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1. 发明申请

WO1990001166A1 METHOD OF ASSAY 审中-公开
标题翻译：测定方法
公开(公告)号：WO1990001166A1
公开(公告)日：1990-02-08
申请号：PCT/GB1989000844
申请日：1989-07-25
申请人： ARES-SERONO RESEARCH & DEVELOPMENT LIMITED ... , ATTRIDGE, John, Worthington , SHANKS, Ian, Alexander
发明人： ARES-SERONO RESEARCH & DEVELOPMENT LIMITED ...
IPC分类号： G01N33/543
CPC分类号： G01N21/648 , G01N21/553 , G01N33/54373
摘要： The invention relates to an improved assay technique which provides an enhanced signal-to-noise ratio and enhances sensitivity. Also described are means for carrying out such assays.
摘要翻译：本发明涉及提供增强的信噪比并增强灵敏度的改进的测定技术。还描述了进行这种测定的方法。

2. 发明申请

WO1990006503A2 SENSOR FOR OPTICAL ASSAY 审中-公开
标题翻译：传感器进行光学测量
公开(公告)号：WO1990006503A2
公开(公告)日：1990-06-14
申请号：PCT/GB1989001420
申请日：1989-11-28
申请人： ARES-SERONO RESEARCH & DEVELOPMENT LIMITED ... , ATTRIDGE, John, Worthington
发明人： ARES-SERONO RESEARCH & DEVELOPMENT LIMITED ...
IPC分类号： G01N21/77
CPC分类号： G01N21/648 , G01N21/6428 , G01N21/7703 , G01N33/54373 , G01N2021/7786 , Y10S435/808 , Y10S436/805 , Y10S436/807
摘要： The invention relates to a device for use in optical methods of assay. The device comprises an optical structure comprising a dielectric substrate (2) and a thin film waveguide (5), between which is interposed a buffer layer (4). The waveguide carries a layer (10) of reagent suitable for a desired assay. The invention also relates to methods of using the device in an assay.
摘要翻译：本发明涉及用于光学测定方法的装置。该装置包括光电结构，该光学结构包括电介质基底（2）和薄膜波导（5），在该介质基片（2）和薄膜波导（5）之间插入有缓冲层（4）。波导载有适合于期望测定的试剂层（10）。本发明还涉及在测定中使用该装置的方法。

3. 发明申请

WO1990015985A1 METHOD OF OPTICAL ANALYSIS 审中-公开
标题翻译：光学分析方法
公开(公告)号：WO1990015985A1
公开(公告)日：1990-12-27
申请号：PCT/GB1990000953
申请日：1990-06-21
申请人： ARES-SERONO RESEARCH & DEVELOPMENT LIMITED ... , ATTRIDGE, John, Worthington
发明人： ARES-SERONO RESEARCH & DEVELOPMENT LIMITED ...
IPC分类号： G01N21/64
CPC分类号： G01N21/648 , G01N21/6428 , G01N2021/0346 , G01N2021/6465
摘要： The invention relates to a method of optical analysis which can advantageoulsy be used in conjunction with optical assay techniques, particularly those wherein evanescent signals are to be analysed. The method makes use of the properties of an optical structure (described herein) which allows easy angular discrimination of optical signals emerging from a test object. The invention also relates to apparatus for use in said method.

4. 发明申请

WO1990014590A1 DEVICES FOR USE IN CHEMICAL TEST PROCEDURES 审中-公开
标题翻译：用于化学测试程序的设备
公开(公告)号：WO1990014590A1
公开(公告)日：1990-11-29
申请号：PCT/GB1990000764
申请日：1990-05-17
申请人： ARES-SERONO RESEARCH & DEVELOPMENT LIMITED ... , ATTRIDGE, John, Worthington , SMITH, Alan, Martin
发明人： ARES-SERONO RESEARCH & DEVELOPMENT LIMITED ...
IPC分类号： G01N21/77
CPC分类号： G01N21/7703 , B01L3/5027 , B01L2300/0822 , B01L2300/168 , B01L2400/0406 , G01N21/6428 , G01N21/648 , G01N33/54373 , G01N2021/0346 , G01N2021/7733 , G01N2021/7786
摘要： The invention relates to a device for use in methods of assay, for example those involving fluorescent moieties. The device possesses a cavity or cavities into which sample liquid may be drawn by capillary action. Each cavity is formed from two transparent solid plates (35, 36): one (36) is adapted to act as a waveguide and carries a suitable immobilised reagent on its surface within the cavity; the other (35) carries on its external surface and optionally also on part only of its internal surface a layer of light-absorbing material (37). The invention also relates to a method of manufacturing devices according to the invention, and to a method of assaying for a ligand in a sample using a device according to the invention.

