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1. 发明申请

WO1989011860A1 COMBINATIONS OF SOLUBLE T4 PROTEINS AND ANTI-RETROVIRAL AGENTS AND METHODS FOR TREATING OR PREVENTING AIDS, ARC AND HIV INFECTION 审中-公开
标题翻译：可溶性T4蛋白和抗逆转录病毒药物的组合以及治疗或预防艾滋病，感染和艾滋病毒感染的方法
公开(公告)号：WO1989011860A1
公开(公告)日：1989-12-14
申请号：PCT/US1989002453
申请日：1989-06-08
申请人： BIOGEN, INC. , THE GENERAL HOSPITAL CORPORATION
发明人： BIOGEN, INC. , THE GENERAL HOSPITAL CORPORATION , FISHER, Richard, A. , SCHOOLEY, Robert, T. , HIRSCH, Martin, S. , JOHNSON, Victoria, A. , WALKER, Bruce, D.
IPC分类号： A61K37/02
CPC分类号： A61K38/1774 , A61K31/437 , A61K31/445 , A61K31/7072 , A61K45/06 , A61K2300/00
摘要： This invention relates to combinations and methods useful for the treatment or prevention of acquired immunodeficiency syndrome, AIDS related complex, and HIV infection. More particularly, this invention relates to pharmaceutically effective combinations of a soluble T4 protein and an anti-retroviral agent for treating or preventing AIDS, ARC and HIV infection. According to this invention, a soluble T4 protein is used in a pharmaceutically effective combination with an anti-retroviral agent, such as AZT or a glucosidase inhibitor, the dosage of the soluble T4 protein and the dosage of the anti-retroviral agent each being less than that required for a desired therapeutic or prophylactic effect when either compound is administered as a monotherapy.
摘要翻译：本发明涉及可用于治疗或预防获得性免疫缺陷综合征，AIDS相关复合物和HIV感染的组合和方法。更具体地，本发明涉及用于治疗或预防AIDS，ARC和HIV感染的可溶性T4蛋白和抗逆转录病毒剂的药学上有效的组合。根据本发明，可溶性T4蛋白与抗逆转录病毒药物如AZT或葡糖苷酶抑制剂的药学上有效的组合使用，可溶性T4蛋白的用量和抗逆转录病毒剂的剂量各自不多当将任一化合物作为单一疗法施用时，所需的治疗或预防效果所需的量。

2. 发明申请

WO1991018618A2 IMMUNOTHERAPEUTIC COMPOSITIONS FOR TREATING AND PREVENTING AIDS, ARC AND HIV INFECTION 审中-公开
标题翻译：用于治疗和预防艾滋病，感染和艾滋病毒感染的免疫组化
公开(公告)号：WO1991018618A2
公开(公告)日：1991-12-12
申请号：PCT/US1991003460
申请日：1991-05-23
申请人： BIOGEN, INC.
发明人： BIOGEN, INC. , FISHER, Richard, A. , HESSION, Catherine , BURKLY, Linda, C.
IPC分类号： A61K37/02
CPC分类号： C12Q1/703 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2227/105 , A01K2267/0337 , A61K38/00 , A61K39/00 , C07K14/70514 , C07K16/2812 , C12N15/8509 , C12N2830/008
摘要： Immunotherapeutic, prophylactic and diagnostic compositions useful in treating or preventing diseases in humans caused by infective agents whose primary targets are T4 lymphocytes, including acquired immune deficiency syndrome, AIDS related complex and human immunodeficiency virus infection. DNA sequences that code for amino acid variants and derivatives of human CD4, or fragments thereof, that elicit in a human antibodies that bind to HIV gp120. Such DNA sequences are useful in the immunotherapeutic, prophylactic and diagnostic compositions of this invention. A novel screening method for selecting amino acid variants and derivatives of human CD4 that elicit in humans antibodies that bind to HIV gp120, human CD4, or both, useful as therapeutic, prophylactic and diagnostic agents for diseases caused by infective agents whose primary targets are T4 lymphocytes, including acquired immune deficiency syndrome, AIDS related complex and human immunodeficiency virus infection.
摘要翻译：免疫治疗，预防和诊断组合物，其用于治疗或预防由主要靶标为T4 +淋巴细胞的感染因子引起的人类疾病，包括获得性免疫缺陷综合征，艾滋病相关复合物和人类免疫缺陷病毒感染。编码氨基酸变体和人CD4或其片段的衍生物的DNA序列，其引起结合HIV gp120的人抗体。这样的DNA序列可用于本发明的免疫治疗，预防和诊断组合物。一种选择氨基酸变体和人CD4的衍生物的新型筛选方法，其引起人类与HIV gp120，人CD4或两者结合的抗体，其可用作主要靶标为T4的感染因子引起的疾病的治疗剂，预防和诊断剂 <+>淋巴细胞，包括获得性免疫缺陷综合征，艾滋病相关复合物和人类免疫缺陷病毒感染。

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