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1. 发明申请

WO2014026146A1 GRAFT ANCHOR DEVICES, SYSTEMS AND METHODS 审中-公开
标题翻译： GRAFT锚固装置，系统和方法
公开(公告)号：WO2014026146A1
公开(公告)日：2014-02-13
申请号：PCT/US2013/054398
申请日：2013-08-09
申请人： ABIOMED, INC. , SPENCE, Paul , DOWLING, Rob , KUNG, Bob , HASTIE, Caitlyn , SIESS, Thorsten , GRATZ, Eric , SPANIER, Gerd
发明人： SPENCE, Paul , DOWLING, Rob , KUNG, Bob , HASTIE, Caitlyn , SIESS, Thorsten , GRATZ, Eric , SPANIER, Gerd
IPC分类号： A61F2/06 , A61F2/07 , A61B17/11
CPC分类号： A61F2/856 , A61B17/11 , A61B2017/1107 , A61B2017/1135 , A61F2002/068 , A61M1/1008 , A61M1/12 , A61M1/125
摘要： The present disclosure provides medical devices, systems and methods and in particular to devices and methods useful for anchoring graft materials to bodily structures.
摘要翻译：本公开提供了医疗装置，系统和方法，特别是用于将移植物材料锚定到身体结构的装置和方法。

2. 发明申请

WO2013043276A1 DEVICES, METHODS AND SYSTEMS FOR COUNTERPULSATION AND BLOOD FLOW CONDUIT CONNECTION 审中-公开
标题翻译：用于计数和血液流量连接的装置，方法和系统
公开(公告)号：WO2013043276A1
公开(公告)日：2013-03-28
申请号：PCT/US2012/050604
申请日：2012-08-13
申请人： ABIOMED, INC. , DOWLING, Rob , KUNG, Bob , SPENCE, Paul , SIESS, Thorsten , SPANIER, Gerd , GRATZ, Eric , HASTIE, Caitlyn
发明人： DOWLING, Rob , KUNG, Bob , SPENCE, Paul , SIESS, Thorsten , SPANIER, Gerd , GRATZ, Eric , HASTIE, Caitlyn
IPC分类号： A61M25/16
CPC分类号： A61M1/1008 , A61B17/11 , A61B2017/00884 , A61B2017/1135 , A61F2/0077 , A61F2/064 , A61F2250/0026 , A61M1/101 , A61M1/1032 , A61M1/106 , A61M1/107 , A61M1/12 , A61M1/122 , A61M1/3653 , A61M1/3655 , A61M25/0043 , A61M25/0071 , A61M25/0074 , A61M2025/006 , A61M2206/10
摘要： A blood flow conduit is disclosure, including:a first conduit portion defining a first portion of a lumen; and a second conduit portion defining a second portion of a lumen. At least one of the first or second conduit portions may include a tip portion and the other of the first or second conduit portions may include an enlarged area.
摘要翻译：公开了一种血流导管，包括：限定内腔的第一部分的第一导管部分; 以及限定腔的第二部分的第二导管部分。第一或第二导管部分中的至少一个可以包括尖端部分，并且第一或第二导管部分中的另一个可以包括放大区域。

3. 发明申请

WO2008112775A1 COMPOSITIONS AND KITS FOR TREATING INFLUENZA 审中-公开
标题翻译：用于治疗流感的组合物和试剂盒
公开(公告)号：WO2008112775A1
公开(公告)日：2008-09-18
申请号：PCT/US2008/056678
申请日：2008-03-12
申请人： ADAMAS PHARMACEUTICALS, INC. , NGUYEN, Jack , WENT, Gregory, T. , SPENCE, Paul , FULTZ, Timothy, J. , CHERNOFF, David
发明人： NGUYEN, Jack , WENT, Gregory, T. , SPENCE, Paul , FULTZ, Timothy, J. , CHERNOFF, David
IPC分类号： A61K31/454 , A61K31/7056
CPC分类号： A61K31/454 , A61K31/7056 , A61K2300/00
摘要： Compositions, kits and methods are provided for the treatment or prophylaxis of influenza.
摘要翻译：提供组合物，试剂盒和方法用于治疗或预防流行性感冒。

4. 发明申请

WO2021113843A1 IMPLANTABLE ENDOVASCULAR, LOW PROFILE INTRACARDIAC LEFT ATRIAL RESTRAINING DEVICES FOR LOW ENERGY ATRIAL CARDIOVERSION, PACING AND SENSING 审中-公开
公开(公告)号：WO2021113843A1
公开(公告)日：2021-06-10
申请号：PCT/US2020/063664
申请日：2020-12-07
申请人： WOLF, Randall K. , SPENCE, Paul
发明人： WOLF, Randall K. , SPENCE, Paul
IPC分类号： A61N1/05
摘要： Disclosed are various configurations of electrodes with accompanying extensions and wires configured to be attached at or near the left atrium of a heart to allow the device to be held snug against the endocardium and out of the blood flow for low energy defibrillation of the atria in response to atrial fibrillation or other atrial arrhythmias. The portion of the lead internal to the atrium (e.g., the left atrium) is restrained against the endocardium of the left atrium by way of a restraint mechanism. In one example, the electrode is configured to attach to the atrial septum, with wires containing memory-shaped metal to keep the wires against the heart wall. In yet another example, the electrode is configured to be part of a mitral valve device.

