专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2017032611A1 METHOD FOR THE REDUCTION OF HOST CELL PROTEINS IN AFFINITY CHROMATOGRAPHY 审中-公开
标题翻译：用于减少亲本色谱中宿主细胞蛋白的方法
公开(公告)号：WO2017032611A1
公开(公告)日：2017-03-02
申请号：PCT/EP2016/069163
申请日：2016-08-11
申请人： F. HOFFMANN-LA ROCHE AG , HOFFMANN-LA ROCHE INC.
发明人： FALKENSTEIN, Roberto , KOEHNLEIN, Wolfgang , SCHWENDNER, Klaus , SPENSBERGER, Bernhard
IPC分类号： C07K16/06
CPC分类号： C07K16/065 , C07K16/18 , C07K16/22 , C07K16/2854 , C07K16/32 , C07K16/36 , C07K2317/31
摘要： Herein is reported a method for producing a human IgG4 or IgG1 isotype antibody comprising the following steps a) cultivating a cell comprising a nucleic acid encoding a human IgG4 or IgG1 isotype antibody, b) recovering the human IgG4 or IgG1 isotype antibody from the cell or the cultivation medium, c) contacting the human IgG4 or IgG1 isotype antibody with a protein A chromatography material, d) washing the protein A chromatography material with an aqueous solution comprising Histidine and Tris, e) recovering the human IgG4 or IgG1 isotype antibody from the protein A chromatography material and thereby producing the human IgG4 or IgG1 isotype antibody.
摘要翻译：本文报道了用于制备人IgG4或IgG1同种型抗体的方法，包括以下步骤：a）培养包含编码人IgG4或IgG1同种型抗体的核酸的细胞，b）从细胞中回收人IgG4或IgG1同种型抗体，或培养介质，c）将人IgG4或IgG1同种型抗体与蛋白质A色谱材料接触，d）用包含组氨酸和Tris的水溶液洗涤蛋白A色谱材料，e）从所述培养基中回收人IgG4或IgG1同种型抗体蛋白A层析材料，从而产生人IgG4或IgG1同种型抗体。

2. 发明申请

WO2016007653A3 PSGL-1 MODULATORS AND USES THEREOF 审中-公开
标题翻译： PSGL-1调制器及其用途
公开(公告)号：WO2016007653A3
公开(公告)日：2016-04-07
申请号：PCT/US2015039586
申请日：2015-07-08
申请人： SANFORD BURNHAM MED RES INST
发明人： BRADLEY LINDA M , TINOCO ROBERTO
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/2854 , A61K48/00 , A61K2039/505 , C07K14/70596 , C07K16/2896 , C07K2317/76
摘要： The present invention relates to the seminal discovery that P-selectin glycoprotein ligand-1 (PSGL-1) modulates the immune system and immune responses. Specifically, the present invention provides PSGL-1 agonists and antagonists which increase the survival of multifunctional T cells and viral clearance. The present invention further provides methods of treating infectious diseases, cancer and immune and inflammatory diseases and disorders using a PSGL-1 modulator.
摘要翻译：本发明涉及P-选择蛋白糖蛋白配体-1（PSGL-1）调节免疫系统和免疫应答的精髓发现。具体地说，本发明提供了增加多功能T细胞存活率和病毒清除率的PSGL-1激动剂和拮抗剂。本发明还提供使用PSGL-1调节剂治疗感染性疾病，癌症和免疫和炎性疾病和病症的方法。

