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1. 发明申请

WO2009108706A3 METHODS FOR INHIBITING SIX 1 AND EYA PROTEINS 审中-公开
标题翻译：抑制第六种和EYA蛋白的方法
公开(公告)号：WO2009108706A3
公开(公告)日：2009-12-10
申请号：PCT/US2009035150
申请日：2009-02-25
申请人： UNIV COLORADO REGENTS , FORD HEIDE L , ZHAO RUI , PATRICK AARON
发明人： FORD HEIDE L , ZHAO RUI , PATRICK AARON
IPC分类号： A61K48/00 , A61K33/24 , A61P35/00
CPC分类号： A61K31/7088 , A61K31/00 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： In some aspects, the invention provides a method of inhibiting interaction of Sixl with Eya2 comprising contacting a cell expressing Sixl and Eya2 with an agent that inhibits binding of Sixl to Eya2 or an agent that inhibits the phostphatase activity of Eya2 on Sixl. In other apsects, the invention provides a method of treating cancer in a subject comprising administering to said subject an effective amount of an agent that inhibits Sixl interaction with Eya2 or an agent that inhibits the phostphatase activity of Eya2 on Sixl. In some embodiments, the invention further provides for the administration of a second cancer therapy to the patient. In still further aspects, the invention provides a method of identifying a candidate anti-cancer agent. The candidate inhibitor may be a nucleic acid, a protein, a peptide or a small molecule.
摘要翻译：在一些方面，本发明提供了抑制SixI与Eya2相互作用的方法，包括使表达Six1和Eya2的细胞与抑制SixI与Eya2结合的试剂或抑制SixI上Eya2的磷酸酶活性的试剂接触。在其它方面，本发明提供了一种治疗受试者的癌症的方法，其包括向所述受试者施用有效量的抑制SixI与Eya2的相互作用的药剂或抑制SixI上Eya2的磷酸酶活性的药剂。在一些实施方案中，本发明还提供了向患者施用第二次癌症治疗。在另外的方面，本发明提供了鉴定候选抗癌剂的方法。候选抑制剂可以是核酸，蛋白质，肽或小分子。

2. 发明申请

WO2012096977A1 INHIBITORS OF EYA2 审中-公开
标题翻译： EYA2抑制剂
公开(公告)号：WO2012096977A1
公开(公告)日：2012-07-19
申请号：PCT/US2012/020805
申请日：2012-01-10
申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE , THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES , ZHAO, Rui , FORD, Heide, L. , SOUTHALL, Noel , ENGLUND, Erika , PATNAIK, Samarjit , FERRER, Marc , ZHANG, Wei , DEHDASHTI, Seameen , MARUGAN, Juan
发明人： ZHAO, Rui , FORD, Heide, L. , SOUTHALL, Noel , ENGLUND, Erika , PATNAIK, Samarjit , FERRER, Marc , ZHANG, Wei , DEHDASHTI, Seameen , MARUGAN, Juan
IPC分类号： A01N33/26 , A61K31/15
CPC分类号： A61K31/443 , A61K31/15 , A61K31/155 , A61K31/255 , A61K31/277 , A61K31/4174 , A61K31/4709
摘要： The invention provides small molecule inhibitors of EYA2 phosphatase activity and EYA2 binding to Six1. These inhibitors are proposed for use in methods of treating cancer in a subject, such as those involving Six1 and/or EYA2 disregulation. In some embodiments, the invention further provides for the administration of a second cancer therapy to the subject.
摘要翻译：本发明提供EYA2磷酸酶活性的小分子抑制剂和与Six1结合的EYA2。这些抑制剂被提出用于治疗受试者的癌症的方法，例如涉及Six1和/或EYA2失调的那些。在一些实施方案中，本发明进一步提供对受试者施用第二次癌症治疗。

3. 发明申请

WO2009108706A2 METHODS FOR INHIBITING SIX 1 AND EYA PROTEINS 审中-公开
标题翻译：抑制六种蛋白质和六种蛋白质的方法
公开(公告)号：WO2009108706A2
公开(公告)日：2009-09-03
申请号：PCT/US2009/035150
申请日：2009-02-25
申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE , FORD, Heide, L. , ZHAO, Rui , PATRICK, Aaron
发明人： FORD, Heide, L. , ZHAO, Rui , PATRICK, Aaron
IPC分类号： A61K48/00 , A61P35/00 , A61K33/24
CPC分类号： A61K31/7088 , A61K31/00 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： In some aspects, the invention provides a method of inhibiting interaction of Sixl with Eya2 comprising contacting a cell expressing Sixl and Eya2 with an agent that inhibits binding of Sixl to Eya2 or an agent that inhibits the phostphatase activity of Eya2 on Sixl. In other apsects, the invention provides a method of treating cancer in a subject comprising administering to said subject an effective amount of an agent that inhibits Sixl interaction with Eya2 or an agent that inhibits the phostphatase activity of Eya2 on Sixl. In some embodiments, the invention further provides for the administration of a second cancer therapy to the patient. In still further aspects, the invention provides a method of identifying a candidate anti-cancer agent. The candidate inhibitor may be a nucleic acid, a protein, a peptide or a small molecule.
摘要翻译：在一些方面，本发明提供了抑制Six1与Eya2相互作用的方法，包括使表达Six1和Eya2的细胞与抑制Six1与Eya2结合的药剂或抑制磷酸酶活性的药剂接触 Eya2对Sixl的评论。在其他方面，本发明提供了治疗受试者癌症的方法，其包括向所述受试者施用有效量的抑制Six1与Eya2相互作用的药剂或抑制Sixl上Eya2的磷酸酶活性的药剂。在一些实施方案中，本发明进一步提供对患者施用第二种癌症疗法。在更进一步的方面，本发明提供了鉴定候选抗癌剂的方法。候选抑制剂可以是核酸，蛋白质，肽或小分子。

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