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1. 发明申请

WO2003103604A2 GAMMA LACTAMS AS PROSTAGLANDIN AGONISTS AND USE THEREOF 审中-公开
标题翻译： GAMMA LACTAMS作为PROSTAGLANDIN AGONISTS及其使用
公开(公告)号：WO2003103604A2
公开(公告)日：2003-12-18
申请号：PCT/US2003/018202
申请日：2003-06-09
申请人： APPLIED RESEARCH SYSTEMS ARS HOLDING N.V , ARALDI, Gian, Luca , REDDY, Adulla, P. , ZHAO, Zhong , MCKENNA, Sean, D. , BAO, Bagna
发明人： ARALDI, Gian, Luca , REDDY, Adulla, P. , ZHAO, Zhong , MCKENNA, Sean, D. , BAO, Bagna
IPC分类号： A61K
CPC分类号： C07D207/26 , C07D405/06 , C07D409/06
摘要： 1,2-substituted 5-pyrrolidinone compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteporosis and other destructive bone disease or disorder, renal dysfunction, an immune deficiency disorder, dry eye, ichthyosis, elevated intraocular pressure, sleep disorder, or gastric ulcer, inflammatory disorders and other diseases and disorders associated with the prostaglandin family of compounds.
摘要翻译：提供了1,2-取代的5-吡咯烷酮化合物，以及使用或包含一种或多种这样的化合物的治疗方法和药物组合物。本发明的化合物可用于多种疗法，包括治疗或预防早产，痛经，哮喘，高血压，不育症或生育障碍，不期望的血液凝固，先兆子痫或子痫，嗜酸性粒细胞紊乱，性功能障碍，骨质疏松症和其他破坏性骨疾病或病症，肾功能障碍，免疫缺陷障碍，干眼症，鱼鳞病，眼内压升高，睡眠障碍或胃溃疡，炎症性疾病和与前列腺素家族化合物相关的其它疾病和病症。

2. 发明申请

WO2003080629A3 PHOSPHORUS-CONTAINING COMPOUNDS WITH POLYMERIC CHAINS, AND METHODS OF MAKING AND USING THE SAME 审中-公开
公开(公告)号：WO2003080629A3
公开(公告)日：2003-10-02
申请号：PCT/US2003/005795
申请日：2003-02-25
申请人： GUILFORD PHARMACEUTICALS, INC. , BRANHAM, Keith , CHAUBAL, Mahesh, V. , ENGLISH, James, P. , HALL, Donna , ZHAO, Zhong
发明人： BRANHAM, Keith , CHAUBAL, Mahesh, V. , ENGLISH, James, P. , HALL, Donna , ZHAO, Zhong
IPC分类号： A61K47/34
摘要： The present invention relates to novel phosphorus-containing compounds with polymeric chains, and methods of making and using the same. In part, subject compositions containing phosphorus-containing compounds with polymeric chains and a therapeutic agent, and methods of making and using the same, are described. Certain of the subject compositions exhibit reverse thermal gelation.