3. 发明申请

WO2011087548A2 THERAPEUTIC COMPOSITIONS AND METHODS FOR TARGETED DELIVERY OF ACTIVE AGENTS 审中-公开
标题翻译：治疗组合物和方法，用于有针对性地递送活性药剂
公开(公告)号：WO2011087548A2
公开(公告)日：2011-07-21
申请号：PCT/US2010/054321
申请日：2010-10-27
申请人： WILLIAM MARSH RICE UNIVERSITY , BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM , TOUR, James, M. , BERLIN, Jacob , PHAM, Tam , MYERS, Jeffrey, N. , SANO, Daisuke
发明人： TOUR, James, M. , BERLIN, Jacob , PHAM, Tam , MYERS, Jeffrey, N. , SANO, Daisuke
IPC分类号： A61K48/00
CPC分类号： C07K16/2854 , A61K47/6929 , A61K47/6949 , A61K51/1268 , B82Y5/00 , Y10S977/746 , Y10S977/75 , Y10S977/842 , Y10S977/906
摘要： The present invention pertains to therapeutic compositions that comprise: (1) a nanovector; (2) an active agent; and (3) a targeting agent, wherein the active agent and the targeting agent are non-covalently associated with the nanovector. The present invention also pertains to methods of treating various conditions in a subject by utilizing the above-described therapeutic compositions. Methods of making the therapeutic compositions are also a subject matter the present invention.
摘要翻译：本发明涉及治疗组合物，其包含：（1）纳米体; （2）活性剂; 和（3）靶向剂，其中活性剂和靶向剂与纳米体非共价结合。本发明还涉及通过利用上述治疗组合物治疗受试者的各种病症的方法。制备治疗组合物的方法也是本发明的主题。

4. 发明申请

WO2009046978A1 PROTEIN EXPRESSION FROM MULTIPLE NUCLEIC ACIDS 审中-公开
标题翻译：来自多种核酸的蛋白质表达
公开(公告)号：WO2009046978A1
公开(公告)日：2009-04-16
申请号：PCT/EP2008/008523
申请日：2008-10-09
申请人： F. HOFFMANN-LA ROCHE AG , GOEPFERT, Ulrich , KNOETGEN, Hendrik , KOPETZKI, Erhard , STERN, Anne
发明人： GOEPFERT, Ulrich , KNOETGEN, Hendrik , KOPETZKI, Erhard , STERN, Anne
IPC分类号： C12N15/69 , C12N15/85 , C07K16/00
CPC分类号： C12N15/85 , C07K16/18 , C07K16/28 , C07K16/2812 , C07K16/2854 , C07K16/2866 , C07K16/2896 , C07K2317/14 , C07K2317/21 , C07K2317/51 , C07K2317/515 , C12P21/00
摘要： The current invention reports a method for the recombinant production of a secreted heterologous immunoglobulin in a CHO cell comprising the following steps: i) providing a CHO cell, which is adapted to growth in suspension culture, adapted to growth in serum-free medium, mycoplasma free, and virus free, ii) providing a vector comprising a prokaryotic origin of replication, a first nucleic acid conferring resistance to a prokaryotic selection agent, a second nucleic acid encoding the heavy chain of said heterologous immunoglobulin, a third nucleic acid encoding the light chain of said heterologous immunoglobulin, a fourth nucleic acid conferring resistance to a eukaryotic selection agent, iii) transfecting said CHO cell, wherein said transfecting comprises a) transfecting said CHO cell with said vector comprising a fourth nucleic acid conferring resistance to a first eukaryotic selection agent, b) selecting a CHO cell by growth in cultivation medium containing said first eukaryotic selection agent, c) transfecting said selected CHO cell with said vector comprising a fourth nucleic acid conferring resistance to a second eukaryotic selection agent different to said first eukaryotic selection agent, d) selecting a CHO cell by selected growth in cultivation medium containing said first and said second eukaryotic selection agent, iv) cultivating said transfected CHO cell in a medium in the presence of said first and second eukaryotic selection agent, under conditions suitable for the expression of said second, and third nucleic acid, and v) recovering said secreted heterologous immunoglobulin from the cultivation medium.
摘要翻译：本发明报告了在CHO细胞中重组产生分泌的异源免疫球蛋白的方法，其包括以下步骤：i）提供适于在悬浮培养物中生长的CHO细胞，适于在无血清培养基中生长，支原体免费和无病毒，ii）提供包含原核复制起点的载体，赋予原核选择剂抗性的第一核酸，编码所述异源免疫球蛋白的重链的第二核酸，编码光的第三核酸所述异源免疫球蛋白链，赋予对真核选择剂的抗性的第四核酸，iii）转染所述CHO细胞，其中所述转染包括a）用包含第四核酸的所述载体转染所述CHO细胞，赋予对第一真核选择性的抗性试剂，b）通过在含有所述第一种真核生物的培养基中生长来选择CHO细胞 c）用所述载体转染所述选择的CHO细胞，所述载体包含赋予与所述第一真核选择试剂不同的第二真核选择剂的抗性的第四核酸，d）通过在含有所述第一和第二真核选择试剂的培养基中选择生长来选择CHO细胞，所述第二真核选择剂，iv）在所述第一和第二真核选择剂的存在下，在适于表达所述第二和第三核酸的条件下，在培养基中培养所述转染的CHO细胞，和v）回收所述分泌的异源免疫球蛋白。

