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1. 发明申请

WO1992020709A1 GALANIN ANTAGONIST 审中-公开
公开(公告)号：WO1992020709A1
公开(公告)日：1992-11-26
申请号：PCT/SE1992000316
申请日：1992-05-14
申请人： AKTIEBOLAGET ASTRA , BARTFAI, Tamas , HÖKFELT, Tomas , LANGEL, Ulo , AHRÉN, Bo , LINDSKOG, Stefan , CONSOLO, Silvana , LAND, Tiit , WIESENFELD-HALLIN, Zsuzsanna
发明人： AKTIEBOLAGET ASTRA
IPC分类号： C07K07/08
CPC分类号： C07K7/22 , A61K38/00 , C07K7/02 , C07K7/18 , C07K14/575 , C07K14/70
摘要： A galanin antagonist which is a galanin receptor ligand is described. Further, new peptides Galanin(1-12)-Pro-Substance P(5-11), Galanin(1-12)-Pro-Bradykinin(2-9), Galanin(1-12)-Pro-Pro-Pro-(Leu5-Enkephalin(5-1)), Galanin(1-12)-Pro-Lys(ε-NH-)Pro-(Leu5-Enkephalin(5-1)) and functional analogues and functional derivates thereof which exhibit substantially the same galanin antagonistic effect as said peptides are disclosed. Use of the galanin antagonist, a pharmaceutical preparation comprising it and a method of treating a disorder in a mammal which depends on the physiological function of galanin at the galanin receptor are also included.

2. 发明申请

WO1994029274A1 NEW ACTIVE COMPOUNDS 审中-公开
标题翻译：新活性化合物
公开(公告)号：WO1994029274A1
公开(公告)日：1994-12-22
申请号：PCT/SE1994000552
申请日：1994-06-08
申请人： AKTIEBOLAGET ASTRA , STARKE, Carl, Ingemar
发明人： AKTIEBOLAGET ASTRA
IPC分类号： C07D215/44
CPC分类号： C07D215/26 , C07D215/44
摘要： The present invention relates to novel quinoline derivatives of formula (I) which inhibit exogenously or endogenously stimulated gastric acid secretion and thus can be used in the prevention and treatment of gastrointestinal inflammatory diseases.
摘要翻译：本发明涉及抑制外源性或内源性刺激的胃酸分泌的式（I）的新喹啉衍生物，因此可用于预防和治疗胃肠炎性疾病。

3. 发明申请

WO1994015959A1 NEW PEPTIDES 审中-公开
标题翻译：新胶囊
公开(公告)号：WO1994015959A1
公开(公告)日：1994-07-21
申请号：PCT/SE1993001090
申请日：1993-12-20
申请人： AKTIEBOLAGET ASTRA
发明人： AKTIEBOLAGET ASTRA , SCHILLER, Peter
IPC分类号： C07K05/10
CPC分类号： C07K7/06 , A61K38/00 , C07K5/0207 , C07K5/06078 , C07K5/0812 , C07K5/1016
摘要： Compounds of formula (I) as well as methods for their preparation, their pharmaceutical preparations and their use. The compounds of formula (I) are useful in therapy, especially as analgesics and as immunosuppressive agents. R3, R4, R5, R6 are all H or R4 and R5 are both H and R3 and R6 are both lower alkyl groups or R3, R5, R6 are all H and R4 is F, Cl, Br, OH, NH2 or NO2; R7 is C = O or CH2; R8 is H or a lower alkyl group; R9 is (II), wherein m is 0-2 or (III) or (IV) or (V) or (VI) or (VII) or (VIII) wherein R10 is H, F, Cl, Br or I and m is 0-2; R11 is OH, NH2 or (IX) wherein R12 is H, NO2, F, Cl, Br or I, m is 0-2, R13 is COOH, CONH2, CH2OH, or any additional amino acid or peptide segment, or R11 is (X) wherein R14 is COOH, CONH2, CH2OH, or any additional amino acid or peptide segment; with the exceptions of the compounds wherein R1, R2, R3, R4, R5, R6 and R8 are all H, R7 is C = O and R9 is (XI) and R11 is Phe-OH, Phe-NH2, OH or NH2.
摘要翻译：式（I）化合物及其制备方法，其药物制剂及其用途。式（I）化合物可用于治疗，特别是作为止痛剂和免疫抑制剂。 R3，R4，R5，R6全部为H或R4，R5均为H和R3，R6均为低级烷基或R3，R5，R6均为H，R4为F，Cl，Br，OH，NH2或NO2; R 7为C = O或CH 2; R8是H或低级烷基; R 9是（II），其中m是0-2或（III）或（IV）或（V）或（VI）或（VII）或（VIII）其中R 10是H，F，Cl，Br或I和m 是0-2; R 11是OH，NH 2或（IX）其中R 12是H，NO 2，F，Cl，Br或I，m是0-2，R 13是COOH，CONH 2，CH 2 OH或任何另外的氨基酸或肽片段，或者R 11是（X）其中R14是COOH，CONH2，CH2OH或任何另外的氨基酸或肽段; 除了其中R 1，R 2，R 3，R 4，R 5，R 6和R 8都是H，R 7是C = O并且R 9是（Ⅺ），R 11是Phe-OH，Phe-NH 2，OH或NH 2的化合物之外。

