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1. 发明申请

WO2012012800A2 A METHOD AND APPARATUS FOR DETECTING THE PRESENCE OF ANISOTROPIC CRYSTALS AND HEMOZOIN PRODUCING PARASITES IN LIQUID BLOOD 审中-公开
标题翻译：检测液体血液中各向异性晶体和HEMOZOIN生产PARASITE的存在的方法和装置
公开(公告)号：WO2012012800A2
公开(公告)日：2012-01-26
申请号：PCT/US2011045224
申请日：2011-07-25
申请人： ABBOTT POINT OF CARE INC , LEVINE ROBERT A , UNFRICHT DARRYN W , WARDLAW STEPHEN C , PORTS BENJAMIN
发明人： LEVINE ROBERT A , UNFRICHT DARRYN W , WARDLAW STEPHEN C , PORTS BENJAMIN
IPC分类号： G01N33/49
CPC分类号： G01N21/23 , G01N21/6458
摘要： An apparatus and method for detecting the presence of anisotropic crystals within a biologic fluid sample is provided. The method includes the steps of: a) disposing the sample within a sample chamber in a sample layer having a height not greater than about fifteen microns (15µ); b) disposing the sample layer within the sample chamber between a polarizing filter and an analyzing filter; c) disposing the polarizing filter, sample chamber, and analyzing filter in a configuration relative to a light source such that polarized light passes through the sample, and subsequently impinges on the analyzing filter; and d) wherein polar orientations of the polarizing filter and the analyzing filter are such that the polarized light will not pass through the analyzing filter, and light passing through an anisotropic crystal disposed within the sample will pass through the analyzing filter and appear as a point of light.
摘要翻译：提供了一种用于检测生物液体样品中各向异性晶体的存在的装置和方法。该方法包括以下步骤：a）将样品置于具有不大于约十五微米（15μ）的高度的样品层内的样品室内; b）将样品层置于样品室内，在偏振滤光片和分析滤光片之间; c）将偏振滤光器，样品室和分析滤光片相对于光源配置成使得偏振光通过样品，随后撞击在分析滤光片上; 和d）其中偏振滤光器和分析滤光器的极性取向使得偏振光不会通过分析滤光器，并且通过设置在样品内的各向异性晶体的光将通过分析滤光器并显现为点的光。

2. 发明申请

WO2009117664A3 METHOD AND APPARATUS FOR DETERMINING RED BLOOD CELL INDICES OF A BLOOD SAMPLE UTILIZING THE INTRINSIC PIGMENTATION OF HEMOGLOBIN CONTAINED WITHIN THE RED BLOOD CELLS 审中-公开
标题翻译：用于确定使用红细胞中含有的HEMOGLOBIN的内在色素的血液样品的红血细胞指数的方法和装置
公开(公告)号：WO2009117664A3
公开(公告)日：2009-12-17
申请号：PCT/US2009037815
申请日：2009-03-20
申请人： ABBOTT POINT OF CARE INC , WARDLAW STEPHEN C , LEVINE ROBERT A , UNFRICHT DARRYN W , LALPURIA NITEN V , HILL JEREMY R
发明人： WARDLAW STEPHEN C , LEVINE ROBERT A , UNFRICHT DARRYN W , LALPURIA NITEN V , HILL JEREMY R
IPC分类号： G01N33/49
CPC分类号： G06T7/0012 , G01N15/05 , G01N33/49 , G01N2015/055
摘要： Method and apparatus for determining the concentration of haemoglobin within red blood cells. An undiluted, whole blood sample is deposited into a transparent analysis chamber (10) whose height is such that the red blood cells are in contact with both surfaces (14, 18). Then the optical density of a portion of the red blood cells in contact with both' surf aces is measured. The haemoglobin concentration of the red blood cell is calculated from the optical density and the known distinction coefficient of haemoglobin. This is repeated with other cells until an average haemoglobin concentration can be determined with confidence. Dependent claims include use of zwitterionic isovolumetric sphering agent make the measurement independent of a geometrical form factor.
摘要翻译：用于测定红细胞内血红蛋白浓度的方法和装置。将未稀释的全血样品沉积到其高度使得红细胞与两个表面（14,18）接触的透明分析室（10）中。然后测量与两个“冲浪”接触的红细胞的一部分的光密度。红细胞的血红蛋白浓度由血红蛋白的光密度和已知的鉴别系数计算。这与其他细胞重复，直到可以置信地测定平均血红蛋白浓度。从属权利要求包括使用两性离子等容量球形试剂使测量独立于几何形状因子。

