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1. 发明申请

WO2012009422A1 METHODS OF GENERATING NATURAL KILLER CELLS 审中-公开
标题翻译：产生自然杀伤细胞的方法
公开(公告)号：WO2012009422A1
公开(公告)日：2012-01-19
申请号：PCT/US2011/043831
申请日：2011-07-13
申请人： ANTHROGENESIS CORPORATION , HARIRI, Robert, J. , HEIDARAN, Mohammad, A. , JASKO, Stephen , KANG, Lin , LAW, Eric , PAL, Ajai , STOUT, Bhavani , VOSKINARIAN-BERSE, Vanessa , ZEITLIN, Andrew , ZHANG, Xiaokui
发明人： HARIRI, Robert, J. , HEIDARAN, Mohammad, A. , JASKO, Stephen , KANG, Lin , LAW, Eric , PAL, Ajai , STOUT, Bhavani , VOSKINARIAN-BERSE, Vanessa , ZEITLIN, Andrew , ZHANG, Xiaokui
IPC分类号： C12N5/0783
CPC分类号： C12N5/0646 , A61K35/17 , A61K2035/124 , C12N2500/05 , C12N2500/25 , C12N2500/33 , C12N2500/36 , C12N2500/38 , C12N2500/44 , C12N2500/46 , C12N2500/84 , C12N2501/125 , C12N2501/145 , C12N2501/2302 , C12N2501/2303 , C12N2501/2307 , C12N2501/2315 , C12N2501/26 , C12N2501/59 , C12N2501/91 , C12N2501/998 , C12N2506/11
摘要： Provided herein are methods of producing natural killer cells using a two-step expansion and differentiation method. Also provided herein are methods of suppressing tumor cell proliferation, of treating individuals having cancer or a viral infection, comprising administering the NK cells produced by the method to an individual having the cancer or viral infection.
摘要翻译：本文提供使用两步膨胀和分化方法生产天然杀伤细胞的方法。本文还提供了抑制肿瘤细胞增殖，治疗患有癌症或病毒感染的个体的方法，包括将通过该方法产生的NK细胞施用于具有癌症或病毒感染的个体。

2. 发明申请

WO2009042201A1 ANGIOGENIC CELLS FROM HUMAN PLACENTAL PERFUSATE 审中-公开
标题翻译：人类细胞来自人类的渗透性细胞
公开(公告)号：WO2009042201A1
公开(公告)日：2009-04-02
申请号：PCT/US2008/011167
申请日：2008-09-26
申请人： CELGENE CELLULAR THERAPEUTICS , ZHANG, Xiaokui , HEIDARAN, Mohammad, A. , VOSKINARIAN-BERSE, Vanessa, A. , KANG, Lin , BARRIGAN, Henry, Rendon
发明人： ZHANG, Xiaokui , HEIDARAN, Mohammad, A. , VOSKINARIAN-BERSE, Vanessa, A. , KANG, Lin , BARRIGAN, Henry, Rendon
IPC分类号： C12N5/06 , A61K35/20
CPC分类号： C12N5/0692 , C12N2501/115 , C12N2501/15 , C12N2501/70
摘要： Provided herein are the production of vasculogenic or angiogenic cells from placental perfusate. Also provided are methods of treating an individual having a cardiac or vascular insufficiency, disease, disorder or condition comprising administering to said individual placental perfusate, placental perfusate cells, or combinations of placental perfusate or perfusate cells with placental or non-placental hematopoietic stem cells or adherent placental stem cells.
摘要翻译：本文提供了从胎盘灌注液产生血管生成或血管生成细胞。还提供了治疗患有心脏或血管功能不全，疾病，障碍或病症的个体的方法，包括向胎盘灌洗液，胎盘灌洗液细胞或胎盘灌洗液或灌洗液细胞与胎盘或非胎盘造血干细胞的组合或贴壁胎盘干细胞。

3. 发明申请

WO2009061447A3 USE OF UMBILICAL CORD BLOOD IN THE TREATMENT OF PREMATURE BIRTH COMPLICATIONS 审中-公开
公开(公告)号：WO2009061447A3
公开(公告)日：2009-05-14
申请号：PCT/US2008/012540
申请日：2008-11-07
申请人： ANTHROGENESIS CORPORATION , HEIDARAN, Mohammad, A. , JOHNSON, Kristine, Erikson , HARIRI, Robert, J.
发明人： HEIDARAN, Mohammad, A. , JOHNSON, Kristine, Erikson , HARIRI, Robert, J.
IPC分类号： A61P43/00 , A61K35/14 , A61K35/18 , A61K38/18
摘要： The present invention provides methods of treating one or more complications of premature birth suffered by premature infants, comprising administering to the premature infant umbilical cord blood stem cells and, optionally, placental stem cells. The present invention also provides methods of combining and administering, and compositions comprising, umbilical cord blood stem cells, particularly autologous cord blood cells, and placental stem cells for the treatment of premature infants.

