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1. 发明申请

WO2020060087A1 HIGHLY EFFICIENT ANTI-TFPI ANTIBODY COMPOSITION 审中-公开
公开(公告)号：WO2020060087A1
公开(公告)日：2020-03-26
申请号：PCT/KR2019/011582
申请日：2019-09-06
申请人： GREEN CROSS CORPORATION
发明人： KIM, Min Jung , YEO, Geun Hye , SONG, Haeng Eun , PARK, Ji Yoon , KIM, Yuna
IPC分类号： C07K16/38 , C07K1/16 , C07K1/22 , C07K1/34 , C07K1/36 , A61P7/02
摘要： The present disclosure relates to a pharmaceutical highly efficient anti-TFPI antibody composition including an anti-TFPI antibody for treating hemophilia, in which the content of HCP in a drug substance is less than 10.0 ng/mg, and the content of LPA in the drug substance or the drug product is less than 1.0 ng/mg. According to the present disclosure, a highly efficient anti-TFPI antibody composition having very low contents of HCP and LPA may be provided by providing a separation/purification process capable of minimizing anti-TFPI antibody polymer generation, and may be effectively used for the treatment of antibody-induced hemophilia patients and for the prevention of blood coagulation disease.

2. 发明申请

WO2012165914A2 NOVEL DIPHENYLMETHANE DERIVATIVES AS SGLT2 INHIBITORS 审中-公开
标题翻译：新型二苯甲基衍生物作为SGLT2抑制剂
公开(公告)号：WO2012165914A2
公开(公告)日：2012-12-06
申请号：PCT/KR2012/004366
申请日：2012-06-01
申请人： GREEN CROSS CORPORATION , CHOI, Soongyu , SONG, Kwang-Seop , LEE, Suk Ho , KIM, Min Ju , SEO, Hee Jeong , PARK, Eun-Jung , KONG, Younggyu , PARK, So Ok , KANG, Hyunku , JUNG, Myung Eun , LEE, Kinam , KIM, Hyun Jung , LEE, Jun Sung , LEE, Min Woo , KIM, Mi-Soon , HONG, Dong Ho , KANG, Misuk
发明人： CHOI, Soongyu , SONG, Kwang-Seop , LEE, Suk Ho , KIM, Min Ju , SEO, Hee Jeong , PARK, Eun-Jung , KONG, Younggyu , PARK, So Ok , KANG, Hyunku , JUNG, Myung Eun , LEE, Kinam , KIM, Hyun Jung , LEE, Jun Sung , LEE, Min Woo , KIM, Mi-Soon , HONG, Dong Ho , KANG, Misuk
IPC分类号： A61K31/357 , A61K31/343 , A61K31/35 , A61K31/015 , A61P3/00
CPC分类号： C07D309/10 , C07D405/10 , C07D405/14 , C07D407/04 , C07D407/10 , C07D407/14 , C07D409/04 , C07D409/10 , C07D409/14 , C07D411/10 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14
摘要： The present invention relates to a compound with a diphenylmethane moiety having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney, and a pharmaceutical composition comprising the same as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly diabetes. The present invention also provides a method for preparing the compound, and a method for preventing or treating metabolic disorders, particularly diabetes, by using the compound.
摘要翻译：本发明涉及具有对存在于肠和肾中的钠依赖性葡萄糖协同转运蛋白2（SGLT2）具有抑制活性的二苯基甲烷部分的化合物和包含其作为活性成分的药物组合物，其可用于预防或治疗代谢紊乱，特别是糖尿病。本发明还提供了一种制备该化合物的方法，以及通过使用该化合物来预防或治疗代谢紊乱，特别是糖尿病的方法。

3. 发明申请

WO2010147430A3 NOVEL C-ARYL GLUCOSIDE SGLT2 INHIBITORS AND PHARMACEUTICAL COMPOSITION COMPRISING SAME 审中-公开
公开(公告)号：WO2010147430A3
公开(公告)日：2010-12-23
申请号：PCT/KR2010/003958
申请日：2010-06-18
申请人： GREEN CROSS CORPORATION , LEE, Jinhwa , LEE, Suk Ho , SEO, Hee Jeong , KIM, Min Ju , KANG, Suk Youn , KIM, Jeongmin , LEE, Sung-Han , JUNG, Myung Eun , SON, Eun Jung , LEE, Junwon , SONG, Kwang-Seop , KIM, Mi-Soon
发明人： LEE, Jinhwa , LEE, Suk Ho , SEO, Hee Jeong , KIM, Min Ju , KANG, Suk Youn , KIM, Jeongmin , LEE, Sung-Han , JUNG, Myung Eun , SON, Eun Jung , LEE, Junwon , SONG, Kwang-Seop , KIM, Mi-Soon
IPC分类号： C07D417/10 , C07D417/14 , C07D405/10 , A61P3/10 , A61K31/433
摘要： A novel C-aryl glucoside compound, or a pharmaceutically acceptable salt or a prodrug thereof having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney; and a pharmaceutical composition comprising the same as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly, diabetes, are provided.

