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1. 发明申请

WO2003009882A3 LOCAL CONCENTRATION MANAGEMENT SYSTEM 审中-公开
公开(公告)号：WO2003009882A3
公开(公告)日：2003-02-06
申请号：PCT/US2002/022813
申请日：2002-07-16
申请人： DURECT CORPORATION , THEEUWES, Felix , YUM, Su, Il
发明人： THEEUWES, Felix , YUM, Su, Il
IPC分类号： A61M29/00
摘要： The invention provides a local concentration management system (LCMS) for delivery of highly concentrated therapeutic agent formulations. The LCMS comprises a device comprising an elongate body (20) defining a lumen (26) between its proximal (21) and distal (23) ends, and a diffuser element (30), a dilutor element (60), or both. The diffuser element, which is selectively permeable to the agent, is operatively associated with the elongate body (20) so that agent flows through the elongate body, and into and through the diffuser element to exit the system. The dilutor element can be operatively associated with the system to be in fluid communication with the elongate body lumen, a diffusion space defined by a diffuser element inner wall, or both. The dilutor element is selectively water permeable, but substantially impermeable to agent, to provide for dilution of the agent during transit through the system. The LCMS system is designed to disperse and/or dilute the drug delivery stream.

2. 发明申请

WO03009882A2 LOCAL CONCENTRATION MANAGEMENT SYSTEM 审中-公开
标题翻译：本地集中管理系统
公开(公告)号：WO03009882A2
公开(公告)日：2003-02-06
申请号：PCT/US0222813
申请日：2002-07-16
申请人： DURECT CORP , THEEUWES FELIX , YUM SU IL
发明人： THEEUWES FELIX , YUM SU IL
IPC分类号： A61M25/00 , A61M25/14 , A61M25/16 , A61M
CPC分类号： A61M25/00 , A61M25/0043 , A61M2025/0057 , A61M2025/105 , A61M2025/1086
摘要： The invention provides a local concentration management system (LCMS) for delivery of highly concentrated therapeutic agent formulations. The LCMS comprises a device comprising an elongate body defining a lumen between its proximal and distal ends, and a diffuser element, a dilutor element, or both. The diffuser element, which is selectively permeable to the agent, is operatively associated with the elongate body so that agent flows through the elongate body, and into and through the diffuser element to exit the system. The dilutor element can be operatively associated with the system to be in fluid communication with the elongate body lumen, a diffusion space defined by a diffuser element inner wall, or both. The dilutor element is selectively water permeable, but substantially impermeable to agent, to provide for dilution of the agent during transit through the system. The LCMS system is designed to disperse and/or dilute the drug delivery stream.
摘要翻译：本发明提供了用于递送高度浓缩的治疗剂制剂的局部浓度管理系统（LCMS）。 LCMS包括装置，其包括在其近端和远端之间限定内腔的细长主体，以及扩散器元件，稀释元件或两者。对试剂选择性渗透的扩散器元件可与细长体可操作地连接，使得试剂流过细长体并进入并通过扩散器元件以离开系统。稀释元件可以与系统可操作地相关联以与细长体腔流体连通，由扩散器元件内壁或两者限定的扩散空间。稀释剂元件选择性地是水可渗透的，但是对试剂基本上是不可渗透的，以便在通过系统运输期间提供试剂的稀释。 LCMS系统被设计成分散和/或稀释药物输送流。

3. 发明申请

WO2002043800A3 DEVICES AND METHODS FOR CONTROLLED DELIVERY FROM A DRUG DELIVERY DEVICE 审中-公开
公开(公告)号：WO2002043800A3
公开(公告)日：2002-06-06
申请号：PCT/US2001/043143
申请日：2001-11-21
申请人： DURECT CORPORATION , BROWN, James, E. , CULWELL, John , FILICE, James, A. , GILLIS, Edward, M. , THEEUWES, Felix , WICKMAN, Peter , YUM, Su, Il
发明人： BROWN, James, E. , CULWELL, John , FILICE, James, A. , GILLIS, Edward, M. , THEEUWES, Felix , WICKMAN, Peter , YUM, Su, Il
IPC分类号： A61M31/00
摘要： The invention features a plug for use with a drug delivery device, wherein the plug defines an expansion control channel, which accommodates thermal expansion of a formulation in a reservoir of a drug delivery device, and an exit channel. In one embodiment, the plug comprises an inner plug member and an outer plug member, which members define an expansion control channel to facilitate release of entrapped air and to accommodate thermal expansion of formulation from the sealed drug reservoir. The plug further defines an exit channel, and may optionally further comprise a frit positioned within the flow pathway just prior to the delivery outlet, or both.