4. 发明申请

WO2009061447A2 TREATMENT OF PREMATURE BIRTH COMPLICATIONS 审中-公开
标题翻译：治疗孕产妇出生体重
公开(公告)号：WO2009061447A2
公开(公告)日：2009-05-14
申请号：PCT/US2008/012540
申请日：2008-11-07
申请人： ANTHROGENESIS CORPORATION , HEIDARAN, Mohammad, A. , JOHNSON, Kristine, Erikson , HARIRI, Robert, J.
发明人： HEIDARAN, Mohammad, A. , JOHNSON, Kristine, Erikson , HARIRI, Robert, J.
IPC分类号： A61P43/00 , A61P11/00 , A61K35/14 , A61K38/18
CPC分类号： A61K35/51 , A61K31/714 , A61K33/26 , A61K35/18 , A61K35/50 , A61K38/1816 , A61K45/06 , A61K2300/00
摘要： The present invention provides methods of treating one or more complications of premature birth suffered by premature infants, comprising administering to the premature infant umbilical cord blood stem cells and, optionally, placental stem cells. The present invention also provides methods of combining and administering, and compositions comprising, umbilical cord blood stem cells, particularly autologous cord blood cells, and placental stem cells for the treatment of premature infants.
摘要翻译：本发明提供了治疗早产儿早产的一种或多种并发症的方法，包括对早产儿脐带血干细胞和任选的胎盘干细胞施用。本发明还提供组合和给药的方法，以及包含脐带血干细胞，特别是自体脐带血细胞和用于治疗早产儿的胎盘干细胞的组合物。

5. 发明申请

WO2009061447A9 TREATMENT OF PREMATURE BIRTH COMPLICATIONS 审中-公开
公开(公告)号：WO2009061447A9
公开(公告)日：2009-05-14
申请号：PCT/US2008/012540
申请日：2008-11-07
申请人： ANTHROGENESIS CORPORATION , HEIDARAN, Mohammad, A. , JOHNSON, Kristine, Erikson , HARIRI, Robert, J.
发明人： HEIDARAN, Mohammad, A. , JOHNSON, Kristine, Erikson , HARIRI, Robert, J.
IPC分类号： A61P43/00 , A61P11/00 , A61K35/14 , A61K38/18
摘要： The present invention provides methods of treating one or more complications of premature birth suffered by premature infants, comprising administering to the premature infant umbilical cord blood stem cells and, optionally, placental stem cells. The present invention also provides methods of combining and administering, and compositions comprising, umbilical cord blood stem cells, particularly autologous cord blood cells, and placental stem cells for the treatment of premature infants.

6. 发明申请

WO2010021756A1 METHODS AND COMPOSITIONS FOR TREATMENT OF BONE DEFECTS WITH PLACENTAL CELL POPULATIONS 审中-公开
标题翻译：用于治疗具有细胞群体的骨缺损的方法和组合物
公开(公告)号：WO2010021756A1
公开(公告)日：2010-02-25
申请号：PCT/US2009/004801
申请日：2009-08-24
申请人： ANTHROGENESIS CORPORATION , ABRAMSON, Sascha, Dawn , GUELAKIS, Marian , HEIDARAN, Mohammad, A. , LABAZZO, Kristen , YACCOBY, Shmuel
发明人： ABRAMSON, Sascha, Dawn , GUELAKIS, Marian , HEIDARAN, Mohammad, A. , LABAZZO, Kristen , YACCOBY, Shmuel
IPC分类号： A61K35/50 , C12N5/071 , A61P35/00
CPC分类号： A61K35/50 , A61K35/12 , C12N5/0605
摘要： Provided herein are osteogenic placental adherent cells (OPACs), methods of using OPACs and OPAC populations, and methods of culturing, proliferating, expanding, or differentiating the OPACs. Further provided herein are methods of using the OPACs to formulate implantable or injectable compositions suitable for administration to a subject. Still further provided herein are provides methods for treating bone defects with OPACs and compositions comprising OPACs. Also provided herein are methods of using OPACs in the treatment and management of multiple myeloma, e.g., reducing the progression of, halting the progression of, or improving, one or more symptoms of multiple myeloma in an individual having multiple myeloma, comprising administering a plurality of OPACs to the individual.
摘要翻译：本文提供了成骨胎盘贴壁细胞（OPAC），使用OPAC和OPAC群体的方法，以及培养，增殖，扩增或分化OPAC的方法。本文还提供了使用OPAC来配制适于给予受试者的可植入或可注射组合物的方法。本文还提供了用OPAC和包含OPAC的组合物治疗骨缺损的方法。本文还提供了在多发性骨髓瘤的治疗和管理中使用OPAC的方法，例如减少多发性骨髓瘤个体中多发性骨髓瘤的一种或多种症状的进展，停止进展或改善多发性骨髓瘤的一种或多种症状的方法，包括施用多个的OPACs给个人。