5. 发明申请

WO2008011094A2 CYTOKINE INDUCTION OF SELECTIN LIGANDS ON CELLS 审中-公开
标题翻译：细胞因子诱导选择素配体对细胞的作用
公开(公告)号：WO2008011094A2
公开(公告)日：2008-01-24
申请号：PCT/US2007016352
申请日：2007-07-18
申请人： SACKSTEIN ROBERT
发明人： SACKSTEIN ROBERT
IPC分类号： A61K38/17 , A61K38/19 , A61K38/20 , A61K39/395 , A61P9/10 , A61P29/00 , A61P35/00 , C12N5/077 , C12N5/078
CPC分类号： A61K35/15 , A61K38/1709 , A61K38/193 , A61K38/20 , A61K38/202 , A61K2035/124 , C07K16/2854 , C07K2317/76 , C12N5/0634 , C12N5/0669 , C12N2501/22
摘要： Methods and compositions for treating cells with cytokines are provided herein.
摘要翻译：本文提供了用细胞因子处理细胞的方法和组合物。

6. 发明申请

WO2005014653A2 HUMANIZED CHICKEN ANTIBODIES 审中-公开
标题翻译：人类鸡肉抗体
公开(公告)号：WO2005014653A2
公开(公告)日：2005-02-17
申请号：PCT/US2004/006343
申请日：2004-02-26
申请人： PROTEIN DESIGN LABS, INC. , TSURUSHITA, Naoya , KUMAR, Shankar , VASQUEZ, Maximiliano
发明人： TSURUSHITA, Naoya , KUMAR, Shankar , VASQUEZ, Maximiliano
IPC分类号： C07K16/46
CPC分类号： C07K16/244 , C07K16/2854 , C07K2317/23 , C07K2317/24 , C07K2317/52 , C07K2317/622 , C07K2319/00
摘要： The present invention concerns chicken antibodies and humanized chicken antibodies and the method of making such antibodies. In a particular embodiment, it provides humanized chicken antibodies that bind to or neutralize human and/or mouse proteins, such IL-12 or L-selectin. It also provides the method for the prevention or treatment of autoimmune diseases by using such antibodies.
摘要翻译：本发明涉及鸡抗体和人源化鸡抗体及其制备方法。在一个具体实施方案中，其提供结合或中和人和/或小鼠蛋白质，例如IL-12或L-选择蛋白的人源化鸡抗体。它还提供了通过使用这种抗体来预防或治疗自身免疫性疾病的方法。

