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1. 发明申请

WO1989011860A1 COMBINATIONS OF SOLUBLE T4 PROTEINS AND ANTI-RETROVIRAL AGENTS AND METHODS FOR TREATING OR PREVENTING AIDS, ARC AND HIV INFECTION 审中-公开
标题翻译：可溶性T4蛋白和抗逆转录病毒药物的组合以及治疗或预防艾滋病，感染和艾滋病毒感染的方法
公开(公告)号：WO1989011860A1
公开(公告)日：1989-12-14
申请号：PCT/US1989002453
申请日：1989-06-08
申请人： BIOGEN, INC. , THE GENERAL HOSPITAL CORPORATION
发明人： BIOGEN, INC. , THE GENERAL HOSPITAL CORPORATION , FISHER, Richard, A. , SCHOOLEY, Robert, T. , HIRSCH, Martin, S. , JOHNSON, Victoria, A. , WALKER, Bruce, D.
IPC分类号： A61K37/02
CPC分类号： A61K38/1774 , A61K31/437 , A61K31/445 , A61K31/7072 , A61K45/06 , A61K2300/00
摘要： This invention relates to combinations and methods useful for the treatment or prevention of acquired immunodeficiency syndrome, AIDS related complex, and HIV infection. More particularly, this invention relates to pharmaceutically effective combinations of a soluble T4 protein and an anti-retroviral agent for treating or preventing AIDS, ARC and HIV infection. According to this invention, a soluble T4 protein is used in a pharmaceutically effective combination with an anti-retroviral agent, such as AZT or a glucosidase inhibitor, the dosage of the soluble T4 protein and the dosage of the anti-retroviral agent each being less than that required for a desired therapeutic or prophylactic effect when either compound is administered as a monotherapy.
摘要翻译：本发明涉及可用于治疗或预防获得性免疫缺陷综合征，AIDS相关复合物和HIV感染的组合和方法。更具体地，本发明涉及用于治疗或预防AIDS，ARC和HIV感染的可溶性T4蛋白和抗逆转录病毒剂的药学上有效的组合。根据本发明，可溶性T4蛋白与抗逆转录病毒药物如AZT或葡糖苷酶抑制剂的药学上有效的组合使用，可溶性T4蛋白的用量和抗逆转录病毒剂的剂量各自不多当将任一化合物作为单一疗法施用时，所需的治疗或预防效果所需的量。

2. 发明申请

WO1992008489A1 TREATMENT FOR INFLAMMATORY BOWEL DISEASE 审中-公开
标题翻译：炎症性皮肤病的治疗
公开(公告)号：WO1992008489A1
公开(公告)日：1992-05-29
申请号：PCT/US1991008257
申请日：1991-11-06
申请人： BIOGEN, INC. , THE GENERAL HOSPITAL CORPORATION
发明人： BIOGEN, INC. , THE GENERAL HOSPITAL CORPORATION , LOBB, Roy, R. , PODOLSKY, Daniel, K.
IPC分类号： A61K39/395
CPC分类号： A61K51/1027 , A61K38/00 , A61K2123/00 , C07K16/2854
摘要： A method for the treatment of inflammatory bowel disease (IBD) is disclosed. The method comprises administration of an antibody, polypeptide or other molecule recognizing ELAM1, a protein induced on the surface of endothelial cells and found to be associated with IBD-involved intestinal tissue.
摘要翻译：公开了一种治疗炎症性肠病（IBD）的方法。该方法包括施用识别ELAM1的抗体，多肽或其他分子，在内皮细胞表面诱导的蛋白质，并发现与IBD相关的肠组织相关。

