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1. 发明申请

WO2008130618A1 METHOD AND APPARATUS FOR SEPARATING PARTICLES, CELLS, MOLECULES AND PARTICULATES 审中-公开
标题翻译：分离颗粒，细胞，分子和颗粒的方法和装置
公开(公告)号：WO2008130618A1
公开(公告)日：2008-10-30
申请号：PCT/US2008/005002
申请日：2008-04-18
申请人： THE CHARLES STARK DRAPER LABORATORY, INC. , CHILDREN'S MEDICAL CENTER CORPORATION , VARGHESE, Mathew , FIERING, Jason, O. , INGBER, Donald, E. , XIA, Shannon , MESCHER, Mark, J. , BORENSTEIN, Jeffrey, T. , YUNG, Chong
发明人： VARGHESE, Mathew , FIERING, Jason, O. , INGBER, Donald, E. , XIA, Shannon , MESCHER, Mark, J. , BORENSTEIN, Jeffrey, T. , YUNG, Chong
IPC分类号： B03C1/033
CPC分类号： B03C1/0332 , B03C2201/18 , B03C2201/26 , Y10T436/2575
摘要： A method and apparatus for continuously separating or concentrating particles that includes flowing two fluids in laminar flow through a magnetic field gradient which causes target particles to migrate to a waste fluid stream, and collecting each fluid stream after being flowed through the magnetic field gradient.
摘要翻译：用于连续分离或浓缩颗粒的方法和装置，其包括使层流中的两种流体流过导致目标颗粒迁移到废流体的磁场梯度，以及在流过磁场梯度之后收集每个流体流。

2. 发明申请

WO2011091037A3 RAPID PATHOGEN DIAGNOSTIC DEVICE AND METHOD 审中-公开
标题翻译：快速病理诊断装置及方法
公开(公告)号：WO2011091037A3
公开(公告)日：2011-12-08
申请号：PCT/US2011021718
申请日：2011-01-19
申请人： HARVARD COLLEGE , YUNG CHONG WING , INGBER DONALD E , COOPER RYAN MCOMBER , VOLLMER FRANK , DOMANSKY KAREL , LESLIE DANIEL CHRISTOPHER , SUPER MICHAEL
发明人： YUNG CHONG WING , INGBER DONALD E , COOPER RYAN MCOMBER , VOLLMER FRANK , DOMANSKY KAREL , LESLIE DANIEL CHRISTOPHER , SUPER MICHAEL
IPC分类号： G01N35/08 , G01N1/38 , G01N33/48 , G01N33/52 , G01N33/58
CPC分类号： C12Q1/04 , B01L3/502761 , B01L2200/0668 , B01L2300/0816 , B01L2400/043 , G01N33/54306 , G01N33/54333 , G01N33/54366 , G01N35/0098
摘要： A microfluidic device of a diagnostic and detection system includes an inlet port connected by one or more microchannels to an outlet port and includes a capture and visualization chamber (CVC) connected to at least one microchannel. A fluid to be analyzed can be mixed with magnetic microbeads that have an affinity to become bound to target components, such as pathogens in the fluid. The fluid including the magnetically bound target components can be injected through the microfluidic device. Magnetic field gradient, such as provided by permanent or elecrto-magnets, can be applied to the fluid and the magnetically bound target components flowing through the microfluidic device to cause the magnetically bound target components to migrate into the (CVC) and become separated from the fluid. The magnetically bound target components can be analyzed and tested using various techniques to detect the presence of specific organic and inorganic materials, such as pathogens in bio-fluids and contamination in liquid food sources (e.g. water). The device and method provide a system for rapidly detecting pathogens and contamination in relatively small fluid samples.
摘要翻译：诊断和检测系统的微流体装置包括通过一个或多个微通道连接到出口的入口端口，并且包括连接到至少一个微通道的捕获和可视化室（CVC）。要分析的流体可以与具有亲和性的磁性微珠混合，以结合到目标组分，例如流体中的病原体。包括磁结合的靶组分的流体可以通过微流体装置注入。磁场梯度，例如由永久磁铁或电磁铁提供的磁场梯度可以被施加到流过微流体装置的流体和磁力结合的目标组分，以使磁结合的目标组分迁移到（CVC）中并与流体。可以使用各种技术来分析和测试磁结合的靶组分，以检测特定有机和无机材料（例如生物流体中的病原体和液体食物来源（例如水））中的污染物的存在。该装置和方法提供用于在相对小的流体样品中快速检测病原体和污染物的系统。

