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1. 发明申请

WO2011127117A1 ANGIOGENESIS USING PLACENTAL STEM CELLS 审中-公开
标题翻译：使用平面干细胞的血管生成
公开(公告)号：WO2011127117A1
公开(公告)日：2011-10-13
申请号：PCT/US2011/031335
申请日：2011-04-06
申请人： ANTHROGENESIS CORPORATION , ABBOT, Stewart , EDINGER, James , FRANCKI, Aleksander , HARIRI, Robert, J. , JANKOVIC, Vladimir , KAPLUNOVSKY, Aleksandr , LABAZZO, Kristen , LAW, Eric , PADLIYA, Neerav , PAREDES, Jennifer , WANG, Jia-Lun
发明人： ABBOT, Stewart , EDINGER, James , FRANCKI, Aleksander , HARIRI, Robert, J. , JANKOVIC, Vladimir , KAPLUNOVSKY, Aleksandr , LABAZZO, Kristen , LAW, Eric , PADLIYA, Neerav , PAREDES, Jennifer , WANG, Jia-Lun
IPC分类号： C12N5/073 , A61K35/50
CPC分类号： A61K35/50 , A61K9/0019 , A61K9/0085 , A61K35/28 , A61L27/3633 , A61L27/3683 , A61L27/3808 , A61L27/3834 , A61L27/3886 , A61L27/3895 , C12N5/0605 , A61K2300/00
摘要： Provided herein are methods of treating individuals having diseases or disorders of the circulatory system, using placental cells, e.g., the placental stem cells and placental multipotent cells (PDACs) described herein, and populations of such placental cells. The invention also provides methods of angiogenesis using such cells or populations of cells comprising such cells.
摘要翻译：本文提供了使用胎盘细胞（例如本文所述的胎盘干细胞和胎盘多潜能细胞（PDAC））以及这些胎盘细胞群来治疗患有循环系统疾病或病症的个体的方法。本发明还提供了使用这种细胞或包含这种细胞的细胞群的血管生成方法。

2. 发明申请

WO2010059828A1 AMNION DERIVED ADHERENT CELLS 审中-公开
标题翻译： AMNION衍生的附属细胞
公开(公告)号：WO2010059828A1
公开(公告)日：2010-05-27
申请号：PCT/US2009/065152
申请日：2009-11-19
申请人： ANTHROGENESIS CORPORATION , ABBOT, Stewart , EDINGER, James, W. , FRANCKI, Aleksandar , KAPLUNOVSKY, Aleksandr , JANKOVIC, Vladimir , LABAZZO, Kristen , LAW, Eric , PADLIYA, Neerav, D. , PAREDES, Jennifer , WANG, Jia-Lun
发明人： ABBOT, Stewart , EDINGER, James, W. , FRANCKI, Aleksandar , KAPLUNOVSKY, Aleksandr , JANKOVIC, Vladimir , LABAZZO, Kristen , LAW, Eric , PADLIYA, Neerav, D. , PAREDES, Jennifer , WANG, Jia-Lun
IPC分类号： C12N5/073
CPC分类号： A61K35/50 , A61K35/12 , C12N5/0605
摘要： Provided herein are novel angiogenic cells from amnion, referred to as amnion derived adherent cells, and populations of, and compositions comprising, such cells. Further provided herein are methods of obtaining such cells and methods of using the cells in the treatment of individuals.
摘要翻译：本文提供了来自羊膜的新型血管生成细胞，称为羊膜来源的贴壁细胞，以及包含这些细胞的群体和组合物。本文还提供了获得这样的细胞的方法和使用细胞治疗个体的方法。