4. 发明申请

WO1994013348A1 INHALER 审中-公开
公开(公告)号：WO1994013348A1
公开(公告)日：1994-06-23
申请号：PCT/EP1993003453
申请日：1993-12-08
申请人： AKTIEBOLAGET ASTRA , HATSCHEK, Rudolph, A. , HURKA, Wilhelm
发明人： AKTIEBOLAGET ASTRA
IPC分类号： A61M15/00
CPC分类号： A61M15/0065 , A61M15/0008 , A61M2202/064
摘要： An inhaler for dosing and distributing solids in breathing air has a body provided with an air inlet (5) and with an air outlet (7) which acts as an air suction opening. Inside the body is arranged a per se closed, at least approximately circular chamber (3), to which is tangentially connected an air inflow channel (4) linked to the air inlet and with which is associated an air outflow system linked to the air outlet (7), through which the air can centripetally flow out of the circular chamber (3). The body is constituted by a support (1) which contains the circular chamber (3), the air inflow channel (4) and the air outflow system as well as by a covering lid (2) provided with the air inlet (5) and the air outlet (7). In order to create an inhaler allowing multiple inhalations, a solid reservoir (7) is arranged in the support (1) and a manually controllable dosing device (11) is provided for drawing an amount of solid sufficient for one inhalation from the reservoir (8) and for transporting it into the path of the suction air current.

5. 发明申请

WO1994001087A1 PRECIPITATION OF ONE OR MORE ACTIVE COMPOUNDS IN SITU 审中-公开
标题翻译：一个或多个活性化合物在原子中的降解
公开(公告)号：WO1994001087A1
公开(公告)日：1994-01-20
申请号：PCT/SE1993000566
申请日：1993-06-24
申请人： AKTIEBOLAGET ASTRA , THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
发明人： AKTIEBOLAGET ASTRA , THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION , BROBERG, Fredrik , BRODIN, Arne , RYDHAG, Lisbet , FRANK, Sylvan, G.
IPC分类号： A61K09/08
CPC分类号： A61K9/0024 , A61K9/0014 , A61K9/0019 , A61K9/08 , A61K31/165 , A61K31/245 , A61K31/445 , A61K47/10 , Y10S514/817 , Y10S514/818
摘要： The present invention relates to an injectable solution for administration of one or more active compounds. According to the invention the active compound, which is in its neutral form, is solved in a biologically acceptable solvent whereby the active compound by administration precipitates, forming a solid phase of the solution in situ. Thus, said solution, which is easy to sterilize, is acting like a suspension when injected.
摘要翻译：本发明涉及一种用于给予一种或多种活性化合物的可注射溶液。根据本发明，其中性形式的活性化合物被溶解在生物学上可接受的溶剂中，其中通过给药沉淀出活性化合物，原位形成溶液的固相。因此，容易灭菌的所述溶液在注射时的作用就像悬浮液。