3. 发明申请

WO1997042849A1 IMPROVED HAIR REMOVAL METHOD 审中-公开
标题翻译：改进的头发去除方法
公开(公告)号：WO1997042849A1
公开(公告)日：1997-11-20
申请号：PCT/US1997008060
申请日：1997-05-13
申请人： THERMOTREX CORPORATION , TANKOVICH, Nikolai, I. , ZHAO, Zhong-Quan , FAIRCHILD, Paul
发明人： THERMOTREX CORPORATION
IPC分类号： A45D26/00
CPC分类号： A61M37/00 , A61B18/1442 , A61B18/20 , A61B18/203 , A61B2017/00747 , A61B2017/00752 , A61B2017/00761 , A61B2017/22085 , A61B2018/00452 , A61B2018/00476 , A61B2217/005 , A61M37/0092 , A61M2037/0007 , A61N5/0616 , A61N5/062 , A61N2005/067
摘要： This invention is a process for the long term or permanent prevention of unwanted hair (33). The upper portions of hair ducts (31) in a section of skin are infiltrated with a contaminant having a high absorption at at least one frequency band of light. The skin is illuminated during a two-phase process. In a mechanical phase, the skin section is illuminated by a laser with at least one pulse of light sufficient to cause tiny explosions in the contaminant forcing portions of the contaminant more deeply into the hair ducts. During a thermal phase, the skin section is illuminated so as to heat the contaminant substantially without further explosion or vaporization of the contaminant. The hot contaminant heats portions of the skin tissue immediately surrounding the contaminant to a temperature high enough to devitalize the tissue. A cleanup phase may follow where a few more pulses cause additional explosions in and vaporization of portions of the contaminant remaining in the ducts causing additional damage to the skin tissue immediately surrounding the contaminant.
摘要翻译：本发明是长期或永久防止不需要的毛发的方法（33）。皮肤部分中的发道（31）的上部在至少一个光频带处具有高吸收的污染物渗透。皮肤在两相过程中被照亮。在机械相中，皮肤部分被激光照射，其具有至少一个足够的光脉冲，使得污染物中的微小爆炸力使污染物的一部分更深地进入发道。在热相期间，照射皮肤部分，以便基本上加热污染物，而不会进一步爆炸或蒸发污染物。热污染物将紧邻污染物周围的皮肤组织的部分加热至足以使组织失活的温度。清除阶段可能会在几个更多的脉冲引起额外的爆炸和残留在管道中的污染物的部分蒸发，导致对污染物立即周围的皮肤组织的额外损害。

4. 发明申请

WO2012129084A3 GLUCOSYLCERAMIDE SYNTHASE INHIBITORS 审中-公开
公开(公告)号：WO2012129084A3
公开(公告)日：2012-09-27
申请号：PCT/US2012/029417
申请日：2012-03-16
申请人： GENZYME CORPORATION , BOURQUE, Elyse , CELATKA, Cassandra , HIRTH, Bradford , METZ, Markus , ZHAO, Zhong , SKERLJ, Renato , XIANG, Yibin , JANCISICS, Katherine , MARSHALL, John , CHENG, Seng , SCHEULE, Ronald , CABRERA-SALAZAR, Mario , GOOD, Andrew
发明人： BOURQUE, Elyse , CELATKA, Cassandra , HIRTH, Bradford , METZ, Markus , ZHAO, Zhong , SKERLJ, Renato , XIANG, Yibin , JANCISICS, Katherine , MARSHALL, John , CHENG, Seng , SCHEULE, Ronald , CABRERA-SALAZAR, Mario , GOOD, Andrew
IPC分类号： A01N43/00
摘要： The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.

5. 发明申请

WO03080629A2 PHOSPHORUS-CONTAINING COMPOUNDS WITH POLYMERIC CHAINS, AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：含聚合物的含磷的化合物及其制备方法和使用方法
公开(公告)号：WO03080629A2
公开(公告)日：2003-10-02
申请号：PCT/US0305795
申请日：2003-02-25
申请人： GUILFORD PHARM INC , BRANHAM KEITH , CHAUBAL MAHESH V , ENGLISH JAMES P , HALL DONNA , ZHAO ZHONG
发明人： BRANHAM KEITH , CHAUBAL MAHESH V , ENGLISH JAMES P , HALL DONNA , ZHAO ZHONG
IPC分类号： A61K9/00 , A61K31/66 , A61K45/06 , A61K47/02 , A61K47/24 , A61K47/34 , C08G65/335 , C08G79/02 , C08L81/02 , C07F9/02
CPC分类号： A61K9/0024 , A61K31/66 , A61K45/06 , A61K47/02 , A61K47/24 , A61K47/34 , C08G65/335 , C08G79/02 , C08L81/02 , C08L2203/02 , A61K2300/00
摘要： The present invention relates to novel phosphorus-containing compounds with polymeric chains, and methods of making and using the same. In part, subject compositions containing phosphorus-containing compounds with polymeric chains and a therapeutic agent, and methods of making and using the same, are described. Certain of the subject compositions exhibit reverse thermal gelation.
摘要翻译：本发明涉及具有聚合物链的新型含磷化合物及其制备和使用方法。一部分描述含有含聚合物链的含磷化合物和治疗剂的主题组合物及其制备和使用方法。某些主题组合物显示出反向热凝胶化。