3. 发明申请

WO2012083024A8 TREATMENT OF SPINAL CORD INJURY AND TRAUMATIC BRAIN INJURY USING PLACENTAL STEM CELLS 审中-公开
公开(公告)号：WO2012083024A8
公开(公告)日：2012-06-21
申请号：PCT/US2011/065170
申请日：2011-12-15
申请人： ANTHROGENESIS CORPORATION , ABBOT, Stewart , EDINGER, James, W. , FRANCKI, Aleksandar , JANKOVIC, Vladimir , KAPLUNOVSKY, Aleksandr , LABAZZO, Kristen , LAW, Eric , LIANG, Bitao , HARIRI, Robert, J.
发明人： ABBOT, Stewart , EDINGER, James, W. , FRANCKI, Aleksandar , JANKOVIC, Vladimir , KAPLUNOVSKY, Aleksandr , LABAZZO, Kristen , LAW, Eric , LIANG, Bitao , HARIRI, Robert, J.
IPC分类号： A61K48/00 , C12N5/00
摘要： Provided herein are methods of treatment of individuals having an injury to the central nervous system, such as a spinal cord injury or a traumatic brain injury, using placental stem cells and placental multipotent stem cells described herein, and populations of such placental cells.

4. 发明申请

WO2012083023A1 TREATMENT OF SPINAL CORD INJURY AND TRAUMATIC BRAIN INJURY USING AMNION DERIVED ADHERENT CELLS 审中-公开
标题翻译：使用粘膜衍生的附属细胞治疗脊髓损伤和TRAUMATIC脑损伤
公开(公告)号：WO2012083023A1
公开(公告)日：2012-06-21
申请号：PCT/US2011/065165
申请日：2011-12-15
申请人： ANTHROGENESIS CORPORATION , ABBOT, Stewart , EDINGER, James, W. , FRANCKI, Aleksandar , JANKOVIC, Vladimir , KAPLUNOVSKY, Aleksandr , LABAZZO, Kristen , LAW, Eric , LIANG, Bitao
发明人： ABBOT, Stewart , EDINGER, James, W. , FRANCKI, Aleksandar , JANKOVIC, Vladimir , KAPLUNOVSKY, Aleksandr , LABAZZO, Kristen , LAW, Eric , LIANG, Bitao
IPC分类号： A61K48/00 , C12N5/00
CPC分类号： C12N5/0605 , A61K35/50 , C12N5/0618 , C12N5/0636 , C12N5/0637 , C12N5/0639 , C12N5/0646 , C12N2502/025 , C12N2506/025
摘要： Provided herein are methods of treating spinal cord and traumatic brain injuries using cells from amnion, and populations of such cells, referred to herein as "amnion derived adherent cells" ("AMDACs").
摘要翻译：本文提供了使用羊膜细胞治疗脊髓和创伤性脑损伤的方法，以及这些细胞群，这里称为“羊膜来源的粘附细胞”（“AMDAC”）。

5. 发明申请

WO2016191449A1 ANGIOGENESIS USING STIMULATED PLACENTAL STEM CELLS 审中-公开
标题翻译：使用刺激的平面干细胞的血管生成
公开(公告)号：WO2016191449A1
公开(公告)日：2016-12-01
申请号：PCT/US2016/034003
申请日：2016-05-25
申请人： ANTHROGENESIS CORPORATION , KARASIEWICZ-MENDEZ, Kathy, E. , FRANCKI, Aleksandar , TURNER, Jeffrey , LAW, Eric , PAREDES, Jennifer , LABAZZO, Kristen , RANA, Hemlata , HOFGARTNER, Wolfgang , HARIRI, Robert, J.
发明人： KARASIEWICZ-MENDEZ, Kathy, E. , FRANCKI, Aleksandar , TURNER, Jeffrey , LAW, Eric , PAREDES, Jennifer , LABAZZO, Kristen , RANA, Hemlata , HOFGARTNER, Wolfgang , HARIRI, Robert, J.
IPC分类号： A01N63/00 , C12N5/00
CPC分类号： C12N5/069 , A61K9/0019 , A61K9/0085 , A61K35/28 , A61K35/50 , A61K47/36 , A61K47/42 , A61L27/3808 , A61L27/3834 , A61L27/3895 , C12N5/0605 , C12N2501/2301 , C12N2502/025
摘要： Provided herein are stimulated placental stem cells and methods of treating individuals having diseases or disorders of the circulatory system using stimulated placental cells. The invention also provides methods of inducing angiogenesis using such stimulated cells or populations of cells comprising such stimulated cells.
摘要翻译：本文提供了刺激的胎盘干细胞和使用受激胎盘细胞治疗患有循环系统疾病或病症的个体的方法。本发明还提供使用这种受激细胞诱导血管发生的方法或包含这种受激细胞的细胞群。

