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1. 发明申请

WO2012027567A1 IMPROVEMENTS IN AND RELATING TO PERFORMANCE OF AN ANALYSER FOR BIOLOGICAL SAMPLES 审中-公开
标题翻译：生物样品分析仪的性能和相关性能的改进
公开(公告)号：WO2012027567A1
公开(公告)日：2012-03-01
申请号：PCT/US2011/049141
申请日：2011-08-25
申请人： SMITH, Stan , DUANE, Brett , HURTH, Cedric , NGUYEN, David , SURVE, Amol , LENIGK, Ralf , ZENHAUSERN, Frederic
发明人： SMITH, Stan , DUANE, Brett , HURTH, Cedric , NGUYEN, David , SURVE, Amol , LENIGK, Ralf , ZENHAUSERN, Frederic
IPC分类号： G01N35/00 , B01L3/00 , G01N35/08
CPC分类号： B01L3/502 , B01L3/502715 , B01L7/52 , B01L9/527 , B01L2200/025 , B01L2200/026 , B01L2200/10 , B01L2200/14 , B01L2300/0816 , B01L2300/1822 , B01L2400/0403 , B01L2400/0475 , G01N27/447 , G01N35/00 , G01N35/00029 , H05K1/0266 , H05K1/11 , H05K1/181
摘要： An apparatus (11) for processing a sample, circuit board ( 8008 ) suited to use in such an apparatus and a method of processing are provided in which the apparatus (11) is provided with alignement features to assist in provided the circuit board and a sample cartridge (9) in the correct position relative to one another. In this way, the plurality of sections for processing a sample in the cartridge (9) are positioned against a plurality of elements, such as a heater (4) for heating the sample cartridge (9) or an electrical contact (EP1 -EP4) for powering features on the sample cartridge (9), correctly and can operate independently of one another.
摘要翻译：提供一种用于处理样品的装置（11），适用于这种装置的电路板（8008）和处理方法，其中装置（11）具有对准特征以辅助提供电路板和样品盒（9）在相对于彼此的正确位置。以这种方式，用于处理盒（9）中的样品的多个部分抵靠多个元件定位，例如用于加热样品盒（9）或电接触（EP1-EP4）的加热器（4）用于为样品盒（9）上的功能供电，并且可以彼此独立地操作。

2. 发明申请

WO2010091400A3 IMPROVEMENTS IN AND RELATING TO MICROFLUIDIC DEVICES FOR PROCESSING A SAMPLE 审中-公开
标题翻译：对于处理样品的微流体装置的改进和相关
公开(公告)号：WO2010091400A3
公开(公告)日：2010-10-14
申请号：PCT/US2010023617
申请日：2010-02-09
申请人： ZENHAUSERN FREDERIC , NORDQUIST ALAN , LENIGK RALF , HURTH CEDRIC , YANG JIANING
发明人： ZENHAUSERN FREDERIC , NORDQUIST ALAN , LENIGK RALF , HURTH CEDRIC , YANG JIANING
IPC分类号： C12Q1/68 , G01N27/447 , G01N35/00 , G02B7/00
CPC分类号： B01L3/502761 , B01L3/502715 , B01L3/502738 , B01L7/52 , B01L7/525 , C12Q1/6806 , C25B9/00 , G01N1/10 , G01N21/01 , G01N21/6428 , G01N21/645 , G01N27/44721 , G01N27/44791 , G01N2021/6484 , G01N2201/062 , G01N2201/0846 , Y10T436/143333
摘要： Analysis methods and apparatus are provided for inspecting a channel, such as a capillary electrophoresis channel, in a device. Configuration and alignment systems are provided, together with optical systems and temperature control.
摘要翻译：提供了用于在装置中检查诸如毛细管电泳通道之类的通道的分析方法和装置。提供了配置和对准系统，以及光学系统和温度控制。

