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1. 发明申请

WO03027274A3 PURIFIED POLYPEPTIDES FROM PSEUDOMONAS AERUGINOSA 审中-公开
标题翻译：来自PSEUDOMONAS AERUGINOSA的纯化多糖
公开(公告)号：WO03027274A3
公开(公告)日：2003-10-02
申请号：PCT/CA0201453
申请日：2002-09-25
申请人： AFFINIUM PHARM INC , EDWARDS ALED , DHARAMSI AKIL , VEDADI MASOUD , ALAM MUHAMMAD ZAHOOR , AWREY DONALD , BEATTIE BRYAN , HOUSTON SIMON , KIMBER MATTHEW , LAM ROBERT , NETHERY KATHLEEN , LI QIN , NECAKOV SASHA , VALLEE FRANCOIS
发明人： EDWARDS ALED , DHARAMSI AKIL , VEDADI MASOUD , ALAM MUHAMMAD ZAHOOR , AWREY DONALD , BEATTIE BRYAN , HOUSTON SIMON , KIMBER MATTHEW , LAM ROBERT , NETHERY KATHLEEN , LI QIN , NECAKOV SASHA , VALLEE FRANCOIS
IPC分类号： C07K14/21 , C12N1/21 , C12N9/90 , C07K17/02 , C07K19/00 , C12Q1/533
CPC分类号： C07K14/21 , C07K2319/00
摘要： The present invention relates to drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.
摘要翻译：本发明涉及病原菌的药物靶标。因此，本发明提供了包含SEQ ID NO：4所示氨基酸序列的纯化蛋白质。本发明还提供本发明多肽的生物化学和生物物理学特征。

2. 发明申请

WO2004058810A3 CRYSTAL STRUCTURES OF NH3-DEPENDENT NAD SYNTHETASES 审中-公开
标题翻译： NH3依赖性NAD合成物的晶体结构
公开(公告)号：WO2004058810A3
公开(公告)日：2004-11-25
申请号：PCT/CA0301935
申请日：2003-12-19
申请人： AFFINIUM PHARM INC , EDWARDS ALED , DHARAMSI AKIL , VEDADI MASOUD , ALAM MUHAMMAD ZAHOOR , HOUSTON SIMON , KIMBER MATTHEW , LAM ROBERT , PINDER BENJAMIN , THALAKADA ROSANNE , VIRAG CRISTINA
发明人： EDWARDS ALED , DHARAMSI AKIL , VEDADI MASOUD , ALAM MUHAMMAD ZAHOOR , HOUSTON SIMON , KIMBER MATTHEW , LAM ROBERT , PINDER BENJAMIN , THALAKADA ROSANNE , VIRAG CRISTINA
IPC分类号： C12N9/00 , G06F19/00 , C07K14/21 , C12N15/52 , G06F17/30
CPC分类号： C12N9/93 , C07K2299/00 , G06F19/16 , Y02A90/26
摘要： The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified P. aeruginosa protein comrising the amino acid sequence set forth in SEQ ID NO: 4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.
摘要翻译：本发明涉及病原菌的新型药物靶标。因此，本发明提供了包含SEQ ID NO：4所示氨基酸序列的经纯化的铜绿假单胞菌蛋白质。本发明还提供本发明多肽的生物化学和生物物理学特性。

3. 发明申请

WO03051916A3 CRYSTAL STRUCTURE OF NH3-DEPENDENT DAD+ SYNTHETASE FROM STREPTOCOCCUS PNEUMONIAE 审中-公开
标题翻译： NH3依赖性DAD + SYNTHETASE从结核杆菌的晶体结构
公开(公告)号：WO03051916A3
公开(公告)日：2003-09-12
申请号：PCT/CA0201934
申请日：2002-12-18
申请人： AFFINIUM PHARM INC , EDWARDS ALED , DHARAMSI AKIL , VEDADI MASOUD , ALAM MUHAMMAD ZAHOOR , HOUSTON SIMON , PINDER BENJAMIN , NG IVY , LAM ROBERT , KIMBER MATTHEW
发明人： EDWARDS ALED , DHARAMSI AKIL , VEDADI MASOUD , ALAM MUHAMMAD ZAHOOR , HOUSTON SIMON , PINDER BENJAMIN , NG IVY , LAM ROBERT , KIMBER MATTHEW
IPC分类号： C12N9/00
CPC分类号： C12N9/93 , C07K2299/00
摘要： The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.
摘要翻译：本发明涉及病原菌的新型药物靶标。因此，本发明提供了包含SEQ ID NO：4所示氨基酸序列的纯化蛋白质。本发明还提供本发明多肽的生物化学和生物物理学特征。