5. 发明申请

WO1989011655A1 METHOD OF ASSAY 审中-公开
标题翻译：测定方法
公开(公告)号：WO1989011655A1
公开(公告)日：1989-11-30
申请号：PCT/GB1989000568
申请日：1989-05-23
申请人： ARES-SERONO RESEARCH & DEVELOPMENT LIMITED ... , ALLEN, Gerald, John , DENYER, Madlyn, Delveda , ROBINSON, Grenville, Arthur
发明人： ARES-SERONO RESEARCH & DEVELOPMENT LIMITED ...
IPC分类号： G01N33/53
CPC分类号： G01N33/76 , G01N33/53 , G01N33/581 , G01N33/74 , G01N33/96 , G01N2333/5756 , Y10S435/975 , Y10S436/815 , Y10S436/817
摘要： The invention relates to a method of assaying for a ligand in a sample which incorporates a non-antigen calibrator. This provides particular advantages when the antigen which it is desired to assay is unstable in liquid form. The invention also relates to a kit for carrying out a method of assay according to the invention.

6. 发明申请

WO1989009408A1 METHOD OF ASSAY 审中-公开
标题翻译：测定方法
公开(公告)号：WO1989009408A1
公开(公告)日：1989-10-05
申请号：PCT/GB1989000320
申请日：1989-03-28
申请人： ARES-SERONO RESEARCH & DEVELOPMENT LIMITED ... , FLANAGAN, Michael, Thomas , ASHWORTH, Robert, Heddle
发明人： ARES-SERONO RESEARCH & DEVELOPMENT LIMITED ...
IPC分类号： G01N33/58
CPC分类号： G01N33/54373 , G01N33/582
摘要： Assay techniques are described which employ the evanescent field properties of optical waveguides combined with a resonance energy transfer step between fluorophores bound to reagents involved in the assay. Also described are a kit and a device for use in such assays.
摘要翻译：描述了测定技术，其采用与在测定中涉及的试剂结合的荧光团之间的共振能量转移步骤结合的光波导的消逝场特性。还描述了用于这种测定的试剂盒和装置。

7. 发明申请

WO1990011830A1 MULTIANALYTE TEST VEHICLE 审中-公开
标题翻译：多媒体测试车
公开(公告)号：WO1990011830A1
公开(公告)日：1990-10-18
申请号：PCT/GB1990000556
申请日：1990-04-11
申请人： ARES-SERONO RESEARCH & DEVELOPMENT LIMITED ... , EASON, Stephen, William , ATTRIDGE, John , DEGROOT, Simon
发明人： ARES-SERONO RESEARCH & DEVELOPMENT LIMITED ...
IPC分类号： B01L03/00
CPC分类号： B01L3/502 , B01L2400/0644 , Y10S436/809 , Y10T436/2575
摘要： The vehicle comprises a sample receiving reservoir (15), a plurality of test stations each comprising an FCFD or other capillary fill sensor cell (3), and means (22) for providing fluid communication between the reservoir and a conduit with which end portions of said cells communicated such that in use sample from the reservoir may be fed to the plurality of cells substantially simultaneously. The vehile makes it easier to know time zero for each assay. Means (22) providing fluid connection may comprise at least one pore in a wall of the reservoir, the or each pore being of a size such that surface tension of the liquid normally prevents escape of ligand. Rotation of the vehicle breaks surface tension and liquid is released into the conduit.
摘要翻译：车辆包括样品接收容器（15），多个测试站，每个测试站均包括FCFD或其它毛细管填充传感器单元（3），以及用于在储存器和导管之间提供流体连通的装置（22）所述细胞通信，使得在使用中，来自储存器的样品可以基本上同时进料到多个细胞。车辆使每个测定更容易知道零时间。提供流体连接的装置（22）可以包括储存器壁中的至少一个孔，或者每个孔的尺寸使得液体的表面张力通常防止配体的逸出。车辆的旋转破坏表面张力，液体被释放到管道中。

