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1. 发明申请

WO2006031366A3 FULL SEQUENCE METAL AND BARRIER LAYER ELECTROCHEMICAL MECHANICAL PROCESSING 审中-公开
标题翻译：全序列金属和障碍层电化学机械加工
公开(公告)号：WO2006031366A3
公开(公告)日：2006-06-29
申请号：PCT/US2005029357
申请日：2005-08-18
申请人： APPLIED MATERIALS INC , MAO DAXIN , JIA RENHE , WANG ZHIHONG , TIAN YUAN , LIU FENG Q , GALBURT VLADIMIR , KO SEN HOU , TSAI STAN D , CHEN LIANG-YUH , HU YONGQI
发明人： MAO DAXIN , JIA RENHE , WANG ZHIHONG , TIAN YUAN , LIU FENG Q , GALBURT VLADIMIR , KO SEN HOU , TSAI STAN D , CHEN LIANG-YUH , HU YONGQI
IPC分类号： B23H5/06 , B23H5/08 , B24B37/04 , H01L21/321 , H01L21/768
CPC分类号： H01L21/7684 , B23H5/06 , B23H5/08 , H01L21/32125
摘要： A method for electrochemically processing metal and barrier materials is provided. In one embodiment, a method for electrochemically processing a substrate includes the steps of establishing an electrically-conductive path through an electrolyte between an exposed layer of barrier material on the substrate and an electrode, pressing the substrate against a processing pad assembly with a force less than about 2 psi, providing motion between the substrate and pad assembly in contact therewith and electrochemically removing a portion of the exposed layer during a first electrochemical processing step in a barrier processing station.
摘要翻译：提供了一种用于电化学处理金属和阻隔材料的方法。在一个实施例中，一种用于电化学处理衬底的方法包括以下步骤：在衬底上的暴露的阻挡材料层与电极之间建立通过电解质的导电路径，将衬底压在处理垫组件上，在约2psi之间提供与衬底和衬垫组件接触的运动，并在屏障处理站中的第一电化学处理步骤期间电化学去除暴露层的一部分。

2. 发明申请

WO2006081589A3 TUNGSTEN ELECTROPROCESSING 审中-公开
标题翻译：钨电镀
公开(公告)号：WO2006081589A3
公开(公告)日：2006-11-23
申请号：PCT/US2006004873
申请日：2006-01-27
申请人： APPLIED MATERIALS INC , JIA RENHE , WANG ZHIHONG , TIAN YUAN , TRAN HUYEN KAREN , MAO DAXIN , TSAI STAN D , KARUPPIAH LAKSH , CHEN LIANG-YUH
发明人： JIA RENHE , WANG ZHIHONG , TIAN YUAN , TRAN HUYEN KAREN , MAO DAXIN , TSAI STAN D , KARUPPIAH LAKSH , CHEN LIANG-YUH
IPC分类号： B24B37/04
CPC分类号： B23H5/08 , B24B37/042 , C25F3/08
摘要： Methods for polishing tungsten are provided. During ECMP, increasing the voltage to the pad is not always enough to increase the polishing rate. When polishing tungsten, simply increasing the applied voltage will, in some cases, actually decrease the removal rate. By increasing the down force pressure between the polishing pad and the substrate, the applied voltage, and the rotation speed of the substrate and the polishing pad, the tungsten removal rate will also increase.
摘要翻译：提供了抛光钨的方法。在ECMP期间，增加到焊盘的电压并不总是足以提高抛光速率。抛光钨时，仅仅增加施加的电压在某些情况下会实际降低去除速率。通过增加抛光垫与基底之间的向下的压力，施加的电压以及基底和抛光垫的旋转速度，钨的移除速率也将增加。