5. 发明申请

WO2010044929A2 EMERGENCY PREPARATIONS FOR AN EPIDEMIC 审中-公开
标题翻译：紧急情况准备工作
公开(公告)号：WO2010044929A2
公开(公告)日：2010-04-22
申请号：PCT/US2009/049337
申请日：2009-06-30
申请人： ADAMAS PHARMACEUTICALS, INC. , FULTZ, Timothy, J. , WENT, Gregory, T. , NGUYEN, Jack , SPENCE, Paul , CHERNOFF, David , BURKOTH, Terry, L. , CHAPMAN, Rowan , URDEA, Mickey, S.
发明人： FULTZ, Timothy, J. , WENT, Gregory, T. , NGUYEN, Jack , SPENCE, Paul , CHERNOFF, David , BURKOTH, Terry, L. , CHAPMAN, Rowan , URDEA, Mickey, S.
IPC分类号： A61J7/04 , B65D83/04 , A61J1/03
CPC分类号： G06Q10/00 , G06F19/00 , G06Q50/22 , G06Q99/00
摘要： Stockpiles and methods of stockpiling a combination antiviral therapy for responding to an epidemic viral outbreak are described. Methods and systems of inventory control for co-deployment of drugs used in combination during a pandemic are described.
摘要翻译：描述了储存组合抗病毒治疗以应对流行性病毒爆发的库存和方法。描述了在大流行期间组合使用的药物共同部署的库存控制方法和系统。

6. 发明申请

WO2002085251A1 METHOD AND APPARATUS FOR PERFORMING CATHETER-BASED ANNULOPLASTY 审中-公开
标题翻译：用于实施基于导管的神经生长的方法和装置
公开(公告)号：WO2002085251A1
公开(公告)日：2002-10-31
申请号：PCT/US2002/010952
申请日：2002-04-09
申请人： DHC SYSTEMS, INC. , HLAVKA, Edwin, J. , SPENCE, Paul
发明人： HLAVKA, Edwin, J. , SPENCE, Paul
IPC分类号： A61F2/06
CPC分类号： A61F2/2445 , A61B2017/00243 , A61B2017/048 , A61F2/2448 , A61F2/2466 , Y10S623/904
摘要： The present invention relates to a minimally invasive method of performing annuloplasty. According to one aspect of the present invention, a method for performing a procedure on a mitral valve (728) of a heart includes inserting an implant (924) into a left ventricle and orienting the implant in the left ventricle substantially below the mitral valve. The implant (924) and tissue (970) around the mitral valve (728) are connected and tension is provided to the implant, in one embodiment, in order to substantially reduce an arc length associated with the mitral valve (728). In another embodiment, the implant (924) is inserted into the left ventricle through the aorta and the aortic valve.
摘要翻译：本发明涉及执行瓣环成形术的微创方法。根据本发明的一个方面，一种用于在心脏的二尖瓣（728）上执行手术的方法包括将植入物（924）插入左心室并将植入物定向在基本上在二尖瓣下方的左心室中。在一个实施例中，围绕二尖瓣（728）的植入物（924）和组织（970）被连接并且在植入物中提供张力，以便基本上减小与二尖瓣（728）相关联的电弧长度。在另一个实施例中，通过主动脉和主动脉瓣将植入物（924）插入左心室。

7. 发明申请

WO2022006375A1 HEART VALVE PROSTHESES AND RELATED METHODS 审中-公开
公开(公告)号：WO2022006375A1
公开(公告)日：2022-01-06
申请号：PCT/US2021/040053
申请日：2021-07-01
申请人： INVALVE THERAPEUTICS, INC. , SPENCE, Paul , PAOLITTO, Anthony
发明人： SPENCE, Paul , PAOLITTO, Anthony
IPC分类号： A61F2/24 , A61F2/2412 , A61F2/246 , A61F2/2463 , A61F2/2466
摘要： Prosthetic valves for treating blood flow regurgitation through a native heart valve can include a body including an inlet portion and an outlet portion having a first limb and a second limb, and defining a flow passage having an inlet in the inlet portion, a first outlet in the first limb and a second outlet in the second limb, a flow control device disposed in the flow passage within the inlet portion, and a clip connector coupled to the body. The prosthetic valve is configured to be disposed in a native valve of a heart that has been clipped to create a first flow control portion and a second flow control portion, with the inlet disposed in an atrium of the heart, and with the first outlet and the second outlet disposed in the ventricle of the heart, with the limbs configured to be disposed in the flow control portions in substantially sealing relationship with the first leaflet and the second leaflet. The prosthetic valve is further configured to permit blood to flow from the atrium to the ventricle through the flow passage, and to substantially prevent blood to flow from the ventricle to the atrium though the flow passage or between the body and the leaflets during systole of the heart. The clip connector is configured to be selectively coupled to the clip and to resist displacement of the body towards the atrium during systole.

