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1. 发明申请

WO2007081517A2 ANTI-VIRAL COMPOUNDS 审中-公开
公开(公告)号：WO2007081517A2
公开(公告)日：2007-07-19
申请号：PCT/US2006/048685
申请日：2006-12-20
申请人： ABBOTT LABORATORIES , BETEBENNER, David, A. , DEGOEY, David, A. , MARING, Clarence, J. , KRUEGER, Allan, C. , IWASAKI, Nobuhiko , ROCKWAY, Todd, W. , COOPER, Curt, S. , ANDERSON, David, D. , DONNER, Pamela, L. , GREEN, Brian, E. , KEMPF, Dale, J. , LIU, Dachun , MCDANIEL, Keith, F. , MADIGAN, Darold, L. , MOTTER, Christopher, E. , PRATT, John, K. , SHANLEY, Jason, P. , TUFANO, Michael, D. , WAGNER, Rolf , ZHANG, Rong , MOLLA, Akhteruzzaman , MO, Hongmei , PILOT-MATIAS, Tami, J. , MASSE, Sherie, VL. , CARRICK, Robert, J. , HE, Weping , LU, Liangjun , GRAMPOVNIK, David, J.
发明人： BETEBENNER, David, A. , DEGOEY, David, A. , MARING, Clarence, J. , KRUEGER, Allan, C. , IWASAKI, Nobuhiko , ROCKWAY, Todd, W. , COOPER, Curt, S. , ANDERSON, David, D. , DONNER, Pamela, L. , GREEN, Brian, E. , KEMPF, Dale, J. , LIU, Dachun , MCDANIEL, Keith, F. , MADIGAN, Darold, L. , MOTTER, Christopher, E. , PRATT, John, K. , SHANLEY, Jason, P. , TUFANO, Michael, D. , WAGNER, Rolf , ZHANG, Rong , MOLLA, Akhteruzzaman , MO, Hongmei , PILOT-MATIAS, Tami, J. , MASSE, Sherie, VL. , CARRICK, Robert, J. , HE, Weping , LU, Liangjun , GRAMPOVNIK, David, J.
IPC分类号： C07D495/04 , C07D471/04 , C07D513/04
CPC分类号： C07D487/04 , C07D471/04 , C07D475/06 , C07D495/04 , C07D513/04
摘要： Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

2. 发明申请

WO2007076034A2 ANTI-VIRAL COMPOUNDS 审中-公开
标题翻译：抗病毒化合物
公开(公告)号：WO2007076034A2
公开(公告)日：2007-07-05
申请号：PCT/US2006/049079
申请日：2006-12-20
申请人： ABBOTT LABORATORIES , BETEBENNER, David, A. , DEGOEY, David, A. , MARING, Clarence, J. , KRUEGER, Allan, C. , IWASAKI, Nobuhiko , ROCKWAY, Todd, W. , COOPER, Curt, S. , ANDERSON, David, D. , DONNER, Pamela, L. , GREEN, Brian, E. , KEMPF, Dale, J. , LIU, Dachun , MCDANIEL, Keith, F. , MADIGAN, Darold, L. , MOTTER, Christopher, E. , PRATT, John, K. , SHANLEY, Jason, P. , TUFANO, Michael, D. , WAGNER, Rolf , ZHANG, Rong , MOLLA, Akhteruzzaman , MO, Hongmei , PILOT-MATIAS, Tami, J. , MASSE, Sherie, VL. , CARRICK, Robert, J. , HE, Weping , LU, Liangjun , GRAMPOVNIK, David, J.
发明人： BETEBENNER, David, A. , DEGOEY, David, A. , MARING, Clarence, J. , KRUEGER, Allan, C. , IWASAKI, Nobuhiko , ROCKWAY, Todd, W. , COOPER, Curt, S. , ANDERSON, David, D. , DONNER, Pamela, L. , GREEN, Brian, E. , KEMPF, Dale, J. , LIU, Dachun , MCDANIEL, Keith, F. , MADIGAN, Darold, L. , MOTTER, Christopher, E. , PRATT, John, K. , SHANLEY, Jason, P. , TUFANO, Michael, D. , WAGNER, Rolf , ZHANG, Rong , MOLLA, Akhteruzzaman , MO, Hongmei , PILOT-MATIAS, Tami, J. , MASSE, Sherie, VL. , CARRICK, Robert, J. , HE, Weping , LU, Liangjun , GRAMPOVNIK, David, J.
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , C07D495/04 , C07D513/04
摘要： Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
摘要翻译：公开了有效抑制丙型肝炎病毒（“HCV”）或其它病毒复制的化合物。本发明还涉及包含此类化合物的组合物，此类化合物与其他抗病毒剂或治疗剂的共同配制或共同施用，用于合成此类化合物的方法和中间体，以及使用此类化合物治疗 HCV或其他病毒感染。