3. 发明申请

WO2007121180A3 BIOSENSOR MEMBRANE MATERIAL 审中-公开
标题翻译：生物传感器膜材料
公开(公告)号：WO2007121180A3
公开(公告)日：2008-10-30
申请号：PCT/US2007066332
申请日：2007-04-10
申请人： ISENSE CORP , WARD ROBERT S , TIAN YUAN , WARD WILLIAM KENNETH , ANDERSON ELLEN M , HOUSE JODY
发明人： WARD ROBERT S , TIAN YUAN , WARD WILLIAM KENNETH , ANDERSON ELLEN M , HOUSE JODY
IPC分类号： C08G77/42 , C08F283/02 , C08G77/448
CPC分类号： C08G64/18 , C08G77/448 , C08G77/458
摘要： Embodiments of the present invention provide various multipolymers and permselective membranes for use with biosensors and other implantable medical devices and prostheses. Embodiments of the present invention may provide structural strength and integrity, and further may control the influx of glucose, oxygen and/or water. Embodiments of the present invention may, for example, minimize or reduce the influx of glucose by minimizing the percentage of hydrophilic segments, which in turn minimizes the percentage of water uptake and the degree of glucose transport.
摘要翻译：本发明的实施方案提供了用于生物传感器和其它可植入医疗装置和假体的各种多聚体和选择渗透膜。本发明的实施方案可以提供结构强度和完整性，并且还可以控制葡萄糖，氧气和/或水的流入。例如，本发明的实施方案可以通过使亲水链段的百分比最小化来最小化或减少葡萄糖的流入，从而使吸水的百分比和葡萄糖转运的程度最小化。

4. 发明申请

WO2010041122A3 METHOD OF USING ACKNOWLEDGMENT TONES FOR DATA CONSISTENCY IN INTRA-VEHICULAR WIRELESS NETWORKS 审中-公开
标题翻译：在车内无线网络中使用确认音调数据一致性的方法
公开(公告)号：WO2010041122A3
公开(公告)日：2010-06-10
申请号：PCT/IB2009007058
申请日：2009-10-06
申请人： BOSCH GMBH ROBERT , HOGENMUELLER THOMAS ALFONS , JAIN VIVEK , VENKATRAMAN LAKSHMI , KESHAVARZIAN ABTIN , CHINTALAPUDI KRISHNA , TOZLU SERBULENT , TIAN YUAN
发明人： HOGENMUELLER THOMAS ALFONS , JAIN VIVEK , VENKATRAMAN LAKSHMI , KESHAVARZIAN ABTIN , CHINTALAPUDI KRISHNA , TOZLU SERBULENT , TIAN YUAN
IPC分类号： H04L1/16
CPC分类号： H04L1/1692 , H04L2001/0097
摘要： A method for providing electronic communications between wireless nodes includes wirelessly transmitting data from a transmitting one of the nodes to a plurality of receiving ones of the nodes. A respective first acknowledgment tone is wirelessly transmitted from each of the receiving nodes to the transmitting node and to each other one of the receiving nodes. Each first acknowledgment tone is transmitted in response to the respective receiving node receiving the transmitted data. Each of the first acknowledgment tones is transmitted in a respective, unique time slot. At least one second acknowledgment tone is wirelessly transmitted from at least one of the nodes to each other one of the nodes. The second acknowledgment tone is transmitted dependent upon whether a group of received first acknowledgment tones matches a group of expected-to-be-received first acknowledgment tones.
摘要翻译：一种用于提供无线节点之间的电子通信的方法包括：将数据从节点中的发送节点无线发送到节点中的多个接收节点。相应的第一确认音调从每个接收节点无线地发送到发送节点和每个接收节点中的每个接收节点。响应于各个接收节点接收发送的数据来发送每个第一确认音。每个第一确认音调在相应的唯一时隙中传输。至少一个第二确认音调从节点中的至少一个无线地发送到节点中的彼此之一。根据接收到的第一确认音的组是否与一组期望接收的第一确认音相匹配来发送第二确认音。

