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1. 发明申请

WO2008133753A3 ANTI-VIRAL COMPOUNDS 审中-公开
标题翻译：抗病毒化合物
公开(公告)号：WO2008133753A3
公开(公告)日：2008-12-24
申请号：PCT/US2007088027
申请日：2007-12-19
申请人： ABBOTT LAB , BETEBENNER DAVID A , MARING CLARENCE J , ROCKWAY TODD W , COOPER CURT S , ANDERSON DAVID D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI J , MASSE SHERIE VL , CARRICK ROBERT J , HE WENPING , LU LIANGJUN
发明人： BETEBENNER DAVID A , MARING CLARENCE J , ROCKWAY TODD W , COOPER CURT S , ANDERSON DAVID D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI J , MASSE SHERIE VL , CARRICK ROBERT J , HE WENPING , LU LIANGJUN
IPC分类号： A01N43/42 , A61K31/44
CPC分类号： C07D471/04 , C07D239/94 , C07D487/04 , C07D487/14 , C07D519/00
摘要： Compounds effective in inhibiting replication of Hepatitis C virus ( HCV ) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, coformulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
摘要翻译：公开了有效抑制丙型肝炎病毒（HCV）或其他病毒复制的化合物。本发明还涉及包含此类化合物的组合物，这类化合物与其它抗病毒剂或治疗剂的共配制或共同施用，用于合成这些化合物的方法和中间体，以及使用此类化合物治疗HCV或其他病毒感染。

2. 发明申请

WO2007076034A3 ANTI-VIRAL COMPOUNDS 审中-公开
公开(公告)号：WO2007076034A3
公开(公告)日：2007-10-04
申请号：PCT/US2006049079
申请日：2006-12-20
申请人： ABBOTT LAB , BETEBENNER DAVID A , DEGOEY DAVID A , MARING CLARENCE J , KRUEGER ALLAN C , IWASAKI NOBUHIKO , ROCKWAY TODD W , COOPER CURT S , ANDERSON DAVID D , DONNER PAMELA L , GREEN BRIAN E , KEMPF DALE J , LIU DACHUN , MCDANIEL KEITH F , MADIGAN DAROLD L , MOTTER CHRISTOPHER E , PRATT JOHN K , SHANLEY JASON P , TUFANO MICHAEL D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI J , MASSE SHERIE VL , CARRICK ROBERT J , HE WEPING , LU LIANGJUN , GRAMPOVNIK DAVID J
发明人： BETEBENNER DAVID A , DEGOEY DAVID A , MARING CLARENCE J , KRUEGER ALLAN C , IWASAKI NOBUHIKO , ROCKWAY TODD W , COOPER CURT S , ANDERSON DAVID D , DONNER PAMELA L , GREEN BRIAN E , KEMPF DALE J , LIU DACHUN , MCDANIEL KEITH F , MADIGAN DAROLD L , MOTTER CHRISTOPHER E , PRATT JOHN K , SHANLEY JASON P , TUFANO MICHAEL D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI J , MASSE SHERIE VL , CARRICK ROBERT J , HE WEPING , LU LIANGJUN , GRAMPOVNIK DAVID J
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , C07D495/04 , C07D513/04
摘要： Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