3. 发明申请

WO2009117683A3 METHOD AND APPARATUS FOR ANALYZING INDIVIDUAL CELLS OR PARTICULATES USING FLUORESCENT QUENCHING AND/OR BLEACHING 审中-公开
标题翻译：使用荧光猝灭和/或漂白分析个体细胞或颗粒物的方法和装置
公开(公告)号：WO2009117683A3
公开(公告)日：2009-11-19
申请号：PCT/US2009037845
申请日：2009-03-20
申请人： ABBOTT POINT OF CARE , LEVINE ROBERT A , WARDLAW STEPHEN C , LALPURIA NITEN V , UNFRICHT DARRYN W
发明人： LEVINE ROBERT A , WARDLAW STEPHEN C , LALPURIA NITEN V , UNFRICHT DARRYN W
IPC分类号： G01N21/64 , G01N15/14 , G01N33/50
CPC分类号： G01N33/49 , G01N15/1463 , G01N15/1475 , G01N21/6428 , G01N21/6456 , G01N33/48 , G01N33/5091 , G01N2015/008 , G01N2015/1477 , G01N2021/6432 , G01N2021/6439 , G01N2201/062
摘要： A method for analyzing a blood sample is provided that includes the steps of: a) providing a blood sample having one or more first constituents and one or more second constituents, which second constituents are different from the first constituents; b) depositing the sample into an analysis chamber adapted to quiescently hold the sample for analysis, the chamber defined by a first panel and a second panel, both of which panels are transparent; c) admixing a colorant with the sample, which colorant is operative to cause the first constituents and second constituents to fluoresce upon exposure to predetermined first wavelengths of light, and which colorant is operative to absorb light at one or more predetermined second wavelengths of light; d) illuminating at least a portion of the sample containing the first constituents and the second constituents at the first wavelengths and at the second wavelengths; e) imaging the at least a portion of the sample, including producing image signals indicative of fluorescent emissions from the first constituents and the second constituents and the optical density of the first constituents and the second constituents; f) determining a fluorescence value for each the first constituents and second constituents using the image signals; g) determining an optical density value for each of the first constituents and second constituents, which optical density is a function of the colorant absorbed by the constituents, using the image signals; and h) identifying the first constituents and the second constituents using the determined fluorescence and optical density values.
摘要翻译：提供了一种用于分析血液样本的方法，其包括以下步骤：a）提供具有一个或多个第一成分和一个或多个第二成分的血液样品，所述第二成分与第一成分不同; b）将样品沉积到适于静态保持样品进行分析的分析室中，所述室由第一面板和第二面板限定，两个面板都是透明的; c）将着色剂与所述样品混合，所述着色剂可操作以使得所述第一组分和第二组分在暴露于预定的第一波长的光时发荧光，并且所述着色剂可操作地吸收一个或多个预定的第二波长的光的光; d）以第一波长和第二波长照射含有第一组分和第二组分的样品的至少一部分; e）对样品的至少一部分进行成像，包括产生指示来自第一组分和第二组分的荧光发射的图像信号和第一组分和第二组分的光密度; f）使用图像信号确定每个第一成分和第二成分的荧光值; g）使用所述图像信号确定所述第一成分和第二成分中的每一个的光密度值，所述光密度值是由所述成分吸收的着色剂的函数; 和h）使用所确定的荧光和光密度值来识别第一组分和第二组分。