5. 发明申请

WO2009073401A4 SILICONE HYDROGELS FOR TISSUE ADHESIVES AND TISSUE DRESSING APPLICATIONS 审中-公开
标题翻译：有机硅水凝胶用于组织粘合剂和组织敷料应用
公开(公告)号：WO2009073401A4
公开(公告)日：2009-12-03
申请号：PCT/US2008084306
申请日：2008-11-21
申请人： DSM IP ASSETS BV , MCCREA KEITH , WARD ROBERT S , TIAN YUAN
发明人： MCCREA KEITH , WARD ROBERT S , TIAN YUAN
IPC分类号： A61L26/00
CPC分类号： A61L15/60 , A61L15/225 , A61L15/26 , A61L26/0019 , A61L26/0076 , A61L26/008 , C08L83/04
摘要： A silicone hydrogel formulation may contains random and/or block copolymers or oligomers or macromers. The silicone copolymer is copolymerized or blended with other polymers or monomers or macromers to obtain final formulation. The silicone hydrogel may contain crosslinking groups to provide a complete or partially crosslinked final structure. The silicone hydrogel formulation may be pre-formed as a film or other structure, or it may be polymerized during application as in the case of an adhesive formulation. A wound dressing comprising a silicone hydrogel formed as a film, either prior to application to a wound or in situ on a wound, which film has gas permeability, moisture permeability, and high water content, wherein said silicone hydrogel is formed from a polymerizable silicone such as a difunctional polydimethylsiloxane methacrylate and crosslinking agents such as N,N-dimethylacrylamide (DMA), 2-hydroxyethyl methacrylate (HEMA), and trimethylsiloxy silane (TRIS).
摘要翻译：硅酮水凝胶制剂可含有无规和/或嵌段共聚物或低聚物或大分子单体。硅氧烷共聚物与其他聚合物或单体或大分子单体共聚或共混以获得最终配方。硅酮水凝胶可以含有交联基团以提供完全或部分交联的最终结构。硅酮水凝胶制剂可以预先形成为膜或其他结构，或者可以在施用期间如在粘合剂制剂的情况下那样聚合。 1.一种创伤敷料，其包含作为膜形成的硅酮水凝胶，所述硅酮水凝胶在应用于伤口之前或原位置于伤口上，所述膜具有气体渗透性，透湿性和高含水量，其中所述硅酮水凝胶由可聚合硅酮如双官能聚二甲基硅氧烷甲基丙烯酸酯和交联剂如N，N-二甲基丙烯酰胺（DMA），甲基丙烯酸2-羟乙酯（HEMA）和三甲基甲硅烷氧基硅烷（TRIS）。

6. 发明申请

WO2012129408A3 BIOMARKERS FOR AGGRESSIVE PROSTATE CANCER 审中-公开
标题翻译：生物标志物用于肿瘤前列腺癌
公开(公告)号：WO2012129408A3
公开(公告)日：2013-01-31
申请号：PCT/US2012030129
申请日：2012-03-22
申请人： UNIV JOHNS HOPKINS , ZHANG HUI , TIAN YUAN , CHAN DANIEL W , CHEN JING
发明人： ZHANG HUI , TIAN YUAN , CHAN DANIEL W , CHEN JING
IPC分类号： G01N33/53 , G01N33/574 , G01N33/68
CPC分类号： G01N33/6893 , G01N33/57434
摘要： The present invention relates to the field of biomarkers and, more specifically, to biomarkers useful in diagnosing aggressive prostate cancer. In specific embodiments, a method for diagnosing aggressive prostate cancer in a patient comprises (a) measuring the levels of one or more biomarkers in a sample collected from the patient; and (b) comparing the levels of the one or more biomarkers with predefined levels of the same biomarkers that correlate to a patient having aggressive prostate cancer and predefined levels of the same biomarkers that correlate to a patient not having aggressive prostate cancer, wherein a correlation to one of the predefined levels provides the diagnosis. In a specific embodiment, the one or more biomarkers may comprise cathepsin-L (CTSL), periostin, microfibrillar-associated protein 4 (MFAP4), collagen XII, neprilysin, clusterin, neutrophil gelatinase associated lipocalin (NGAL), epithelial cell activating molecule (EpCAM), prostate specific antigen (PSA), membrane metallo-endopeptidase (MME) and asporin (ASPN).
摘要翻译：本发明涉及生物标记领域，更具体地涉及可用于诊断侵略性前列腺癌的生物标志物。在具体实施方案中，用于诊断患者中侵袭性前列腺癌的方法包括（a）测量从患者收集的样品中的一种或多种生物标志物的水平; 和（b）将一种或多种生物标志物的水平与与具有侵袭性前列腺癌的患者相关的相同生物标志物的预定水平和与不具有侵袭性前列腺癌的患者相关的相同生物标志物的预定水平进行比较，其中相关性到其中一个预定义的级别提供诊断。在一个具体的实施方案中，一种或多种生物标志物可以包含组织蛋白酶-L（CTSL），骨膜素，微原纤维相关蛋白4（MFAP4），胶原XII，起泡蛋白，聚集蛋白，嗜中性粒细胞明胶酶相关脂质运载蛋白（NGAL），上皮细胞活化分子 EpCAM），前列腺特异性抗原（PSA），膜金属内肽酶（MME）和阿泊菌（ASPN）。