4. 发明申请

WO1998006822A1 CULTURE MEDIUM AND USE OF THE SAME 审中-公开
标题翻译：文化中介及其使用
公开(公告)号：WO1998006822A1
公开(公告)日：1998-02-19
申请号：PCT/JP1997002749
申请日：1997-08-06
申请人： THE GREEN CROSS CORPORATION , AMATSUJI, Yasuo , TAMASHIMA, Hiroshi , KOBAYASHI, Kaoru , OHMURA, Takao
发明人： THE GREEN CROSS CORPORATION
IPC分类号： C12N05/02
CPC分类号： C12N5/0037 , C12N2500/25 , C12N2500/84
摘要： A culture medium containing human serum albumin obtained by genetic manipulations (rHSA); a method for culturing animal cells characterized by culturing the cells in the above-mentioned medium; and a process for producing a physiologically active substance characterized by culturing animal cells capable of producing the physiologically active substance in the above-mentioned medium and taking up the produced physiologically active substance from the culture. The use of rHSA with uniform qualities makes it possible to achieve the proliferation of the cells and the productivity of the physiologically active substance each comparable to those achieved by using a serum-containing medium and/or a conventional serum-free medium containing HSA originating in plasma while stabilizing the medium qualities and ensuring the reproducibility of the culture.
摘要翻译：通过遗传操作（rHSA）获得含有人血清白蛋白的培养基; 用于培养以上述培养基培养细胞为特征的动物细胞的方法; 以及生产生物活性物质的方法，其特征在于培养能够在上述培养基中生产生理活性物质的动物细胞，并从培养物中吸收生成的生理活性物质。使用具有均匀质量的rHSA使得可以实现细胞的增殖和生理活性物质的生产力，其与通过使用含有血清的培养基和/或含有HSA的常规无血清培养基（其源自于同时稳定培养基质量并确保培养物的再现性。

5. 发明申请

WO1998000521A1 SERUM-FREE MEDIA, METHOD FOR CULTURING ANIMAL CELLS, AND PROCESS FOR PRODUCING PHYSIOLOGICALLY ACTIVE SUBSTANCES 审中-公开
标题翻译：无血清培养基，培养动物细胞的方法和生产生理活性物质的方法
公开(公告)号：WO1998000521A1
公开(公告)日：1998-01-08
申请号：PCT/JP1997002167
申请日：1997-06-23
申请人： THE GREEN CROSS CORPORATION , AMATSUJI, Yasuo , TAMASHIMA, Hiroshi , UEMURA, Yahiro
发明人： THE GREEN CROSS CORPORATION
IPC分类号： C12N05/00
CPC分类号： C12N5/0037
摘要： Serum-free media characterized by containing insulin and peptone but being substantially free from albumin and transferrin; a method for culturing animal cells characterized by culturing the cells in the above-mentioned media; and a process for producing physiologically active substances characterized by culturing animal cells capable of producing the substances in the above-mentioned media and recovering the substances thus produced from the cultures. These serum-free media allow sufficient proliferation of cells, facilitate the recovery of the physiologically active substances from the cultures, and are scarcely contaminated, thus enabling the provision of the above-mentioned culture method and production process.
摘要翻译：无血清培养基，其特征在于含有胰岛素和蛋白胨，但基本上不含白蛋白和转铁蛋白; 用于培养以上述培养基培养细胞为特征的动物细胞的方法; 以及生产生理活性物质的方法，其特征在于培养能够在上述培养基中产生物质的动物细胞，并从培养物中回收由此产生的物质。这些无血清培养基允许细胞的充分增殖，促进培养物中生理活性物质的回收，几乎不被污染，从而能够提供上述培养方法和生产方法。

