , B01L2300/024 , B01L2300/0803 , B01L2300/0806 , C40B40/10 , C40B70/00 , G01N2035/00158 , G01N2035/00366
摘要： Disclosed are systems and methods for manipulating chemical, biological, and/or biochemical samples, optionally supported on substrates and/or within chambers, for example biological samples contained on chips, within biological chambers, etc. In certain embodiments, an apparatus configured to be able to position a chamber or other substrate in one or more modules surrounding the apparatus is disclosed. The apparatus may be configured to be able to move the chamber or substrate in any set of directions, such as radially, vertically, and/or rotationally, with respect to the apparatus. The apparatus may be manually operated and/or automatically controlled. Examples of modules include, but are not limited to, stacking or holding modules, barcode readers, filling modules, sampling modules, incubation modules, sensor modules (e.g., for determining cell density, cell viability, pH, oxygen concentration, nutrient concentration, fluorescence measurements, etc.), assay modules (e.g., for ELISA or other biological assays), data analysis and management modules, control modules, etc. Sensors, control systems, and the like may also be positioned to facilitate operation of the device. Certain embodiments of the invention may be used, for example, to promote or optimize chemical synthesis or cell or biological growth, for instance, for the production of compounds such as drugs or other therapeutics.
摘要翻译：公开了用于操纵化学，生物和/或生物化学样品的系统和方法，所述化学，生物和/或生物化学样品可选地支撑在衬底上和/或室内，例如包含在芯片上，生物室内的生物样品等。在某些实施例中，能够将腔室或其他衬底定位在围绕装置的一个或多个模块中。该设备可以被配置为能够相对于设备以任何方向组（诸如径向地，垂直地和/或旋转地）来移动腔室或基板。该装置可以手动操作和/或自动控制。模块的例子包括但不限于：堆叠或保持模块，条形码读取器，填充模块，取样模块，孵育模块，传感器模块（例如，用于确定细胞密度，细胞存活力，pH，氧浓度，营养物浓度，荧光测量模块等），测定模块（例如，用于ELISA或其他生物测定），数据分析和管理模块，控制模块等。传感器，控制系统等也可以被定位成便于设备的操作。例如，本发明的某些实施方案可用于促进或优化化学合成或细胞或生物生长，例如用于生产诸如药物或其他治疗剂的化合物。

6. 发明申请

WO2006138743A3 FLUID TRANSFER DEVICE 审中-公开
标题翻译：流体传输装置
公开(公告)号：WO2006138743A3
公开(公告)日：2007-03-15
申请号：PCT/US2006024529
申请日：2006-06-23
申请人： BIOPROCESSORS CORP , LEBLANC SEAN J , MACGREGOR IAN K , AUMOND BERNARDO , VELLA GEORGE J , RUSSO A PETER , RODGERS SETH T , ZARUR ANDREY J
发明人： LEBLANC SEAN J , MACGREGOR IAN K , AUMOND BERNARDO , VELLA GEORGE J , RUSSO A PETER , RODGERS SETH T , ZARUR ANDREY J
IPC分类号： B01L3/02
CPC分类号： B01L3/0275 , B01L2200/026 , B01L2200/027 , B01L2200/0689 , B01L2300/044 , B01L2300/0672 , B01L2300/0681
摘要： Fluid transfer devices described herein can include a body portion and a tip portion. A fluid pathway extends through the body and tip portions through which fluid may be transferred, for example, from a fluid-dispensing apparatus to a fluidic chamber of a microreactor. In some embodiments, the fluid transfer device is connected to the fluid-dispensing apparatus with an engaging element. The engaging element may be part of the body, and can enable the dispensing apparatus to repeatedly engage the body at one predetermined position. The body is capable of storing the fluid received from the dispensing apparatus. The tip portion may be formed of a rigid material (e.g., a metal), and/or may be configured to repeatedly pierce a septum without damaging either the tip or the body. Advantageously, in certain embodiments, the fluid transfer device can controllably transfer small volumes of fluid (e.g., 1 µL) with a high degree of accuracy.
摘要翻译：本文所述的流体输送装置可以包括主体部分和尖端部分。流体通道延伸穿过主体和尖端部分，流体可通过该尖端部分例如从流体分配装置传送到微反应器的流体室。在一些实施例中，流体输送装置用接合元件连接到流体分配装置。接合元件可以是主体的一部分，并且能够使得分配装置能够在一个预定位置反复地接合身体。身体能够储存从分配装置接收的流体。尖端部分可以由刚性材料（例如，金属）形成，和/或可以构造成反复刺穿隔膜而不损坏尖端或者身体。有利地，在某些实施方案中，流体转移装置可以高度准确地可控地传递小体积的流体（例如1μL）。

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