3. 发明申请

WO2010091406A2 IMPROVEMENTS IN AND RELATING TO DEVICES 审中-公开
标题翻译：改进和相关设备
公开(公告)号：WO2010091406A2
公开(公告)日：2010-08-12
申请号：PCT/US2010/023631
申请日：2010-02-09
申请人： FORENSIC SCIENCE SERVICE LIMITED , ZENHAUSERN, Frederic , NORDQUIST, Alan , LENIGK, Ralf , HURTH, Cedric , YANG, Jianing , CHEN, Xiaojia , ESTES, Matthew , LEE-EDGEHILL, John , MORAN, Nina , HOPWOOD, Andrew , KOUMI, Pieris
发明人： ZENHAUSERN, Frederic , NORDQUIST, Alan , LENIGK, Ralf , HURTH, Cedric , YANG, Jianing , CHEN, Xiaojia , ESTES, Matthew , LEE-EDGEHILL, John , MORAN, Nina , HOPWOOD, Andrew , KOUMI, Pieris
IPC分类号： C12Q1/68
CPC分类号： B01L3/502761 , B01L3/502715 , B01L3/502738 , B01L7/52 , B01L7/525 , C12Q1/6806 , C25B9/00 , G01N1/10 , G01N21/01 , G01N21/6428 , G01N21/645 , G01N27/44721 , G01N27/44791 , G01N2021/6484 , G01N2201/062 , G01N2201/0846 , Y10T436/143333
摘要： A method of analysis, instrument for analysis and device for use in such an instrument are provided, which perform a number of processes need to reach a useful result in the context of a wide variety of samples. The sequence of those processes being optimised. A device, instrument using the device and method of use are also provided which offer reliable performance of a heating based process, with minimal condensation and/or sample loss issues.
摘要翻译：提供了一种分析方法，用于分析仪器和用于这种仪器的装置，其执行多种方法需要在各种样品的上下文中获得有用的结果。这些过程的顺序被优化。还提供了使用该装置和使用方法的装置，仪器，其提供基于加热的工艺的可靠性能，具有最少的冷凝和/或样品损失问题。

4. 发明申请

WO2009021240A2 SENSING AND IDENTIFYING BIOLOGICAL SAMPELS ON MICROFLUIDIC DEVICES 审中-公开
标题翻译：感应和识别微流体装置的生物学实验
公开(公告)号：WO2009021240A2
公开(公告)日：2009-02-12
申请号：PCT/US2008/072819
申请日：2008-08-11
申请人： ARIZONE BOARD OF REGENTS for and on behalf of ARIZONA STATE UNIVERSITY , ZENHAUSERN, Frederic , LENIGK, Ralf , YANG, Jianing , CAI, Zhi , NORDQUIST, Alan , SMITH, Stanley, D. , MAGGIANO, David , MCCARTY, Glen , PRASAD, Mrinalini , LINAN, Karem , THOMAS, Baiju , OLAYA, Edward , HURTH, Cedric , COX, Darryl , RICHARD, Mark
发明人： ZENHAUSERN, Frederic , LENIGK, Ralf , YANG, Jianing , CAI, Zhi , NORDQUIST, Alan , SMITH, Stanley, D. , MAGGIANO, David , MCCARTY, Glen , PRASAD, Mrinalini , LINAN, Karem , THOMAS, Baiju , OLAYA, Edward , HURTH, Cedric , COX, Darryl , RICHARD, Mark
IPC分类号： G01N33/50 , C12Q1/68
CPC分类号： C12Q1/686 , B01L3/5027 , B01L7/52 , B01L2200/10 , B01L2200/143 , B01L2300/0816 , B01L2300/1827 , B01L2400/0421 , B01L2400/0672 , B01L2400/0677 , G01N2035/00158 , G06F19/00
摘要： A method, system, and apparatus for analysis of a biological sample includes receiving the sample, wherein the sample includes deoxyribonucleic acid (DNA), lysing the sample to obtain access to the DNA included in the sample, purifying the DNA in the sample to isolate the DNA from other components in the sample, amplifying the DNA, separating fragments of the amplified DNA, detecting the separated fragments using laser induced fluorescence, based on the detecting, generating a profile of the DNA in the received sample, comparing the generated profile with profiles of DNA stored in a database, and upon determining that the generated profile matches one of the stored profiles, identifying the source from which the stored profile was obtained, wherein the receiving, lysing, purifying, amplifying, and detecting are performed on corresponding portions of a microfluidic device, and wherein transporting the sample and the DNA to the portions of the microfluidic device and enabling the lysing, purifying, amplifying, separating, detecting, generating, comparing, and identifying are performed automatically without user interaction.
摘要翻译：用于分析生物样品的方法，系统和装置包括接收样品，其中样品包括脱氧核糖核酸（DNA），裂解样品以获得样品中包含的DNA，纯化样品中的DNA以分离来自样品中的其他成分的DNA，扩增DNA，分离扩增的DNA片段，使用激光诱导的荧光检测分离的片段，基于检测，产生所接收的样品中DNA的谱，比较生成的分布与存储在数据库中的DNA的简档，以及在确定生成的简档与所存储的简档中的一个匹配时，识别从其获得存储的简档的源，其中对相应部分执行接收，裂解，净化，放大和检测的微流体装置，并且其中将样品和DNA运输到微流体装置的部分并且使得能够进行裂解，净化，放大，分离，检测，生成，比较和识别是自动执行的，无需用户交互。