4. 发明申请

WO2010148135A3 HARVESTING TARGET MATERIALS FROM CENTRIFUGED SUSPENSIONS 审中-公开
标题翻译：从离心悬架收集目标材料
公开(公告)号：WO2010148135A3
公开(公告)日：2011-04-28
申请号：PCT/US2010038887
申请日：2010-06-16
申请人： LEVINE ROBERT A , WARDLAW STEPHEN C
发明人： LEVINE ROBERT A , WARDLAW STEPHEN C
IPC分类号： G01N33/483 , C12M1/10 , G01N1/14 , G01N1/28 , G01N35/10
CPC分类号： G01N33/491 , Y10T436/25 , Y10T436/25375
摘要： Embodiments of the present invention are directed to harvesting a target material from a suspension using a tube and float system. A suspension suspected of containing a target material is combined with a solution having one or more labels that distinguish the target material from other materials in the suspension. The tube, float, and suspension are centrifuged to separate various materials in the suspension according to associated specific gravities. The float expands the axial length of the target material layer and displaces the target material to a narrow space between the float and the inner wall of the tube. The space is illuminated with light that causes the labels to emit light identifying the location of the target material within the tube. One or more openings can then be formed in the tube at or near the point where the target material is located and the target material harvested.
摘要翻译：本发明的实施方案涉及使用管和浮子系统从悬浮液中收获目标材料。怀疑含有目标材料的悬浮液与具有一种或多种将目标材料与悬浮液中的其它材料区分开的标签的溶液合并。将管，浮子和悬浮液离心以根据相关的比重分离悬浮液中的各种材料。浮子膨胀目标材料层的轴向长度，并将目标材料移位到浮子和管内壁之间的狭窄空间。该空间用光照亮，导致标签发光以识别管内的目标材料的位置。然后可以在管中或靶附近所处的点附近形成一个或多个开口，并收集目标材料。

5. 发明申请

WO2012142450A2 QUALITY CONTROL METHOD AND APPARATUS FOR AUTOMATED ANALYSES OF BIOLOGIC FLUID SAMPLE 审中-公开
标题翻译：生物流体样品自动分析的质量控制方法和装置
公开(公告)号：WO2012142450A2
公开(公告)日：2012-10-18
申请号：PCT/US2012033576
申请日：2012-04-13
申请人： WARDLAW STEPHEN C , LEVINE ROBERT A
发明人： WARDLAW STEPHEN C , LEVINE ROBERT A
IPC分类号： G06F3/048
CPC分类号： G01N35/00613 , B01L3/508 , B01L3/545 , B01L2300/021 , G01N2035/00851
摘要： An apparatus and method for analyzing a biologic sample is provided. The apparatus includes a capillary tube, a machine readable identity tag, and an analysis device. The tube is operable to hold the biologic sample. The machine readable identity tag is disposed on the tube, and indicates a production source of the tube. The analysis device is operable to analyze the biologic sample. The analysis device includes a reader adapted to read the identity tag, and the analysis device is operable to authenticate the tube based on the identity tag read from the tube.
摘要翻译：提供了用于分析生物样品的装置和方法。该装置包括毛细管，机器可读身份标签和分析装置。管可操作以保持生物样品。机器可读身份标签设置在管上，并指示管的生产源。分析装置可操作以分析生物样品。分析装置包括适于读取身份标签的读取器，并且分析装置可操作以基于从管中读取的身份标签来认证管。

6. 发明申请

WO9945386A9 METHOD FOR PERFORMING BLOOD CELL COUNTS 审中-公开
标题翻译：执行血液细胞计数的方法
公开(公告)号：WO9945386A9
公开(公告)日：2000-07-13
申请号：PCT/US9904976
申请日：1999-03-05
申请人： LEVINE ROBERT A , WARDLAW PARTNERS LP , WARDLAW STEPHEN C
发明人： WARDLAW STEPHEN C
IPC分类号： G01N33/49 , A01N1/02 , G01N1/18 , G01N15/05 , G01N15/14 , G01N21/03 , G01N21/76 , G01N33/48 , G01N33/50 , G01N33/72 , G01N33/86
CPC分类号： G01N33/5005 , G01N15/05 , G01N33/5002 , Y10T436/25375
摘要： A method for evaluating constituents of a sample of substantially undiluted anti-coagulated whole blood is provided which includes the steps of: a) providing a sample chamber (10); b) admixing a sensible colorant with the sample of whole blood; c) inserting the admixed sample into the sample chamber; d) quiescently holding the admixed sample for a period until rouleaux (30) and lacunae (32) form within the sample; and e) evaluating a target constituent disposed within the lacunae (32).
摘要翻译：提供一种用于评估基本上未稀释的抗凝血全血样品的成分的方法，其包括以下步骤：a）提供样品室（10）; b）将明显的着色剂与全血样品混合; c）将混合的样品插入样品室; d）将混合样品静置一段时间，直到样品中形成（40）和空白（32）; 以及e）评价设在所述空隙（32）内的目标成分。

