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1. 发明申请

WO2007024711A9 OSCILLATOR AND METHOD OF MAKING FOR ATOMIC FORCE MICROSCOPE AND OTHER APPLICATIONS 审中-公开
标题翻译：振荡器和原子力显微镜及其他应用的制造方法
公开(公告)号：WO2007024711A9
公开(公告)日：2007-11-22
申请号：PCT/US2006032386
申请日：2006-08-18
申请人： BEYDER ARTHUR , SACHS FREDERICK
发明人： BEYDER ARTHUR , SACHS FREDERICK
IPC分类号： G01Q10/00 , G01Q60/24 , G01Q60/38
CPC分类号： G01Q10/045 , G01Q60/38 , Y10T29/49 , Y10T29/49007 , Y10T74/10
摘要： A device having an oscillator such as a sensor for use in an atomic force microscope. A pair of co-axial members interconnect support structure and the oscillator for torsionally suspending the oscillator. The co-axial members are portions of a layer of silicon nitride or other material that is connected to the oscillator and support structure, which are composed of silicon or other material. A process for making a device which includes an oscillator, which includes depositing on silicon or other first material a layer of silicon nitride or other second material, forming in the first material a support structure and the oscillator, including applying an etchant which is selective for the first material to etch all the way through the first material and leave the second material substantially unetched to thereby form the at least one flexible hinge of the second material. A device such as a sensor for use in an atomic force microscope. The device comprises a first oscillator, a second oscillator, a pair of first co-axial members interconnecting the first and second oscillators for torsionally suspending the first oscillator, a support structure, and a pair of second co-axial members whose axis is orthogonal to an axis of the first co-axial members and which interconnect the second oscillator and the support structure for torsionally suspending the second oscillator.
摘要翻译：具有振荡器的装置，例如用于原子力显微镜的传感器。一对同轴部件将支撑结构和用于扭转悬挂振荡器的振荡器互连。同轴元件是连接到振荡器和支撑结构的氮化硅或其他材料层的部分，其由硅或其他材料构成。一种制造包括振荡器的器件的方法，该器件包括在硅或其它第一材料上沉积氮化硅或其它第二材料层，在第一材料中形成支撑结构和振荡器，包括施加选择性蚀刻剂所述第一材料一路蚀刻穿过所述第一材料并且使所述第二材料基本未被蚀刻从而形成所述第二材料的所述至少一个柔性铰链。用于原子力显微镜的装置，如传感器。该装置包括第一振荡器，第二振荡器，互连第一和第二振荡器用于扭转悬挂第一振荡器的一对第一同轴部件，支撑结构和一对第二同轴部件，其轴线正交于所述第一同轴部件的轴线并且将所述第二振荡器和所述支撑结构互连以用于扭转地悬挂所述第二振荡器。

2. 发明申请

WO2007024711A3 OSCILLATOR AND METHOD OF MAKING FOR ATOMIC FORCE MICROSCOPE AND OTHER APPLICATIONS 审中-公开
标题翻译：振荡器和原子力显微镜及其他应用的制作方法
公开(公告)号：WO2007024711A3
公开(公告)日：2009-04-23
申请号：PCT/US2006032386
申请日：2006-08-18
申请人： BEYDER ARTHUR , SACHS FREDERICK
发明人： BEYDER ARTHUR , SACHS FREDERICK
IPC分类号： G02B26/02 , G01Q10/00 , G01Q60/24 , G01Q60/38
CPC分类号： G01Q10/045 , G01Q60/38 , Y10T29/49 , Y10T29/49007 , Y10T74/10
摘要： A device having an oscillator such as a sensor for use in an atomic force microscope. A pair of co-axial members interconnect support structure and the oscillator for torsionally suspending the oscillator. The co-axial members are portions of a layer of silicon nitride or other material that is connected to the oscillator and support structure, which are composed of silicon or other material. A process for making a device which includes an oscillator, which includes depositing on silicon or other first material a layer of silicon nitride or other second material, forming in the first material a support structure and the oscillator, including applying an etchant which is selective for the first material to etch all the way through the first material and leave the second material substantially unetched to thereby form the at least one flexible hinge of the second material.
摘要翻译：具有诸如用于原子力显微镜的传感器的振荡器的装置。一对同轴构件互连支撑结构和振荡器，用于扭转振荡器的悬挂。共轴构件是连接到由硅或其它材料构成的振荡器和支撑结构的氮化硅或其它材料层的部分。一种制造包括振荡器的方法，该振荡器包括在硅或其它第一材料上沉积氮化硅或其它第二材料层，在第一材料中形成支撑结构和振荡器，包括施加选择性的蚀刻剂所述第一材料一直蚀刻通过所述第一材料并且使所述第二材料基本上未被蚀刻，从而形成所述第二材料的所述至少一个柔性铰链。

3. 发明申请

WO2008133882A9 FACTORY-ALIGNABLE COMPACT CANTILEVER PROBE 审中-公开
标题翻译：工厂可拆卸紧凑型悬臂探针
公开(公告)号：WO2008133882A9
公开(公告)日：2008-12-18
申请号：PCT/US2008005192
申请日：2008-04-23
申请人： SACHS FREDERICK
发明人： SACHS FREDERICK
IPC分类号： G01B5/28 , H01J37/26
CPC分类号： G01Q10/04 , G01Q20/02 , G01Q60/38
摘要： A scanner which includes a gradient index lens for passing and focusing beams from a radiation emitter to a cantilevered member reflective surface of a probe and from the reflective surface to a radiation detector. The lens also serves as a mechanical support for attachment of the radiation emitter and the radiation detector and is also attached to a support for the cantilevered member. The resulting fixed positions of the radiation emitter and the radiation detector relative to the reflective cantilevered member surface allows the scanner to be compact and factory focally alignable.
摘要翻译：一种包括梯度折射率透镜的扫描仪，用于使来自辐射发射器的光束通过并聚焦到探测器的悬臂构件反射表面并且从反射表面到辐射探测器。该透镜还用作用于连接辐射发射器和辐射检测器的机械支撑件，并且还附连到用于悬臂构件的支撑件。辐射发射器和辐射检测器相对于反射式悬臂构件表面的最终固定位置允许扫描器紧凑并且工厂局部对齐。