6. 发明申请

WO1997029128A1 GPIb-LIPID COMPLEX AND USES THEREOF 审中-公开
标题翻译： GPIb-LIPID复合物及其用途
公开(公告)号：WO1997029128A1
公开(公告)日：1997-08-14
申请号：PCT/JP1997000284
申请日：1997-02-06
申请人： THE GREEN CROSS CORPORATION , MATSUDA, Hiroshi , KAMIDE, Kaeko , AMATSUJI, Yasuo , IMAGAWA, Takashi , IKEDA, Yasuo , MURATA, Mitsuru
发明人： THE GREEN CROSS CORPORATION
IPC分类号： C07K14/705
CPC分类号： A61K9/1271 , A61K38/00 , A61K47/62 , A61K47/6911 , C07K14/705 , C07K14/70596
摘要： A complex comprising GPIb and a lipid having a functional group. As it can bind with vWF and can form aggregates, it is useful as a platelet substitute, medicines for preventing and curing vascular lesion, vascular injury and thrombosis, a diagnostic agent for vWF deficiency, biological-medical reagents, and reagents for screening platelet aggregation inhibitors and antithrombotic agents. Also, as it is apt to specifically concentrate around the lesioned vascular parts, it is useful as diagnostic agents for testing vascular lesion, injured parts and thrombosed parts or remedies therefor.
摘要翻译：包含GPIb和具有官能团的脂质的复合物。由于它可以与vWF结合并且可以形成聚集体，它可用作血小板替代物，用于预防和治疗血管损伤，血管损伤和血栓形成的药物，用于vWF缺陷的诊断剂，生物医学试剂和用于筛选血小板聚集的试剂抑制剂和抗血栓形成剂。此外，由于易于特异性地集中在损伤的血管部分周围，因此它可用作测试血管损伤，受伤部件和血栓部位的诊断剂或其补救措施。

7. 发明申请

WO1996009839A1 IMMUNOGLOBULIN PREPARATION 审中-公开
标题翻译：免疫球蛋白准备
公开(公告)号：WO1996009839A1
公开(公告)日：1996-04-04
申请号：PCT/JP1995001979
申请日：1995-09-28
申请人： THE GREEN CROSS CORPORATION , TAKAHASHI, Tuyoshi , MIYANO, Kenmi , NISHIMAKI, Hideo , IRIE, Koichi , SAKI, Toshiyuki , TOMIOKA, Shinji
发明人： THE GREEN CROSS CORPORATION
IPC分类号： A61K39/395
CPC分类号： C07K16/00
摘要： A more safe immunoglobulin preparation, especially one used for intramuscular injection, that can be obtained by an efficient and well-operable production process without causing viral contamination. The preparation is HCV genome negative, contains HCV genome in a concentration of at most 1 PCR unit/ml in a 0.1-15 w/v % immunoglobulin solution, and has a HCV genome removal rate of 10 or above.
摘要翻译：更安全的免疫球蛋白制剂，特别是用于肌内注射的免疫球蛋白制剂，其可以通过有效且良好可操作的生产方法获得而不引起病毒污染。该制备物为HCV基因组阴性，含0.1至15w / v％免疫球蛋白溶液中至多1个PCR单位/ ml浓度的HCV基因组，HCV基因组去除率为10 3或更高。

8. 发明申请

WO1995019789A1 MOTOR-FUNCTION DISORDER PREVENTIVE OR REMEDY 审中-公开
标题翻译：预防或补救电机故障
公开(公告)号：WO1995019789A1
公开(公告)日：1995-07-27
申请号：PCT/JP1995000057
申请日：1995-01-20
申请人： THE GREEN CROSS CORPORATION , OKAJIMA, Kenji , TAOKA, Yuji
发明人： THE GREEN CROSS CORPORATION
IPC分类号： A61K38/57
CPC分类号： A61K38/57
摘要： A motor-function disorder preventive or remedy, tissue trouble preventive or remedy, spinal ischemia preventive or remedy, and spinal injury preventive or remedy, each containing a human-origin antithrombin III as the active ingredient. The antithrombin III has the activity of ameliorating mammalian tissue troubles and motor-function disorders, especially those caused by spinal ischemia or spinal injury, for example, paralysis.
摘要翻译：运动功能障碍预防或治疗，组织麻醉预防或治疗，脊髓缺血预防或治疗，以及脊髓损伤预防或治疗，每个含有人源抗凝血酶III作为活性成分。抗凝血酶III具有改善哺乳动物组织麻烦和运动功能障碍，特别是由脊髓缺血或脊髓损伤引起的功能障碍，例如麻痹的活性。