5. 发明申请

WO2005016533A2 METHOD AND APPARATUS FOR NANOMOTORS IN MICROFLUIDIC DEVICES 审中-公开
标题翻译：微流体装置中的纳米电极的方法和装置
公开(公告)号：WO2005016533A2
公开(公告)日：2005-02-24
申请号：PCT/US2004/026476
申请日：2004-08-16
申请人： ARIZONA BOARD OF REGENTS , LIU, Yingjie , CHOU, ChiaFu , ZENHAUSERN, Frederic
发明人： LIU, Yingjie , CHOU, ChiaFu , ZENHAUSERN, Frederic
IPC分类号： B01L3/00
CPC分类号： F04B19/006 , B01L3/50273 , B01L2200/0636 , B01L2300/0636 , B01L2300/0896 , B82Y5/00 , B82Y30/00 , C12N9/14
摘要： A microfluidic device having one or more nanomotors which each have one or more arms or rods attached thereto where the free end of the arms or rods may be chemically altered to capture a target from a sample solution within the microfluidic device. The present invention also includes a nano-robotic assembly line contained within a microfluidic device having multiple microchannels with different sets of nanorobots for multi-step molecule synthesis or molecule/cell modification.
摘要翻译：具有一个或多个纳米电动机的微流体装置，每个纳米电动机各自具有连接到其上的一个或多个臂或杆，其中臂或杆的自由端可被化学改变以从微流体装置内的样品溶液捕获靶。本发明还包括包含在具有多个微通道的微流体装置内的纳米机器人装配线，所述微通道具有不同组的纳米机器，用于多步分子合成或分子/细胞修饰。