4. 发明申请

WO2005086784A2 METHOD AND APPARATUS FOR MEASURING CHANGES IN CELL VOLUME 审中-公开
标题翻译：用于测量细胞体积变化的方法和装置
公开(公告)号：WO2005086784A2
公开(公告)日：2005-09-22
申请号：PCT/US2005007461
申请日：2005-03-04
申请人： UNIV NEW YORK STATE RES FOUND , SACHS FREDERICK , HUA ZONGLU , BESCH STEPHEN , CHOPRA HARSH DEEP , AUERBACH ANTHONY , GOTTLIEB PHILIP , ATEYA DANIEL A
发明人： SACHS FREDERICK , HUA ZONGLU , BESCH STEPHEN , CHOPRA HARSH DEEP , AUERBACH ANTHONY , GOTTLIEB PHILIP , ATEYA DANIEL A
IPC分类号： C12Q1/00 , C12Q1/02 , G01N15/02 , G01N33/487 , G01N33/50 , G01N33/569
CPC分类号： G01N15/0266 , G01N33/5026 , G01N33/569
摘要： A method and apparatus for measuring changes in cell volume generally includes introducing cells into a chamber having a volume between 2 and 100 times the volume of the introduced cell. A first electrically conductive extracellular fluid is introduced into the chamber and a current is applied. The current flow is measured. The first fluid is exchanged with a second electrically conductive extracellular fluid and a current is applied. The current flow is measured. The first current flow result and the second current flow result are used in conjunction with known current flows to monitor changes in the volume corresponding to fluid flow between the cell and an extracellular fluid.
摘要翻译：用于测量细胞体积变化的方法和装置通常包括将细胞引入具有介入细胞的体积的2至100倍之间的体积的室中。将第一导电细胞外液引入腔室并施加电流。测量电流。将第一流体与第二导电细胞外液相互交换并施加电流。测量电流。第一电流流动结果和第二电流流动结果与已知电流一起使用以监测对应于细胞和细胞外液体之间的流体流动的体积变化。

5. 发明申请

WO2008151279A3 METHOD AND SYSTEM FOR SYNCHRONOUS RECTIFICATION 审中-公开
标题翻译：同步整流方法与系统
公开(公告)号：WO2008151279A3
公开(公告)日：2009-01-29
申请号：PCT/US2008065914
申请日：2008-06-05
申请人： UNIV NEW YORK STATE RES FOUND , BESCH STEPHEN , SACHS FREDERICK
发明人： BESCH STEPHEN , SACHS FREDERICK
IPC分类号： H02M3/155
CPC分类号： G01D3/036 , G01D18/002
摘要： The method and system of the present invention uses synchronous rectification and frequency domain analysis to remove the need for calibration of the A/D and D/A components. It is applicable to any sensor based measurement in which either the sensor can be excited with an AC voltage or current, or in which the signal can be modulated with an AC voltage or current.
摘要翻译：本发明的方法和系统使用同步整流和频域分析来消除对A / D和D / A组件校准的需要。它适用于任何基于传感器的测量，其中传感器可以用交流电压或电流激励，或者可以用交流电压或电流调制信号。

6. 发明申请

WO2006014493A3 MECHANICALLY ACTIVATED CHANNEL BLOCKER 审中-公开
标题翻译：机械激活的通道阻塞器
公开(公告)号：WO2006014493A3
公开(公告)日：2006-06-01
申请号：PCT/US2005023990
申请日：2005-07-07
申请人： YORK STOR THE RES FOUNDATION O , SACHS FREDERICK , SUCHYNA THOMAS , GOTTLIEB PHILLIP
发明人： SACHS FREDERICK , SUCHYNA THOMAS , GOTTLIEB PHILLIP
IPC分类号： C07K14/435 , A61K38/17 , A61P9/06
CPC分类号： C07K14/43518 , A61K38/00 , Y10S530/858
摘要： The present invention discloses a peptide of SEQ ID NO: 1 and its variants that blocks stretch-activated ion channels. All amino acids in this peptide are D-amino acids. The peptide, designated as D-GsMTx4, is an enantiomer of a peptide GsMTX-4 present in the venom of the spider Grammostola spatulata. The present invention also discloses a method for inhibition of stretch activated ion channels in a cell. This peptide can be used for the treatment of cardiac arrhythmias and other pathologies that involve alteartions in mechanical stress.
摘要翻译：本发明公开了SEQ ID NO：1的肽及其变体，其阻断拉伸活化的离子通道。该肽中的所有氨基酸都是D-氨基酸。称为D-GsMTx4的肽是存在于蜘蛛Grammostola spatulata的毒液中的肽GsMTX-4的对映异构体。本发明还公开了用于抑制细胞中的拉伸活化离子通道的方法。该肽可用于治疗心律失常和其他涉及机械应力改变的病理。

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