6. 发明申请

WO1993021179A1 NOVEL AMIDOALKYL- AND IMIDOALKYL-PIPERAZINES 审中-公开
标题翻译：新型氨基甲酰基和咪唑烷基哌嗪
公开(公告)号：WO1993021179A1
公开(公告)日：1993-10-28
申请号：PCT/SE1993000295
申请日：1993-04-06
申请人： AKTIEBOLAGET ASTRA
发明人： AKTIEBOLAGET ASTRA , BENGTSSON, Stefan , FLORVALL, Lennart , HALLNEMO, Gerd , JACKSON, David , ROSS, Svante , TOLF, Bo-Ragnar , ULFF, Bengt , ZHANG, Lian , ÅKESSON, Christina
IPC分类号： C07D403/06
CPC分类号： C07D221/20 , C07D209/48 , C07D209/66 , C07D295/13 , C07D295/135 , C07D307/68
摘要： Compounds of general formula (I) wherein R is a hydrogen atom or a phenyl group, m is an integer 3 to 8, R4 is an NO2 group or a group NR7R8 wherein R7 and R8 are the same or different and each is hydrogen or alkyl, R5 is hydrogen, halogen or CF3, R6 is halogen, or CF3, W is an optionally substituted aromatic ring(s), a heterocyclic ring, a carbocyclic ring(s), or an optionally substituted methylene group, A is a hydrogen atom, a hydroxy group, a halogen atom, CF3, an alkyl group, an alkoxy group, a phenyl group, or a phenoxy group, B is a hydrogen atom, or A and B together constitute a carbonyl group, n1 is 0 or 1, and n2 is 0 or 1, processes and intermediates for their preparation, pharmaceutical preparation containing them and the use of the compounds in the treatment of mental disturbances.
摘要翻译：通式（I）的化合物，其中R为氢原子或苯基，m为整数3至8，R4为NO2基团或NR7R8基团，其中R7和R8相同或不同，各自为氢或烷基 R 5为氢，卤素或CF 3，R 6为卤素，或CF 3，W为任选取代的芳香环，杂环，碳环或任选取代的亚甲基，A为氢原子，羟基，卤素原子，CF 3，烷基，烷氧基，苯基或苯氧基，B为氢原子，或A和B一起构成羰基，n1为0或1，和n2为0或1，其制备方法和中间体，含有它们的药物制剂以及该化合物在精神障碍治疗中的应用。

7. 发明申请

WO1992013872A1 NOVEL STEROIDS 审中-公开
标题翻译：新的STEROIDS
公开(公告)号：WO1992013872A1
公开(公告)日：1992-08-20
申请号：PCT/SE1992000055
申请日：1992-01-29
申请人： AKTIEBOLAGET ASTRA , ANDERSSON, Paul , AXELSSON, Bengt , BRATTSAND, Ralph , THALEN, Arne
发明人： AKTIEBOLAGET ASTRA
IPC分类号： C07J71/00
CPC分类号： C07J5/0092 , C07J71/0031
摘要： Compounds of general formula (I) in the form of a 22R and 22S epimer, wherein X1 and X2 are the same or different and each represents a hydrogen atom or a fluorine atom, provided that X1 and X2 are not simultaneously a hydrogen atom, processes for their preparation, pharmaceutical preparations containing them and the use of the compounds in the treatment of inflammatory and allergic conditions.
摘要翻译： 22R和22S差向异构体形式的通式（I）化合物，其中X1和X2相同或不同，各自表示氢原子或氟原子，条件是X1和X2不同时为氢原子，用于制备它们，含有它们的药物制剂以及该化合物在治疗炎性和过敏性疾病中的用途。