6. 发明申请

WO2011139806A2 INTEGRATED METHODS AND SYSTEMS FOR PROCESSING A MOLECULAR PROFILE 审中-公开
标题翻译：用于处理分子谱的综合方法和系统
公开(公告)号：WO2011139806A2
公开(公告)日：2011-11-10
申请号：PCT/US2011/034222
申请日：2011-04-27
申请人： DIOMICS CORPORATION , ZENHAUSERN, Frederic
发明人： ZENHAUSERN, Frederic
IPC分类号： G06F19/18 , G06F19/22 , G06F19/28 , C12Q1/68
CPC分类号： G06F19/18 , G06F19/24 , Y02A90/26 , Y10T436/11
摘要： An automated and integrated matching of a biological specimen to an individual, can include a collector (12) having substrate materials and configured to selectively collect and release at least one bio-molecular species from a biological specimen; a self-contained mobile automated testing instrument (14) configured to receive the biological specimen and further configured to generate, store and output a molecular profile (16) of the at least one predetermined bio-molecular species; a processor based system (24) communicatively coupled to the self-contained mobile automated testing instrument and configured to receive the molecular profile; and wherein the processor based system is configured to provide a quantitative comparative analysis and report of the molecular profile with a selected molecular profile. In one approach, at least one predetermined bio-molecular species and stored pre-selected molecular profile is for a predetermined sequence of interest, such as a DNA-profile as defined by a Combined DNA Index System (CODIS) system.
摘要翻译：生物样本与个体的自动和集成的匹配可以包括具有底物材料并被配置为选择性地从生物样品中收集和释放至少一种生物分子物质的收集器（12）一种独立的移动自动化测试仪器（14），其被配置为接收所述生物学样本并进一步被配置为生成，存储和输出所述至少一个预定生物分子物质的分子谱（16）基于处理器的系统（24），其通信地耦合到所述独立的移动自动化测试仪器并且被配置为接收所述分子轮廓; 并且其中基于处理器的系统被配置为提供具有选定分子轮廓的分子轮廓的定量比较分析和报告。在一种方法中，至少一种预定的生物分子物质和储存的预先选择的分子谱用于预期的感兴趣的序列，例如由组合DNA指数系统（CODIS）系统定义的DNA谱。

7. 发明申请

WO2009021240A3 SENSING AND IDENTIFYING BIOLOGICAL SAMPELS ON MICROFLUIDIC DEVICES 审中-公开
标题翻译：感知和识别微流控装置上的生物标本
公开(公告)号：WO2009021240A3
公开(公告)日：2009-05-22
申请号：PCT/US2008072819
申请日：2008-08-11
申请人： ARIZONE BOARD OF REGENTS FOR A , ZENHAUSERN FREDERIC , LENIGK RALF , YANG JIANING , CAI ZHI , NORDQUIST ALAN , SMITH STANLEY D , MAGGIANO DAVID , MCCARTY GLEN , PRASAD MRINALINI , LINAN KAREM , THOMAS BAIJU , OLAYA EDWARD , HURTH CEDRIC , COX DARRYL , RICHARD MARK
发明人： ZENHAUSERN FREDERIC , LENIGK RALF , YANG JIANING , CAI ZHI , NORDQUIST ALAN , SMITH STANLEY D , MAGGIANO DAVID , MCCARTY GLEN , PRASAD MRINALINI , LINAN KAREM , THOMAS BAIJU , OLAYA EDWARD , HURTH CEDRIC , COX DARRYL , RICHARD MARK
IPC分类号： G01N33/50 , C12Q1/68
CPC分类号： C12Q1/686 , B01L3/5027 , B01L7/52 , B01L2200/10 , B01L2200/143 , B01L2300/0816 , B01L2300/1827 , B01L2400/0421 , B01L2400/0672 , B01L2400/0677 , G01N2035/00158
摘要： A method, system, and apparatus for analysis of a biological sample includes receiving the sample, wherein the sample includes deoxyribonucleic acid (DNA), lysing the sample to obtain access to the DNA included in the sample, purifying the DNA in the sample to isolate the DNA from other components in the sample, amplifying the DNA, separating fragments of the amplified DNA, detecting the separated fragments using laser induced fluorescence, based on the detecting, generating a profile of the DNA in the received sample, comparing the generated profile with profiles of DNA stored in a database, and upon determining that the generated profile matches one of the stored profiles, identifying the source from which the stored profile was obtained, wherein the receiving, lysing, purifying, amplifying, and detecting are performed on corresponding portions of a microfluidic device, and wherein transporting the sample and the DNA to the portions of the microfluidic device and enabling the lysing, purifying, amplifying, separating, detecting, generating, comparing, and identifying are performed automatically without user interaction.
摘要翻译：用于分析生物样品的方法，系统和设备包括接收样品，其中样品包括脱氧核糖核酸（DNA），裂解样品以获得包含在样品中的DNA，纯化样品中的DNA以分离来自样品中其它组分的DNA，扩增DNA，分离扩增的DNA的片段，基于检测，使用激光诱导荧光检测分离的片段，在接收的样品中产生DNA分布，将产生的分布与存储在数据库中的DNA的概况，并且在确定生成的概况与存储的概况之一匹配时，识别获得存储的概况的源，其中接收，裂解，纯化，放大和检测在相应的部分并且其中将所述样品和所述DNA运送到所述微流体装置的所述部分并且能够裂解所述微流体装置，纯化，放大，分离，检测，生成，比较和识别在没有用户交互的情况下自动执行。