3. 发明申请

WO2001035903A2 COMPOSITIONS AND METHODS FOR REGULATING TUMOR-ASSOCIATED ANTIGEN EXPRESSION 审中-公开
标题翻译：用于调节肿瘤相关抗原表达的组合物和方法
公开(公告)号：WO2001035903A2
公开(公告)日：2001-05-25
申请号：PCT/US2000031508
申请日：2000-11-15
申请人： THE GENERAL HOSPITAL CORPORATION , RIJKSUNIVERSITEIT LEIDEN , KURNICK, James, T. , VAN DEN ELSEN, Peter, J.
发明人： THE GENERAL HOSPITAL CORPORATION , RIJKSUNIVERSITEIT LEIDEN
IPC分类号： A61K
CPC分类号： C07K16/18 , A61K38/00 , A61K39/00 , C07K14/47 , C07K14/4748 , C12N5/0693 , G01N33/5011
摘要： This invention relates to methods and compositions for the treatment of tumors. In particular, the invention relates to methods and agents for the treatment of tumors expressing a tumor-antigen [also known as a tumor-associated antigen TAA , lineage specific, differentiation, or self-antigens], and more specifically to methods and agents for the treatment of melanomas expressing the Melan-A/MART-1 antigen. The invention also relates to methods for identifying agents that regulate expression of tumor-antigens .
摘要翻译：本发明涉及治疗肿瘤的方法和组合物。特别地，本发明涉及用于治疗表达肿瘤抗原的肿瘤的方法和试剂（也称为与肿瘤相关的抗原TAA ，谱系特异性，分化，或自身抗原]，更具体地涉及用于治疗表达Melan-A / MART-1抗原的黑素瘤的方法和试剂。本发明还涉及用于鉴定调节肿瘤抗原表达的试剂的方法。

4. 发明申请

WO1998026045A1 STRESS-PROTECTED TRANSGENIC PLANTS 审中-公开
标题翻译：受应力保护的转基因植物
公开(公告)号：WO1998026045A1
公开(公告)日：1998-06-18
申请号：PCT/US1997023019
申请日：1997-12-12
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： THE GENERAL HOSPITAL CORPORATION , SHEEN, Jen
IPC分类号： C12N05/04
CPC分类号： C12N9/1205
摘要： Disclosed are methods for increasing a plant's tolerance to environmental stress.
摘要翻译：公开了增加植物对环境胁迫耐受性的方法。

5. 发明申请

WO1998021358A1 HUNTINGTIN-RELATED THERAPEUTICS AND BIOASSAY 审中-公开
标题翻译：与营养相关的治疗和生物学
公开(公告)号：WO1998021358A1
公开(公告)日：1998-05-22
申请号：PCT/US1997020745
申请日：1997-11-14
申请人： UNIVERSITY OF MASSACHUSETTS , THE GENERAL HOSPITAL CORPORATION
发明人： UNIVERSITY OF MASSACHUSETTS , THE GENERAL HOSPITAL CORPORATION , DilFIGLIA, Marian , ARONIN, Neil , VELIER, James
IPC分类号： C12Q01/00
CPC分类号： G01N33/5008 , G01N33/502 , G01N33/5044 , G01N33/5058 , G01N33/6896 , G01N2500/10
摘要： A method of identifying a compound useful in the treatment of a disease characterized by the presence of mutant huntingtin by: (a) providing a cell which expresses mutant huntingtin; (b) contacting the cell with a test compound; and (c) determining whether the level of clathrin-mediated endocytosis is increased in the presence of the test compound, compared to the level in the absence of the test compound. An increase in clathrin-mediated endocytosis is an indication that the test compound is useful in treating the disease.
摘要翻译：鉴定通过以下方法鉴定用于治疗特征在于存在突变型亨廷汀的疾病的化合物的方法：（a）提供表达突变型亨廷汀的细胞; （b）使细胞与测试化合物接触; 和（c）与不存在测试化合物的水平相比，确定在测试化合物存在下网格蛋白介导的内吞水平是否增加。网格蛋白介导的内吞作用的增加表明该试验化合物可用于治疗该疾病。