3. 发明申请

WO1991016894A1 QUINOLIZINONE TYPE COMPOUNDS 审中-公开
标题翻译：喹诺酮类化合物
公开(公告)号：WO1991016894A1
公开(公告)日：1991-11-14
申请号：PCT/US1991002998
申请日：1991-05-01
申请人： ABBOTT LABORATORIES , CHU, Daniel, T. , LEE, Cheuk, M. , LI, Qun , COOPER, Curt, S. , PLATTNER, Jacob, J.
发明人： ABBOTT LABORATORIES
IPC分类号： A61K31/54
CPC分类号： C07D471/04 , A61K38/00 , C07D213/68 , C07D455/02 , C07K5/06026
摘要： Novel compounds are disclosed having formula (I) as well as pharmaceutically acceptable salts, esters and amides thereof, wherein R is selected from (a) loweralkyl, (b) loweralkenyl, (c) halo(loweralkyl), (d) loweralkoxy, (e) cycloalkyl of from 3 to 8 carbons, (f) phenyl, (g) halo, (h) cyano, (i) nitro, (j) bicycloalkyl, (k) loweralkynyl, (l) alkoxycarbonyl, (m) nitrogen-containing aromatic heterocycle and (n) a group of the formula -NR R ; R is selected from the group consisting of halogen, loweralkoxy, carbocyclic aryloxy or carbocyclic aryl(loweralkyl)oxy, loweralkyl, loweralkenyl, cycloalkyl of from 3 to 8 carbons, cycloalkenyl of from 4 to 8 carbons, carbocyclic aryl(loweralkyl), cycloalkyl(loweralkyl), phenyl, amino, (loweralkyl)amino, carbocyclic aryl(loweralkyl)amino, hydroxy-substituted (loweralkyl)amino, nitrogen-containing aromatic heterocycle, bicyclic nitrogen-containing heterocycle and nitrogen-containing heterocycle having formula (II), wherein x is 0 to 3; R is selected from (a)-(CH2)m-, wherein m is 1, 2 or 3, and (b) -(CH2)nR (CH2)p-, wherein R is selected from S, O and N, n is 1 or 2, and p is 1 or 2; and Y is a non-hydrogen substituent independently selected from loweralkyl, halo(loweralkyl), loweralkoxy, hydroxy-substituted loweralkyl, hydroxy, amino(loweralkyl), halogen and a group having the formula -NR R ; R is hydrogen, halogen or loweralkoxy; R is selected from the group consisting of hydrogen, loweralkyl, a pharmaceutically acceptable cation and a prodrug ester group; R is selected from the group consisting of hydrogen, halogen, hydroxy, loweralkyl, halo(loweralkyl), loweralkoxy and a group having the formula -NR R ; and A is N or CR , wherein R is selected from hydrogen, halogen, loweralkyl, halo(loweralkyl), hydroxy-substituted loweralkyl, loweralkoxy(loweralkyl), loweralkoxy and amino(loweralkyl) or, alternatively, R and R , taken together with the atoms to which they are attached, form a 6-membered saturated ring which may contain an oxygen or a sulfur atom and which may be substituted with loweralkyl; with the proviso that when R is hydrogen and A is CH then either (a) R is NR R , or (b) R is a group having formula (III), wherein x is 1-3 and R and Y are as defined above.
摘要翻译：公开了具有式（I）化合物及其药学上可接受的盐，酯和酰胺的新型化合物，其中R 1选自（a）低级烷基，（b）低级链烯基，（c）卤代（低级烷基），（d）（f）苯基，（g）卤素，（h）氰基，（i）硝基，（j）双环烷基，（k）低级炔基，（I）烷氧基羰基，（m））含氮芳族杂环和（n）式-NR 7 R 8的基团; R 2选自卤素，低级烷氧基，碳环芳氧基或碳环芳基（低级烷基）氧基，低级烷基，低级烯基，3至8个碳的环烷基，4至8个碳的环烯基，碳环芳基（低级烷基），环烷基（低级烷基），苯基，氨基，（低级烷基）氨基，碳环芳基（低级烷基）氨基，羟基取代的（低级烷基）氨基，含氮芳族杂环，双环含氮杂环和含有式），其中x为0至3; R 9选自（a） - （CH 2）m - ，其中m为1,2或3，和（b） - （CH 2）n R 10（CH 2）p - ，其中R 10为选自S，O和N，n为1或2，p为1或2; 并且Y是独立地选自低级烷基，卤代（低级烷基），低级烷氧基，羟基取代的低级烷基，羟基，氨基（低级烷基），卤素和具有式-NR 11 R 12的基团的非氢取代基。 R 3是氢，卤素或低级烷氧基; R 4选自氢，低级烷基，药学上可接受的阳离子和前药酯基; R 5选自氢，卤素，羟基，低级烷基，卤代（低级烷基），低级烷氧基和具有式-NR 13 R 14的基团。并且A是N或CR 6，其中R 6选自氢，卤素，低级烷基，卤代（低级烷基），羟基取代的低级烷基，低级烷氧基（低级烷基），低级烷氧基和氨基（低级烷基），或者，R 1和R 6与它们所连接的原子一起形成可含有氧或硫原子并且可以被低级烷基取代的6元饱和环; 条件是当R 5为氢且A为CH时，则（a）R 1为NR 7 R 8，或（b）R 2为具有式（III）的基团，，其中x为1-3且R 9和Y如上所定义。