8. 发明申请

WO2009021240A9 SENSING AND IDENTIFYING BIOLOGICAL SAMPELS ON MICROFLUIDIC DEVICES 审中-公开
公开(公告)号：WO2009021240A9
公开(公告)日：2009-04-09
申请号：PCT/US2008072819
申请日：2008-08-11
申请人： ARIZONE BOARD OF REGENTS FOR A , ZENHAUSERN FREDERIC , LENIGK RALF , YANG JIANING , CAI ZHI , NORDQUIST ALAN , SMITH STANLEY D , MAGGIANO DAVID , MCCARTY GLEN , PRASAD MRINALINI , LINAN KAREM , THOMAS BAIJU , OLAYA EDWARD , HURTH CEDRIC , COX DARRYL , RICHARD MARK
发明人： ZENHAUSERN FREDERIC , LENIGK RALF , YANG JIANING , CAI ZHI , NORDQUIST ALAN , SMITH STANLEY D , MAGGIANO DAVID , MCCARTY GLEN , PRASAD MRINALINI , LINAN KAREM , THOMAS BAIJU , OLAYA EDWARD , HURTH CEDRIC , COX DARRYL , RICHARD MARK
IPC分类号： G01N33/50 , C12Q1/68
CPC分类号： C12Q1/686 , B01L3/5027 , B01L7/52 , B01L2200/10 , B01L2200/143 , B01L2300/0816 , B01L2300/1827 , B01L2400/0421 , B01L2400/0672 , B01L2400/0677 , G01N2035/00158
摘要： A method, system, and apparatus for analysis of a biological sample includes receiving the sample, wherein the sample includes deoxyribonucleic acid (DNA), lysing the sample to obtain access to the DNA included in the sample, purifying the DNA in the sample to isolate the DNA from other components in the sample, amplifying the DNA, separating fragments of the amplified DNA, detecting the separated fragments using laser induced fluorescence, based on the detecting, generating a profile of the DNA in the received sample, comparing the generated profile with profiles of DNA stored in a database, and upon determining that the generated profile matches one of the stored profiles, identifying the source from which the stored profile was obtained, wherein the receiving, lysing, purifying, amplifying, and detecting are performed on corresponding portions of a microfluidic device, and wherein transporting the sample and the DNA to the portions of the microfluidic device and enabling the lysing, purifying, amplifying, separating, detecting, generating, comparing, and identifying are performed automatically without user interaction.