3. 发明申请

WO2010123594A3 DEVICE FOR FILTRATION OF FLUIDS THERE THROUGH AND ACCOMPANYING METHOD 审中-公开
公开(公告)号：WO2010123594A3
公开(公告)日：2010-11-18
申请号：PCT/US2010021195
申请日：2010-01-15
申请人： CHILDRENS MEDICAL CENTER , YUNG CHONG WING , INGBER DONALD E
发明人： YUNG CHONG WING , INGBER DONALD E
IPC分类号： B03C5/02 , B01D17/032 , B03C1/02 , G01N1/34 , G01N33/48
CPC分类号： B03C1/01 , B03C1/288 , B03C2201/18 , G01N1/40 , G01N33/54326 , G01N33/54366
摘要： A microfluidic device for separating target components from a source fluid includes one or more source channels connected to one or more collection channels by one or more transfer channels. The target components of the source fluid can be magnetic or bound to magnetic particles using a know binding agent. A source fluid containing magnetically bound target components can be pumped through the source channel of the microfluidic device. A magnetic field gradient can be applied to the source fluid in the source channel causing the magnetically bound target components to migrate through the transfer channel into the collection channel. The collection channel can include a collection fluid that is stagnant until a predefined volume of source fluid is processed or a predefined volume of target components accumulate in the collection channel, at which point collection fluid can be pumped into the collection channel to flush the target components out of the collection channel. The target components can be subsequently analyzed for detection and diagnosis.

4. 发明申请

WO2010123594A9 DEVICE FOR FILTRATION OF FLUIDS THERE THROUGH AND ACCOMPANYING METHOD 审中-公开
公开(公告)号：WO2010123594A9
公开(公告)日：2010-10-28
申请号：PCT/US2010/021195
申请日：2010-01-15
申请人： CHILDREN'S MEDICAL CENTER CORPORATION , YUNG, Chong Wing , INGBER, Donald, E.
发明人： YUNG, Chong Wing , INGBER, Donald, E.
IPC分类号： B03C5/02 , B03C1/02 , B01D17/032 , G01N1/34 , G01N33/48
摘要： A microfluidic device for separating target components from a source fluid includes one or more source channels connected to one or more collection channels by one or more transfer channels. The target components of the source fluid can be magnetic or bound to magnetic particles using a know binding agent. A source fluid containing magnetically bound target components can be pumped through the source channel of the microfluidic device. A magnetic field gradient can be applied to the source fluid in the source channel causing the magnetically bound target components to migrate through the transfer channel into the collection channel. The collection channel can include a collection fluid that is stagnant until a predefined volume of source fluid is processed or a predefined volume of target components accumulate in the collection channel, at which point collection fluid can be pumped into the collection channel to flush the target components out of the collection channel. The target components can be subsequently analyzed for detection and diagnosis.

5. 发明申请

WO2011091037A2 RAPID PATHOGEN DIAGNOSTIC DEVICE AND METHOD 审中-公开
标题翻译：快速病原体诊断装置和方法
公开(公告)号：WO2011091037A2
公开(公告)日：2011-07-28
申请号：PCT/US2011/021718
申请日：2011-01-19
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , YUNG, Chong Wing , INGBER, Donald E. , COOPER, Ryan Mcomber , VOLLMER, Frank , DOMANSKY, Karel , LESLIE, Daniel Christopher , SUPER, Michael
发明人： YUNG, Chong Wing , INGBER, Donald E. , COOPER, Ryan Mcomber , VOLLMER, Frank , DOMANSKY, Karel , LESLIE, Daniel Christopher , SUPER, Michael
IPC分类号： G01N35/08 , G01N33/48 , G01N33/52 , G01N33/58 , G01N1/38
CPC分类号： C12Q1/04 , B01L3/502761 , B01L2200/0668 , B01L2300/0816 , B01L2400/043 , G01N33/54306 , G01N33/54333 , G01N33/54366 , G01N35/0098
摘要： A microfluidic device of a diagnostic and detection system includes an inlet port connected by one or more microchannels to an outlet port and includes a capture and visualization chamber (CVC) connected to at least one microchannel. A fluid to be analyzed can be mixed with magnetic microbeads that have an affinity to become bound to target components, such as pathogens in the fluid. The fluid including the magnetically bound target components can be injected through the microfluidic device. Magnetic field gradient, such as provided by permanent or elecrto-magnets, can be applied to the fluid and the magnetically bound target components flowing through the microfluidic device to cause the magnetically bound target components to migrate into the (CVC) and become separated from the fluid. The magnetically bound target components can be analyzed and tested using various techniques to detect the presence of specific organic and inorganic materials, such as pathogens in bio-fluids and contamination in liquid food sources (e.g. water). The device and method provide a system for rapidly detecting pathogens and contamination in relatively small fluid samples.
摘要翻译：诊断和检测系统的微流体装置包括通过一个或多个微通道连接到出口端口的入口端口，并且包括连接到至少一个微通道的捕获和可视化腔室（CVC）。待分析的流体可以与具有亲和力的磁性微珠混合，以与目标组分（例如流体中的病原体）结合。包括磁性结合的目标组分的流体可以通过微流体装置注入。诸如由永久磁体或电磁体提供的磁场梯度可以施加到流体和流过微流体装置的磁性结合的目标组分，以使磁性结合的目标组分迁移到（CVC）中并与流体。可以使用各种技术来分析和测试磁性结合的目标组分，以检测特定有机和无机材料（例如生物流体中的病原体和液体食物源（例如水）中的污染）的存在。该装置和方法提供了用于快速检测相对较小的流体样品中的病原体和污染物的系统。