4. 发明申请

WO2007081517A3 ANTI-VIRAL COMPOUNDS 审中-公开
公开(公告)号：WO2007081517A3
公开(公告)日：2007-12-21
申请号：PCT/US2006048685
申请日：2006-12-20
申请人： ABBOTT LAB , BETEBENNER DAVID A , DEGOEY DAVID A , MARING CLARENCE J , KRUEGER ALLAN C , IWASAKI NOBUHIKO , ROCKWAY TODD W , COOPER CURT S , ANDERSON DAVID D , DONNER PAMELA L , GREEN BRIAN E , KEMPF DALE J , LIU DACHUN , MCDANIEL KEITH F , MADIGAN DAROLD L , MOTTER CHRISTOPHER E , PRATT JOHN K , SHANLEY JASON P , TUFANO MICHAEL D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI J , MASSE SHERIE VL , CARRICK ROBERT J , HE WEPING , LU LIANGJUN , GRAMPOVNIK DAVID J
发明人： BETEBENNER DAVID A , DEGOEY DAVID A , MARING CLARENCE J , KRUEGER ALLAN C , IWASAKI NOBUHIKO , ROCKWAY TODD W , COOPER CURT S , ANDERSON DAVID D , DONNER PAMELA L , GREEN BRIAN E , KEMPF DALE J , LIU DACHUN , MCDANIEL KEITH F , MADIGAN DAROLD L , MOTTER CHRISTOPHER E , PRATT JOHN K , SHANLEY JASON P , TUFANO MICHAEL D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI J , MASSE SHERIE VL , CARRICK ROBERT J , HE WEPING , LU LIANGJUN , GRAMPOVNIK DAVID J
IPC分类号： C07D495/04 , C07D471/04 , C07D513/04
CPC分类号： C07D487/04 , C07D471/04 , C07D475/06 , C07D495/04 , C07D513/04
摘要： Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

5. 发明申请

WO2005075477A1 ANTIBACTERIAL COMPOUNDS 审中-公开
标题翻译：抗菌化合物
公开(公告)号：WO2005075477A1
公开(公告)日：2005-08-18
申请号：PCT/US2004/040993
申请日：2004-12-08
申请人： ABBOTT LABORATORIES , ANDERSON, David, A. , BEUTEL, Bruce, A. , COOPER, Curt, S. , GU, Yu-Gui , HINMAN, Mira, M. , KALVIN, Douglas, M. , KEYES, Robert, F. , SEARLE, Xenia, B. , WAGNER, Rolf
发明人： ANDERSON, David, A. , BEUTEL, Bruce, A. , COOPER, Curt, S. , GU, Yu-Gui , HINMAN, Mira, M. , KALVIN, Douglas, M. , KEYES, Robert, F. , SEARLE, Xenia, B. , WAGNER, Rolf
IPC分类号： C07D471/04
CPC分类号： C07D513/04 , C07D207/12 , C07D207/16 , C07D239/48 , C07D277/36 , C07D471/04
摘要： Bacterial protein synthesis-inhibiting compounds having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates in the processes, compositions containing the compounds, and methods of using the compounds are disclosed.
摘要翻译：公开了具有式（I）的具有式（I）的细菌蛋白质合成抑制化合物及其前体药物的前体药物，其制备方法，含该化合物的组合物，使用该化合物的方法。

6. 发明申请

WO2008133753A2 ANTI-VIRAL COMPOUNDS 审中-公开
标题翻译：反虚构化合物
公开(公告)号：WO2008133753A2
公开(公告)日：2008-11-06
申请号：PCT/US2007/088027
申请日：2007-12-19
申请人： ABBOTT LABORATORIES , BETEBENNER, David A. , MARING, Clarence J. , ROCKWAY, Todd W. , COOPER, Curt S. , ANDERSON, David D. , WAGNER, Rolf , ZHANG, Rong , MOLLA, Akhteruzzaman , MO, Hongmei , PILOT-MATIAS, Tami J. , MASSE, Sherie Vl. , CARRICK, Robert J. , HE, Wenping , LU, Liangjun
发明人： BETEBENNER, David A. , MARING, Clarence J. , ROCKWAY, Todd W. , COOPER, Curt S. , ANDERSON, David D. , WAGNER, Rolf , ZHANG, Rong , MOLLA, Akhteruzzaman , MO, Hongmei , PILOT-MATIAS, Tami J. , MASSE, Sherie Vl. , CARRICK, Robert J. , HE, Wenping , LU, Liangjun
IPC分类号： A61K31/675
CPC分类号： C07D471/04 , C07D239/94 , C07D487/04 , C07D487/14 , C07D519/00
摘要： Compounds effective in inhibiting replication of Hepatitis C virus ( HCV ) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, coformulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
摘要翻译：公开了有效抑制丙型肝炎病毒（HCV）或其他病毒复制的化合物。本发明还涉及包含这些化合物的组合物，这些化合物与其它抗病毒剂或治疗剂的共配制或共同给药，用于合成这些化合物的方法和中间体，以及使用这些化合物治疗HCV或其他病毒感染。