8. 发明申请

WO1988010418A1 WAVEGUIDE SENSOR 审中-公开
标题翻译：波导传感器
公开(公告)号：WO1988010418A1
公开(公告)日：1988-12-29
申请号：PCT/GB1988000471
申请日：1988-06-17
申请人： ARES-SERONO RESEARCH & DEVELOPMENT LIMITED ... , SAWYERS, Craig, George
发明人： ARES-SERONO RESEARCH & DEVELOPMENT LIMITED ...
IPC分类号： G01N21/75
CPC分类号： G01N21/7743 , G01N33/54373
摘要： This invention concerns assay techniques by which qualitative and/or quantitative detection of chemical, biochemical or biological species in a sample can be determined and also concerns sensors suitable for use in such techniques. In particular it relates to a method of assaying for a ligand in a sample which comprises a) incubating the sample in contact with the surface of an optical structure, said optical structure comprising a substrate with a first refractive index N1 and a surface layer with a second refractive index N2, said surface layer being such that, in use, a guided wave mode of resonant radiation may be propagated therein, and said surface layer having adsorbed thereon or bound thereto, either directly or indirectly, a specific binding partner for the ligand it is desired to detect; b) irradiating the optical structure at an angle or range of angles to the normal; c) analysing the reflected, transmitted and/or propagated radiation in order to determine whether, and if desired the extent to which and/or rate at which, the guided wave mode characteristics of the optical structure are altered by formation of a complex between the ligand and the specific binding partner.
摘要翻译：本发明涉及可以确定样品中化学，生物化学或生物物质的定性和/或定量检测的测定技术，并且还涉及适用于这种技术的传感器。特别涉及一种测定样品中配体的方法，该方法包括：a）将样品与光学结构的表面接触孵育，所述光学结构包括具有第一折射率N1的基底和具有第一折射率的表面层第二折射率N2，所述表面层使得在使用中可以在其中传播谐振辐射的导波模式，并且所述表面层直接或间接地吸附在其上或与其结合，用于配体的特异性结合配偶体需要检测; b）以与正常的角度或角度范围照射光学结构; c）分析反射的，透射的和/或传播的辐射，以便确定以及如果需要，光学结构的导波模式特性的变化程度和/或速率通过在配体和特异性结合配偶体。

9. 发明申请

WO1989009394A1 WAVEGUIDE SENSOR 审中-公开
标题翻译：波导传感器
公开(公告)号：WO1989009394A1
公开(公告)日：1989-10-05
申请号：PCT/GB1989000321
申请日：1989-03-28
申请人： ARES-SERONO RESEARCH & DEVELOPMENT LIMITED ... , FLANAGAN, Michael, Thomas , SLOPER, Andrew, Nigel
发明人： ARES-SERONO RESEARCH & DEVELOPMENT LIMITED ...
IPC分类号： G01N21/77
CPC分类号： G01N21/7703
摘要： Waveguides are described which possess at least one grating structure and at least one transduction region, and which are suitable for use in optical assay techniques. Also described are methods of assay employing such waveguides.

10. 发明申请

WO1988007203A1 POLYMER-COATED OPTICAL STRUCTURES 审中-公开
标题翻译：聚合物涂层光学结构
公开(公告)号：WO1988007203A1
公开(公告)日：1988-09-22
申请号：PCT/GB1988000177
申请日：1988-03-09
申请人： ARES-SERONO RESEARCH & DEVELOPMENT LIMITED ... , SAWYERS, Craig, George , DRAKE, Rosemary, Ann, Lucy
发明人： ARES-SERONO RESEARCH & DEVELOPMENT LIMITED ...
IPC分类号： G01N33/553
CPC分类号： G01N21/553 , G01N21/4788 , G01N33/531 , G01N33/54373 , G01N33/545 , G01N33/553 , Y10S436/805
摘要： A method of treating the surface of an optical structure which comprises forming on said surface a thin layer of a material which is capable of cross-polymerising on exposure to light and subsequently exposing said material to light whereby polymerisation occurs. Preferably the process includes the subsequent treatment of the polymer layer with a solution of a specific ligand. Complex formation between the bound ligand and its specific binding partner present in a sample to be analysed alters the optical properties of the diffraction grating surface and the change can form the basis of an assay method.

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