7. 发明申请

WO2007142683A3 SELF-ASSEMBLING MONOMERS AND OLIGOMERS AS SURFACE-MODIFYING ENDGROUPS FOR POLYMERS 审中-公开
标题翻译：自组装单体和低聚物作为表面修饰聚合物的终端
公开(公告)号：WO2007142683A3
公开(公告)日：2008-10-30
申请号：PCT/US2006046586
申请日：2006-12-07
申请人： POLYMER TECHNOLOGY GROUP INC , WARD ROBERT S , MCCREA KEITH R , TIAN YUAN , PARAKKA JAMES P , WANG SHANGER
发明人： WARD ROBERT S , MCCREA KEITH R , TIAN YUAN , PARAKKA JAMES P , WANG SHANGER
IPC分类号： A61K47/00
CPC分类号： A61K31/785 , C08G18/0895 , C08G18/2875 , C08G18/288 , C08G18/44 , C08G18/6266
摘要： Polymers having the formula R(LE) x wherein R is a polymeric core having a number average molecular weight of from 5000 to 7,000,000 daltons and having x endgroups, E is an endgroup covalently linked to polymeric core R by linkage L, L is a divalent oligomeric chain, having at least 5 identical repeat units, capable of self-assembly with L chains on adjacent molecules of the polymer, and the moieties (LE) x in the polymer may be the same as or different from one another. Design of monomers, oligomers, or other reactive structures otherwise analogous to known Self Assembled Monolayers but with at least one reactive chemical group capable of binding them to the terminus of a polymer, so that the thiol-free SAM analogue becomes the self-assembling surface modifying endgroup of that polymer. Use of the polymer to fabricate a configured article from the surface-modified polymer or a coating or topical treatment on an article made from another material.
摘要翻译：具有式R（LE）x X的聚合物其中R是数均分子量为5000-7,000,000道尔顿并具有x个端基的聚合物芯，E是通过共价键与聚合物芯R共价连接的端基连接L，L是具有至少5个相同重复单元的二价低聚链，其能够与聚合物的相邻分子上的L链自组装，并且聚合物中的部分（LE）x < 可以彼此相同或不同。单体，低聚物或其它类似于已知的自组装单层的单体，低聚物或其它反应性结构的设计，但具有至少一个能够将它们结合到聚合物末端的反应性化学基团，使得无硫醇的SAM类似物变成自组装表面修饰该聚合物的端基。使用聚合物从表面改性的聚合物制造配置的制品，或者对由另一种材料制成的制品进行包衣或局部处理。

8. 发明申请

WO2006102050A2 PROCESS FOR THE PRODUCTION OF MONODISPERSE AND NARROW DISPERSE MONOFUNCTIONAL SILICONES 审中-公开
标题翻译：单分散和单分散单功能硅生产工艺
公开(公告)号：WO2006102050A2
公开(公告)日：2006-09-28
申请号：PCT/US2006009666
申请日：2006-03-16
申请人： JOHNSON & JOHNSON VISION CARE , PARAKKA JAMES P , TIAN YUAN , WARD ROBERT S , WANG SHANGER , MAHADEVAN SHIVKUMAR , MOLOCK FRANK
发明人： PARAKKA JAMES P , TIAN YUAN , WARD ROBERT S , WANG SHANGER , MAHADEVAN SHIVKUMAR , MOLOCK FRANK
CPC分类号： C08G77/045 , C07F7/0874 , C08G77/06 , C08G77/08 , C08G77/20 , C08G77/36 , C08G77/38 , G02B1/043 , C08L83/06
摘要： Synthesis and purification of mono and narrow disperse monofunctional polydimethylsiloxane methacrylate derivatives with different molecular weights are disclosed.
摘要翻译：公开了具有不同分子量的单分散和单分散单官能聚二甲基硅氧烷甲基丙烯酸酯衍生物的合成和纯化。