9. 发明申请

WO1995017819A1 CONTROLLED-RELEASE AIT PREPARATION, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF 审中-公开
标题翻译：控制释放准备，其生产方法及其使用
公开(公告)号：WO1995017819A1
公开(公告)日：1995-07-06
申请号：PCT/JP1994002299
申请日：1994-12-28
申请人： RENGO CO., LTD. , THE GREEN CROSS CORPORATION , FUJITA, Masao , KAMEI, Kiyoshi , KAWAZU, Kiyoko , HIROHAMA, Shuji , MIZUKAMI, Yuichi , SEKIYAMA, Yasushi , TAKATA, Asami , NUMATA, Shoko
发明人： RENGO CO., LTD. , THE GREEN CROSS CORPORATION
IPC分类号： A01N47/48
CPC分类号： A01N47/46 , A01N63/00 , A01N25/34 , A01N25/12 , A01N25/18 , A01N2300/00
摘要： A controlled-release AIT (allyl isothiocyanate) preparation comprising AIT and shellac serving as a barrier against AIT release; the above preparation comprising a shellac containing AIT incorporated therein (an AIT-incorporating shellac); the above preparation wherein the AIT-incorporating shellac is in the form of plate, block or granule; the above preparation wherein the AIT-incorporating shellac has been adhered onto or mixed into a base material; the above preparation wherein the base material is one selected from among plastic plate, paper, non-woven fabric and woven fabric; and the above preparation wherein the AIT of the AIT-incorporating shellac is supported on a carrier. The AIT vapor release rate can be varied by appropriately selecting the chemical composition, preparation process and so forth of the AIT-incorporating shellac. Sustained release of AIT vapor for long is also possible. As the AIT-incorporating shellac can be easily worked into various forms, the AIT preparation can be provided in various forms. It is useful in various fields of food, packaging material, construction material and so forth as a functional material which is highly stable and has antimicrobial, antimold, freshness-retaining and insectproof properties.
摘要翻译： AIT（烯丙基异硫氰酸烯丙酯）制剂，其包含AIT和虫胶作为AIT释放的屏障; 包含含有AIT的紫胶的上述制剂（掺有AIT的紫胶）; 上述制剂，其中含有AIT的紫胶是板，块或颗粒的形式; 上述制备其中掺入了AIT的紫胶已经粘附到基质上或混合到基材中; 上述制剂，其中基材是选自塑料板，纸，无纺布和机织织物中的一种; 以及其中载有AIT的紫胶的AIT负载在载体上的制备。 AIT蒸汽释放速率可以通过适当选择掺入AIT的虫胶的化学成分，制备过程等来改变。长时间持续释放AIT蒸气也是可能的。由于加入AIT的紫胶可以容易地加工成各种形式，因此可以以各种形式提供AIT制剂。在食品，包装材料，建筑材料等的各个领域中，作为高度稳定且具有抗菌，防霉，保鲜和防虫性能的功能材料是有用的。

10. 发明申请

WO1994022875A1 PYRIDOTHIAZINEACETIC ACID COMPOUND, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF 审中-公开
标题翻译：吡嗪酸化合物，其生产方法及其用途
公开(公告)号：WO1994022875A1
公开(公告)日：1994-10-13
申请号：PCT/JP1994000508
申请日：1994-03-29
申请人： THE GREEN CROSS CORPORATION , SENJU PHARMACEUTICAL CO., LTD. , HOSONO, Hiroshi , AOTSUKA, Tomoji , NAKAMURA, Yoshiyuki , MATSUI, Tetsuo , ISHIKAWA, Hiromichi
发明人： THE GREEN CROSS CORPORATION , SENJU PHARMACEUTICAL CO., LTD.
IPC分类号： C07D513/04
CPC分类号： C07D513/04
摘要： A pyridothiazineacetic acid compound represented by general formula (I) or a pharmaceutically acceptable salt thereof, a process for producing the same, and a pharmaceutical composition, an aldose reductase inhibitor and a preventive and therapeutic agent for the complications of diabetes, wherein each symbol is as defined in the specification. The compound and pharmaceutically acceptable salts thereof have an aldose reductase inhibitor activity and an excellent stability, and hence they are useful as preventive and therapeutic agents for the complications of diabetes, such as faulty union of injured cornea, cataract, neurosis, retinopathy and nephropathy, in particular, cataract and neurosis. The invention process serves to produce the above compound efficiently.
摘要翻译：由通式（I）表示的吡啶并噻吩乙酸化合物或其药学上可接受的盐，其制备方法，药物组合物，醛糖还原酶抑制剂和糖尿病并发症的预防和治疗剂，其中每个符号是如说明书中所定义。该化合物及其药学上可接受的盐具有醛糖还原酶抑制剂活性和优异的稳定性，因此它们可用作糖尿病并发症的预防和治疗剂，例如受损的角膜错位，白内障，神经症，视网膜病变和肾病，特别是白内障和神经症。本发明方法有效地生产上述化合物。

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