7. 发明申请

WO0162895A3 SIMULTANEOUS STIMULATION AND CONCENTRATION OF CELLS 审中-公开
标题翻译：细胞的同时刺激和浓度
公开(公告)号：WO0162895A3
公开(公告)日：2002-02-28
申请号：PCT/US0106139
申请日：2001-02-26
申请人： XCYTE THERAPIES INC , BERENSON RON , LAW CHE , BONYHADI MARK , SAUND NARINDER , CRAIG STEWART , KALAMASZ DALE , HARDWICK ALAN , MCMILLEN DAVID
发明人： BERENSON RON , LAW CHE , BONYHADI MARK , SAUND NARINDER , CRAIG STEWART , KALAMASZ DALE , HARDWICK ALAN , MCMILLEN DAVID
IPC分类号： G01N33/53 , A61K35/12 , A61K35/14 , A61L27/38 , A61P35/00 , C07K16/28 , C12N5/0781 , C12N5/0783 , C12N5/0789 , C12N5/00 , A61K9/70 , A61L31/02 , A61L31/04 , B03C1/00 , C07K1/00 , C07K14/00 , C07K16/18 , C08F10/00 , C08L1/00 , C08L5/00 , C08L25/02 , C08L25/04 , C08L31/04 , C08L75/00 , C12N5/06
CPC分类号： A61L27/3804 , A61K2035/124 , A61K2039/57 , A61L27/3895 , C07K16/2803 , C07K16/2806 , C07K16/2809 , C07K16/2812 , C07K16/2815 , C07K16/2818 , C07K16/2821 , C07K16/2827 , C07K16/2833 , C07K16/2845 , C07K16/2854 , C07K16/2866 , C07K16/2875 , C07K16/2878 , C07K16/289 , C07K16/2896 , C12N5/0635 , C12N5/0636 , C12N5/0647 , C12N2500/32 , C12N2501/23 , C12N2501/51 , C12N2501/515 , C12N2501/53 , C12N2533/12 , C12N2533/14 , C12N2533/18 , C12N2533/30 , C12N2533/40 , C12N2533/54 , C12N2533/70 , C12N2533/72 , C12N2533/90
摘要： The present invention relates generally to methods for stimulating cells, and more particularly, to a novel method to concentrate and stimulate cells that maximizes stimulation and/or proliferation of such cells. In the various embodiments, cells are stimulated and concentrated with a surface yielding enhanced proliferation, cell signal transduction, and/or cell surface moiety aggregation. In certain aspects methods for stimulating a population of cells such as T-cells, by simultaneous concentration and cell surface moiety ligation are provided by contacting the population of cells with a surface, that has attached thereto one or more agents that ligate a cell surface moiety and applying a force that predominantly drives cell concentration and cell surface moiety ligation, thereby inducing cell stimulation, cell surface moiety aggregation, and/or receptor signaling enhancement. Also provided are methods for producing phenotypically tailored cells, including T-cells for the use in diagnostics, drug discovery, and the treatment of a variety of indications, including cancer, viral infections, and immune related disorders. Compositions of cells having specific phenotypic properties produced by these processes are further provided.
摘要翻译：本发明一般涉及刺激细胞的方法，更具体地，涉及一种浓缩和刺激使这种细胞的刺激和/或增殖最大化的细胞的新方法。在各种实施方案中，刺激细胞并用表面产生增强的增殖，细胞信号转导和/或细胞表面部分聚集来浓缩细胞。在某些方面，通过使细胞群与表面连接，通过同时浓缩和细胞表面部分连接来刺激诸如T细胞的细胞群体的方法，其中附着有一种或多种连接细胞表面部分的试剂并施加主要驱动细胞浓度和细胞表面部分连接的力，从而诱导细胞刺激，细胞表面部分聚集和/或受体信号增强。还提供了用于产生表型定制细胞的方法，包括用于诊断，药物发现和治疗各种适应症（包括癌症，病毒感染和免疫相关疾病）的T细胞。还提供了由这些方法产生的具有特定表现性质的细胞的组成。