8. 发明申请

WO1992010171A1 NEW PHARMACEUTICAL FORMULATIONS CONTAINING A PHARMACOLOGICALLY ACTIVE IONIZABLE SUBSTANCE AS WELL AS PROCESS FOR THE PREPARATION THEREOF 审中-公开
标题翻译：包含药物活性可离子化物质的新药物制剂作为其制备方法
公开(公告)号：WO1992010171A1
公开(公告)日：1992-06-25
申请号：PCT/SE1991000814
申请日：1991-12-03
申请人： AKTIEBOLAGET ASTRA
发明人： AKTIEBOLAGET ASTRA , LINDSTEDT, Bengt , LUNDBERG, Per, Johan
IPC分类号： A61K09/18
CPC分类号： A61K9/2054 , A61K47/585
摘要： A preparation of a pharmacologically active ionizable substance, wherein active substance is ionically complexed to an ion-exchanger resin, which is embedded in a hydrophilic eroding matrix as well as a process for the manufacture thereof.
摘要翻译：药物活性可离子化物质的制备方法，其中活性物质与嵌入亲水侵蚀基质中的离子交换树脂离子络合，以及制备方法。

9. 发明申请

WO1992005147A1 NEW PROCESS FOR PREPARING FORMOTEROL AND RELATED COMPOUNDS 审中-公开
标题翻译：制备异戊醇及相关化合物的新工艺
公开(公告)号：WO1992005147A1
公开(公告)日：1992-04-02
申请号：PCT/SE1991000643
申请日：1991-09-25
申请人： AKTIEBOLAGET ASTRA , TROFAST, Jan, William , JAKUPOVIC, Edib , MÅNSSON, Lena, Katarina
发明人： AKTIEBOLAGET ASTRA
IPC分类号： C07C231/14
CPC分类号： C07C233/43 , C07C231/14
摘要： The present invention is directed to a process for preparing formoterol and related compounds and derivatives thereof and their pharmacologically and pharmaceutically acceptable fumarate salts and/or solvates. The present invention is also directed to certain formoterol related compounds per se.
摘要翻译：本发明涉及制备福莫特罗及其相关化合物及其衍生物及其药理学和药学上可接受的延胡索酸盐和/或溶剂合物的方法。本发明还涉及某些福莫特罗相关化合物本身。

10. 发明申请

WO1991019711A1 SUBSTITUTED BENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE 审中-公开
标题翻译：替代苯西泮，其制备方法及其药物用途
公开(公告)号：WO1991019711A1
公开(公告)日：1991-12-26
申请号：PCT/SE1991000415
申请日：1991-06-11
申请人： AKTIEBOLAGET ASTRA
发明人： AKTIEBOLAGET ASTRA , BRÄNDSTRÖM, Arne, Elof , LINDBERG, Per, Lennart , SUNDÉN, Gunnel, Elisabeth
IPC分类号： C07D401/12
CPC分类号： C07D401/12 , C07D405/14
摘要： The novel compounds of formula (I), wherein R and R , which are different, is each H, alkyl containing 1-4 carbon atoms or -C(O)-R ; one of R or R is always selected from the group -C(O)-R ; wherein R is alkyl containing 1-4 carbon atoms or alkoxy containing 1-4 carbon atoms, R is the group -CH2OCOOR , wherein R is alkyl containing 1-6 carbon atoms or benzyl; R and R are the same or different and selected from -CH3, -C2H5, (a), (b) and -CH2CH2OCH3, or R and R form together with the adjacent oxygen atoms attached to the pyridine ring and the carbon atoms in the pyridine ring a ring, wherein the part constituted by R and R is -CH2CH2CH2-, -CH2CH2- or -CH2- as well as pharmaceutical compositions containing such compounds as active ingredient, and the use of the compounds in medicine.
摘要翻译：式（I）的新化合物，其中不同的R 1和R 2各自为H，含有1-4个碳原子的烷基或-C（O）-R 6; R 1或R 2中的一个总是选自基团-C（O）-R 6; 其中R 6是含有1-4个碳原子的烷基或含有1-4个碳原子的烷氧基，R 3是基团-CH 2 COOOR 7，其中R 7是含有1-6个碳原子的烷基或苄基 ; R 4和R 5相同或不同，选自-CH 3，-C 2 H 5，（a），（b）和-CH 2 CH 2 OCH 3，或R 4和R 5与相邻的氧连接到吡啶环上的原子和吡啶环中的碳原子是一个环，其中由R 4和R 5构成的部分是-CH 2 CH 2 CH 2 - ， - CH 2 CH 2 - 或-CH 2 - 以及含有这样的药物组合物化合物作为活性成分，以及该化合物在药物中的用途。

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