6. 发明申请

WO2014028453A3 NATURAL KILLER CELLS AND USES THEREOF 审中-公开
公开(公告)号：WO2014028453A3
公开(公告)日：2014-02-20
申请号：PCT/US2013/054677
申请日：2013-08-13
申请人： ANTHROGENESIS CORPORATION , LAW, Eric , KANG, Lin , JANKOVIC, Vladimir , ZHANG, Xiaokui , ABBOT, Stewart , HARIRI, Robert, J.
发明人： LAW, Eric , KANG, Lin , JANKOVIC, Vladimir , ZHANG, Xiaokui , ABBOT, Stewart , HARIRI, Robert, J.
IPC分类号： C12N5/07 , C12N5/078 , C12N5/0783
摘要： Provided herein are methods of producing natural killer (NK) cells and NK progenitor cell populations using a two-step expansion and differentiation method. Also provided herein are methods of producing populations of NK cells and NK progenitor cell populations using a three-step expansion and differentiation method. Also provided herein are methods of suppressing tumor cell proliferation using the NK cells, the NK cell populations, and the NK progenitor cell populations produced by the methods described herein, as well as methods of treating individuals having cancer or a viral infection, comprising administering the NK cells, the NK cell populations, and the NK progenitor cell populations produced by the methods described herein to an individual having the cancer or viral infection.

7. 发明申请

WO2012009422A1 METHODS OF GENERATING NATURAL KILLER CELLS 审中-公开
标题翻译：产生自然杀伤细胞的方法
公开(公告)号：WO2012009422A1
公开(公告)日：2012-01-19
申请号：PCT/US2011/043831
申请日：2011-07-13
申请人： ANTHROGENESIS CORPORATION , HARIRI, Robert, J. , HEIDARAN, Mohammad, A. , JASKO, Stephen , KANG, Lin , LAW, Eric , PAL, Ajai , STOUT, Bhavani , VOSKINARIAN-BERSE, Vanessa , ZEITLIN, Andrew , ZHANG, Xiaokui
发明人： HARIRI, Robert, J. , HEIDARAN, Mohammad, A. , JASKO, Stephen , KANG, Lin , LAW, Eric , PAL, Ajai , STOUT, Bhavani , VOSKINARIAN-BERSE, Vanessa , ZEITLIN, Andrew , ZHANG, Xiaokui
IPC分类号： C12N5/0783
CPC分类号： C12N5/0646 , A61K35/17 , A61K2035/124 , C12N2500/05 , C12N2500/25 , C12N2500/33 , C12N2500/36 , C12N2500/38 , C12N2500/44 , C12N2500/46 , C12N2500/84 , C12N2501/125 , C12N2501/145 , C12N2501/2302 , C12N2501/2303 , C12N2501/2307 , C12N2501/2315 , C12N2501/26 , C12N2501/59 , C12N2501/91 , C12N2501/998 , C12N2506/11
摘要： Provided herein are methods of producing natural killer cells using a two-step expansion and differentiation method. Also provided herein are methods of suppressing tumor cell proliferation, of treating individuals having cancer or a viral infection, comprising administering the NK cells produced by the method to an individual having the cancer or viral infection.
摘要翻译：本文提供使用两步膨胀和分化方法生产天然杀伤细胞的方法。本文还提供了抑制肿瘤细胞增殖，治疗患有癌症或病毒感染的个体的方法，包括将通过该方法产生的NK细胞施用于具有癌症或病毒感染的个体。