9. 发明申请

WO2016004807A3 PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA 审中-公开
标题翻译：人类磷脂酰肌醇三激酶三磷酸抑制剂
公开(公告)号：WO2016004807A3
公开(公告)日：2016-02-18
申请号：PCT/CN2015081059
申请日：2015-06-09
申请人： MERCK SHARP & DOHME , MCGOWAN MEREDETH ANN , FONG KIN CHIU , ANTHONY NEVILLE JOHN , ZHOU HUA , KATZ JASON D , YANG LIHU , LI CHAOMIN , TIAN YUAN , MU CHANGWEI , YE BAIJUN , SHI FENG , ZHAO XIAOLI , FU JIANMIN , LI YABIN
发明人： MCGOWAN MEREDETH ANN , FONG KIN CHIU , ANTHONY NEVILLE JOHN , ZHOU HUA , KATZ JASON D , YANG LIHU , LI CHAOMIN , TIAN YUAN , MU CHANGWEI , YE BAIJUN , SHI FENG , ZHAO XIAOLI , FU JIANMIN , LI YABIN
IPC分类号： C07D473/34 , A61K31/52 , A61P11/00 , A61P19/02 , A61P35/00 , A61P37/00 , C07D473/30
CPC分类号： C07D519/00 , A61K31/52 , C07D473/30 , C07D473/34
摘要： The instant invention provides compounds of formula (I) which are PI3K-delta inhibitors, and as such are useful for the treatment of PI3K-delta-mediated diseases such as inflammation, asthma, COPD and cancer.
摘要翻译：本发明提供了作为PI3K-δ抑制剂的式（I）化合物，因此可用于治疗PI3K-δ介导的疾病如炎症，哮喘，COPD和癌症。

10. 发明申请

WO2010147779A3 PHOSPHORYLCHOLINE-BASED AMPHIPHILIC SILICONES FOR MEDICAL APPLICATIONS 审中-公开
标题翻译：用于医疗应用的基于磷酰胆碱的AMPHIPILILIC硅
公开(公告)号：WO2010147779A3
公开(公告)日：2011-02-17
申请号：PCT/US2010037576
申请日：2010-06-07
申请人： DSM IP ASSETS BV , PARAKKA JAMES , IYER ANANTH V , WANG ANFENG , JIANG XUWEI , TIAN YUAN , WARD ROBERT
发明人： PARAKKA JAMES , IYER ANANTH V , WANG ANFENG , JIANG XUWEI , TIAN YUAN , WARD ROBERT
IPC分类号： C08G77/395 , A61L15/26 , A61L31/06 , C08F230/08 , C08L83/08 , C08L83/10 , G02B1/04
CPC分类号： C08G77/395 , A61F13/00017 , A61L15/26 , A61L26/0019 , A61L27/18 , A61L27/34 , A61L31/06 , A61L31/10 , C07F9/091 , C07F9/092 , C07F9/65742 , C07F9/65746 , C08F230/02 , C08F230/08 , C08L83/08 , C08L83/10 , G02B1/043 , C08L83/04
摘要： Amphiphilic biomimetic phosphorylcholine-containing silicone compounds for use in both topical and internal applications as components in biomedical devices. The silicone compounds, which include zwitterionic phosphorylcholine groups, may be polymerizable or non-polymerizable. Specific examples of applications include use as active functional components in ophthalmic lenses, ophthalmic lens care solutions, liquid bandages, wound dressings, and lubricious and anti-thrombogenic coatings.
摘要翻译：用于局部和内部应用的两亲仿生磷酰胆碱的硅氧烷化合物作为生物医学装置的组件。包含两性离子磷酰胆碱基团的硅氧烷化合物可以是可聚合的或不可聚合的。应用的具体实例包括用作眼科镜片中的活性功能组分，眼用晶状体护理溶液，液体绷带，伤口敷料以及润滑和抗血栓形成的涂层。

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