6. 发明申请

WO1998011827A1 MODULATION OF WOUND HEALING BY PHOTODYNAMIC THERAPY 审中-公开
标题翻译：通过光化疗治疗伤口愈合的调节
公开(公告)号：WO1998011827A1
公开(公告)日：1998-03-26
申请号：PCT/US1997016188
申请日：1997-09-12
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： THE GENERAL HOSPITAL CORPORATION , TRAUNER, Kenneth , HASAN, Tayyaba , HAMBLIN, Michael, R.
IPC分类号： A61B17/00
CPC分类号： A61B17/00 , A61K41/0071 , A61N5/062 , Y10S977/932
摘要： Disclosed is a method for modulating wound healing in a mammal. The method includes the steps of: (a) administering a photosensitizer to a mammal that has an unhealed or partially-healed wound; (b) waiting for the photosensitizer to reach an effective tissue concentration at the wound site; (c) photoactivating the photosensitizer by delivering specifically to the wound site light of an effective wavelength and intensity, for an effective length of time. The modulation of wound healing can include hastening healing by administering a low dose of photodynamic therapy. Alternatively, the modulation can include inhibiting fibrosis by administering a high dose of photodynamic therapy. The photosensitizer can be targeted, for example, to macrophages or myofibroblasts. Targeting can be by conjugation to a targeting moiety such as a protein, peptide or microparticle.
摘要翻译：公开了一种调节哺乳动物伤口愈合的方法。该方法包括以下步骤：（a）向具有未愈合或部分愈合的伤口的哺乳动物施用光敏剂; （b）等待光敏剂在伤口部位达到有效的组织浓度; （c）通过在有效的时间长度内特异性地输送有效波长和强度的伤口部位的光来光敏化光敏剂。伤口愈合的调节可以包括通过施用低剂量的光动力疗法来加速愈合。或者，调节可以包括通过施用高剂量的光动力疗法来抑制纤维化。光敏剂可以靶向例如巨噬细胞或肌成纤维细胞。靶向可以通过与靶向部分如蛋白质，肽或微粒共轭。

7. 发明申请

WO1998003549A1 MELATONIN 1a RECEPTOR GENE REGULATORY REGIONS AND USES THEREOF 审中-公开
标题翻译： MELATONIN 1a受体基因监管区及其用途
公开(公告)号：WO1998003549A1
公开(公告)日：1998-01-29
申请号：PCT/US1997012526
申请日：1997-07-17
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： THE GENERAL HOSPITAL CORPORATION , REPPERT, Steven, M.
IPC分类号： C07K14/72
CPC分类号： C12N15/85 , A01K2217/05 , A61K38/00 , C07K14/72 , C12N2830/00 , C12N2830/85
摘要： Disclosed are DNAs encoding melatonin 1a receptor gene promoter regions, recombinant polypeptides expressed from such DNAs, and methods of using such expression constructs to screen for promoter activators or inhibitors. Transcriptional activators are useful as therapeutics to reentrain endogenous melatonin rhythms as a means of treating circadian rhythm disorders in humans and control reproductive cycles in seasonally breeding animals. Transcriptional inhibitors are useful as therapeutics to control the initiation or timing of puberty in humans.
摘要翻译：公开了编码褪黑激素1a受体基因启动子区域的DNA，从这些DNA表达的重组多肽，以及使用这些表达构建体筛选启动子活化剂或抑制剂的方法。转录激活剂可用作治疗内源性褪黑素节律作为治疗人类昼夜节律紊乱和控制季节性繁殖动物繁殖周期的手段。转录抑制剂可用作治疗人类控制青春期的起始或时机。

8. 发明申请

WO1998002170A1 METHOD OF INDUCING VASODILATION AND TREATING PULMONARY HYPERTENSION USING ADENOVIRAL-MEDIATED TRANSFER OF THE NITRIC OXIDE SYNTHASE GENE 审中-公开
标题翻译：使用硝酸氧合酶基因的腺病毒转染诱导血管扩张和治疗肺动脉高压的方法
公开(公告)号：WO1998002170A1
公开(公告)日：1998-01-22
申请号：PCT/US1997012510
申请日：1997-07-17
申请人： THE GENERAL HOSPITAL CORPORATION , LEUVEN RESEARCH AND DEVELOPMENT, V.Z.M.
发明人： THE GENERAL HOSPITAL CORPORATION , LEUVEN RESEARCH AND DEVELOPMENT, V.Z.M. , JANSSENS, Stefan , BLOCH, Kenneth, D. , COLLEN, Désiré
IPC分类号： A61K31/70
CPC分类号： C12N9/0075 , A61K48/00 , C12N2799/027
摘要： This invention relates to a gene therapy method for inducing pulmonary vasodilation. More specifically, this invention involves introducing the nitric oxide synthase gene into lungs resulting in pulmonary vasodilation. This results in a hypotensive effect in the pulmonary circulation which does not significantly affect systemic blood pressure or cardiac index. This method is useful to treat primary pulmonary hypertension or pulmonary hypertension secondary to various disease states.
摘要翻译：本发明涉及一种用于诱导肺血管舒张的基因治疗方法。更具体地，本发明涉及将一氧化氮合酶基因导入肺中，导致肺血管舒张。这导致肺循环中的低血压效应，其不显着影响全身血压或心脏指数。该方法可用于治疗原发性肺动脉高压或继发于各种疾病状态的肺动脉高压。