6. 发明申请

WO2003053923A3 PYRROLIDINE DERIVATIVES AS PROSTAGLANDIN MODULATORS 审中-公开
公开(公告)号：WO2003053923A3
公开(公告)日：2003-07-03
申请号：PCT/EP2002/014593
申请日：2002-12-19
申请人： APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. , LIAO, Yihua , ZHAO, Zhong , ARALDI, Gian, Luca
发明人： LIAO, Yihua , ZHAO, Zhong , ARALDI, Gian, Luca
IPC分类号： C07D207/10
摘要： Substituted pyrrolidine compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteporosis and other destructive bone disease or disorder, and other diseases and disorders associated with the prostaglandin family of compounds. In a preferred aspect, a substituted pyrrolidine compound is administered to a subject in coordination with a phosphodiesterase inhibitor compound.

7. 发明申请

WO2003035064A1 PYRAZOLIDINONE COMPOUNDS AS LIGANDS OF THE PROSTAGLANDIN EP2 AND/OR EP4 RECEPTORS 审中-公开
标题翻译：作为PROSTAGLANDIN EP2和/或EP4受体的配体的吡唑啉酮化合物
公开(公告)号：WO2003035064A1
公开(公告)日：2003-05-01
申请号：PCT/US2002/033964
申请日：2002-10-23
申请人： APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. , ARALDI, Gian, Luca , LIAO, Yihua , REDDY, Adulla P. , ZHAO, Zhong
发明人： ARALDI, Gian, Luca , LIAO, Yihua , REDDY, Adulla P. , ZHAO, Zhong
IPC分类号： A61K31/4152
CPC分类号： A61K31/4152 , C07D231/08
摘要： The invention provides substituted pyrazolidinone compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteporosis and other destructive bone disease or disorder, and other diseases and disorders associated with the prostaglandin EP2 and/or EP4 receptors.
摘要翻译：本发明提供取代的吡唑烷酮化合物，以及使用或包含一种或多种这些化合物的治疗方法和药物组合物。本发明的化合物可用于多种疗法，包括治疗或预防早产，痛经，哮喘，高血压，不育症或生育障碍，不期望的血液凝固，先兆子痫或子痫，嗜酸性粒细胞紊乱，性功能障碍，骨质疏松症和其他破坏性骨疾病或病症，以及与前列腺素EP2和/或EP4受体相关的其它疾病和病症。

8. 发明申请

WO2004012656A3 THIOPHENE AND FURAN DERIVATIVES AS PROSTAGLANDIN AGONISTS AND USE THEREOF 审中-公开
标题翻译：噻吩和呋喃衍生物作为前列腺素激动剂及其用途
公开(公告)号：WO2004012656A3
公开(公告)日：2004-07-01
申请号：PCT/US0323165
申请日：2003-07-25
申请人： APPLIED RESEARCH SYSTEMS , ARALDI GIAN LUCA , KARRA SRINIVASA , REDDY ADULLA P , LIAO YIHUA , ZHAO ZHONG
发明人： ARALDI GIAN LUCA , KARRA SRINIVASA , REDDY ADULLA P , LIAO YIHUA , ZHAO ZHONG
IPC分类号： C07D307/68 , C07D405/04 , C07D405/12 , C07D407/12 , C07D413/12 , A61K31/34 , C07D307/02
CPC分类号： C07D405/04 , C07D307/68 , C07D405/12 , C07D407/12 , C07D413/12
摘要： Substituted furan and thienyl compounds are provided, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteporosis and other destructive bone disease or disorder, renal dysfunction, an immune deficiency disorder, dry eye, ichthyosis, elevated intraocular pressure, sleep disorder, gastric ulcer, urinary dysfunction, pain, gastric motility disorders, hyperchlorhydia, inflammatory disorders and other diseases and disorders associated with the prostaglandin family of compounds.
摘要翻译：提供了取代的呋喃和噻吩基化合物，以及使用或包含一种或多种这样的化合物的治疗方法和药物组合物。本发明化合物可用于多种治疗，包括治疗或预防早产，痛经，哮喘，高血压，不孕或生育障碍，不希望的血液凝固，先兆子痫或子痫，嗜酸性粒细胞病症，性功能障碍，骨质疏松症和其他破坏性骨疾病或病症，肾功能障碍，免疫缺陷病症，干眼症，鱼鳞病，眼内压升高，睡眠障碍，胃溃疡，排尿功能障碍，疼痛，胃动力障碍，胃酸过多症，炎性病症和与前列腺素家族有关的其他疾病和病症的化合物。