7. 发明申请

WO2007146123A2 PLACENTAL NICHE AND USE THEREOF TO CULTURE STEM CELLS 审中-公开
标题翻译：特别的NICHE及其用于培养干细胞
公开(公告)号：WO2007146123A2
公开(公告)日：2007-12-21
申请号：PCT/US2007/013507
申请日：2007-06-08
申请人： ANTHROGENESIS CORPORATION , HEIDARAN, Mohammad, A.
发明人： HEIDARAN, Mohammad, A.
IPC分类号： C12N5/073
CPC分类号： C12N5/0605 , C12N2500/25 , C12N2500/36 , C12N2501/11 , C12N2501/135 , C12N2501/39 , C12N2533/92
摘要： The present invention provides methods for culturing, expanding and differentiating stem cells, particularly human embryonic stem cells. The methods comprise culturing the stem cells for a period of time on a collagen biofabric, particularly a collagen biofabric derived from the amniotic membrane, chorion, or both, from mammalian placenta.
摘要翻译：本发明提供了培养，扩增和分化干细胞，特别是人胚胎干细胞的方法。所述方法包括在哺乳动物胎盘上胶原生物制剂，特别是衍生自羊膜，绒毛膜或两者的胶原生物制剂将干细胞培养一段时间。

8. 发明申请

WO2005034625A1 COVALENTLY ATTACHED COLLAGEN VI FOR CELL ATTACHMENT AND PROLIFERATION 审中-公开
标题翻译：共同附着胶原六用于细胞附着和增殖
公开(公告)号：WO2005034625A1
公开(公告)日：2005-04-21
申请号：PCT/US2004/027733
申请日：2004-08-26
申请人： BECTON, DICKINSON AND COMPANY , GUARINO, Richard, David , ROWLEY, Jonathan, A. , LIEBMANN-VINSON, Andrea , HEMPERLY, John, Jacob , HEIDARAN, Mohammad, A. , PRESNELL, Sharon, C.
发明人： GUARINO, Richard, David , ROWLEY, Jonathan, A. , LIEBMANN-VINSON, Andrea , HEMPERLY, John, Jacob , HEIDARAN, Mohammad, A. , PRESNELL, Sharon, C.
IPC分类号： A01N1/02
CPC分类号： G01N33/54393 , C12N5/0068 , C12N2500/90 , C12N2533/52 , C12N2533/54 , C12N2533/80
摘要： Surfaces useful for cell culture comprise a support to which is bound a CAR material, and, bound to the CAR material, collagen VI or a biologically active fragment or variant thereof and, optionally, one or more other ECM proteins (or fragments or variants thereof) such as elastin, fibronectin, vitronectin, tenascin, laminin, entactin, aggrecan, decorin, collagen 1, collagen 111, and collagen IV. Also, optionally present on the surface is one or more polycationic polymers, such as poly-D-lysine or poly-D-omithine. This surface is used in cell culture to promote cell attachment, survival, and/or proliferation of a number of different cell types such as (a) liver cells ( e.g ., HepG2 tumor cells, and a newly discovered line of rat liver epithelial stem cells) (b) osteoblasts, such as the murine cell line MC3T3 cell line and (c) primary bone marrow cells. Kits comprising the surfaces and additional reagents are also disclosed.
摘要翻译：用于细胞培养物的表面包括与CAR材料结合的载体，并结合CAR材料，胶原VI或其生物活性片段或变体，以及任选的一种或多种其它ECM蛋白（或其片段或变体）），例如弹性蛋白，纤连蛋白，玻连蛋白，腱生蛋白，层粘连蛋白，内含子，聚集蛋白聚糖，核心蛋白聚糖，胶原蛋白1，胶原蛋白111和胶原IV。此外，表面上任选存在的是一种或多种聚阳离子聚合物，例如聚-D-赖氨酸或聚-D-鸟氨酸。该表面用于细胞培养以促进许多不同细胞类型的细胞附着，存活和/或增殖，例如（a）肝细胞（例如，HepG2肿瘤细胞和新发现的大鼠肝上皮干细胞系）（b）成骨细胞，例如鼠细胞系MC3T3细胞系和（c）原代骨髓细胞。还公开了包含表面和附加试剂的试剂盒。