3. 发明申请

WO2010075380A1 ANTI-VIRAL COMPOUNDS 审中-公开
公开(公告)号：WO2010075380A1
公开(公告)日：2010-07-01
申请号：PCT/US2009/069188
申请日：2009-12-22
申请人： ABBOTT LABORATORIES , DEGOEY, David, A. , DONNER, Pamela, L. , KATI, Warren, M. , HUTCHINS, Charles, W. , KRUEGER, Allan, C. , RANDOLPH, John, T. , MOTTER, Christopher, E. , KRISHNAN, Preethi , MISTRY, Neeta, C. , PILOT-MATIAS, Tami, J. , PATEL, Sachin, V. , LI, Xiaoyan , SOLTWEDEL, Todd, N. , NELSON, Lissa, T.
发明人： DEGOEY, David, A. , DONNER, Pamela, L. , KATI, Warren, M. , HUTCHINS, Charles, W. , KRUEGER, Allan, C. , RANDOLPH, John, T. , MOTTER, Christopher, E. , KRISHNAN, Preethi , MISTRY, Neeta, C. , PILOT-MATIAS, Tami, J. , PATEL, Sachin, V. , LI, Xiaoyan , SOLTWEDEL, Todd, N. , NELSON, Lissa, T.
IPC分类号： C07D471/04 , A61K31/4375 , A61K31/519 , A61P31/14
CPC分类号： C07D471/04 , C07D239/48
摘要： Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

4. 发明申请

WO1993025533A1 METHODS AND REAGENTS FOR THE DETERMINATION OF IMMUNOSUPPRESSIVE AGENTS 审中-公开
标题翻译：用于确定免疫抑制剂的方法和试剂
公开(公告)号：WO1993025533A1
公开(公告)日：1993-12-23
申请号：PCT/US1993005197
申请日：1993-06-01
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , LANE, Benjamin, Clay , LULY, Jay, Richard , SMITH, Allan, H. , BOLLING, Timothy, J. , MANDECKI, Wldozimierz , PILOT-MATIAS, Tami, J.
IPC分类号： C07D221/18
CPC分类号： C07D498/18 , C07K14/715 , C07K2319/32 , C07K2319/61 , C12N9/1241
摘要： Assay methods and reagents for determining the presence or amount of immunophilin ligands and immunophilins thereof employing a recombinant fusion protein comprising (i) an immunosuppressant binding protein and (ii) a heterologous protein are disclosed. The recombinant fusion protein can also be employed for the evaluation of immunosuppressive activities of immunosuppressive agents in order to determine the efficacy of an immunosuppressive agent during the course of therapeutic treatment of a patient therewith. Preferably, the recombinant fusion protein comprises a macrolide immunosuppressive agent and CTP:CMP-3-deoxy-D-manno-octulosonate cytidylyl transferase. When employed in a binding assay format, the recombinant fusion protein provides higher reactivity for the immunophilin ligand under determination than does the native immunosuppressant binding protein. In particular, an immunosuppressant assay reagent comprising FK-506 binding protein (FKBP) and CKS immobilized to a solid support material provides a higher signal-to-noise ratio when employed in a competitive heterogeneous assay format than when native FKBP immobilized to a solid support material is employed in such assay format.
摘要翻译：公开了使用包含（i）免疫抑制剂结合蛋白和（ii）异源蛋白质）的重组融合蛋白来测定免疫亲和素配体及其免疫亲和物的存在或量的测定方法和试剂。重组融合蛋白也可以用于评估免疫抑制剂的免疫抑制活性，以确定免疫抑制剂在其患者治疗过程中的功效。优选地，重组融合蛋白包含大环内酯免疫抑制剂和CTP：CMP-3-脱氧-D-壬烯 - 辛酸酯胞苷酰转移酶。当以结合测定形式使用时，重组融合蛋白质在测定时比天然免疫抑制剂结合蛋白提供更高的免疫亲和素配体的反应性。特别地，当以竞争性异质测定格式使用时，固定在固体支持物质上的包含FK-506结合蛋白（FKBP）和CKS的免疫抑制剂测定试剂提供比当固定在固体支持物上的天然FKBP时更高的信噪比材料以这种测定形式使用。