4. 发明申请

WO2004042044A3 CRYSTAL STRUCTURES OF BACTERIAL GUANYLATE KINASES 审中-公开
标题翻译：细菌棒状晶体的晶体结构
公开(公告)号：WO2004042044A3
公开(公告)日：2005-02-24
申请号：PCT/CA0301673
申请日：2003-11-05
申请人： AFFINIUM PHARM INC , EDWARDS ALED , DHARAMSI AKIL , VEDADI MASOUD , DOMAGALA MEGAN , PINDER BENJAMIN , ALAM MUHAMMAD ZAHOOR , KIMBER MATTHEW , CLARKE TERESA , LAM ROBERT
发明人： EDWARDS ALED , DHARAMSI AKIL , VEDADI MASOUD , DOMAGALA MEGAN , PINDER BENJAMIN , ALAM MUHAMMAD ZAHOOR , KIMBER MATTHEW , CLARKE TERESA , LAM ROBERT
IPC分类号： C12N9/12 , C07K14/315 , G01N33/483
CPC分类号： C12N9/1229 , C07K2299/00 , C12Y207/04008
摘要： The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.
摘要翻译：本发明涉及病原菌的新型药物靶标。因此，本发明提供了包含SEQ ID NO：4所示氨基酸序列的纯化蛋白质。本发明还提供本发明多肽的生物化学和生物物理学特征。

5. 发明申请

WO2004058954A3 CRYSTAL STRUCTURE OF ASPARTATE SEMIALDEHYDE DEHYDROGENASES FROM PSEUDOMONAS AERUGINOSA AND USES THEREOF 审中-公开
标题翻译：白藜芦醇阿司匹林的盐酸半胱氨酸脱氢酶的晶体结构及其用途
公开(公告)号：WO2004058954A3
公开(公告)日：2004-09-10
申请号：PCT/CA0301936
申请日：2003-12-22
申请人： AFFINIUM PHARM INC , EDWARDS ALED , DHARAMSI AKIL , VEDADI MASOUD , THALAKADA ROSANNE , VIRAG CRISTINA , KANAGARAJAH DHUSHY , TAI MATTHEW , HOUSTON SIMON , BUZADZIJA KRISTINA , LAM ROBERT , KIMBER MATTHEW
发明人： EDWARDS ALED , DHARAMSI AKIL , VEDADI MASOUD , THALAKADA ROSANNE , VIRAG CRISTINA , KANAGARAJAH DHUSHY , TAI MATTHEW , HOUSTON SIMON , BUZADZIJA KRISTINA , LAM ROBERT , KIMBER MATTHEW
IPC分类号： C12N9/02 , C07K14/195 , C12N15/09 , G01N33/50
CPC分类号： C12N9/0008 , C07K2299/00 , Y02A90/26
摘要： The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.
摘要翻译：本发明涉及病原菌的新型药物靶标。因此，本发明提供了包含SEQ ID NO：4所示氨基酸序列的纯化蛋白质。本发明还提供本发明多肽的生物化学和生物物理学特征。