8. 发明申请

WO99049880A1 METHODS FOR TREATING AN ISCHEMIC DISORDER AND IMPROVING STROKE OUTCOME 审中-公开
标题翻译：治疗疾病的方法和改善症状的方法
公开(公告)号：WO99049880A1
公开(公告)日：1999-10-07
申请号：PCT/US1999/007175
申请日：1999-04-01
IPC分类号： C12P21/08 , A61K31/20 , A61K31/21 , A61K38/00 , A61K38/48 , A61K39/395 , A61K45/00 , A61K49/00 , A61P7/02 , A61P7/06 , A61P9/10 , A61P11/00 , C07K14/645 , C07K14/705 , C07K16/26 , C07K16/28 , C12N9/64 , A61K38/16 , A61K38/17 , A61K38/36 , C07K14/745
CPC分类号： C12N9/644 , A61K38/4846 , C07K14/70564 , C07K16/2854 , C12Y304/21022
摘要： The present invention provides for a method for treating an ischemic disorder in a subject which comprises administering to the subject a pharmaceutically acceptable Factor IXa compound in a sufficient amount over a sufficient time period so as to treat the ischemic disorder in the subject. The invention further provides a method for treating an ischemic disorder in a subject which comprises administering to the subject a pharmaceutically acceptable form of inactivated Factor IXa in a sufficient amount over a sufficient period of time to inhibit coagulation so as to treat the ischemic disorder in the subject.
摘要翻译：本发明提供了治疗受试者的缺血性疾病的方法，其包括在足够的时间内向受试者施用足够量的药学上可接受的因子IXa化合物，以治疗受试者的缺血性疾病。本发明进一步提供了一种治疗受试者的缺血性疾病的方法，该方法包括在足够的时间内以足够的时间向受试者施用药学上可接受的形式的灭活因子IXa，以抑制凝血，从而治疗缺血性障碍学科。

9. 发明申请

WO99043353A2 COMBINATION ANTI-SELECTIN AND IMMUNOSUPPRESSANT THERAPY 审中-公开
标题翻译：组合抗选择素和免疫抑制剂治疗
公开(公告)号：WO99043353A2
公开(公告)日：1999-09-02
申请号：PCT/US1999/002967
申请日：1999-02-12
IPC分类号： A61K38/00 , A61K38/13 , A61K38/17 , A61K39/395 , C07K16/28 , A61K45/06
CPC分类号： C07K16/2854 , A61K31/702 , A61K38/13 , A61K39/39541 , A61K45/06 , A61K2300/00
摘要： A combination therapy of administering to a patient at least one selectin inhibitor and at least one immunosuppressant is employed in methods for modulating the patient's immune response, and in treatment regimens for organ and tissue transplant rejections and various inflammatory disorders. In some embodiments, the selectin inhibitor is an antibody to L-selectin or P-selectin such as Dreg series of monoclonal antibody, or a functional fragment thereof, or SLe or a SLe derivative or mimetic, and the immunosuppressant is cyclosporin A.
摘要翻译：在患者的免疫应答调节方法以及器官和组织移植排斥和各种炎性疾病的治疗方案中使用对患者施用至少一种选择蛋白抑制剂和至少一种免疫抑制剂的组合疗法。在一些实施方案中，选择蛋白抑制剂是L-选择素或P-选择蛋白的抗体，例如单克隆抗体的Dreg系列或其功能片段，或SLe x或SLe x衍生物或模拟物，以及免疫抑制剂是环孢菌素A.

10. 发明申请

WO98033526A1 REMEDIES FOR CARDIOMYOPATHY 审中-公开
标题翻译：心脏病的补救措施
公开(公告)号：WO98033526A1
公开(公告)日：1998-08-06
申请号：PCT/JP1998/000426
申请日：1998-02-02
IPC分类号： C07K16/28 , A61K45/00 , A61K38/57 , A61K39/395
CPC分类号： C07K16/2854
摘要： Preventives/remedies for cardiomyopathy or myocarditis containing selecting inihibitors, e.g., preventives/remedies for cardiomyopathy or myocarditis containing antiselectin antibodies or sialyl Lewis X derivatives as the selectin inhibitor.
摘要翻译：含有选择抑制剂的心肌病或心肌炎的预防/治疗方法，例如用于选择素抑制剂的心肌病或心肌炎含有抗丝氨酸抗体或唾液酸路易斯X衍生物的预防药物/治疗药物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式