4. 发明申请

WO1995009006A1 MONOGLYCERIDE/LACTATE ESTER PERMEATION ENHANCER 审中-公开
标题翻译：单糖/乳酸盐渗透增强剂
公开(公告)号：WO1995009006A1
公开(公告)日：1995-04-06
申请号：PCT/US1994011120
申请日：1994-09-29
申请人： ALZA CORPORATION , TASKOVICH, Lina, Tormen , YUM, Su, Il , LEE, Eun, Soo , CRISOLOGO, Nieves, Marzan
发明人： ALZA CORPORATION
IPC分类号： A61K47/14
CPC分类号： A61K9/7053 , A61K9/0014 , A61K9/7084 , A61K31/215 , A61K31/216 , A61K31/57 , A61K47/14 , Y10S514/946 , Y10S514/947 , A61K31/565 , A61K2300/00
摘要： A composition of matter for application to a body surface or membrane to administer a drug by permeation through the body surface or membrane, the composition comprising, in combination, the drug to be administered, in a therapeutically effective amount; and a permeation-enhancing mixture comprising a monoglyceride or a mixture of monoglycerides, and a lactate ester or a mixture of lactate esters.
摘要翻译：一种用于施用于身体表面或膜的物质组合物，用于通过穿过身体表面或膜渗透来施用药物，所述组合物组合物以治疗有效量组合包含待施用的药物; 以及包含单酸甘油酯或单酸甘油酯和乳酸酯或乳酸酯混合物的混合物的渗透增强混合物。

5. 发明申请

WO1994008572A1 DELAYED ONSET TRANSDERMAL DELIVERY DEVICE 审中-公开
标题翻译：延迟ONSET TRANSDERMAL交付设备
公开(公告)号：WO1994008572A1
公开(公告)日：1994-04-28
申请号：PCT/US1993009637
申请日：1993-10-07
申请人： ALZA CORPORATION , LEE, Eun, Soo , YUM, Su, Il , THEEUWES, Felix
发明人： ALZA CORPORATION
IPC分类号： A61K09/70
CPC分类号： A61K9/7084 , A61K47/585
摘要： The present invention is directed to a transdermal delivery device (10) for the controlled release of a drug or other therapeutic agent to skin or mucosa and adapted to delay the onset of therapeutic agent delivery at a therapeutically effective rate for a predetermined time after placement of the device onto the skin or mucosa. The device comprises a nonaqueous reservoir (104) which contains a therapeutic agent in complexation with an ion-exchange resin and also contains an activating agent, the reservoir having a surface through which the therapeutic agent is released to the skin or mucosa; and a rate-controlling membrane (106) disposed between the skin or mucosa and the releasing surface of the reservoir (104) for controlling the rate at which water is absorbed into the reservoir, the rate-controlling membrane (106) being substantially free of therapeutic agent prior to placement of the device onto the skin or mucosa. The present invention has the additional advantage of providing the therapeutic agent in a stable form prior to placement on the skin or mucosa as well as in a form suitable for absorption after such placement.
摘要翻译：本发明涉及一种用于将药物或其它治疗剂受控释放至皮肤或粘膜并适于在治疗有效率之后以预定时间延迟治疗剂递送开始的透皮递送装置（10）该装置在皮肤或粘膜上。该装置包括非水储存器（104），其含有与离子交换树脂络合的治疗剂并且还含有活化剂，所述储存器具有治疗剂通过其释放到皮肤或粘膜的表面; 以及设置在皮肤或粘膜与储存器（104）的释放表面之间的速率控制膜（106），用于控制水被吸收到储存器中的速率，速率控制膜（106）基本上不含在将装置置于皮肤或粘膜上之前的治疗剂。本发明具有额外的优点，即在放置在皮肤或粘膜之前以及在这种放置之后适合吸收的形式，以稳定的形式提供治疗剂。