8. 发明申请

WO2015200311A1 MANUAL SQUEEZE BOTTLE APPLICATOR FOR ATOMIZING LIQUIDS 审中-公开
标题翻译：手动液体瓶应用程序用于引导液体
公开(公告)号：WO2015200311A1
公开(公告)日：2015-12-30
申请号：PCT/US2015/037159
申请日：2015-06-23
申请人： TIMMS, Broadus , SPENCE, Paul
发明人： TIMMS, Broadus , SPENCE, Paul
IPC分类号： B65D83/62 , B65D83/20 , B65D1/02
CPC分类号： B05B11/046 , B05B11/001 , B05B11/0043 , B05B11/0054 , B05B11/0064 , B05B11/047 , B65D83/20 , B65D83/62
摘要： A squeeze bottle, useful for atomizing liquids such as perfumes, medications, insecticides, or the like, by manually squeezing the bottle while orienting the bottle to direct the resulting atomized spray for a desired application. The squeeze bottle utilizes ambient air and contains an inner, compliant pouch for storing a liquid. The pouch is configured so that it deforms by the hydrostatic air pressure generated within the bottle during a squeezing action. This deformation assists in transferring liquid from the pouch into the bottle's spray nozzle where the liquid is atomized in a swirl airflow and dispersed by the expelled ambient air.
摘要翻译：挤压瓶，用于通过在定向瓶子的同时手动挤压瓶子以引导所得到的雾化喷雾器以期望的应用来雾化液体如香料，药物，杀虫剂等。挤压瓶使用环境空气，并包含一个用于储存液体的内部柔顺袋。该袋被构造成使得其在挤压作用期间通过在瓶内产生的静水压力而变形。这种变形有助于将液体从袋中转移到瓶的喷嘴中，其中液体被旋转的气流雾化并被排出的环境空气分散。

9. 发明申请

WO2009091932A3 TREATMENT OF MILD DEMENTIA OF THE ALZHEIMER'S DISEASE TYPE 审中-公开
公开(公告)号：WO2009091932A3
公开(公告)日：2009-07-23
申请号：PCT/US2009/031167
申请日：2009-01-15
申请人： ADAMAS PHARMACEUTICALS, INC. , SPENCE, Paul , WENT, Gregory, T. , FULTZ, Timothy, J.
发明人： SPENCE, Paul , WENT, Gregory, T. , FULTZ, Timothy, J.
IPC分类号： A61K31/13 , A61P25/28 , A61K31/445
摘要： Methods, compositions, and kits for slowing progression of Alzheimer's disease symptoms in a patient with mild Alzheimer's disease are described.

10. 发明申请

WO2007136737A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF VIRAL INFECTIONS 审中-公开
标题翻译：用于治疗病毒感染的方法和组合物
公开(公告)号：WO2007136737A1
公开(公告)日：2007-11-29
申请号：PCT/US2007/011887
申请日：2007-05-18
申请人： NEUROMOLECULAR PHARMACEUTICALS, INC. , WENT, Gregory , CHERNOFF, David , SPENCE, Paul , BURKOTH, Terry , FULTZ, Timothy
发明人： WENT, Gregory , CHERNOFF, David , SPENCE, Paul , BURKOTH, Terry , FULTZ, Timothy
IPC分类号： A61K31/13 , A61P31/12
CPC分类号： A61K45/06 , A61K9/2009 , A61K9/2054 , A61K9/2846 , A61K9/5026 , A61K9/5047 , A61K9/5073 , A61K9/5084 , A61K31/13 , A61K2300/00
摘要： Compositions for treating flu comprise an M2 inhibitor, and optionally a neuraminidase inhibitor, wherein at least one of said M2 inhibitor or said neuraminidase inhibitor is provided in an extended release dosage form.
摘要翻译：用于治疗流感的组合物包含M2抑制剂和任选的神经氨酸酶抑制剂，其中所述M2抑制剂或所述神经氨酸酶抑制剂中的至少一种以延长释放剂型提供。

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