6. 发明申请

WO2004041856A3 CRYSTAL STRUCTURES OF BACTERIAL INORGANIC PYROPHOSPHATASES 审中-公开
标题翻译：细菌无机焦磷酸盐的晶体结构
公开(公告)号：WO2004041856A3
公开(公告)日：2004-08-26
申请号：PCT/CA0301704
申请日：2003-11-07
申请人： AFFINIUM PHARM INC , EDWARDS ALED , DHARAMSI AKIL , VEDADI MASOUD , VIRAG CRISTINA , TAI MATTHEW , HOUSTON SIMON , LAM ROBERT
发明人： EDWARDS ALED , DHARAMSI AKIL , VEDADI MASOUD , VIRAG CRISTINA , TAI MATTHEW , HOUSTON SIMON , LAM ROBERT
IPC分类号： C12N9/14 , C12N15/55 , C12N5/10 , G01N23/20 , G01N33/573
CPC分类号： C12N9/14 , C07K2299/00
摘要： The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.
摘要翻译：本发明涉及用于病原菌的新型药物靶标。因此，本发明提供了包含SEQ ID NO：4所示氨基酸序列的纯化蛋白质。本发明还提供了本发明多肽的生物化学和生物物理学特征。

7. 发明申请

WO2009026129A3 HIGH TEMPERATURE FIBERS AND COMBINATIONS FOR FRICTION MATERIALS 审中-公开
标题翻译：摩擦材料用高温纤维和复合材料
公开(公告)号：WO2009026129A3
公开(公告)日：2009-05-07
申请号：PCT/US2008073266
申请日：2008-08-15
申请人： BORGWARNER INC , LAM ROBERT , DONG FENG
发明人： LAM ROBERT , DONG FENG
IPC分类号： C09K3/14 , C08J5/14 , F16D69/02
CPC分类号： F16D69/026 , F16D2200/0065 , Y10T428/2918 , Y10T428/298
摘要： One embodiment of the invention may include a product comprising: a friction material comprising a plurality of fibers having a fiber diameter ranging from about 1 to about 20 micrometers, the fibers comprising ceramic or mineral fibers and reinforcing fibers to add strength, the reinforcing fibers being fibrillated with a Canadian Standard Freeness greater than 300.
摘要翻译：本发明的一个实施方案可包括产品，其包含：包含多根纤维的摩擦材料，所述纤维具有约1至约20微米的纤维直径，所述纤维包含陶瓷或矿物纤维和增强纤维以增加强度，所述增强纤维为纤维化的加拿大标准游离度大于300。

8. 发明申请

WO2009152167A2 DELIVERY OF THERAPEUTICS 审中-公开
标题翻译：交付治疗
公开(公告)号：WO2009152167A2
公开(公告)日：2009-12-17
申请号：PCT/US2009046773
申请日：2009-06-09
申请人： UNIV NORTHWESTERN , HO DEAN , LAM ROBERT , CHEN MARK , HUANG HOUJIN , PIERSTORFF ERIK
发明人： HO DEAN , LAM ROBERT , CHEN MARK , HUANG HOUJIN , PIERSTORFF ERIK
IPC分类号： A61K9/70 , A61K31/573 , A61K31/704 , A61K47/04 , A61K47/06 , A61P29/00 , A61P35/00
CPC分类号： A61K31/573 , A61K9/0024 , A61K9/5115 , A61K9/7007 , A61K31/704 , A61K47/6957 , A61L27/34 , A61L27/54 , A61L2300/222 , A61L2300/41 , A61L2300/416 , A61L2300/602 , A61L2300/608 , A61L2300/624 , A61L2420/08 , C08L65/04
摘要： The present invention provides materials and devices for the controlled release of therapeutics, and methods for uses thereof.
摘要翻译：本发明提供用于控制释放治疗剂的材料和装置及其用途的方法。