6. 发明申请

WO2004054542A2 ORAL DRUG DELIVERY SYSTEM 审中-公开
标题翻译：口服药物递送系统
公开(公告)号：WO2004054542A2
公开(公告)日：2004-07-01
申请号：PCT/US2003/040156
申请日：2003-12-15
申请人： DURECT CORPORATION , YUM, Su, Il , SCHOENHARD, Grant , TIPTON, Arthur, J. , GIBSON, John, W. , MIDDLETON, John, C.
发明人： YUM, Su, Il , SCHOENHARD, Grant , TIPTON, Arthur, J. , GIBSON, John, W. , MIDDLETON, John, C.
IPC分类号： A61K9/00
CPC分类号： A61K31/485 , A61K9/0053 , A61K9/48 , A61K9/4825 , A61K9/4858 , A61K9/4866 , A61K31/4458 , A61K47/14 , A61K47/26 , A61K47/38 , Y10S514/96
摘要： Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.
摘要翻译：适用于药物化合物和组合物施用的剂型和药物递送装置，包括化合物的口服药物施用。

7. 发明申请

WO02102278A2 DEVICE AND METHOD FOR DELIVERING MICRODOSES OF AGENT TO THE EAR 审中-公开
标题翻译：用于将药剂微粒体递送至耳朵的装置和方法
公开(公告)号：WO02102278A2
公开(公告)日：2002-12-27
申请号：PCT/US0219290
申请日：2002-06-17
申请人： DURECT CORP , ARENBERG MICHAEL H , RAMPERSAUD CHARLES , GILLIS EDWARD M , YUM SU IL , THEEUWES FELIX
发明人： ARENBERG MICHAEL H , RAMPERSAUD CHARLES , GILLIS EDWARD M , YUM SU IL , THEEUWES FELIX
IPC分类号： A61F11/00 , A61F
CPC分类号： A61F11/00
摘要： The present invention provides devices and methods for delivery of very low dosages to the inner ear. The device is a self-contained unit that reproducibly and consistently delivers a dose of therapeutic agent that is effective, yet below the ototoxic threshold for that agent. The invention further provides therapeutic methods using the device of the invention.
摘要翻译：本发明提供了用于将非常低剂量递送到内耳的装置和方法。该装置是一种独立的单元，其可重复地和一致地递送有效剂量的治疗剂，但低于该药剂的耳毒性阈值。本发明还提供了使用本发明的装置的治疗方法。

8. 发明申请

WO9640259A3 SKIN PERMEATION ENHANCER COMPOSITIONS COMPRISING GLYCEROL MONOLAURATE AND LAURYL ACETATE 审中-公开
标题翻译：包含甘油单酯和乙酸铝的皮肤渗透增强剂组合物
公开(公告)号：WO9640259A3
公开(公告)日：1997-02-27
申请号：PCT/US9608105
申请日：1996-05-30
申请人： ALZA CORP , BURKOTH TERRY L , TASKOVICH LINA T , CRISOLOGO NIEVES MARZAN , BESTE RUSSELL , HAMLIN RICHARD D , GALE ROBERT M , LEE EUN SOO , YUM SU IL
发明人： BURKOTH TERRY L , TASKOVICH LINA T , CRISOLOGO NIEVES MARZAN , BESTE RUSSELL , HAMLIN RICHARD D , GALE ROBERT M , LEE EUN SOO , YUM SU IL
IPC分类号： A61K9/00 , A61K9/70 , A61K47/14
CPC分类号： A61K9/7053 , A61K9/0014 , A61K9/7069 , A61K9/7084 , A61K47/14 , Y10S514/946 , Y10S514/947
摘要： Compositions, devices, and methods for transdermal administration of an active agent are disclosed using a novel dual permeation enhancer mixture comprising lauryl acetate and a monoglyceride, preferably glycerol monolaurate. The dual permeation enhancer mixture comprising lauryl acetate is a potent permeation enhancer and provides stable systems which are more readily characterized.