8. 发明申请

WO2016057755A1 PLACENTA-DERIVED ADHERENT CELL EXOSOMES AND USES THEREOF 审中-公开
标题翻译：特异性衍生的附加细胞外植体及其用途
公开(公告)号：WO2016057755A1
公开(公告)日：2016-04-14
申请号：PCT/US2015/054629
申请日：2015-10-08
申请人： ANTHROGENESIS CORPORATION
发明人： LAW, Eric , MORSCHAUSER, Andrew , FRANCKI, Aleksandar , PAREDES, Jennifer , KARASIEWICZ-MENDEZ, Kathy E. , REDUTA, Allan , JANKOVIC, Vladimir , DJURETIC, Ivana
IPC分类号： A61K35/50
CPC分类号： A61K35/50 , A61K31/7105 , A61K35/28 , A61P9/00 , A61P17/02 , C12N5/0605 , C12N5/0668
摘要： Provided herein are compositions of placenta-derived adherent cell exosomes and methods of making and using the same. In one aspect, provided herein are compositions comprising exosomes produced by and/or derived from placental cells, e.g., placenta-derived adherent cells. In certain embodiments, the exosomes provided herein are produced by placenta-derived adherent cells that have been cultured in vitro for, e.g., 1, 2, 3, 4, 5, 6 or more passages.
摘要翻译：本文提供了胎盘衍生的粘附细胞外来体的组合物及其制备和使用方法。一方面，本文提供的是包含由胎盘细胞产生的和/或衍生自胎盘细胞例如胎盘衍生的贴壁细胞的外来体的组合物。在某些实施方案中，本文提供的外来体由已经在体外培养例如1,2,3,4,5,6或更多次传代的胎盘衍生的贴壁细胞产生。

9. 发明申请

WO2014123879A1 NATURAL KILLER CELLS FROM PLACENTA 审中-公开
标题翻译：自然杀伤细胞从PLACENTA
公开(公告)号：WO2014123879A1
公开(公告)日：2014-08-14
申请号：PCT/US2014/014632
申请日：2014-02-04
申请人： ANTHROGENESIS CORPORATION
发明人： ZHANG, Xiaokui , HARIRI, Robert, J. , VOSKINARIAN-BERSE, Vanessa , KANG, Lin , LAW, Eric , ABBOT, Stewart
IPC分类号： A61K35/14
CPC分类号： A61K35/17 , A61K31/454 , A61K2035/122 , C12N5/0646 , C12N2501/05
摘要： Provided herein are placental perfusate, placental perfusate cells, placenta-derived intermediate natural killer cells, combined natural killer cells from placenta and umbilical cord blood, and combinations thereof. Also provided herein are compositions comprising the same, and methods of using placental perfusate, placental perfusate cells, placenta-derived intermediate natural killer cells, and combined natural killer cells and combinations thereof, to suppress the growth or proliferation of tumor cells, cancer cells, and the like, and to treat individuals having tumor cells. Also provided herein are methods of treating an individual having a tumor or graft-versus-host disease with placental perfusate, placental perfusate-derived cells, natural killer cells from placenta, e.g ., from placental perfusate, and/or combined natural killer cells comprising natural killer cells from placenta, e.g ., from placental perfusate, and umbilical cord blood.
摘要翻译：本文提供胎盘灌洗液，胎盘灌洗液细胞，胎盘衍生的中间体天然杀伤细胞，来自胎盘和脐带血的合并的天然杀伤细胞及其组合。本文还提供了包含其的组合物，以及使用胎盘灌注液，胎盘灌洗液细胞，胎盘衍生的中间体天然杀伤细胞和组合的天然杀伤细胞及其组合的方法，以抑制肿瘤细胞，癌细胞的生长或增殖，并且治疗患有肿瘤细胞的个体。本文还提供了用胎盘灌注液，胎盘灌洗液衍生的细胞，来自胎盘的天然杀伤细胞（例如胎盘灌注液）和/或包含天然的组合的天然杀伤细胞来治疗具有肿瘤或移植物抗宿主病的个体的方法来自胎盘的杀伤细胞，例如胎盘灌洗液和脐带血。

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