6. 发明申请

WO2010123594A2 DEVICE FOR FILTRATION OF FLUIDS THERE THROUGH AND ACCOMPANYING METHOD 审中-公开
标题翻译：用于通过并伴随方法过滤流体的装置
公开(公告)号：WO2010123594A2
公开(公告)日：2010-10-28
申请号：PCT/US2010021195
申请日：2010-01-15
申请人： CHILDRENS MEDICAL CENTER , YUNG CHONG WING , INGBER DONALD E
发明人： YUNG CHONG WING , INGBER DONALD E
IPC分类号： B03C5/02 , B01D17/032 , B03C1/02 , G01N1/34 , G01N33/48
CPC分类号： B03C1/01 , B03C1/288 , B03C2201/18 , G01N1/40 , G01N33/54326 , G01N33/54366
摘要： A microfluidic device for separating target components from a source fluid includes one or more source channels connected to one or more collection channels by one or more transfer channels. The target components of the source fluid can be magnetic or bound to magnetic particles using a know binding agent. A source fluid containing magnetically bound target components can be pumped through the source channel of the microfluidic device. A magnetic field gradient can be applied to the source fluid in the source channel causing the magnetically bound target components to migrate through the transfer channel into the collection channel. The collection channel can include a collection fluid that is stagnant until a predefined volume of source fluid is processed or a predefined volume of target components accumulate in the collection channel, at which point collection fluid can be pumped into the collection channel to flush the target components out of the collection channel. The target components can be subsequently analyzed for detection and diagnosis.
摘要翻译：用于从源流体分离目标组分的微流体装置包括通过一个或多个传输通道连接到一个或多个收集通道的一个或多个源通道。源流体的目标组分可以是磁性的或使用已知粘合剂结合到磁性颗粒。含有磁性结合的目标组分的源流体可以通过微流体装置的源通道泵送。磁场梯度可以应用于源通道中的源流体，使得磁性结合的目标组分通过传输通道迁移到收集通道中。收集通道可包括静止的收集流体，直到预定量的源流体被处理或预定体积的目标组分积聚在收集通道中，在该点处收集流体可被泵送到收集通道中以冲洗目标组分脱离收集渠道。随后可以分析目标组分以进行检测和诊断。