9. 发明申请

WO2005033833A2 COMPUTER SOFTWARE AND ALGORITHMS FOR SYSTEMS BIOLOGICALLY LINKED TO CELLULAR PHENOTYPE 审中-公开
标题翻译：系统的计算机软件和算法生物学链接到细胞基因
公开(公告)号：WO2005033833A2
公开(公告)日：2005-04-14
申请号：PCT/US2004/027862
申请日：2004-08-26
申请人： BECTON, DICKINSON AND COMPANY , HAALAND, Perry, D. , HEIDARAN, Mohammad, A.
发明人： HAALAND, Perry, D. , HEIDARAN, Mohammad, A.
IPC分类号： G06F
CPC分类号： G06F19/18 , B01J2219/00306 , B01J2219/00691 , B01J2219/00695 , B01J2219/007 , B01J2219/00743 , C40B60/14 , G06F19/20 , G06F19/28
摘要： An automated method and system for identifying agents capable of eliciting a phenotypic change in a cell-type is provided. The method includes the steps of: providing receptacles in an array; and providing a statistical design including generic factor names, factor levels and experimental runs. The method further includes the steps of utilizing a software program to generate a computer representation of the statistical design by automatically mapping the identities of the agents to the generic factor names, by mapping the concentration or amounts of the agents to the factor levels and by mapping the locations of the receptacles within the array to the experimental runs. The method also includes placing different mixtures of single agents into receptacles in the array based on the computer representation of the statistical design; contacting the placed mixtures with cells; acquiring experimental data from the contacted cells; and utilizing a processor including an algorithm for comparing the acquired data with the statistical design to identify particular agent mixtures or single agents that cause a phenotypic change in the contacted cells.
摘要翻译：提供了一种用于鉴定能够引发细胞型表型变化的试剂的自动化方法和系统。该方法包括以下步骤：提供阵列中的插座; 并提供统计设计，包括通用因素名称，因子水平和实验运行。该方法还包括以下步骤：利用软件程序通过将代理的身份自动映射到通用因素名称来生成统计设计的计算机表示，通过将代理的浓度或数量映射到因子级别并通过映射阵列内的插座的位置到实验运行。该方法还包括基于统计设计的计算机表示将单个试剂的不同混合物放置在阵列中的容器中; 将放置的混合物与细胞接触; 从接触的细胞获取实验数据; 以及利用包括用于将所获取的数据与所述统计设计进行比较的算法的处理器，以识别在所接触的细胞中引起表型变化的特定试剂混合物或单一试剂。

10. 发明申请

WO2005029071A1 HIGH THROUGHPUT METHOD TO IDENTIFY LIGANDS FOR CELL ATTACHMENT 审中-公开
标题翻译：识别细胞附着配体的高通量方法
公开(公告)号：WO2005029071A1
公开(公告)日：2005-03-31
申请号：PCT/US2004/029578
申请日：2004-09-10
申请人： BECTON, DICKINSON AND COMPANY , LIEBMANN-VINSON, Andrea , ROWLEY, Jonathan, A. , BODILY, Chris, H. , HEIDARAN, Mohammad, A.
发明人： LIEBMANN-VINSON, Andrea , ROWLEY, Jonathan, A. , BODILY, Chris, H. , HEIDARAN, Mohammad, A.
IPC分类号： G01N33/50
CPC分类号： G01N33/5011 , G01N33/5008 , G01N33/502 , G01N33/5029 , G01N33/54393
摘要： A high througtput method is provided for identifying agents capable of producing a desired biological response in whole cells. The method includes the steps of providing receptacles having a culture surface; placing different mixtures of single agents into selective ones of the receptacles according to a statistical design; and immobilizing the mixtures of single agents to the culture surface. The method further includes contacting the immobilized agents with the whole cells; and acquiring data which is indicative of a desired biological response in the contacted cells. The method also includes using statistical modeling of the acquired data to determine which mixtures of single agents and/or which single agents in these mixtures are affective in producing the desired biological response in the contacted cells.
摘要翻译：提供了一种高通量方法，用于鉴定能够在整个细胞中产生所需生物反应的试剂。该方法包括提供具有培养表面的容器的步骤; 根据统计设计将单一试剂的不同混合物置于选择性容器中; 并将单一试剂的混合物固定到培养表面。该方法还包括使固定化的试剂与整个细胞接触; 并且获取指示所接触细胞中所需生物反应的数据。该方法还包括使用获取的数据的统计建模来确定单个试剂的哪些混合物和/或这些混合物中的哪一种试剂在产生所接触的细胞中所需的生物学应答中是有意义的。

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