9. 发明申请

WO2003103604A3 GAMMA LACTAMS AS PROSTAGLANDIN AGONISTS AND USE THEREOF 审中-公开
公开(公告)号：WO2003103604A3
公开(公告)日：2003-12-18
申请号：PCT/US2003/018202
申请日：2003-06-09
申请人： APPLIED RESEARCH SYSTEMS ARS HOLDING N.V , ARALDI, Gian, Luca , REDDY, Adulla, P. , ZHAO, Zhong , MCKENNA, Sean, D. , BAO, Bagna
发明人： ARALDI, Gian, Luca , REDDY, Adulla, P. , ZHAO, Zhong , MCKENNA, Sean, D. , BAO, Bagna
IPC分类号： C07D207/27
摘要： 1,2-substituted 5-pyrrolidinone compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteporosis and other destructive bone disease or disorder, renal dysfunction, an immune deficiency disorder, dry eye, ichthyosis, elevated intraocular pressure, sleep disorder, or gastric ulcer, inflammatory disorders and other diseases and disorders associated with the prostaglandin family of compounds.

10. 发明申请

WO0019976A9 BIODEGRADABLE TEREPHTHALATE POLYESTER-POLY(PHOSPHONATE) AND POLYESTER-POLY(PHOSPHITE) COMPOSITIONS, ARTICLES, AND METHODS OF USING THEM 审中-公开
标题翻译：可生物降解的癸二酸酯聚酯（磷酸酯）和聚酯（磷酸酯）组合物，制品及其使用方法
公开(公告)号：WO0019976A9
公开(公告)日：2000-10-26
申请号：PCT/US9922898
申请日：1999-10-01
申请人： GUILFORD PHARM INC , UNIV JOHNS HOPKINS MED , MAO HAI QUAN , LEONG KAM W , ZHAO ZHONG , DANG WENBIN , ENGLISH JAMES P , NOWOTNIK DAVID P
发明人： MAO HAI-QUAN , LEONG KAM W , ZHAO ZHONG , DANG WENBIN , ENGLISH JAMES P , NOWOTNIK DAVID P
IPC分类号： A61K47/34 , A61K9/00 , A61K9/16 , A61K9/48 , A61K9/52 , A61K45/00 , A61L17/00 , A61L17/10 , A61L24/04 , A61L27/00 , A61L31/06 , A61P7/02 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/12 , A61P35/00 , C08G63/692 , C08G79/04 , C08L101/16
CPC分类号： C08G63/6926 , A61K9/0024 , A61K9/1647 , A61L17/105 , A61L24/046 , A61L31/06 , C08L67/00
摘要： The invention comprises biodegradable terephthalate polymers comprising the recurring monomeric units shown in formula (I), wherein R is a divalent organic moiety; R' is hydrogen, an aliphatic, aromatic or heterocyclic residue; x is >/= 1; and n is 3-7,500, where the biodegradable polymer is sufficiently pure to be biocompatible and is capable of forming biocompatible residues upon biodegradation. Medical and drug delivery devices comprising the polymers and a biologically active substance, articles useful for implantation or injection into the body, fabricated using the polymers, and methods for controlled release of biologically active substances using the polymers, are also described.
摘要翻译：本发明包括可生物降解的对苯二甲酸酯聚合物，其包含式（I）所示的重复单体单元，其中R是二价有机部分; R'是氢，脂族，芳族或杂环残基; x是> / = 1; 并且n为3-7,500，其中生物可降解聚合物足够纯以生物相容并且在生物降解时能够形成生物相容性残基。还描述了包括聚合物和生物活性物质的药物和药物递送装置，用于植入或注射到体内的制品，使用聚合物制造的方法，以及使用该聚合物控制释放生物活性物质的方法。

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