9. 发明申请

WO2010138837A3 NANODIAMOND PARTICLE COMPLEXES 审中-公开
标题翻译：纳米颗粒复合物
公开(公告)号：WO2010138837A3
公开(公告)日：2011-03-24
申请号：PCT/US2010036610
申请日：2010-05-28
申请人： UNIV NORTHWESTERN , HO DEAN , CHEN MARK , PIERSTORFF ERIK , ROBINSON ERIK , LAM ROBERT , SHIMKUNAS RAFAEL , ZHANG XUEQING
发明人： HO DEAN , CHEN MARK , PIERSTORFF ERIK , ROBINSON ERIK , LAM ROBERT , SHIMKUNAS RAFAEL , ZHANG XUEQING
IPC分类号： B82B3/00 , C01B31/00 , C01B31/06
CPC分类号： C07K17/14 , A61K47/6921 , A61K47/6929 , B82Y5/00
摘要： The present invention provides various functionalized nanodiamond particles. In particular, the present invention provides soluble complexes of nanodiamond particles and therapeutic agents, for example insoluble therapeutics, anthracycline and/or tetracycline compounds, nucleic acids, proteins, etc.
摘要翻译：本发明提供了各种官能化纳米金刚石颗粒。特别地，本发明提供了纳米金刚石颗粒和治疗剂的可溶性复合物，例如不溶性治疗剂，蒽环类抗生素和/或四环素化合物，核酸，蛋白质等。

10. 发明申请

WO0101320A8 SYSTEM AND METHOD OF PROVIDING PROMOTIONAL PRICES TO A USER AND ACCUMULATING INCENTIVES TO A USER 审中-公开
标题翻译：向用户提供促销价格的系统和方法以及对用户的累积激励
公开(公告)号：WO0101320A8
公开(公告)日：2001-03-15
申请号：PCT/US9914752
申请日：1999-06-28
申请人： PLANET RX , CHONG JAMES , CHAN JOSEPH , TANG HENRY , LAM ROBERT
发明人： CHONG JAMES , CHAN JOSEPH , TANG HENRY , LAM ROBERT
IPC分类号： G06Q30/00 , G06F19/00 , G06F17/60
CPC分类号： G06Q30/02
摘要： A computer-implemented method and system for promoting a business are provided. The method can be used with an electronic network, preferably the World Wide Web. A vendor program running on a vendor system (330) displays promotional items on a promotional Web page (302). When a customer selects promotional items (306), the vendor program queries a database (304) to determine the customer's eligibility to participate in the business promotion. An ineligible customer (318) is offered the opportunity to purchase the items at a non-promotional rate (324), or to cancel the order (326). The promotional items are delivered (342) to an eligible customer (344) at the promotional rate. An eligible customer is also sent a persistent cookie (316) that is used to notify the vendor program to display a non-promotional Web page during the customer's subsequent visits to the vendor's Web site. The eligible customer is sent a URL link with an encrypted unique key (336) for associating referred new customers (400) to the customer. An incentive is rewarded (406) to the customer for each referred customer who participates in the business program. A tally Web page displays referred customer information. Incentive awards can be selected from a redemption Web page. Upon selection of an incentive award, the vendor program updates the tally and redemption pages, and the database. The vendor program makes arrangements to have the incentives delivered to the referring customer. Each additional customer is provided a URL with a unique encrypted key and has the opportunity to earn incentives by referring others to the vendor's business promotion.
摘要翻译：提供了一种用于促进业务的计算机实现的方法和系统。该方法可以与电子网络一起使用，优选地是万维网。在供应商系统（330）上运行的供应商程序在促销网页上显示促销品（302）。当客户选择促销项目（306）时，供应商程序查询数据库（304）以确定客户参与促销活动的资格。提供不合格客户（318）以非促销价（324）购买商品或取消订单（326）的机会。促销品以促销价格交付给合格客户（344）（342）。符合条件的客户还会发送持久性Cookie（316），用于在客户随后访问供应商的网站期间通知供应商程序显示非促销网页。向符合条件的客户发送带有加密唯一密钥（336）的URL链接，用于将所引用的新客户（400）与客户相关联。对于参与业务计划的每个参与客户，奖励（406）给客户。统计网页显示参考客户信息。激励奖励可以从兑换网页中选择。在选择奖励奖励后，供应商计划更新计数和兑换页面以及数据库。供应商计划作出安排，将激励措施交付给转介客户。每个额外的客户都提供了一个带有唯一加密密钥的URL，并有机会通过引用他人来提供供应商的业务促销来获得奖励。

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