9. 发明申请

WO2005050763A1 MICROFLUIDIC FUEL CELL SYSTEM AND METHOD FOR PORTABLE ENERGY APPLICATIONS 审中-公开
标题翻译：微型燃料电池系统及便携式能源应用方法
公开(公告)号：WO2005050763A1
公开(公告)日：2005-06-02
申请号：PCT/US2004/038653
申请日：2004-11-15
申请人： ARIZONA BOARD OF REGENTS , GERVASIO, Dominic , ZENHAUSERN, Frederic
发明人： GERVASIO, Dominic , ZENHAUSERN, Frederic
IPC分类号： H01M4/86
CPC分类号： C01B3/065 , C01B2203/02 , C01B2203/066 , C01B2203/1047 , C01B2203/148 , H01M8/065 , H01M8/1007 , H01M8/1023 , H01M8/1039 , H01M8/1067 , H01M2250/30 , Y02B90/18 , Y02E60/362
摘要： A system and method for generating and separating gaseous fuel components, as well as the partitioning of liquid and gaseous byproducts, in the operation of a portable fuel cell device comprises: a microfluidic containment volume (140, 230); a substrate for supporting a catalytic composition (150, 215, 315) that is suitably adapted to promote hydrolysis of a substantially liquid-borne fuel precursor (330) to generate a gaseous fuel component; a liquid/gas separator (155, 220, 363) for at least partially partitioning a gaseous component from a liquid component; a fuel cell (210, 310) comprising an anode (125) and a cathode (135); and electrical connections coupled thereto to power a load (120). Various features and parameters of the present invention may be suitably adapted to optimize the gas/liquid transport and/or partition functions for any specific fuel cell design. The present invention provides improved control of the rate of delivery/removal of gaseous components to/from a fuel cell fuel solution in addition to improved application of fuel cell technology to power inter alia portable electronic devices.
摘要翻译：在便携式燃料电池装置的操作中，用于产生和分离气体燃料部件以及液体和气体副产物的分配的系统和方法包括：微流体容纳体积（140,230）; 用于支撑催化组合物（150,215,315）的基底，其适于适于促进基本上液体燃料前体（330）的水解以产生气态燃料组分; 液体/气体分离器（155,220,363），用于至少部分地从液体组分分配气态组分; 包括阳极（125）和阴极（135）的燃料电池（210,310）; 以及耦合到其上的电连接以为负载（120）供电。本发明的各种特征和参数可以适合于优化用于任何特定燃料电池设计的气体/液体输送和/或分配功能。本发明除了改进燃料电池技术的应用之外，还特别提供了对燃料电池燃料溶液中的气体组分的输送/除去速率的改进控制。

10. 发明申请

WO2004009787A2 METHOD AND APPARATUS FOR MANIPULATING POLARIZABLE ANALYTES VIA DIELECTROPHORESIS 审中-公开
标题翻译：用于通过电介质手段控制极化分析仪的方法和装置
公开(公告)号：WO2004009787A2
公开(公告)日：2004-01-29
申请号：PCT/US2003/022929
申请日：2003-07-22
申请人： MOTOROLA, INC. , ZENHAUSERN, Frederic , CHOU, Chia-Fu , TERBRUEGGEN, Robert, Henry
发明人： ZENHAUSERN, Frederic , CHOU, Chia-Fu , TERBRUEGGEN, Robert, Henry
IPC分类号： C12N
CPC分类号： B82Y30/00 , B01L3/502746 , B01L3/502761 , B01L2200/0647 , B01L2400/0424 , B01L2400/046 , B03C5/026 , B82Y15/00 , G01N33/5438
摘要： The present invention is directed to devices and methods for manipulating polarizable analytes via dielectrophoresis to allow for improved detection of target analytes. Microfluidic devices are configured such that the application of a voltage between field-generating electrodes results in the generation of an asymmetric electric field within the device. Some embodiments of the invention provide a physical constriction, and electrically floating conductive material or a combination of the two techniques to generating an asymmetrical field. Using dielectrophoresis, target analytes are concentrated or separated from contaminant analytes and transported to a detection module.
摘要翻译：本发明涉及通过介电电泳操作可极化分析物以允许改进的靶分析物检测的装置和方法。微流体装置被配置为使得在场产生电极之间施加电压导致在该装置内产生非对称电场。本发明的一些实施例提供物理收缩和电浮动导电材料或两种技术的组合以产生不对称场。使用介电电泳，将目标分析物从污染物分析物中浓缩或分离，并传输到检测模块。

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