7. 发明申请

WO9945386A8 METHOD FOR PERFORMING BLOOD CELL COUNTS 审中-公开
标题翻译：进行血细胞计数的方法
公开(公告)号：WO9945386A8
公开(公告)日：2000-04-13
申请号：PCT/US9904976
申请日：1999-03-05
申请人： LEVINE ROBERT A , WARDLAW PARTNERS LP , WARDLAW STEPHEN C
发明人： WARDLAW STEPHEN C
IPC分类号： G01N33/49 , A01N1/02 , G01N1/18 , G01N15/05 , G01N15/14 , G01N21/03 , G01N21/76 , G01N33/48 , G01N33/50 , G01N33/72 , G01N33/86
CPC分类号： G01N33/5005 , G01N15/05 , G01N33/5002 , Y10T436/25375
摘要： A method for evaluating constituents of a sample of substantially undiluted anti-coagulated whole blood is provided which includes the steps of: a) providing a sample chamber (10); b) admixing a sensible colorant with the sample of whole blood; c) inserting the admixed sample into the sample chamber; d) quiescently holding the admixed sample for a period until rouleaux (30) and lacunae (32) form within the sample; and e) evaluating a target constituent disposed within the lacunae (32).
摘要翻译：提供了一种评估基本上未稀释的抗凝全血样品成分的方法，该方法包括以下步骤：a）提供样品室（10）; b）将合理的着色剂与全血样品混合; c）将混合的样品插入样品室中; d）静止地将混合的样品保持一段时间直到样品内形成rouleaux（30）和空隙（32）; 和e）评估设置在空隙（32）内的目标成分。

8. 发明申请

WO2005100539A3 DISPOSABLE CHAMBER FOR ANALYZING BIOLOGIC FLUIDS 审中-公开
标题翻译：用于分析生物流体的可拆卸的室
公开(公告)号：WO2005100539A3
公开(公告)日：2006-01-19
申请号：PCT/US2005011602
申请日：2005-04-07
申请人： LEVINE ROBERT A , WARDLAW PARTNERS LP , WARDLAW STEPHEN C
发明人： WARDLAW STEPHEN C
IPC分类号： C12M1/34 , C12M1/40 , G01N1/31 , G01N15/14 , G01N33/48
CPC分类号： G01N33/48764 , B01L3/5027 , B01L3/502738 , B01L2200/025 , B01L2200/12 , B01L2300/0877 , B01L2300/0887 , B01L2400/0406 , G01N1/2813 , G01N1/312 , G01N21/03 , G01N33/492 , G01N35/00009 , G01N2015/008 , G01N2015/1006 , G01N2015/1486 , G01N2021/0346 , G01N2021/0364 , Y10T436/101666 , Y10T436/25375
摘要： An apparatus for analyzing biologic fluid is provided that includes a first planar member, a second planar member, and at least three separators. At least one of planar members is transparent. The separators are disposed between the members, and separate the members to form a chamber having a height. At least one of the members or separators is sufficiently flexible to permit the chamber height to approximate the mean size of the separators. During use, the biologic fluid to be analyzed is disposed within the chamber.
摘要翻译：提供一种用于分析生物流体的装置，其包括第一平面构件，第二平面构件和至少三个分隔件。平面构件中的至少一个是透明的。分离器设置在构件之间，并且分离构件以形成具有高度的室。构件或分隔件中的至少一个具有足够的柔性，以允许室的高度接近分隔件的平均尺寸。在使用过程中，待分析的生物流体设置在室内。