7. 发明申请

WO2012135834A3 DIALYSIS LIKE THERAPEUTIC (DLT) DEVICE 审中-公开
公开(公告)号：WO2012135834A3
公开(公告)日：2012-10-04
申请号：PCT/US2012/031864
申请日：2012-04-02
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , CHILDREN'S MEDICAL CENTER CORPORATION , YUNG, Chong, Wing , DOMANSKY, Karel , TERRY, Richard , KALISH, David , SCHULTE, Alexa , KANG, Joo, Hun , INGBER, Donald, E. , SUPER, Mike , COOPER, Ryan, M.
发明人： YUNG, Chong, Wing , DOMANSKY, Karel , TERRY, Richard , KALISH, David , SCHULTE, Alexa , KANG, Joo, Hun , INGBER, Donald, E. , SUPER, Mike , COOPER, Ryan, M.
IPC分类号： G01N33/569 , G01N35/10 , G01N35/08 , B81B1/00
摘要： A dialysis like therapeutic (DLT) device is provided. The DLT device includes at least one source channel connected at least one collection channels by one or more transfer channels. Fluid contacting surface of the channels can be an anti-fouling surface such as slippery liquid-infused porous surface (SLIPS). Fluids can be flown at high flow rates through the channels. The target components of the source fluid can be magnetic or bound to magnetic particles using an affinity molecule. A source fluid containing magnetically bound target components can be pumped through the source channel of the microfluidic device. A magnetic field gradient can be applied to the source fluid in the source channel causing the magnetically bound target components to migrate through the transfer channel into the collection channel. The collection channel can include a collection fluid to flush the target components out of the collection channel. The target components can be subsequently analyzed for detection and diagnosis. The source channel and the collection channels of the microfluidic device are analogous to the splenic arterioles and venules, respectively; the transfer channels mimic the vascular sinusoids of the spleen where opsonized particles are retained. Thus, the device acts as a dialysis like therapeutic device by combining fluidics and magnetics.

8. 发明申请

WO2012135834A2 DIALYSIS LIKE THERAPEUTIC (DLT) DEVICE 审中-公开
标题翻译： DIALYSIS LIKE THERAPEUTIC（DLT）DEVICE
公开(公告)号：WO2012135834A2
公开(公告)日：2012-10-04
申请号：PCT/US2012031864
申请日：2012-04-02
申请人： HARVARD COLLEGE , CHILDRENS MEDICAL CENTER , YUNG CHONG WING , DOMANSKY KAREL , TERRY RICHARD , KALISH DAVID , SCHULTE ALEXA , KANG JOO HUN , INGBER DONALD E , SUPER MIKE , COOPER RYAN M
发明人： YUNG CHONG WING , DOMANSKY KAREL , TERRY RICHARD , KALISH DAVID , SCHULTE ALEXA , KANG JOO HUN , INGBER DONALD E , SUPER MIKE , COOPER RYAN M
IPC分类号： G01N33/569 , B81B1/00 , G01N35/08 , G01N35/10
CPC分类号： C12Q1/04 , A61M1/36 , A61M1/3618 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L3/56 , B01L2200/0652 , B01L2300/0864 , B01L2300/0867 , B01L2300/0887 , B01L2400/043 , B01L2400/0487 , B03C1/002 , B03C1/01 , B03C1/0332 , B03C1/0335 , B03C1/288 , B03C2201/26
摘要： A dialysis like therapeutic (DLT) device is provided. The DLT device includes at least one source channel connected at least one collection channels by one or more transfer channels. Fluid contacting surface of the channels can be an anti-fouling surface such as slippery liquid-infused porous surface (SLIPS). Fluids can be flown at high flow rates through the channels. The target components of the source fluid can be magnetic or bound to magnetic particles using an affinity molecule. A source fluid containing magnetically bound target components can be pumped through the source channel of the microfluidic device. A magnetic field gradient can be applied to the source fluid in the source channel causing the magnetically bound target components to migrate through the transfer channel into the collection channel. The collection channel can include a collection fluid to flush the target components out of the collection channel. The target components can be subsequently analyzed for detection and diagnosis. The source channel and the collection channels of the microfluidic device are analogous to the splenic arterioles and venules, respectively; the transfer channels mimic the vascular sinusoids of the spleen where opsonized particles are retained. Thus, the device acts as a dialysis like therapeutic device by combining fluidics and magnetics.
摘要翻译：提供透析治疗（DLT）装置。 DLT设备包括通过一个或多个传输信道连接至少一个收集信道的至少一个源信道。通道的流体接触表面可以是防污表面，例如滑动的液体注入的多孔表面（SLIPS）。流体可以通过通道以高流速流动。源流体的目标组分可以是磁性的或使用亲和分子结合到磁性颗粒。含有磁结合的靶组分的源流体可以泵送通过微流体装置的源通道。磁场梯度可以施加到源通道中的源流体，使得磁结合的目标分量通过传输通道迁移到收集通道中。收集通道可以包括收集流体以将目标组分冲洗出收集通道。随后分析目标成分进行检测和诊断。微流体装置的源通道和收集通道分别类似于脾小动脉和小静脉; 转移通道模拟脾脏的血管窦状，其中保留调理颗粒。因此，该装置通过组合流体学和磁性作为透析像治疗装置。

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