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    • 4. 发明申请
    • MEDICAL TUBING HAVING VARIABLE CHARACTERISTICS AND METHOD OF MAKING SAME
    • 具有可变特性的医疗管道及其制造方法
    • WO2005072806A2
    • 2005-08-11
    • PCT/US2005/001129
    • 2005-01-12
    • APPLIED MEDICAL RESOURCES CORPORATIONBRUSTAD, John, R.HILAL, Said, S.HILAL, NabilHART, Charles, C.JOHNSON, Gary, M.HILAL, SereneSAKAKINE, GhassanGADBERRY, Donald, L.PINGLETON, Edward, D.PETRIME, Matthew, N.ADLPARVAR, PayamHADLEY, Carl, B.VU, Kenneth, K.
    • BRUSTAD, John, R.HILAL, Said, S.HILAL, NabilHART, Charles, C.JOHNSON, Gary, M.HILAL, SereneSAKAKINE, GhassanGADBERRY, Donald, L.PINGLETON, Edward, D.PETRIME, Matthew, N.ADLPARVAR, PayamHADLEY, Carl, B.VU, Kenneth, K.
    • A61M25/00
    • A61M25/0012A61B1/0011A61B1/0055A61B17/3421A61B2017/003A61M25/0043
    • The invention primarily is directed to a medical tubing adapted for insertion into a body tissue or cavity and method of manufacturing different variations of the tubing along a length of the tubing. The tubing comprises a plurality of individual, discrete, generally ring-shaped elements arranged in series and fused or bonded together forming a continuous tubular structure. The ring-shaped elements may be formed of a thermoplastic or a thermoset material. The ring-shaped elements may include plastic rings, metallic rings, un-reinforced plastic rings and/or metal reinforced plastic rings assembled along the length of the tubular structure to provide variable flexibility and kink-resistance. The tubular structure may have a cross-section of any geometric shape and it may be bent, twisted or curved without kinking. The ring-shaped elements may have different flexural modulus. The ring-shaped elements may include a combination of flexible and rigid ring-shaped elements assembled along different portions or sections of the tubular structure. The ring-shaped elements may be metallic and may be bonded with a resilient, flexible elastomeric adhesive, wherein the ring-shaped elements may have different lengths and may be fused closer or further apart to one another depending on the characteristics of a portion or section of the tubing. In another aspect of the invention, the medical tubing may further comprise a secondary lumen and a pull wire to control the tubular structure. The ring-shaped elements may be truncated to provide a bending bias. In another aspect of the invention, the ring-shaped elements may vary in diameter and/or composition in different portions or sections of the tubular structure. In yet another aspect of the invention, some of the ring-shaped elements may be radiopaque, or the ring-shaped elements may comprise of different colors to operate as indicators along the tubular structure.
    • 本发明主要针对适于插入身体组织或空腔的医用管道以及沿管道长度制造管道的不同变化的方法。 管道包括多个独立的,分立的,大致环形的元件,其串联布置并且熔合或粘合在一起,形成连续的管状结构。 环形元件可以由热塑性材料或热固性材料形成。 环形元件可以包括沿着管状结构的长度组装的塑料环,金属环,未增强塑料环和/或金属增强塑料环,以提供可变的柔性和抗扭结性。 管状结构可以具有任何几何形状的横截面,并且其可以弯曲,扭曲或弯曲而没有扭结。 环形元件可以具有不同的弯曲模量。 环形元件可以包括沿着管状结构的不同部分或部分组装的柔性和刚性环形元件的组合。 环形元件可以是金属的并且可以用弹性的柔性弹性体粘合剂粘合,其中环形元件可以具有不同的长度,并且可以根据部分或部分的特性彼此靠近或更远地彼此熔合 的管道。 在本发明的另一方面,医疗管道还可包括用于控制管状结构的次管腔和拉线。 环形元件可以被截断以提供弯曲偏压。 在本发明的另一方面,环形元件可以在管状结构的不同部分或部分中的直径和/或组成变化。 在本发明的另一方面,一些环形元件可以是不透射线的,或者环形元件可以包括不同的颜色以作为沿着管状结构的指示器。
    • 9. 发明申请
    • SURFACE TREATMENTS AND MODIFICATIONS USING NANOSTRUCTURE MATERIALS
    • 表面处理和使用纳米结构材料的改性
    • WO2005042646A2
    • 2005-05-12
    • PCT/US2004/036166
    • 2004-10-29
    • APPLIED MEDICAL RESOURCES CORPORATIONBRUSTAD, John, R.HILAL, NabilJOHNSON, Gary, M.HART, Charles, C.
    • BRUSTAD, John, R.HILAL, NabilJOHNSON, Gary, M.HART, Charles, C.
    • C09D
    • A61B17/064A61B17/02A61B17/06166A61B17/122A61B2017/00345A61B2017/00858A61F2002/0086A61L27/30A61L31/082A61L2400/12A61L2400/18
    • The invention is directed to nanostructure surface treatments, coatings or modifications formed from nanoscale building blocks. The nanostructure surface treatments, modifications or coatings have hydrophobic, hydrophilic and surface adherence properties. The nanoscale building blocks Nave orientation, geometry, packing density and composition that may be adjusted to control the unique surface characteristics of the desired treatment, coating or modification. Applications of this nanostructure technology include surgical clips, staples, retractors, sutures and manipulators where an improvement in traction, retention or occlusion is desired without excessive material or tissue deformation or where high compressive forces would be undesirable, dangerous or ineffective. In one aspect, a nanostructure surface treatment for a medical device having an external surface is disclosed wherein the treatment is applied on the external surface to provide a hydrophobic or a hydrophilic surface. With this aspect, the treatment comprises titanium dioxide and provides nanoscopic structures having nearly vertical sidewalls. The treated surface of the device has contact angles greater than or equal to 150 degrees. The vertical sidewalls provide a negative capillary effect and Nave a width of about 200 nm. The vertical sidewalls attach to a wet surface by the negative capillary effect. The van der Waals forces of the vertical sidewalls enable the treated surface to attach to a dry surface. The treatment may be vapor deposited and cured on the device, or the treatment may be laser blasted on the device.
    • 本发明涉及纳米结构表面处理,由纳米级构建块形成的涂层或改性。 纳米结构表面处理,改性或涂层具有疏水性,亲水性和表面附着性。 纳米尺度构件可以调节以调节所需处理,涂层或改性的独特表面特性,以确定方向,几何形状,包装密度和组成。 该纳米结构技术的应用包括手术夹,钉,牵开器,缝合线和操纵器,其中希望改善牵引力,保持力或闭塞,而不会产生过多的材料或组织变形,或者高压缩力是不希望的,危险的或无效的。 一方面,公开了一种具有外表面的医疗装置的纳米结构表面处理,其中将处理施加在外表面上以提供疏水或亲水表面。 在这方面,处理包括二氧化钛并提供具有近似垂直侧壁的纳米结构。 该设备的被处理表面具有大于或等于150度的接触角。 垂直侧壁提供负毛细管效应,并具有约200nm的宽度。 垂直侧壁通过负毛细管效应附着在潮湿的表面上。 垂直侧壁的范德华力使得经处理的表面附着在干燥的表面上。 处理可以在装置上气相沉积和固化,或者可以在装置上激光喷射处理。