9. 发明申请

WO9945384A8 DETERMINATION OF WHITE BLOOD CELL DIFFERENTIAL AND RETICULOCYTE COUNTS 审中-公开
标题翻译：白细胞分化和细胞计数的测定
公开(公告)号：WO9945384A8
公开(公告)日：2000-02-03
申请号：PCT/US9903775
申请日：1999-02-22
申请人： WARDLAW PARTNERS LP , BECTON DICKINSON CO , WARDLAW STEPHEN C , LEVINE ROBERT A
发明人： WARDLAW STEPHEN C , LEVINE ROBERT A , RODRIGUEZ RODOLFO R
IPC分类号： G01N33/48 , G01N15/00 , G01N15/14 , G01N21/03 , G01N33/49 , G01N33/50
CPC分类号： G01N15/1475 , G01N33/5094 , G01N2015/0076 , G01N2015/0092 , G01N2015/1472 , G01N2015/1497 , Y10T436/10 , Y10T436/101666
摘要： Target nucleated cells, and target cells containing remanant ribosomal material, which are present in a quiescent anticoagulated whole blood sample are optically detected, enumerated, and analyzed in a sample chamber (14) that has a varying through plane thickness due to convergent opposing sample chamber walls. At least one of the convergent walls (8) of the chamber is transparent so that the blood sample can be observed. The chamber's varying thickness produces a first lesser thickness region (A) in the chamber wherein individual red cells (32) and quiescent monolayers (31) of red cells in the sample will reside after the sample is introduced into and fills the chamber. Larger formed constituents such as white blood cells (34) and nucleated red blood cells present in the sample will reside in greater thickness regions (B) of the chamber, and non-nucleated red cells which reside in such greater thickness regions will agglomerate to form rouleaux (33). By admixing fluorescent dyes with the blood sample, target cells in the sample can be enumerated and differentiated by means of a scanning instrument (54) which is able to measure different wave length color signals emitted from the target cells in the sample, and differentiate the target cells one from another by reason of the nature of the emitted color signals.
摘要翻译：存在于静止抗凝血全血样品中的目标有核细胞和含有残留核糖体材料的靶细胞在样品室（14）中光学检测，计数和分析，样品室（14）由于收敛的相对样品室墙壁。室的收敛壁（8）中的至少一个是透明的，使得可以观察血液样本。室的变化的厚度在腔室中产生第一较小厚度的区域（A），其中样品中的红细胞中的各个红细胞（32）和静止单层（31）将在样品被引入并填充室之后驻留。存在于样品中的较大的形成成分如白细胞（34）和有核红细胞将驻留在室的较大厚度区域（B）中，并且驻留在这样较厚的区域中的非成核红细胞将聚集形成 rouleaux（33）。通过将荧光染料与血液样品混合，样品中的靶细胞可以通过能够测量从样品中的靶细胞发射的不同波长颜色信号的扫描仪器（54）进行计数和分化，由于发射的颜色信号的性质，目标细胞是彼此之间的。

10. 发明申请

WO2007047908A3 APPARATUS AND METHOD FOR PERFORMING COUNTS WITHIN A BIOLOGIC FLUID SAMPLE 审中-公开
标题翻译：用于在生物流体样品中执行计数的装置和方法
公开(公告)号：WO2007047908A3
公开(公告)日：2007-06-14
申请号：PCT/US2006041011
申请日：2006-10-17
申请人： WARDLAW PARTNERS LP , LEVINE ROBERT A , WARDLAW STEPHEN C
发明人： WARDLAW STEPHEN C
IPC分类号： G06M11/00 , G01N33/49
CPC分类号： G01N15/1463 , B01L3/5027 , B01L3/508 , B01L2200/0684 , B01L2300/0822 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/1486 , G02B21/34 , Y10T436/101666
摘要： A method and an apparatus for enumerating one or more specific elements within a biologic fluid sample are provided. An embodiment of the method includes the steps of: a) providing a chamber formed between a first planar member that is transparent and a second planar member, which members are separated from one another by a substantially uniform height; b) introducing the biologic fluid sample into the chamber, wherein the chamber height is sized such that the sample extends between the first and second members, and sized relative to the specific elements within the sample such that the specific elements non-uniformly distribute within the sample upon introduction into the chamber; c) examining substantially all of the sample within the chamber and enumerating all of at least one of the specific elements; d) determining the volume of sample contained within the chamber; and e) determining the number of the at least one of the specific elements per unit volume.
摘要翻译：提供了用于列举生物流体样本内的一种或多种特定元素的方法和设备。该方法的一个实施例包括以下步骤：a）提供形成在透明的第一平面构件和第二平面构件之间的室，所述构件彼此分开大致均匀的高度; b）将生物流体样品引入腔室中，其中腔室高度的大小使得样品在第一和第二部件之间延伸，并且相对于样品内的特定元件确定尺寸，使得特定元件非均匀地分布在在引入腔室后进行采样; c）检查所述室内的基本上全部样品并列举至少一种所述特定元素的全部; d）确定容纳在腔室内的样品的体积; 和e）确定每单位体积的至少一个特定元素的数量。

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