7. 发明申请

WO2007081517A2 ANTI-VIRAL COMPOUNDS 审中-公开
公开(公告)号：WO2007081517A2
公开(公告)日：2007-07-19
申请号：PCT/US2006/048685
申请日：2006-12-20
申请人： ABBOTT LABORATORIES , BETEBENNER, David, A. , DEGOEY, David, A. , MARING, Clarence, J. , KRUEGER, Allan, C. , IWASAKI, Nobuhiko , ROCKWAY, Todd, W. , COOPER, Curt, S. , ANDERSON, David, D. , DONNER, Pamela, L. , GREEN, Brian, E. , KEMPF, Dale, J. , LIU, Dachun , MCDANIEL, Keith, F. , MADIGAN, Darold, L. , MOTTER, Christopher, E. , PRATT, John, K. , SHANLEY, Jason, P. , TUFANO, Michael, D. , WAGNER, Rolf , ZHANG, Rong , MOLLA, Akhteruzzaman , MO, Hongmei , PILOT-MATIAS, Tami, J. , MASSE, Sherie, VL. , CARRICK, Robert, J. , HE, Weping , LU, Liangjun , GRAMPOVNIK, David, J.
发明人： BETEBENNER, David, A. , DEGOEY, David, A. , MARING, Clarence, J. , KRUEGER, Allan, C. , IWASAKI, Nobuhiko , ROCKWAY, Todd, W. , COOPER, Curt, S. , ANDERSON, David, D. , DONNER, Pamela, L. , GREEN, Brian, E. , KEMPF, Dale, J. , LIU, Dachun , MCDANIEL, Keith, F. , MADIGAN, Darold, L. , MOTTER, Christopher, E. , PRATT, John, K. , SHANLEY, Jason, P. , TUFANO, Michael, D. , WAGNER, Rolf , ZHANG, Rong , MOLLA, Akhteruzzaman , MO, Hongmei , PILOT-MATIAS, Tami, J. , MASSE, Sherie, VL. , CARRICK, Robert, J. , HE, Weping , LU, Liangjun , GRAMPOVNIK, David, J.
IPC分类号： C07D495/04 , C07D471/04 , C07D513/04
CPC分类号： C07D487/04 , C07D471/04 , C07D475/06 , C07D495/04 , C07D513/04
摘要： Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

8. 发明申请

WO2007081517A8 ANTI-VIRAL COMPOUNDS 审中-公开
标题翻译：反虚构化合物
公开(公告)号：WO2007081517A8
公开(公告)日：2007-09-20
申请号：PCT/US2006048685
申请日：2006-12-20
申请人： ABBOTT LAB , BETEBENNER DAVID A , DEGOEY DAVID A , MARING CLARENCE J , KRUEGER ALLAN C , IWASAKI NOBUHIKO , ROCKWAY TODD W , COOPER CURT S , ANDERSON DAVID D , DONNER PAMELA L , GREEN BRIAN E , KEMPF DALE J , LIU DACHUN , MCDANIEL KEITH F , MADIGAN DAROLD L , MOTTER CHRISTOPHER E , PRATT JOHN K , SHANLEY JASON P , TUFANO MICHAEL D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI J , MASSE SHERIE VL , CARRICK ROBERT J , HE WEPING , LU LIANGJUN , GRAMPOVNIK DAVID J
发明人： BETEBENNER DAVID A , DEGOEY DAVID A , MARING CLARENCE J , KRUEGER ALLAN C , IWASAKI NOBUHIKO , ROCKWAY TODD W , COOPER CURT S , ANDERSON DAVID D , DONNER PAMELA L , GREEN BRIAN E , KEMPF DALE J , LIU DACHUN , MCDANIEL KEITH F , MADIGAN DAROLD L , MOTTER CHRISTOPHER E , PRATT JOHN K , SHANLEY JASON P , TUFANO MICHAEL D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI J , MASSE SHERIE VL , CARRICK ROBERT J , HE WEPING , LU LIANGJUN , GRAMPOVNIK DAVID J
IPC分类号： C07D495/04 , C07D471/04 , C07D513/04
CPC分类号： C07D487/04 , C07D471/04 , C07D475/06 , C07D495/04 , C07D513/04
摘要： Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
摘要翻译：公开了有效抑制丙型肝炎病毒（“HCV”）或其他病毒复制的化合物。本发明还涉及包含这些化合物的组合物，这些化合物与其它抗病毒剂或治疗剂的共同配制或共同给药，用于合成这些化合物的方法和中间体，以及使用这些化合物治疗 HCV或其他病毒感染。

