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    • 6. 发明申请
    • EXTRACELLULAR MATRIX COMPOSITIONS
    • 细胞基质组成
    • WO2016033041A1
    • 2016-03-03
    • PCT/US2015/046690
    • 2015-08-25
    • ANTHROGENESIS CORPORATION
    • BHATIA, Mohit, B.HERZBERG, UriKAPLUNOVSKY, AleksandrZAKA, RaihanaYE, Qian
    • A61K38/39
    • A61K38/39A61K9/70A61K35/50A61K2300/00
    • Provided herein are placental extracellular matrix (ECM) compositions and methods of making the same. Also provided herein are uses of the placental ECM compositions provided herein. In one aspect, provided herein are extracellular matrix (ECM) compositions prepared using placental tissue, e.g., human placental tissue. In certain embodiments, the ECM compositions provided herein comprise about 30% to about 60% collagen and about 10% to about 35% elastin. In addition, such ECM compositions comprise (i) very low amounts of fibronectin (e.g., less than 0.1% fibronectin), e.g., as measured by ELISA; (ii) no or an undetectable amount of laminin, e.g., as measured by ELISA; and/or no or an undetectable amount of glycosaminoglycans, e.g., as measured by ELISA.
    • 本文提供胎盘细胞外基质(ECM)组合物及其制备方法。 本文还提供了本文提供的胎盘ECM组合物的用途。 在一个方面,本文提供了使用胎盘组织例如人胎盘组织制备的细胞外基质(ECM)组合物。 在某些实施方案中,本文提供的ECM组合物包含约30%至约60%的胶原和约10%至约35%的弹性蛋白。 此外,这种ECM组合物包含(i)非常低量的纤连蛋白(例如,小于0.1%的纤连蛋白),例如通过ELISA测量; (ii)无或不可检测量的层粘连蛋白,例如通过ELISA测量; 和/或没有或不可检测量的糖胺聚糖,例如通过ELISA测量。