9. 发明申请

WO1997042995A1 MICROPROCESSOR-CONTROLLED VENTILATOR SYSTEM AND METHODS 审中-公开
标题翻译：微处理器控制的通风系统和方法
公开(公告)号：WO1997042995A1
公开(公告)日：1997-11-20
申请号：PCT/US1997008359
申请日：1997-05-16
申请人： CHILDREN'S MEDICAL CENTER CORPORATION , THE GENERAL HOSPITAL CORPORATION , SCHNITZER, Jay, J. , THOMPSON, John, E. , WILSON, Jay, M.
发明人： CHILDREN'S MEDICAL CENTER CORPORATION , THE GENERAL HOSPITAL CORPORATION
IPC分类号： A61M16/00
CPC分类号： A61M16/04 , A61M16/0051 , A61M16/024 , A61M16/042 , A61M16/16 , A61M2016/0027 , A61M2016/0039 , A61M2016/0042 , A61M2016/1025 , A61M2202/0275 , A61M2205/16 , A61M2230/432 , A61M2230/435 , G06F19/00
摘要： A microprocessor controlled ventilator (10) controls a patient's breathing selectively. The ventilator utilizes an intratracheal pulmonary ventilation using a reverse thrust catheter (12) for inspiration, and a microprocessor (22) for selectively controlling the ventilation parameters.
摘要翻译：微处理器控制的呼吸机（10）选择性地控制患者的呼吸。呼吸机利用使用反向推力导管（12）进行吸气的气管内肺通气，以及用于选择性地控制通气参数的微处理器（22）。

10. 发明申请

WO1997041777A1 OPTICAL BIOPSY FORCEPS AND METHODS OF DIAGNOSING TISSUE 审中-公开
标题翻译：光学生物力学和诊断组织的方法
公开(公告)号：WO1997041777A1
公开(公告)日：1997-11-13
申请号：PCT/US1997007784
申请日：1997-05-07
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： THE GENERAL HOSPITAL CORPORATION , NISHIOKA, Norman, S. , SCHOMACKER, Kevin, T.
IPC分类号： A61B10/00
CPC分类号： A61B10/06 , A61B2017/00061 , A61B2090/3614
摘要： An integrated optical biopsy forceps device (10) and a method for tissue identification by optical analysis and biopsy sampling at a site within the body. The device includes an elongated catheter body for introduction into the body and navigation to an area of interest. An optical fiber (50) extends through the device, from the proximal end, where it may be connected to electro-optical spectral analysis equipment, to a distal tip for illuminating and receiving light energy from tissue at the location of the tip. The distal end of the device has a pair of cutting jaws (80, 81) pivotally mounted at the distal end of the catheter body and controlled by control wires (40, 41) extending through the catheter body to a control handle at the proximal end, or by the optical fiber. The device may be spectroscopically guided to a site of interest within the body. The fiber tip (50) is positioned coaxially with the jaws at the zone of contact and cutting of the jaws, and is retracted as the jaws close, so that the biopsy sample is taken exactly at the spot being viewed by the optical fiber.
摘要翻译：一种综合光学活检钳装置（10）以及通过在体内部位进行光学分析和活组织检查取样的组织鉴别方法。该装置包括用于引入身体并导航到感兴趣区域的细长导管体。光纤（50）从近端（其可以连接到电光谱分析设备）延伸穿过该设备到远端，用于照射和接收来自尖端位置处的组织的光能。装置的远端具有一对可枢转地安装在导管主体的远端处的切割钳口（80,81），并由延伸穿过导管主体的控制线（40,41）控制在近端的控制手柄，或通过光纤。该装置可以被光谱地引导到身体内的感兴趣部位。纤维尖端（50）在钳口的接触和切割区域处与颚骨同轴地定位，并且随着颚关闭而缩回，使得活检样本准确地在被光纤观察的位置处被拍摄。

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