9. 发明申请

WO2007076035A3 ANTI-VIRAL COMPOUNDS 审中-公开
公开(公告)号：WO2007076035A3
公开(公告)日：2007-07-05
申请号：PCT/US2006/049080
申请日：2006-12-20
申请人： ABBOTT LABORATORIES , ROCKWAY, Todd, W. , BETEBENNER, David, A. , KRUEGER, Allan, C. , IWASAKI, Nobuhiko , COOPER, Curt, S. , ANDERSON, David, D. , KEMPF, Dale, J. , MADIGAN, Darold, L. , MOTTER, Christopher, E. , SHANLEY, Jason, P. , TUFANO, Michael, D. , WAGNER, Rolf , ZHANG, Rong , MOLLA, Akhteruzzaman , MO, Hongmei , PILOT-MATIAS, Tami , MASSE, Sherie, VL. , CARRICK, Robert, J. , HE, Weping , LU, Liangjun
发明人： ROCKWAY, Todd, W. , BETEBENNER, David, A. , KRUEGER, Allan, C. , IWASAKI, Nobuhiko , COOPER, Curt, S. , ANDERSON, David, D. , KEMPF, Dale, J. , MADIGAN, Darold, L. , MOTTER, Christopher, E. , SHANLEY, Jason, P. , TUFANO, Michael, D. , WAGNER, Rolf , ZHANG, Rong , MOLLA, Akhteruzzaman , MO, Hongmei , PILOT-MATIAS, Tami , MASSE, Sherie, VL. , CARRICK, Robert, J. , HE, Weping , LU, Liangjun
IPC分类号： C07D471/04
摘要： Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

10. 发明申请

WO2007076035A2 ANTI-VIRAL COMPOUNDS 审中-公开
标题翻译：抗病毒化合物
公开(公告)号：WO2007076035A2
公开(公告)日：2007-07-05
申请号：PCT/US2006049080
申请日：2006-12-20
申请人： ABBOTT LAB , ROCKWAY TODD W , BETEBENNER DAVID A , KRUEGER ALLAN C , IWASAKI NOBUHIKO , COOPER CURT S , ANDERSON DAVID D , KEMPF DALE J , MADIGAN DAROLD L , MOTTER CHRISTOPHER E , SHANLEY JASON P , TUFANO MICHAEL D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI , MASSE SHERIE VL , CARRICK ROBERT J , HE WEPING , LU LIANGJUN
发明人： ROCKWAY TODD W , BETEBENNER DAVID A , KRUEGER ALLAN C , IWASAKI NOBUHIKO , COOPER CURT S , ANDERSON DAVID D , KEMPF DALE J , MADIGAN DAROLD L , MOTTER CHRISTOPHER E , SHANLEY JASON P , TUFANO MICHAEL D , WAGNER ROLF , ZHANG RONG , MOLLA AKHTERUZZAMAN , MO HONGMEI , PILOT-MATIAS TAMI , MASSE SHERIE VL , CARRICK ROBERT J , HE WEPING , LU LIANGJUN
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
摘要翻译：公开了有效抑制丙型肝炎病毒（“HCV”）或其他病毒复制的化合物。本发明还涉及包含此类化合物的组合物，此类化合物与其他抗病毒剂或治疗剂的共同配制或共同施用，用于合成此类化合物的方法和中间体，以及使用此类化合物治疗 HCV或其他病毒感染。

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