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    • 3. 发明申请
    • PHYSICAL VAPOR DEPOSITION (PVD) AND COLD ANODIZATION METAL COLORING
    • 物理蒸气沉积(PVD)和冷沉淀金属色彩
    • WO2011063310A2
    • 2011-05-26
    • PCT/US2010057537
    • 2010-11-20
    • LAIRD TECHNOLOGIES INCZHAO RUINIEDERKORN REED JOHNZHENG KANWANG JUNLIU XIANQIU
    • ZHAO RUINIEDERKORN REED JOHNZHENG KANWANG JUNLIU XIANQIU
    • C25D11/26C23C14/14C25D11/22
    • C25D11/26C23C14/0015C23C14/028C23C14/16C23C14/5846
    • Exemplary embodiments of the present disclosure include colored metallic articles, which may include cold anodized, niobium-coated metallic substrates. Also disclosed herein are exemplary embodiments of methods relating to and/or for providing colored metallic articles, which may include cold anodized, niobium-coated metallic substrates. In an example embodiment, an article generally includes an anodized, niobium-coated metallic substrate having a hardness equal to or greater than about 350 HV (the Vickers Diamond Pyramid Hardness Number). An exemplary embodiment of a method generally includes anodizing a niobium-coated metallic substrate, such as to a hardness equal to or greater than about 350 HV (Vickers Diamond Pyramid Hardness Number) and/or at a temperature within a temperature range from about 0 degrees Celsius to about 5 degrees Celsius and with an electrical current within an electrical current range not exceeding about 1.5 Amps.
    • 本公开的示例性实施例包括着色金属制品,其可以包括冷阳极化,铌涂覆的金属基底。 本文还公开了涉及和/或用于提供着色金属制品的方法的示例性实施方案,其可以包括冷阳极化,铌涂覆的金属基材。 在一个示例性实施例中,制品通常包括具有等于或大于约350HV(维氏钻石金字塔硬度值)的硬度的阳极氧化的铌涂覆的金属基底。 方法的示例性实施方案通常包括阳极氧化铌涂覆的金属基底,例如达到等于或大于约350HV(维氏金刚石金字塔硬度值)的硬度和/或在约0度的温度范围内的温度 摄氏度至约5摄氏度,电流范围不超过约1.5安培。
    • 4. 发明申请
    • METHODS FOR INHIBITING SIX 1 AND EYA PROTEINS
    • 抑制第六种和EYA蛋白的方法
    • WO2009108706A3
    • 2009-12-10
    • PCT/US2009035150
    • 2009-02-25
    • UNIV COLORADO REGENTSFORD HEIDE LZHAO RUIPATRICK AARON
    • FORD HEIDE LZHAO RUIPATRICK AARON
    • A61K48/00A61K33/24A61P35/00
    • A61K31/7088A61K31/00A61K33/24A61K45/06A61K2300/00
    • In some aspects, the invention provides a method of inhibiting interaction of Sixl with Eya2 comprising contacting a cell expressing Sixl and Eya2 with an agent that inhibits binding of Sixl to Eya2 or an agent that inhibits the phostphatase activity of Eya2 on Sixl. In other apsects, the invention provides a method of treating cancer in a subject comprising administering to said subject an effective amount of an agent that inhibits Sixl interaction with Eya2 or an agent that inhibits the phostphatase activity of Eya2 on Sixl. In some embodiments, the invention further provides for the administration of a second cancer therapy to the patient. In still further aspects, the invention provides a method of identifying a candidate anti-cancer agent. The candidate inhibitor may be a nucleic acid, a protein, a peptide or a small molecule.
    • 在一些方面,本发明提供了抑制SixI与Eya2相互作用的方法,包括使表达Six1和Eya2的细胞与抑制SixI与Eya2结合的试剂或抑制SixI上Eya2的磷酸酶活性的试剂接触。 在其它方面,本发明提供了一种治疗受试者的癌症的方法,其包括向所述受试者施用有效量的抑制SixI与Eya2的相互作用的药剂或抑制SixI上Eya2的磷酸酶活性的药剂。 在一些实施方案中,本发明还提供了向患者施用第二次癌症治疗。 在另外的方面,本发明提供了鉴定候选抗癌剂的方法。 候选抑制剂可以是核酸,蛋白质,肽或小分子。