5. 发明申请

WO1993008208A1 BORRELIA BURGDORFERI ANTIGENS AND USES THEREOF 审中-公开
标题翻译： BORRELIA BURGDORFERI抗生素及其用途
公开(公告)号：WO1993008208A1
公开(公告)日：1993-04-29
申请号：PCT/US1992009199
申请日：1992-10-21
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , ROBINSON, John, M. , PILOT-MATIAS, Tami, J. , HUNT, Jeffrey, C.
IPC分类号： C07H21/00
CPC分类号： C07K14/20 , C07K2319/00 , Y10S530/825
摘要： This invention relates generally to an assay for Lyme disease which detects the antibody to Borrelia burgdorferi, the causative agent of Lyme disease. More specifically, the assay employs antigens derived from amino acid regions in the flagellum of Borrelia burgdorferi. These antigens are immunoreactive with antibodies to Borrelia burgdorferi but are not substantially immunoreactive with antibodies to Treponema pallidum, the syphilis causing agent. DNA sequences of the antigens, clones and vectors containing the DNA sequences are also disclosed. Polypeptides derived therefrom can be used as reagents for the detection of antibody to Borrelia burgdorferi in the body fluids from individuals with Lyme disease.
摘要翻译：本发明一般涉及莱姆病的检测方法，该检测法检测勃氏疏螺旋体的抗体，其是莱姆病的致病因子。更具体地，该测定使用来源于布氏疏螺旋体鞭毛中的氨基酸区域的抗原。这些抗原与布氏疏螺旋体的抗体具有免疫反应性，但与梅毒螺旋体梅毒引发剂的抗体基本上不具有免疫反应性。还公开了抗原的DNA序列，克隆和含有DNA序列的载体。从其衍生的多肽可用作检测来自具有莱姆病的个体的体液中的布氏疏螺旋体的抗体的试剂。

6. 发明申请

WO1988004324A1 PULMONARY HYDROPHOBIC SURFACTANT-ASSOCIATED PROTEINS 审中-公开
标题翻译：肺血浆表面活性剂相关蛋白
公开(公告)号：WO1988004324A1
公开(公告)日：1988-06-16
申请号：PCT/US1987003180
申请日：1987-12-03
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , WHITSETT, Jeffrey, A. , FOX, J., Lawrence , PILOT-MATIAS, Tami, J. , MEUTH, Joseph, L. , SARIN, Virender, K.
IPC分类号： C12P21/00
CPC分类号： C12N15/72 , A61K35/42 , A61K38/1709 , C07K14/785 , C07K16/18 , C07K2319/00 , C07K2319/035 , C12N9/00 , A61K2300/00
摘要： Novel, isolated, substantially pure, hydrophobic surfactant-associated proteins of 4,000-7,000 dalton simple molecular weight, SAP(Val) and SAP(Phe); multimers thereof, and substitution, addition and deletion analogs and fragments thereof are disclosed. When SAP(Val) and/or SAP(Phe) is combined with lipids, its surfactant-like property imparts to the combination significant pulmonary biophysical activity. Such a combination results in enhanced adsorption of the lipids with properties similar to that of natural pulmonary surfactant material. SAP(Val) and/or SAP(Phe) in combination with lipids is highly useful for replacing or supplementing natural pulmonary surfactant material for reducing or maintaining normal surface tension in the lungs, especially in the lungs of patients suffering from hyaline membrane disease, HMD, or other syndromes associated with the lack or insufficient amounts of natural pulmonary surfactant material. A combination of SAP(Val) and/or SAP(Phe) and lipids may be administered as an aerosol spray or in aqueous normal saline with or without calcium chloride for treating or preventing HMD and other surfactant deficiency states. Also disclosed are methods of isolating the SAP(Val) from animal tissue and methods for making SAP(Val) and SAP(Phe) by recombinant DNA techniques and direct peptide synthesis; genomic clones of SAP(Val) and SAP(Phe); expression systems and products for SAP(Val) DNA; and polyclonal and monoclonal antibodies to SAP(Val) and SAP(Phe).

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