9. 发明申请

WO1993007870A1 DEVICE FOR THE TRANSDERMAL ADMINISTRATION OF MELATONIN 审中-公开
标题翻译： MELATONIN的超导管理设备
公开(公告)号：WO1993007870A1
公开(公告)日：1993-04-29
申请号：PCT/US1992008919
申请日：1992-10-16
申请人： ALZA CORPORATION , YATES, F., Eugene , TASKOVICH, Lina, T. , YUM, Su, Il , CRISOLOGO, Nieves, Marzan
发明人： ALZA CORPORATION
IPC分类号： A61K31/40
CPC分类号： A61K9/7084 , A61K9/0014 , A61K31/40 , A61K47/14
摘要： The present invention is directed to the transdermal administration of melatonin together with a suitable permeation enhancer. The invention includes a transdermal drug delivery device (10) comprising a matrix (12) adapted to be placed in melatonin- and permeation enhancer-transmitting relation with the skin site (18). The matrix (12) contains sufficient amounts of a permeation enhancer and of melatonin, in combination, to continuously administer to the skin (18) for a predetermined period of time the melatonin to provide an effective therapeutic result. The invention is also directed to a method for the transdermal administration of a therapeutically effective amount of melatonin together with a skin permeation-enhancing amount of a suitable permeation enhancer. The invention further includes methods for time- and rate-patterned transdermal delivery of melatonin to simulate the natural circadian rhythmic profile of melatonin in mammals.
摘要翻译：本发明涉及褪黑激素与合适的渗透增强剂的透皮给药。本发明包括透皮药物递送装置（10），其包括适于与皮肤部位（18）放置在与褪黑激素和渗透增强剂 - 传递关系中的基质（12）。基质（12）含有足够量的渗透促进剂和褪黑激素组合，以连续给予皮肤（18）一段预定的时间，以提供有效的治疗结果。本发明还涉及一种用于透皮施用治疗有效量的褪黑激素以及皮肤渗透增强量的合适的渗透增强剂的方法。本发明还包括用于模拟褪黑激素的褪黑激素的天然昼夜节律谱的用于时间和速率图案的经皮肤递送褪黑激素的方法。

10. 发明申请

WO0243800A2 DEVICES AND METHODS FOR CONTROLLED DELIVERY FROM A DRUG DELIVERY DEVICE 审中-公开
标题翻译：用于从药物递送装置进行控制的装置和方法
公开(公告)号：WO0243800A2
公开(公告)日：2002-06-06
申请号：PCT/US0143143
申请日：2001-11-21
申请人： DURECT CORP , BROWN JAMES E , CULWELL JOHN , FILICE JAMES A , GILLIS EDWARD M , THEEUWES FELIX , WICKMAN PETER , YUM SU IL
发明人： BROWN JAMES E , CULWELL JOHN , FILICE JAMES A , GILLIS EDWARD M , THEEUWES FELIX , WICKMAN PETER , YUM SU IL
IPC分类号： A61M37/00 , A61K9/00 , A61K9/22 , A61M5/142 , A61M5/168 , A61M5/36 , A61M31/00 , A61M39/00
CPC分类号： A61M5/14276 , A61K9/0004 , A61M5/168 , A61M5/16804 , A61M5/36 , A61M31/002 , A61M2205/0294
摘要： The invention features a plug for use with a drug delivery device, wherein the plug defines an expansion control channel, which accommodates thermal expansion of a formulation in a reservoir of a drug delivery device, and an exit channel. In one embodiment, the plug comprises an inner plug member and an outer plug member, which members define an expansion control channel to facilitate release of entrapped air and to accommodate thermal expansion of formulation from the sealed drug reservoir. The plug further defines an exit channel, and may optionally further comprise a frit positioned within the flow pathway just prior to the delivery outlet, or both.
摘要翻译：本发明的特征在于一种用于药物递送装置的塞子，其中塞子限定扩张控制通道，其适应制剂在药物递送装置的储存器中的热膨胀和出口通道。在一个实施例中，塞子包括内塞构件和外塞构件，这些构件限定了膨胀控制通道，以便于捕获的空气的释放和适应制剂从密封的药物储存器的热膨胀。插头进一步限定出口通道，并且可以任选地进一步包括刚刚在输送出口之前或两者位于流动通道内的玻璃料。

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